Clinical trials: Type 1 Diabetes, completed
Type 1 Diabetes, Hypoglycemia Unawareness
Naltrexone and Hypoglycemia in Type 1 Diabetes
Low blood sugar is also called hypoglycemia. Usually, it is mild and can be treated quickly and easily by eating or drinking a small amount of a sugar-rich food.
- Trial name
- Naltrexone (NCT01053078)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Diabetes, Diabetes Mellitus, Type 1
Observational Study to Evaluate the Safety of Levemir® in Diabetes
This observational study is conducted in North America. The aim of this observational study is to evaluate the incidence of adverse events while using Levemir® under normal clinical practice conditions.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- PREDICTIVE™ (NCT00706017)
- Testing
- insulin detemir
- Where
- Mexico
- Volunteers
- 2,282 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Closing the Loop in People with Type 1 Diabetes
The main objective of this study is to determine whether home use of fully closed-loop glucose control applying age-approved ultra-rapid insulin (Phase 2) is superior to standard insulin pump therapy with continuous glucose…
- Trial name
- CLEAR Phase 2 (NCT05653050)
- Testing
- CamAPS HX, Standard insulin pump therapy with CGM
- Where
- 4 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Cambridge
Hypertension, Cardiovascular Diseases
OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study
The purpose of this study is to investigate whether high-dose angiotensin II receptor blocker (ARB) monotherapy or combination therapy with ARB and calcium channel blockers is more effective in reducing the incidence of…
- Trial name
- NCT00134160
- Testing
- Olmesartan medoxomil, Calcium channel blockers (amlodipine, azelnidipine)
- Where
- 2 sites in Japan
- Volunteers
- 1,000 people
- Sponsor
- OSCAR Study
Type 1 Diabetes
Outpatient Automated Blood Glucose Control With a Bi-hormonal Bionic Endocrine Pancreas
This study will test the hypothesis that a wearable automated bionic pancreas system that automatically delivers both insulin and glucagon can improved glycemic control vs. usual in the outpatient environment.
- Trial name
- NCT01762059
- Testing
- Bi-homonal Bionic Pancreas, Usual care
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Type 1
Safety and Efficacy of Empagliflozin (BI 10773) in Type 1 Diabetes Mellitus Patients With or Without Renal Hyperfiltration
This open-label study aims to evaluate the impact of BI 10773 treatment on glomerular filtration rate under controlled conditions of euglycaemia and hyperglycaemia in subjects with type 1 diabetes mellitus with or without renal…
- Trial name
- NCT01392560
- Testing
- BI 10773
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- Boehringer Ingelheim
Type1diabetes
The Effect of Bolus Speed of Rapid-Acting Insulin Analog Absorption and Action in Individuals With Type 1 Diabetes
Rapid Action Insulin (RAI) absorption and action measured by time to reach maximum insulin concentration and glucose infusion rate.
- Trial name
- NCT03542682
- Testing
- Quick Bolus, Standard Bolus
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Yale University
Type1diabetes
Clinical Trial to Evaluate the Efficacy of the Smart Insulin Pen Compared to a Closed Loop System in Patients With Type 1 Diabetes (EBIACE-1)
Analysis of glycemic control, frequency of hypoglycemia, glycemic variability, patient satisfaction and patient-perceived quality of life in patients with type 1 diabetes mellitus and continuous real-time glucose monitoring, the…
- Trial name
- EBIACE-1 (NCT05708040)
- Testing
- InPen Medtronic, Minimed 780G system
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Diabetes Mellitus, Type 2
Efficacy and Safety of B I1356 (Linagliptin) vs. Placebo Added to Metformin Background Therapy in Patients With Type 2 Diabetes
The objective of the current study is to investigate the efficacy, safety and tolerability of BI 1356 (5 mg once daily) compared to placebo given for 24 weeks as add-on therapy to metformin in patients with type 2 diabetes…
- Trial name
- NCT00601250
- Testing
- linagliptin
- Where
- 82 sites in United States, Czechia and 8 more
- Volunteers
- 701 people
- Sponsor
- Boehringer Ingelheim
Diabetes Type 1, Endothelial Dysfunction
Cardiovascular Risk Factors After Single Pancreas Transplantation
Patients accepted for the waiting list for single pancreas transplantation suffer from severe glucose instability with hyperglycemia due to diabetes type 1, but do not have significant diabetes-related complications.
- Trial name
- Diamant (NCT02066350)
- Testing
- Single pancreas transplantation
- Where
- Norway
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Type1diabetes
Gluten and Amylase Trypsin Inhibitors (ATI) Free Diet
Siblings of those with type 1 diabetes are at an increased risk of developing the disease themselves. Through prior research, the investigators have found that siblings as well as those with type 1 diabetes have a general level…
- Trial name
- NCT03443180
- Testing
- Gluten and Amylase Trypsin Inhibitors (ATI)-free diet
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Type 1 Diabetes Mellitus, Vitamin D Deficiency
Vitamin D Supplementation and Glycemic Control Improvement Among Type 1 Diabetic Children
Type 1 diabetes mellitus (T1DM) is an immune-mediated disease characterized by diminished insulin secretion due to damage to islets of Langerhans in the pancreas, which eventually results in high levels of glucose in the blood.
- Trial name
- NCT05141968
- Testing
- vitamin D supplements (2000 IU/day)
- Where
- Palestinian Territories
- Volunteers
- 80 people
- Sponsor
- Al-Azhar University
Diabetes Mellitus Type 1
Comparison of the Management of Post-prandial Hyperglycemia by Multiple Bolus Calculators
This prospective, non-randomized, non-controlled, interventional study will determine whether the Roche automated bolus caclulator (ABC) reduces post-meal hyperglycemia better than the competitor's ABC without causing significant…
- Trial name
- NCT01050868
- Testing
- Accu-Chek Combo Kit mg DE/de
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Hoffmann-La Roche
Diabetes Mellitus, Type 1, Adrenal Insufficiency
Hypoglycaemia (Low Blood Sugar) in Adults With Diabetes and Adrenal Failure
The purpose of this study is to measure how often low blood sugars occur in people who live with both adrenal insufficiency (AI) and diabetes and need to take insulin.
- Conditions
- Diabetes Mellitus, Type 1, Adrenal Insufficiency, Diabetes Mellitus Type 2 - Insulin-Treated
- Trial name
- HYPO-DIAD (NCT05806190)
- Testing
- Continuous Glucose Monitoring
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Imperial College Healthcare NHS Trust
Type 1 Diabetes, Type 2 Diabetes
Accuracy Comparison of Two CGMs in Hospitalized Patients
The purpose of the study is to determine the accuracy of two different continuous blood sugar monitoring systems in hospitalized patients by comparing them standard laboratory blood sugar testing in the hospital.
- Trial name
- NCT05081817
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Diego
Type 1 Diabetes
Use of an Automated Insulin Delivery System Compared to Sensor Augmented Pump at Patients With Type 1 Diabetes (T1D)
Title: An open-label, three-center, randomized, cross-over study to evaluate the safety and efficacy of day and night closed-loop control using the MD-Logic automated insulin delivery system compared to sensor augmented pump…
- Trial name
- DREAM5 (NCT02636491)
- Testing
- MD-Logic-Automated Insulin Delivery System, MiniMed Paradigm® Veo™ System
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Type 1 Diabetes Mellitus
TEDDY - The Environmental Determinants of Diabetes in the Young
The long-term goal of the TEDDY study is the identification of infectious agents, dietary factors, or other environmental agents, including psychosocial factors which trigger T1DM in genetically susceptible individuals or which…
- Trial name
- NCT00279318
- Where
- 7 sites in United States, Finland and 2 more
- Volunteers
- 8,667 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes, Diabetes Mellitus, Type 1
A Survey to Evaluate Diabetes Management, Control, Chronic Complications, Psychosocial Aspects of Diabetic Subjects in Singapore
This study is conducted in Asia. The aim of this observational study is to evaluate current status of diabetes management, control and complications in diabetic subjects in Asia.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- DiabCare Asia (NCT00836030)
- Testing
- No treatment given
- Where
- Singapore
- Volunteers
- 854 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
A Study on the Effect of 2 Pen Devices on HbA1c
The purpose of this study is to test the hypothesis that the HumaPen Memoir with memory function, when used over 24 weeks for prandial insulin injections achieves superior glycemic control, when compared to the conventional…
- Trial name
- NCT00985712
- Testing
- Insulin Lispro, Huminsulin Regular, HumaPen Memoir
- Where
- 29 sites in Germany
- Volunteers
- 263 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetic Nephropathy
Resveratol in Diabetic Nephropathy
Background: Food-derived compounds have been shown to have beneficial effects in type 1 diabetes mellitus (T1DM). Among these compounds, resveratrol (3,5,4'-trihydroxystilbene) which is found in grapes, peanuts, cranberries.
- Trial name
- NCT07332819
- Testing
- Resveratol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
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