Clinical trials: Type 1 Diabetes, completed
Diabetes Mellitus, Type 1
Safety and Efficacy of RT-CGMS in Patients With Type 1 Diabetes Mellitus Treated With an Implantable Pump
To investigate the effectiveness and safety of a Real Time Continuous Glucose Monitoring System (RT-CGMS in a population of patients with type 1 diabetes mellitus treated with insulin through an implanted pump.
- Trial name
- IP_RT-CGMS (NCT00501072)
- Testing
- Real-Time Continuous Glucose monitoring System (RT-CGMS)
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Medical Research Foundation, The Netherlands
Brittle Type I Diabetes Mellitus
Effectiveness of Oral Insulin in Unstable Type 1 Diabetes Patients
The intent of the proposed study is to assess the potential of oral insulin to mitigate diabetic instability and reduce the frequency and severity of hypoglycemic episodes in patients with type 1 diabetes.
- Trial name
- NCT00867594
- Testing
- ORMD 0801
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Hadassah Medical Organization
Type 1 Diabetes
Islet Transplantation Using Campath-1H and Infliximab Induction
Islet transplantation has been investigated as a treatment for Type 1 diabetes mellitus in selected patients with inadequate glucose control despite insulin therapy.
- Trial name
- NCT00175266
- Testing
- alemtuzumab, islet transplant, infliximab
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Alberta
Type 1 Diabetes
Effect of Metformin on Vascular and Mitochondrial Function in Type 1 Diabetes
Insulin resistance (IR) is an important contributor to increased cardiovascular disease risk in type 1 diabetes (T1D). The purpose of this study is to measure the effect of metformin on insulin sensitivity, vascular function and…
- Trial name
- MeT1 (NCT01813929)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Colorado, Denver
1- Microvascular Function, 2-oxidative Stress
Acute and Short-term Chronic Effects of Galvus (Vildagliptin) in Diabetes Type 2 Obese Women
The prevalence of obesity and type 2 diabetes mellitus (T2DM) has increased progressively in the past decades, and consequently, a higher incidence of cardiovascular diseases is observed.
- Conditions
- 1- Microvascular Function, 2-oxidative Stress, 3-inflammation
- Trial name
- NCT01827280
- Testing
- Vildagliptin
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Rio de Janeiro State University
Type 1 Diabetes
Measurement of Glucose/Glycogen Metabolism in Humans Using Magnetic Resonance at 4 or 7 Tesla
The long-range goal of this project is to determine the effects of diabetes and the hypoglycemic consequences of intensive therapy on in vivo brain glucose metabolism in humans.
- Trial name
- Glycogen (NCT00786825)
- Testing
- somatostatin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Type 1 Diabetes, Hypoglycemia
Investigation Into the Effects Upon Brain Response to Change in Circulating Glucose Levels in Diabetes Mellitus
This study is designed to investigate the effects of diabetes mellitus and its treatment upon the body's responses to low blood glucose (blood sugar) levels.
- Trial name
- NCT00580710
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Yale University
Diabetes Mellitus, Type 1
Avoidance of Hyperglycaemia in People With Type 1 Diabetes
This study aims to learn more about avoidance of hyperglycaemia in adults with type 1 diabetes. People who attend a type 1 diabetes clinic will be invited to complete a number of self-report questionnaires and a survey.
- Trial name
- HYPE (NCT04732780)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 253 people
- Sponsor
- Imperial College London
Diabetic Neuropathies
Eye-tracking-based Artificial Intelligence Detects Abnormalities of the Oculomotor System in Type 1 Diabetes
Abnormalities of the oculomotor system may represent an early sign of diabetic neuropathy and are currently poorly studied. The investigators designed an eye-tracking-based test to evaluate the oculomotor function in patients…
- Trial name
- EyekonT1D (NCT04608890)
- Testing
- Eye-tracking video test
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Milan
Diabetes, Diabetes Mellitus, Type 1
Comparison of NN1250 Plus Insulin Aspart With Insulin Detemir Plus Insulin Aspart in Type 1 Diabetes
This trial is conducted in Asia, Europe, Japan and South America. The aim of the trial is to compare the efficacy, safety and tolerability of NN1250 (insulin degludec ([Deg]) with insulin detemir (IDet), both combined with…
- Trial name
- BEGIN™ (NCT01074268)
- Testing
- insulin degludec, insulin detemir, insulin aspart
- Where
- 69 sites in Argentina, Brazil and 6 more
- Volunteers
- 456 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Impact of Introducing Basaglar Insulin to the Treatment Regimen of Youth With Diabetes in Pakistan
This study aimed to determine the effect of introducing Basaglar and insulin pen injection devices on clinical and quality of life (QOL) parameters in children and young adults with type 1 diabetes in Pakistan
- Trial name
- NCT06717191
- Testing
- biosimilar insulin glargine
- Where
- Pakistan
- Volunteers
- 296 people
- Sponsor
- Life for a Child Program, Diabetes Australia
Type 2 Diabetes
A Phase 1/2a Study of the 2S,4R Enantiomer of Ketoconazole in Subjects With Type 2 Diabetes Mellitus
The study is designed to test the safety, tolerability of a newly developed form of ketoconazole (DIO-902) for the treatment of elevated blood sugars in type 2 diabetes.
- Trial name
- NCT00302224
- Testing
- 2S, 4R Ketoconazole (DIO-902)
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- DiObex
Diabetes Mellitus, Type 2
AT278, NovoRapid® and Humulin® R (U500) in Glucose Clamp Study
This is a phase 1, single dose, randomised, double-blind, two-way crossover study to compare ultra-rapid-acting concentrated insulin aspart AT278 (U500/mL) with standard insulin aspart NovoRapid® (U100/mL) in participants with…
- Trial name
- NCT05754424
- Testing
- AT278, NovoRapid, Humulin R 500 UNT/ML Injectable Solution
- Where
- Austria
- Volunteers
- 41 people
- Sponsor
- Arecor Limited
Diabetes, Diabetes Mellitus, Type 1
Post Marketing Surveillance Study of Biphasic Insulin Aspart 30
This study is conducted in Asia. The aim of this study is to review the safety and efficacy of biphasic insulin aspart 30 in post-marketing use.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01536613
- Testing
- biphasic insulin aspart 30
- Where
- South Korea
- Volunteers
- 5,346 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Diabetes Mellitus, Type 1
Safety of Insulin Detemir Produced by a New Process as Measured by Antibody Formation in Subjects With Type 1 Diabetes
The trial was conducted in Germany, The Republic of Macedonia, Russian Federation, Serbia and South Africa. The aim of this trial was to make a safety comparison of insulin detemir produced by a new production method (NN729) with…
- Trial name
- NCT00447382
- Testing
- insulin detemir, insulin aspart
- Where
- 5 sites in Germany, North Macedonia and 3 more
- Volunteers
- 330 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
Evaluation of the Efficacy and Safety of Insulin Detemir Compared With That of NPH Insulin in Subjects With Type 1 Diabetes.
The aim of this trial is to evaluate the efficacy and safety of insulin detemir using the 2400 nmol/mL formulation to optimise dosing in subjects with type 1 diabetes on a basal (once daily)-bolus regimen.
- Trial name
- NCT03220425
- Testing
- Insulin detemir, NPH insulin
- Where
- 93 sites in Australia, Belgium and 8 more
- Volunteers
- 752 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
To Compare the Effects of Non-nutritive Sweeteners Intake in Subjects With T2DM
ABSTRACT Introduction: There is no current data about the effects of non-nutritive sweeteners (NNS) about important factors, such as the energy intake, appetite and its relationship in people with diabetes when tasting sweet.
- Trial name
- NCT03680482
- Testing
- Intervention ingest a 48 mg of sucralose, Intervention ingest a 96 mg of stevia
- Volunteers
- 17 people
- Sponsor
- University of Chile
Type 1 Diabetes
Artificial Pancreas in Pediatric Patients (PEDarPAN)
The purpose of this study is to determine safety, feasibility and efficacy (with respect to sensor- augmented pump therapy) of an Artificial Pancreas (AP) prototype in day and night closed-loop control in children and adolescents…
- Trial name
- PEDarPAN (NCT02620878)
- Testing
- artificial pancreas, sensor augmented pump
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- University of Padova
Type 1 Diabetes Mellitus
Closed Loop Control in Adolescents Using Heart Rate as Exercise Indicator
The purpose of this study is to see if the Artificial Pancreas (AP) Platform can successfully control blood sugar in people with type 1 diabetes mellitus on insulin pump therapy in a hospital setting.
- Trial name
- NCT01945060
- Testing
- heart rate Control to Range System (hrCTR) using DiAs Platform, DiAs Control-to-Range System not informed for heart rate
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Marc Breton
Diabetes Mellitus, Type 1, Healthy Volunteers
A Study to Look at How Safe NNC0268-0965 is in Healthy People and People With Type 1 Diabetes
This study is investigating the safety and tolerability of the new medicine NNC0268-0965 (referred to as insulin 965), its concentrations in the blood and its effect on blood sugar for the treatment of diabetes.
- Trial name
- NCT03965013
- Testing
- NNC0268-0965, insulin glargine
- Where
- Germany
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
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