Clinical trials: Type 1 Diabetes, completed
Diabetes Mellitus, Type 1
A Study of SIMPONI® to Arrest Beta-cell Loss in Type 1 Diabetes
The primary purpose of this study is to determine if golimumab can preserve beta-cell function in children and young adults with newly diagnosed Type 1 Diabetes (T1D).
- Trial name
- T1GER (NCT02846545)
- Testing
- Golimumab
- Where
- 33 sites in United States
- Volunteers
- 84 people
- Sponsor
- Janssen Research & Development, LLC
Type 1 Diabetes, Sleep Apnea Syndrome
Sleep Apnea in Type 1 Diabetes
Sleep apnea syndrome is strongly associated to type 2 diabet, partly and this is partly due to obesity. Treatment of sleep apnea may improve hypertension, cardiovascular risk and in some studies diabetes status.
- Trial name
- DIASOM (NCT01935765)
- Testing
- Polysomnography, Evaluation of the autonomous nervous system, Clinical examination of the sleep
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Type II
GOLO Open-Label Pilot 1
The objective of this open-label pilot study is to evaluate the effect of the commercially available GOLO for Life (GFL) weight management program on body weight in a type 2 diabetic patient population after approximately 3…
- Trial name
- NCT03478202
- Testing
- GOLO RELEASE
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Golo
Type 1 Diabetes Mellitus
Structured Carbohydrate-Counting Education in Adults With Type 1 Diabetes
This study evaluated changes in glycemic outcomes following a structured carbohydrate-counting education program in adults with type 1 diabetes using continuous glucose monitoring (CGM).
- Trial name
- NCT07834801
- Testing
- Carbohydrate counting education
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Acibadem University
Diabetes Mellitus, Type 1
Improving Control and Reducing the Risk of Hypoglycemic Episodes in Type 1 Diabetes
The purpose of this study is to test two newly developed computer programs, Integrated Biobehavioral Monitoring and Feedback (IBMF) IBMF-1 and IBMF-2. The computer programs are considered experimental.
- Trial name
- BPK002 (NCT00315939)
- Testing
- Integrated Biobehavioral Monitoring & Feedback - 1 (IBMF-1), Integrated Biobehavioral Monitoring & Feedback - 2 (IBMF-2)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Boris Kovatchev, PhD
Type 1 Diabetes Mellitus, Continuous Glucose Monitor
Web-Based Intervention Designed to Educate and Improve Adherence Through Learning to Use Continuous Glucose Monitoring
The goal of this pilot study is to produce a high-quality, theory-driven, therapeutic, web-based intervention that provides extended training and peer support to adolescents and young adults with type 1 diabetes who are newly…
- Trial name
- IDEAL CGM (NCT03367351)
- Testing
- Web-Based Education, Social Support, Standard of Care
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Type 1 Diabetes
Two Way Crossover Closed Loop MPC vs Control IQ
An artificial pancreas (AP) is a control system for automatic insulin delivery. The investigators have implemented a missed meal bolus detection algorithm for use within an AP control system.
- Trial name
- NCT05799781
- Testing
- MPC closed-loop system, t:slim X2 pump with Dexcom G6 CGM and Control IQ
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes, Hypoglycemia Associated Autonomic Failure
Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus (DM)
Exercise is a cornerstone of diabetes management. It helps reduce blood pressure, promote weight loss, lower insulin resistance and improve glucose and lipid (triglyceride and HDL-cholesterol) profiles.
- Trial name
- NCT01672255
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Diabetes Mellitus, Type 1
Omega-3 Fatty Acids Supplementation Improves Early-stage Diabetic Nephropathy and Subclinical Atherosclerosis in Pediatric Patients With Type 1 Diabetes
The investigators conducted this randomized-controlled trial to assess the effect of oral omega-3 supplementation on glycemic control, lipid profile, albuminuria level, kidney injury molecule-1 (KIM-1) and carotid intima media…
- Trial name
- NCT05980026
- Testing
- oral omega-3 fatty acids supplementation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Type 1 Diabetes Mellitus
Insulet Artificial Pancreas Evaluating Meal Performance and Moderate Exercise (IDE2)
To assess the safety and performance of the Insulet AP (artificial pancreas) system, using the Omnipod® insulin management system, Dexcom G4 Share® AP System and personalized model predictive control algorithm in adults with type…
- Trial name
- IDE2 (NCT03064906)
- Testing
- Insulet AP (artificial pancreas) System
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Insulet Corporation
Type 1 Diabetes
A Euglycemic Insulin Clamp Study in Type 1 Diabetic Patients With Oral Insulin (ORAMED)
ORAMED has developed an oral insulin that, in preliminary studies, has shown promise. In the present study investigators will perform a pharmacodynamic/pharmacokinetic study to evaluate this novel insulin preparation as a…
- Trial name
- NCT02535715
- Testing
- ORMD-0801 capsules- 2x8mg, ORMD-0801 capsules- 3x8mg, ORMD-0801 capsules- 1x16mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Type 2 Diabetes, Nephropathy
A Research Study to Evaluate the Renal (Kidney) Protective Effects of Losartan in Patients With Non-insulin Dependent Diabetes (0954-147)(COMPLETED)
Evaluate the effect of Losartan in reducing kidney disease in patients with Non-insulin Dependent Diabetes and Nephropathy (kidney damage that usually accompanies late stage Diabetes Mellitus).
- Trial name
- NCT00308347
- Testing
- MK0954, losartan / Duration of Treatment: mean 3.4 years
- Volunteers
- 1,513 people
- Sponsor
- Organon and Co
Type 1 Diabetes Mellitus, Exercise
Impact of Physical Activity on Blood Glucose Stability and Energy Stores in Individuals With Type 1 Diabetes
Whereas physical activity clearly results in improvements in glycemic control in type 2 diabetes, in individuals with type 1 diabetes (T1DM) the impact of exercise on blood sugar control is more complex.
- Conditions
- Type 1 Diabetes Mellitus, Exercise, Hypoglycemia, Carbohydrate Metabolism
- Trial name
- CARBEX1 (NCT02068638)
- Testing
- IHE first, CONT second, CONT first, IHE second, GLU first, GLU-FRU second
- Where
- Switzerland
- Volunteers
- 27 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Type1diabetes
Safety of Closed-loop Hybrid Insulin Administration During Ramadan Fasting in People Living With Type 1 Diabetes
Fasting in Ramadan is not recommended for people with type 1 diabetes. The main risk associated with fasting is dysglycemia (hypoglycemia, hyperglycemia, diabetic ketosis) and dehydration.
- Trial name
- RAMDAM (NCT05747352)
- Testing
- closed-loop hybrid insulin administration
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Sud Francilien
Type 1 Diabetes
Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Q.3
It has been found that in some cases, when a person with Diabetes Mellitus has an episode of low blood sugar,or hypoglycemia, and then later exercises, he or she is vulnerable to another bout of hypoglycemia during that exercise.
- Trial name
- NCT00742521
- Testing
- glucose clamp
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Vanderbilt University
Type 1 Diabetes
Coin2Dose: Behavioral Economics to Promote Insulin BOLUS Activity and Improve HbA1c in Teens
Our objective is to test the feasibility, acceptability, and initial efficacy of using behavioral economics incentives (BEI) in a novel, semi-automated intervention to target daily insulin BOLUS scores in adolescents with…
- Trial name
- Coin2Dose (NCT05280184)
- Testing
- Coin2Dose
- Where
- 2 sites in United States
- Volunteers
- 173 people
- Sponsor
- Nemours Children's Clinic
Type 1 Diabetes Mellitus
Nerve Conduction Velocity in Diabetic Children
The investigators intend to study children and adolescents from 8 to 18 years suffering from diabetes mellitus type 1 for more than one year.
- Trial name
- NCT01017718
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Landeskrankenhaus Feldkirch
Type 1 Diabetes
Bone Marrow vs Liver as Site for Islet Transplantation
The goal of this study is to evaluate safety and efficacy of bone marrow (BM) as site for pancreatic islet transplantationin humans.
- Trial name
- IsletBOM2 (NCT01722682)
- Testing
- Human pancreatic islet transplantation
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- Ospedale San Raffaele
Diabetic Kidney Disease, Diabetic Nephropathy
Effect of LIXIsenatide on the Renal System
Based on preclinical and small-sized studies in non-diabetic individuals, incretin-based therapies, i.e. glucagon-like peptide (GLP)-1 receptor agonists and dipeptidyl peptidase-4 inhibitors, may hold promise in preventing the…
- Conditions
- Diabetic Kidney Disease, Diabetic Nephropathy, Diabetes Mellitus, Glucagon-Like Peptide 1
- Trial name
- ELIXIRS (NCT02276196)
- Testing
- Lixisenatide, Insulin glulisine
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc
Diabetes Mellitus, Type 1, Child, Only
The Effect of Animated Movies and Storybooks on Fear and Anxiety Levels in Children With Type 1 Diabetes
This study aims to evaluate the effects of animated films and story books on the fear and anxiety levels of children with newly diagnosed type 1 diabetes.
- Conditions
- Diabetes Mellitus, Type 1, Child, Only, Anxiety, Fear
- Trial name
- NCT06350513
- Testing
- Animation movie, story book
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Selverhan Yurttutan
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