Clinical trials: Type 1 Diabetes
Type 1 Diabetes
PK/PD Study of Intranasal Insulin in Type I Diabetes
This study is designed to compare the safety and tolerability of two different doses of intranasally administered regular human insulin with those of a single dose of the rapid-acting insulin analog lispro Humalog® after…
- Trial name
- NCT01201278
- Testing
- Insulin, Insulin LISPRO
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hompesch, Marcus, M.D.
Type 1 Diabetes Mellitus
Wireless Innovation for Seniors With Diabetes Mellitus
The primary objective of the study is to determine if CGM can reduce hypoglycemia and improve quality of life in older adults with T1D.
- Trial name
- WISDM (NCT03240432)
- Testing
- Dexcom CGM
- Where
- 22 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus
Optimising Health in Type 1 Diabetes
Type 1 diabetes is an autoimmune condition where circulating immune cells destroy the beta-cells in the pancreas that make insulin, resulting in a degree of insulin deficiency, whereby blood glucose levels rise and diabetes…
- Trial name
- NCT02903615
- Testing
- Novel diet, Standard diet
- Where
- 2 sites in Australia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Garvan Institute of Medical Research
Type 1 Diabetes
An Outpatient Pump Shutoff Pilot Feasibility and Safety Study
The purpose of this study is to evaluate an overnight system that will turn off the insulin pump automatically if the system predicts that a low blood sugar is likely.
- Trial name
- PSO1 (NCT01736930)
- Testing
- Pump suspension
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Jaeb Center for Health Research
Hypertension, Diabetes Mellitus, Type 1
Community Models for Hypertension and Diabetes Care for Refugees
The project will investigate and improve a community health worker (CHW) based model for non-communicable disease (NCD) care in a humanitarian emergency.
- Conditions
- Hypertension, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Comorbidities and Coexisting Conditions
- Trial name
- NCT04229667
- Testing
- Improved Community Health Volunteer (CHV) program
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- International Rescue Committee
Type 1 Diabetes
Pharmacokinetic and Injection Site Toleration of BIOD-238 and BIOD-250 Compared to Humalog® in Subjects With Type 1 Diabetes
A Double-blind Study of the Pharmacokinetic Properties of BIOD-238 and BIOD-250 Compared to Humalog® in Subjects with Type 1 Diabetes
- Trial name
- NCT01811849
- Testing
- Insulin LISPRO
- Volunteers
- 12 people
- Sponsor
- Biodel
Telemedicine, Insulin Dependent Diabetes Mellitus 1
Effectiveness of Video Consultations in Type 1 Diabetes Patients Treated With Insulin Pumps in the Outpatient Clinic
Telemedicine is a solution to overcome distance and ensure the provision of healthcare services. This study aims to investigate the effects of conducting outpatient clinic visits remotely, for patients living with insulin pumps.
- Trial name
- NCT04612933
- Testing
- Intervention group video consultations
- Where
- Denmark
- Volunteers
- 76 people
- Sponsor
- University of Southern Denmark
Type 1 Diabetes, Adolescent Development
Emoticare: Serious Game for the Adaptation to the Disease of Adolescents With Type 1 Diabetes Mellitus.
The intervention program targets adolescents with chronic Type 1 Diabetes Mellitus. Given the critical developmental stage and life transitions, necessitating robust personal resources, psychological support becomes imperative.
- Trial name
- NCT06331429
- Testing
- EmoTiCare
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- University of Valencia
Diabetic Children
Prevalence and Factors Associated With Pancreatic Enzyme Elevations Among Diabetic Children
Acute pancreatitis was reported as a DKA associated complication. The true incidence and clinical significance of pancreatitis in children with DKA is unclear.
- Trial name
- NCT05392166
- Testing
- blood glucose, blood gases, serum electrolytes, HbA1c, complete blood count and serum creatinine. Serum calcium, serum amylase, serum lipase and serum triglycerides , abdominal ultrasound
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Diabetes Mellitus, Diabetes Mellitus, Type 1
An Open-Label, FIH Study Evaluating the Safety and Tolerability of VCTX210A Combination Product in Subjects With T1D
This is an open-label, multicenter, Phase 1 study evaluating the safety and tolerability of VCTX210A combination product in patients with T1D
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- NCT05210530
- Testing
- VCTX210A unit
- Where
- 3 sites in Canada
- Volunteers
- 7 people
- Sponsor
- CRISPR Therapeutics AG
Type 1 Diabetes
Gene-virus Interactions Implicated in Type 1 Diabetes
Type 1 diabetes (T1D) is the most common endocrine disorder in children. In France, T1D prevalence is estimated to 12.2 per 100 000. Worldwide T1D incidence increased rapidly in the last decades, around 3% per year.
- Trial name
- GENEVIR (NCT02804165)
- Testing
- Enterovirus vaccination
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Type 1 Diabetes
Study for the Artificial Pancreas Project : Determination of a Tuning Strategy of Metabolic Profiles
The Artificial Pancreas Project developed by SUPELEC and the University Hospital of Rennes is focused on the evaluation of an original control algorithm that computes appropriate subcutaneous insulin infusion in response to…
- Trial name
- NCT01282567
- Testing
- Blood samples
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Rennes University Hospital
Diabetes
Automated Insulin Delivery Amongst Pregnant Women With Type 1 Diabetes
Evaluation of the biomedical and psychosocial impact of automated Closed-Loop (Artificial Pancreas) insulin delivery in women with type 1 diabetes during pregnancy
- Trial name
- AiDAPT (NCT04938557)
- Testing
- Automated closed-loop insulin delivery (AiD), A standard insulin delivery system
- Where
- United Kingdom
- Volunteers
- 124 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Diabetes Mellitus
Single Ascending Dose Trial in Patients With Type 2 Diabetes
The purpose of this study is to determine whether AMG 876 is safe and well tolerated in subjects with type 2 diabetes.
- Trial name
- NCT01492465
- Testing
- AMG 876
- Where
- 3 sites in United States
- Volunteers
- 47 people
- Sponsor
- Amgen
Diabetes Mellitus, Type 1
Influence of the Phases of the Menstrual Cycle on Glycemic Control When Performing Aerobic Exercise in Women With T1D
This study corresponds to Task 8.1 of the project "Patient-tailored solutions for blood glucose control in type 1 diabetes- TAILOR" (PID2019-107722RB-C21).
- Trial name
- TAILOR/1a (NCT06086067)
- Testing
- Aerobic session
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- University of Valencia
Type 2 Diabetes Mellitus
Study of Multiple Oral Doses of PF-07081532 in Adult Participants With Type 2 Diabetes Mellitus
This is a Phase 1, randomized, placebo-controlled, double-blind (investigator- and participant-blinded), sponsor-open study of PF-07081532.
- Trial name
- NCT05158244
- Testing
- PF-07081532
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Pfizer
Diabetes
Improved Glycemic Control in Adult Subjects With Type 1 Diabetes on MDI Using Insulin Guidance Software
140 subjects will be enrolled into the clinical study and randomized into the Control Group or the Experimental Group by block randomization. The subjects must meet all inclusion and none of the exclusion criteria.
- Trial name
- NCT00552734
- Testing
- Insulin Guidance Software
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
Efficacy of Extracorporeal Photopheresis (ECP) in the Treatment of Type 1 Diabetes Mellitus
OPERA Study is a randomized, open-label, prospective, pilot, and a monocentric clinical trial involving outpatients within Abu Dhabi Stem Cells Center (ADSCC) with a confirmed diagnosis of type 1 diabetes mellitus (T1DM).
- Trial name
- OPERA (NCT05413005)
- Testing
- ECP regular-intensity arm, ECP accelerated-intensity arm, T1DM standard of care
- Where
- United Arab Emirates
- Volunteers
- 10 people
- Sponsor
- Abu Dhabi Stem Cells Center
Type 1 Diabetes Mellitus, Stage 2 Type 1 Diabetes
Information, Follow-up and Early Diagnosis of Children at Risk for Type 1 Diabetes
The aim is to investigate whether screening for islet autoantibodies, regular follow-up, and increased knowledge in families about the progression of the disease in children at high genetic risk or with single or multiple islet…
- Conditions
- Type 1 Diabetes Mellitus, Stage 2 Type 1 Diabetes, Stage 1 Type 1 Diabetes, Stage 3 Type 1 Diabetes
- Trial name
- iT1D (NCT06676566)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Lund University
Esophageal Squamous Cell Carcinoma
Cadonilimab/Anlotinib in Locally Advanced or Relapsed/Metastatic ESCC Patients After Failure of PD-1 Combined With Platinum-containing Chemotherapy
Advanced esophageal squamous cell carcinoma patients who have failed first-line PD-1 inhibitor combined with chemotherapy lack a standard treatment option.
- Trial name
- NCT05990231
- Testing
- Cadonilimab combined Anlotinib
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine