Clinical trials: Type 1 Diabetes, completed
Type 1 Diabetes Mellitus
Home Video-based Telemedicine to Reduce Hypoglycemia Fear in Parents of Young Children
Investigators developed REDCHiP (Reducing Emotional Distress for Childhood Hypoglycemia in Parents), an innovative video-based telemedicine intervention.
- Trial name
- REDCHiP (NCT03914547)
- Testing
- REDCHiP, ATTN
- Where
- 2 sites in United States
- Volunteers
- 394 people
- Sponsor
- Nemours Children's Clinic
Type 1 Diabetes
Safety of Artificial Pancreas Therapy in Preschoolers, Age 2-6
A single-arm, multi-center, clinical study to assess the safety profile of the Tandem t:slim X2 with Control-IQ system in children with T1D aged 2-6 years old under free living condition
- Trial name
- NCT04084171
- Testing
- Tandem t:slim X2 with Control-IQ Technology + Dexcom G6
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Assessment of an iPhone Application on Glycemic Control in Type 1 Diabetes
The purpose of the study is to assess whether an electronic self-management tool, specifically an iPhone application entitled bant, can improve glycemic control in Adolescents who have Type 1 Diabetes Mellitus (T1DM).
- Trial name
- NCT01899274
- Testing
- bant iPhone application
- Where
- 2 sites in Canada
- Volunteers
- 92 people
- Sponsor
- The Hospital for Sick Children
Type 1 Diabetes Mellitus With Hypoglycemia
DailyDose Smart Snack Study for T1D on MDI
This is a single-center, open-label, crossover trial with two arms and two periods (2x2) and one-week washout period. The study is designed to evaluate the efficacy of an AI-based bedtime smart snack intervention in reducing…
- Trial name
- NCT05967260
- Testing
- DailyDose Smart Snack app, Dexcom G6 CGM
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes Mellitus
Optimizing Adherence and Glycemia in Youth With New Insulin-dependent Diabetes Mellitus (IDDM)
This 2-year randomized, controlled trial examined the impact of a clinic-based, family teamwork intervention on glycemic control in youth with recently diagnosed type 1 diabetes.
- Trial name
- NCT00745342
- Testing
- Family Teamwork Intervention
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Joslin Diabetes Center
Ketosis Prone Diabetes
Study of Arginine and Nitric Oxide in Patients With Diabetes
This study will test the effect of citrulline versus placebo supplementation in ketosis-prone diabetes (KPD) patients on arginine and nitric oxide production and on glucose- and arginine-stimulated insulin secretion and arterial…
- Trial name
- NCT03566524
- Testing
- Citrulline, Alanine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor College of Medicine
Type1diabetes
The Effect of Bolus Speed of Rapid-Acting Insulin Analog Absorption and Action in Individuals With Type 1 Diabetes
Rapid Action Insulin (RAI) absorption and action measured by time to reach maximum insulin concentration and glucose infusion rate.
- Trial name
- NCT03542682
- Testing
- Quick Bolus, Standard Bolus
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Yale University
Diabetes Mellitus, Type 2
A Study of PF-05175157 in Healthy Volunteers and Type 2 Diabetic Patients
The primary purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple ascending doses of PF-05175157 in healthy volunteers and patients with type 2 diabetes mellitus.
- Trial name
- NCT01396161
- Where
- 3 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Pfizer
Type 1 Diabetes
Closing the Loop in Adults With Sub-optimally Controlled Type 1 Diabetes Under Free Living Conditions
The main objective of this study is to determine whether day and night closed-loop insulin delivery for 12 weeks under free living conditions is superior to addition of real-time continuous glucose monitoring in adults with type…
- Trial name
- AP@home04 (NCT01961622)
- Testing
- Florence D2A or similar closed loop glucose control system, CSII with real-time CGM
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 33 people
- Sponsor
- University of Cambridge
Diabetes Mellitus, Type 1, Adolescent Behavior
Pet Ownership and Glucose Control in Early Adolescents With Type 1 Diabetes
This study evaluates the short-term effects of incorporating the structured care of a pet fish into a diabetes self-care routine on glucose control in early adolescents with type 1 diabetes.
- Trial name
- NCT03761251
- Testing
- Pet Fish
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Texas Southwestern Medical Center
Type 1 Diabetes
The Effect of Sea Buckthorn Extract in Patients With Type 1 Diabetes
Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing β-cells by autoreactive T cells.
- Trial name
- SBTT1D (NCT07787754)
- Testing
- Sea buckthorn
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Type 1 Diabetes, Type 2 Diabetes
A 2-Month Safety Follow-Up Trial
The main purpose of the trial is to evaluate pulmonary function in subjects who had completed any one of the 4 MKC parent trials (MKC-TI-009, MKC-TI-102, MKC-TI-103, or MKC-TI-030) for an additional 2-month safety follow-up.
- Trial name
- NCT00741429
- Testing
- Technosphere Insulin Inhalation Powder, Comparator
- Where
- 150 sites in United States, Brazil and 2 more
- Volunteers
- 649 people
- Sponsor
- Mannkind Corporation
Type 1 Diabetes Mellitus
Phase 2 Trial of BMF-219 in Participants With Type 1 Diabetes Mellitus
Phase 2 Trial of BMF-219 in Participants with Type 1 Diabetes Mellitus.
- Trial name
- NCT06152042
- Testing
- BMF-219
- Where
- 11 sites in United States, Canada
- Volunteers
- 37 people
- Sponsor
- Biomea Fusion Inc.
Diabete Type 2, Abdominal Obesity
Translational Study Using Human Abdominal Adipose Tissue Biopsies to Investigate the Role of Cannabinoid Receptor 1 (CB1) in Controlling Endocannabinoid and Adipokine Secretion
Abdominal obesity and type 2 diabetes are associated with the hyperactivation of the endocannabinoid system. Several animal and human studies indicate that circulating endocannabinoid (EC) levels are correlated with body fat.
- Trial name
- ENDOCATA (NCT04940962)
- Testing
- Sampling of adipose tissue
- Where
- France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Type 1 Diabetes
Anti-Interleukin-1 in Diabetes Action
A draw trial of the effect of Interleukin-1 Receptor Antagonist (anakinra, Kineret®) on the insulin production in patients with new onset Type 1 diabetes.
- Trial name
- AIDA (NCT00711503)
- Testing
- anakinra, saline
- Where
- 17 sites in Denmark, Germany and 5 more
- Volunteers
- 69 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes, Hypoglycemia
Glucagon and Advanced HCL System to Prevent Exercise-Induced Hypoglycaemia in People With Type 1 Diabetes
The primary aim of the study is to evaluate the glucose response to low-dose glucagon (single 150 µg dose) administered immediately before aerobic exercise in individuals with AHCL-treated T1D.
- Trial name
- HYPOAVOID (NCT05379686)
- Testing
- GlucaGen
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes (T1D)
Lactobacillus Johnsonii in Children and Adolescents With T1D
While genetics demonstrated a major risk factor for the development of type 1 diabetes (T1D), microbiota dysbiosis has been suggested as an elicitor in immunological tolerance and of beta cell autoimmunity.
- Trial name
- NCT03961854
- Testing
- L. johnsonii Probiotic
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Type 1 Diabetes (T1D)
Stretching and Diabetes
Diabetes mellitus is a persistent disease characterized by alterations in glucose metabolism due to insufficient insulin production or decreased sensitivity to insulin.
- Trial name
- STREDIB (NCT06774105)
- Testing
- Static Stretching
- Where
- Italy
- Volunteers
- 27 people
- Sponsor
- University of Palermo
Diabetes Mellitus, Type 1
Early Feasibility Study 2 of Outpatient Control-to-Range - Testing System Efficacy
An unblinded, randomized, cross-over design with each patient participating in two 40-hour outpatient admissions: (a) Experimental involving automated Control-to-Range (CTR) and (b) Control using Continuous Glucose Monitor (CGM)…
- Trial name
- NCT01714505
- Testing
- Diabetes Assistant (DiAs)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus
Human Islet Transplantation in Brittle Type 1 Diabetes Mellitus. The GRAGIL 2 Study.
This research project is supported by a multicentric network of collaborators whose goal is to assess the efficacy of transplanting allogenic pancreas islets to restore insulin secretion in patients with brittle type 1…
- Trial name
- NCT00321256
- Testing
- human pancreatic islet transplantation
- Where
- 6 sites in France, Switzerland
- Volunteers
- 22 people
- Sponsor
- University Hospital, Grenoble
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