Clinical trials: Type 1 Diabetes, completed
Diabetes Mellitus Type 2
Multiple Dose Safety Tolerability, Pharmacokinetics And Midazolam Interaction In Healthy Overweight And Obese Subjects
This study is designed to assess the safety, tolerability and pharmacokinetics of multiple oral 200-mg doses of PF-05175157 administered twice daily for 14 days in healthy overweight and obese subjects.
- Trial name
- NCT01807377
- Testing
- PF-05175157, Midazolam
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Pfizer
Hypoglycemia
Effect of Naltrexone on Counterregulatory Mechanisms in Hypoglycemia
Insulin treatment often causes the blood glucose levels to fall too low. The body usually responds to low blood glucose levels by releasing hormones which act against the insulin to help correct the low blood glucose levels.
- Trial name
- NCT01462227
- Testing
- Naltrexone High Dose, Naltrexone Low Dose
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Yale University
Type 1 Diabetes
Hormone Responses During Hypoglycemia and the Accuracy of Continuous Glucose Monitors
The primary objective of this study will be to compare the glucose level at which counter-regulatory hormone responses occur during hypoglycemia in young children with diabetes, with the glucose level counter regulatory hormone…
- Trial name
- NCT00607139
- Where
- 6 sites in United States
- Volunteers
- 28 people
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes Mellitus
Verapamil for Beta Cell Survival Therapy in Type 1 Diabetes
The overall purpose of this trial is to assess the efficacy and safety of using oral verapamil in subjects with recent onset T1D in order to downregulate TXNIP and enhance the patients' endogenous beta cell mass and insulin…
- Trial name
- NCT02372253
- Testing
- Verapamil
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Alabama at Birmingham
Hypoglycemia
Effect of Hypoglycemia on Sleep
Growing evidence provided by many observational studies has established a strong link between decreased sleep duration and poor glucoregulation.
- Trial name
- NCT02687893
- Testing
- Aerobic Exercise, Resistance Exercise
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes Mellitus, Diet Modification
Safety of Low and Very Low Carbohydrate Diets in Young Children With Type 1 Diabetes
The purpose of the study is to evaluate the safety of short-term (6 month) low or very-low carbohydrate diets in prepubertal children 2 to <12 years old with type 1 diabetes.
- Conditions
- Type 1 Diabetes Mellitus, Diet Modification, Child, Only
- Trial name
- NCT03862521
- Testing
- Low carbohydrate diet, Very low carbohydrate diet
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Nemours Children's Clinic
Colorectal Neoplasms
Combination Immunotherapy in Colorectal Cancer
This is a pilot study to see whether a combination of two investigational drugs that target the immune system can be given to people with colorectal cancer before surgically removing the tumor.
- Trial name
- NEST-1 (NCT05571293)
- Testing
- Botensilimab, Balstilimab
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- Weill Medical College of Cornell University
Type1diabetes, Hypoglycemia Unawareness
Hybrid Closed Loop Insulin Delivery System in Hypoglycemia
Can a type 1 diabetic adult avoid low glucoses and regain hypoglycemia awareness using a hybrid closed loop insulin delivery system? Involvement is 22 months (13 visits) and includes a 4-week Screening Phase and an 18-month…
- Conditions
- Type1diabetes, Hypoglycemia Unawareness, Nocturnal Hypoglycemia, Hypoglycemia Night
- Trial name
- Aim2 (NCT03215914)
- Testing
- MiniMed 670G system
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Peripheral Neuropathy, Type 1 Diabetes
Pilot Study to Determine Effects of Salsalate in Type 1 Diabetes and Painful Peripheral Neuropathy
This 12 week study will examine the effects of daily Salsalate treatment on markers of neuropathic pain and intra-epidermal nerve fiber density.
- Trial name
- SALP (NCT01480297)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Michigan
Diabetes Mellitus
Study of Safety, Tolerability and Pharmacokinetics of Single Oral JTT-251 Doses in Healthy and Type 2 Diabetic Subjects
The purpose of this study is to evaluate the safety, tolerability, and PK (Pharmacokinetics) of single oral doses of JTT-251 in healthy and type 2 diabetes mellitus subjects and to evaluate the effect of food on the PK of JTT-251…
- Trial name
- NCT02106585
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Shionogi Inc.
Non Insulin Dependent Diabetes
Curcumin Supplementation and Patients With Type 2 Diabetes
Diabetes mellitus is the most common endocrine disorder, causes many complications such as micro- and macro-vascular diseases. Various kinds of antidiabetic drugs have been developed, but most of them have side effects.
- Trial name
- NCT02529982
- Testing
- Curcumin
- Where
- Iran
- Volunteers
- 44 people
- Sponsor
- National Nutrition and Food Technology Institute
Cardiovascular Diseases, Diabetes Mellitus
Markers and Mechanisms of Macrovascular Disease in IDDM
To elucidate the biochemical, metabolic, and genetic markers and mechanisms of macrovascular disease in insulin dependent diabetes mellitus (IDDM).
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Atherosclerosis, Heart Diseases
- Trial name
- NCT00005474
- Volunteers
- 1,063 people
- Sponsor
- Medical University of South Carolina
Type 1 Diabetes
Safety and Efficacy of DUO Extended Set: Combined Glucose Sensor and Infusion Set.
The study will follow subjects for 28 days while using an DUO extended infusion set combined with glucose sensor. the objective is to evaluate saftey and efficacy of the set in adult patient with type 1 diabetes.
- Trial name
- NCT04810780
- Testing
- DUO Extended Set
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Type 1 Diabetes Mellitus
Efficacy and Safety of Sotagliflozin in Young Adult Patients With Type 1 Diabetes Mellitus and Elevated Hemoglobin A1C
This Phase 2 study was intended to demonstrate superiority of sotagliflozin versus placebo on Hemoglobin A1C (A1C) reduction at Week 12 in young adult participants with type 1 diabetes mellitus (T1DM) who have poor glycemic…
- Trial name
- NCT02383940
- Testing
- Sotagliflozin
- Where
- 15 sites in United States
- Volunteers
- 87 people
- Sponsor
- Lexicon Pharmaceuticals
Type 1 Diabetes
Children's Mercy Teens With Type 1 Diabetes Will Participate in an Online Peer Support Group.
The goal of this observational study is to examine the impact of an online peer support group in Children's Mercy teens with Type 1 Diabetes.
- Trial name
- NCT06412146
- Testing
- Peer Support Group
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Diabetes Mellitus, Type 1
Diabetes Pump With Predictive Low Glucose Suspend Pivotal Trial
A 6-week crossover study will compare PLGS to SAP outcomes in adults and youth > 6 years old with type 1 diabetes (T1D).
- Trial name
- NCT03195140
- Testing
- Predictive Low Glucose Suspend
- Where
- 4 sites in United States
- Volunteers
- 103 people
- Sponsor
- Tandem Diabetes Care, Inc.
Diabetes, Diabetes Mellitus, Type 1
Special Survey for Paediatric Subjects
This study is conducted in Japan. The aim of this study is to collect safety and efficacy data when using NovoRapid® (insulin aspart) in children with type 1 and type 2 diabetes under normal clinical practice conditions.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01487382
- Testing
- insulin aspart
- Where
- Japan
- Volunteers
- 241 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Effect of Canagliflozin in T1DM (Type 1 Diabetes Melitus) After Interruption of Continuous Subcutaneous Insulin Infusion
This study will be an open-label, cross-over study as subjects will be studied under both study conditions - suspension of subcutaneous insulin infusion via pump during treatment with insulin alone (control) vs.
- Trial name
- NCT02673138
- Testing
- canagliflozin, basal interruption without canagliflozin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Immunosuppression, Hyperlipidemias
Cholesterol and Fatty Acid Synthesis in Islet and Liver Transplant Patients and Effect of Dietary Intervention
The purpose is to investigate possible mechanisms of increased blood lipid levels following transplantation, and also to see if a comprehensive dietary intervention is effective in reducing blood lipid levels in post-transplant…
- Conditions
- Immunosuppression, Hyperlipidemias, Diabetes Mellitus, Type 1
- Trial name
- NCT00947635
- Testing
- Dietary intervention - supplements
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Type 1 Diabetes Mellitus, MDI
Evaluation of Physician-based Decision Support
The goal of this study is to assess the impact of physician-driven insulin setting changes in type 1 patients using multiple daily injection insulin therapy with exercise.
- Conditions
- Type 1 Diabetes Mellitus, MDI, CGM, Exercise
- Trial name
- NCT03443713
- Testing
- Dexcom G6 CGM
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Oregon Health and Science University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.