Clinical trials: Type 1 Diabetes, completed
Hypoglycemia, Diabetes Mellitus
Hippocampal Metabolism and Function in Patients With Type 1 Diabetes
The hippocampus is an area of brain which plays an essential role in learning and memory processing and is thought to be particularly vulnerable to effects of hypoglycemia (low blood glucose).
- Trial name
- NCT01852968
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Type 1 Diabetes (T1D), Islet Transplantation
Extended Follow-Up After Islet Transplantation in T1D
The purpose of this study is to provide patients who have received at least one islet transplant as a previous participant in a Clinical Islet Transplantation Consortium (CIT) clinical trial with maintenance immunosuppressive…
- Trial name
- NCT01369082
- Testing
- Maintenance Immunosuppressive Treatment
- Where
- 8 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type 1
Optimizing Closed-Loop Control of Type 1 Diabetes Mellitus in Adolescents
The purpose of this study is to use a closed-loop Control-to-Range (CTR) system in adolescents with type 1 diabetes in an outpatient setting, and to evaluate the CTR system's ability to significantly improve blood glucose levels…
- Trial name
- NCT01890954
- Testing
- Diabetes Assistant (DiAs)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Virginia
Type 1 Diabetes, Type 2 Diabetes
Adult Accuracy Study of the Enlite 3 Glucose Sensor
The purpose of this study is to demonstrate the performance of the Enlite 3 Sensor over 168 hours (7 days) when inserted in the abdomen and used with the Guardian Mobile App and 640G Pump in subjects aged 14-75 years with type 1…
- Trial name
- E3 (NCT02246582)
- Testing
- Enlite 3, Guardian Mobile App, 640G Insulin Pump
- Where
- 6 sites in United States
- Volunteers
- 118 people
- Sponsor
- Medtronic MiniMed, Inc.
Diabetes Mellitus, Type 2
4 Weeks Treatment With Empagliflozin (BI 10773) in Japanese Type 2 Diabetic Patients (T2DM)
The objective of this trial is to evaluate the pharmacodynamics, pharmacokinetics, safety, and tolerability of once daily oral administration of BI 10773 administered for 28 days in Japanese patients with T2DM.
- Trial name
- NCT00885118
- Testing
- BI 10773
- Where
- 5 sites in Japan
- Volunteers
- 100 people
- Sponsor
- Boehringer Ingelheim
Type 1 Diabetes
Effects of Low-calorie Sweetened Beverage Restriction in Youth With Type 1 Diabetes
This study will investigate whether low-calorie sweeteners (LCS) are helpful or harmful for preventing diabetes complications among children with Type 1 Diabetes (T1D).
- Trial name
- NCT04385888
- Testing
- Low-calorie sweetener restriction
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Allison Sylvetsky (Meni)
Type 1 Diabetes, Type 2 Diabetes
Blood Glucose Response to Meals of Varying Glycemic Index in Youth With Type 1 & 2 Diabetes
Research to date suggests that the selection of lower glycemic index foods, that is, foods provoking a slower, more sustained blood sugar response, may result in improved glycemic control in youth with diabetes.
- Conditions
- Type 1 Diabetes, Type 2 Diabetes, Impaired Glucose Metabolism
- Trial name
- NCT00545727
- Testing
- Diet, Standard diet
- Volunteers
- 36 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Diabetes Mellitus, Type 1
Evaluation of Minimed 670G in T1D Patients on Multiple Daily Injection
Introduction. Sensor Augmented Pump has demonstrated superiority over insulin pump and Multiple Daily Injection (MDI) in achieving optimal glucose control and can improve quality of life in Type 1 Diabetes (T1D) patients.
- Trial name
- NCT03755479
- Testing
- Hybrid Closed Loop Insulin Pump Minimed 670G
- Where
- Qatar
- Volunteers
- 30 people
- Sponsor
- Sidra Medicine
Type 1 Diabetes
Investigation of the Impact of Different Application Volumes of Insulin Aspart in Subjects With Type 1 Diabetes
Rationale: For the development of a closed loop system, faster insulin absorption after bolus administration could help to reduce the system's delay and thus increase patient safety.
- Trial name
- NCT01399346
- Testing
- Insulin aspart
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Graz
Hypertension, Diabetes Mellitus, Type 1
Improving Blood Pressure Management in Patients With Diabetes
About 22% of Canadians have high blood pressure, or hypertension. However, studies have shown that only 1 out of 5 people with hypertension have their blood pressure controlled.
- Conditions
- Hypertension, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- SCRIP-HTN (NCT00374270)
- Testing
- Lifestyle Counselling; Opinion Leader Influence Statements
- Where
- Canada
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Type 1 Diabetes
Repeatability of Blood Glucose Responses to Resistance Exercise in Type 1 Diabetes
This study proposes to examine the impact of time of day (morning versus afternoon) on the variability of blood glucose responses to high resistance exercise in a single group of patients with type 1 diabetes.
- Trial name
- NCT05168488
- Testing
- Fasted morning resistance exercise, Afternoon resistance exercise
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of Alberta
Type 1 Diabetes Mellitus, Hypoglycemia Unawareness
The Effects of RT-CGM on Glycemia and QoL in Patients With T1DM and IHA
The purpose of this study is to determine what the effects are of real-time continuous glucose monitoring on glycemia and quality of life in patients with type 1 diabetes mellitus and impaired hypoglycemia awareness.
- Trial name
- INCONTROL (NCT01787903)
- Testing
- Real-time continuous glucose monitor
- Where
- Netherlands
- Volunteers
- 52 people
- Sponsor
- Amsterdam UMC, location VUmc
Diabetes Mellitus, Type 1
Long-term, Implantable Sensor Improves Health Outcomes in Patients With T1D
The implantable Eversense ® CGM System obtained CE marking in 2016 for the 90-day device and in 2017 for the 180-day device.There is interest in real-world clinical evidence on the use of Eversense regarding changes in HbA1c and…
- Trial name
- NCT04160156
- Testing
- Long term sensor
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University Magna Graecia
Type 2 Diabetes Mellitus
Insulin Receptor Substrate 1 (IRS-1) Regulation in Insulin Resistance
The study is being conducted to find out why too much fat in your blood stream may cause insulin resistance in your muscles. Insulin is the hormone, produced normally by your body, which causes your blood sugar to return to…
- Trial name
- NCT01240252
- Testing
- Human insulin
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Type 1
Improving Metabolic Assessments in Type 1 Diabetes Mellitus Clinical Trials
OBJECTIVE: This study is being conducted by the Type 1 Diabetes TrialNet Study Group, funded by the National Institutes of Health, in collaboration with the European C-Peptide Group.
- Trial name
- NCT00105352
- Testing
- Mixed Meal Tolerance Test, Glucagon Stimulation Test
- Where
- 18 sites in United States, Australia and 4 more
- Volunteers
- 120 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Evaluation of the Bioavailability of Pramlintide
This is a randomized, open-label, crossover study to examine the bioavailability of pramlintide in normal weight and overweight subjects with type 1 and type 2 diabetes mellitus using insulin.
- Trial name
- NCT00042471
- Testing
- Pramlintide acetate
- Where
- 4 sites in United States
- Volunteers
- 75 people
- Sponsor
- AstraZeneca
Type 1 Diabetes Mellitus
Islet Transplantation Through an Indwelling Catheter in the Umbilical Vein
Islet transplantation is one of the effective and promising options for type 1 diabetes mellitus treatment1-4. The liver is the primary target location for infusion and portal vein catheterization is generally used.
- Trial name
- NCT02367534
- Testing
- umbilical vein catheterization
- Volunteers
- 12 people
- Sponsor
- Fuzhou General Hospital
Biomedical Technology, Type 1 Diabetes
Analysis of Glycemic Control in Type 1 Diabetes Patients Using Hybrid Closed Loop Insulin Pump Therapy (Medtronic 670G)
Observational study of patients at Boston Childrens Hospital with type 1 diabetes (T1D) who elected to treat their diabetes with the Medtronic 670 G hybrid closed loop insulin pump.
- Trial name
- NCT04051632
- Testing
- Medtronic 670G insulin pump
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Boston Children's Hospital
Diabetes Mellitus, Type 1, Diabetes Mellitus
Diamyd Administered Into Lymph Nodes in Combination With Vitamin D in Type 1 Diabetes
The objective of DIAGNODE-2 is to evaluate the efficacy of Diamyd compared to Placebo, upon administration directly into a lymph node in combination with an oral vitamin D/Placebo regimen, in terms of preserving endogenous…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Autoimmune Diseases, Metabolic Disease
- Trial name
- NCT03345004
- Testing
- Diamyd, Vitamin D
- Where
- 18 sites in Czechia, Netherlands and 2 more
- Volunteers
- 109 people
- Sponsor
- Diamyd Medical AB
Diabetes Mellitus, Type 2, Adult
Effects of Once and Twice Daily Dosing Regimen of Ertugliflozin (PF-04971729, MK-8835) In Participants With Type 2 Diabetes (MK-8835-040)
This is a Phase 1 randomized, double-blind, sponsor open, 4 arm, 2 way cross-over study using 2 cohorts. The objective of the study is to evaluate the pharmacodynamics (PD) effects and the pharmacokinetic (PK) of single day…
- Trial name
- NCT01054300
- Testing
- Ertugliflozin 2 mg single dose, Ertugliflozin 2 mg split into twice daily, Ertugliflozin 4 mg single dose
- Volunteers
- 52 people
- Sponsor
- Merck Sharp & Dohme LLC
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