Clinical trials: Type 1 Diabetes
Metabolic Acidosis, Diabetic Ketoacidosis
Diabetic Ketoacidosis Diagnosis and Management
This is the first and only study conducted on the use of capnography in children diagnosed with DKA to evaluate the initial clinical grading of DKA, monitor clinical improvement, and predict complications such as brain edema.
- Conditions
- Metabolic Acidosis, Diabetic Ketoacidosis, Brain Edema
- Trial name
- NCT06327737
- Testing
- Capnography
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Akdeniz University
Diabetes Mellitus, Type 1
Insulin-plus-pramlintide Closed-loop Strategy to Regulate Glucose Levels Without Carbohydrate Counting
Closed-loop system systems that are shown to alleviate the burden of carbohydrate counting without degrading glucose control are still lacking.
- Trial name
- Dual (NCT03800875)
- Testing
- 27-hour inpatient intervention
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McGill University
Type1diabetes
The Current Health Status of Patients Living With Type 1 Diabetes From the LMC Diabetes Patient Registry
This retrospective study uses the Canadian LMC Diabetes Registry to describe the current health status of Canadians with type 1 diabetes.
- Trial name
- NCT04162067
- Where
- Canada
- Volunteers
- 3,600 people
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Type 1 Diabetes Mellitus, Glycemic Variability
Impact of Dietary Fat and Menstrual Cycle Phases in Type 1 Diabetes
This clinical trial aims to evaluate how variations in dietary fat content and hormonal status influence postprandial glycemic response in individuals with type 1 diabetes (T1D), with a special focus on women.
- Conditions
- Type 1 Diabetes Mellitus, Glycemic Variability, Sex Characteristics, Menstrual Cycle
- Trial name
- DIABETEXX/3 (NCT07278063)
- Testing
- Low Fat Mixed Meal, High Fat Mixed Meal
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Type 1 Diabetes
Treatment of Hypoglycemia in Type 1 Diabetes
According to guidelines, when a mild-to-moderate hypoglycemia occurs (capillary blood glucose < 4.0 mmol/L), 15-20g of rapidly absorbed carbohydrates should be ingested.
- Trial name
- NCT03489967
- Testing
- Induced-hypoglycemia test
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Weight Loss
VK2735 for Weight Management Phase 3
This is a phase 3, multicenter, 78-week randomized, double-blind, placebo-controlled, parallel arm study that will evaluate the weight loss efficacy as well as safety, tolerability, pharmacodynamic effects, and pharmacokinetics…
- Trial name
- VANQUISH 1 (NCT07104500)
- Testing
- VK2735
- Where
- 137 sites in United States, Puerto Rico
- Volunteers
- 4,500 people
- Sponsor
- Viking Therapeutics, Inc.
Type 1 Diabetes
Patients Perceptions of Using the "Libre" System Compared With Conventional SMBG in Adolescents With Type 1 Diabetes The Libre Sat Trial
The Libre- flash glucose monitoring system is an episodic real-time data on demand device. This means that patients can measure their glucose level when they choose by scanning the device, while at the same time a sensor…
- Trial name
- NCT02776007
- Testing
- Libre Flash CGMS, Self-Measurement Blood Glucose
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
Type 1 Diabetes
CSII in Type 1 Diabetes: Diet, Quality of Life & Cardiometabolic Risks - A Longitudinal Study
Glycaemic control is an important aspect of Type 1 diabetes (T1D) management for diabetologists and patients alike. Evidence suggests continuous subcutaneous insulin infusion (CSII) is an effective method of achieving this.
- Trial name
- NCT02258932
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Liverpool John Moores University
Insulin Dependent Diabetes Mellitus, Feeding and Eating Disorders
The diabEAT Study: Insulin dElivery Technologies And eaTing Behaviours in People With Type 1 Diabetes
Type 1 diabetes is an autoimmune health condition that requires daily injections of insulin. Insulin allows the body to use energy from carbohydrates in food.
- Conditions
- Insulin Dependent Diabetes Mellitus, Feeding and Eating Disorders, Eating Behavior, Type 1 Diabetes
- Trial name
- NCT07348432
- Testing
- Automated Insulin Delivery (AID) Systems, Carbohydrate Counting Inaccuracy Percentage
- Where
- Canada
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- McGill University
Type 1 Diabetes Mellitus
Verapamil for Beta Cell Survival Therapy in Type 1 Diabetes
The overall purpose of this trial is to assess the efficacy and safety of using oral verapamil in subjects with recent onset T1D in order to downregulate TXNIP and enhance the patients' endogenous beta cell mass and insulin…
- Trial name
- NCT02372253
- Testing
- Verapamil
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Alabama at Birmingham
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Post-marketing Surveillance (Special Use-results Surveillance) on Long-term Use With Tresiba®
This study is conducted in Asia. The aim of this post marketing surveillance (PMS) is to assess safety and effectiveness of long-term treatment with Tresiba® (insulin degludec) in patients with diabetes mellitus requiring insulin…
- Trial name
- NCT01984372
- Testing
- insulin degludec
- Where
- Japan
- Volunteers
- 6,163 people
- Sponsor
- Novo Nordisk A/S
Type One Diabetes Mellitus
Evaluation of a Mobile Application Designed to Support Type 1 Diabetic Patients in Adjusting Their Insulin Doses.
Title: Evaluating a Mobile Application for Insulin Management in Iraqi Type 1 Diabetes Patients. The goal of this clinical trial is to determine whether a mobile health application can improve insulin management and blood sugar…
- Trial name
- NCT07234500
- Testing
- mHealth Mobile Application, Standard Care (in control arm)
- Where
- Iraq
- Volunteers
- 50 people
- Sponsor
- University of Baghdad
End-Stage Renal Disease (ESRD) Chronic Kidney Disease, Stage 5 Renal Regeneration Anuria Diabetic Nephropathy, Anuria
Clinical Observation of Renal Function Reactivation Following a GRAS-Based Protocol in Patients With Chronic Kidney Disease and Long-Term Renal Arrest.
This observational study documents the impact of a specific oral protocol (based on FDA-GRAS ingredients) on patients with Stage 5 Chronic Kidney Disease (CKD).
- Conditions
- End-Stage Renal Disease (ESRD) Chronic Kidney Disease, Stage 5 Renal Regeneration Anuria Diabetic Nephropathy, Anuria, End-Stage Renal Disease (ESRD), Chronic Kidney Disease, Stage 5
- Trial name
- NCT07555327
- Testing
- CSR-CKD Oral Protocol
- Where
- Algeria
- Volunteers
- 8 people
- Sponsor
- Amar h Zireg
Diabetes Mellitus Type 1, Glucose Metabolism Disorder
Real-life Follow-up of the Physical Activity in Type 1 Diabetes Participants Equipped With an Insulin Pump With Hybrid Closed Loop
This is a non-interventional, prospective, multi-site study conducted in France among adults with type 1 diabetes mellitus using automated insulin delivery (AID) systems and engaging in at least two exercise sessions per week…
- Conditions
- Diabetes Mellitus Type 1, Glucose Metabolism Disorder, Glycemic Control for Diabetes Mellitus, Fear of Hypoglycemia
- Trial name
- RAPPID (NCT07015970)
- Testing
- No Intervention: Observational Cohort
- Where
- 4 sites in France
- Volunteers
- 87 people
- Sponsor
- ISIS Diabete Service
Type 1 Diabetes Mellitis, Celiac Disease
Metabolic Control and Glycemic Variability in Type 1 Diabetes and Celiac Disease
This is an observational, retrospective study focused on differences of time-in-range and glycemic variability between a cohort of patients with both type 1 diabetes and celiac disease, and a cohort of patients with only type 1…
- Trial name
- NCT06717841
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Diabetes, Diabetes Mellitus, Type 1
Investigating the Safety and Effectiveness of Insulin Degludec in a Real World Population With Type 1 and 2 Diabetes Mellitus
This study is conducted in Europe. The aim of this non-interventional study is to investigate the safety and effectiveness of insulin degludec (Tresiba®) in a real world population with type 1 (T1DM) and 2 (T2DM) diabetes…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- ReFLeCT (NCT02392117)
- Testing
- insulin degludec
- Where
- 8 sites in Denmark, Germany and 6 more
- Volunteers
- 1,262 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Type 2 Diabetes (T2DM)
CGM Use in Non-insulin Patients With DM2
The U.S. Food and Drug Administration (FDA) has approved multiple Continuous Glucose Monitoring (CGM) devices from different manufacturers to be used as an aide in patients with type 1 and type 2 diabetes who require medications…
- Conditions
- Diabetes, Type 2 Diabetes (T2DM), Obesity Type 2 Diabetes Mellitus, Non Insulin Dependent Diabetes Mellitus
- Trial name
- CGM-DWI (NCT07128342)
- Testing
- CGM Group, FSBG group
- Volunteers
- 100 people
- Sponsor
- Milwaukee VA Medical Center
Diabetes Mellitus Type I, Hypoglycemia
Intracellular Counter-regulatory Mechanisms Following Low Blood Glucose
Diabetes mellitus type I (DMI) is characterized by lack of endogenous insulin and these patients are 100% dependent on insulin substitution to survive.
- Trial name
- NCT01919788
- Testing
- Insulin (Insuman Rapid), Glucose, Saline
- Where
- Denmark
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Type 1 Diabetes
Screening For Social Determinants Of Health In Routine Diabetes Care
Social determinants of health (SDOH) exert a powerful influence on the everyday management of type 1 diabetes (T1D) and short and long term outcomes of T1D.
- Trial name
- SDOH (NCT07706803)
- Testing
- Social Determinants of Health (SDOH) Screening and Referral
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, Los Angeles
Type 1 Diabetes Mellitus
User Performance and System Accuracy Evaluations Using Glucose Adjustment
This is an open-label, non-randomised pilot study, to evaluate user performance and system accuracy in blood Glucose monitoring system with glucose adjustment.
- Trial name
- NCT02374879
- Testing
- Blood Glucose Monitoring Systems.
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- LifeScan