Clinical trials: Type 2 Diabetes, completed
Type 2 Diabetes, Insulin Resistance
Dietary Advanced Glycation End-products and Insulin Resistance in Overweight and Obese Humans
We hypothesize that reduction in dietary advance glycation endproducts (AGE) intake will increase insulin sensitivity and normalise insulin secretion in overweight and obese individuals through reduction of chronic low grade…
- Conditions
- Type 2 Diabetes, Insulin Resistance, Obesity
- Trial name
- NCT00422253
- Testing
- dietary intervention
- Where
- Australia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Diabetes Mellitus
Efficacy of Pioglitazone and Metformin on Cardiovascular Risk in Subjects With Insulin-Treated Type 2 Diabetes Mellitus.
The purpose of this study is to determine the Anti-Inflammation Effects of Pioglitazone, twice daily (BID), and Pioglitazone/Metformin Combination Therapy BID in Type 2 Diabetes Subjects Treated with Insulin.
- Trial name
- PIOcomb (NCT00770445)
- Testing
- Pioglitazone and insulin, Pioglitazone and metformin and insulin, Metformin and insulin
- Where
- 18 sites in Germany
- Volunteers
- 121 people
- Sponsor
- Takeda
Type 2 Diabetes
Spanish Diabetes Self-Management Program
Type II diabetes is a growing health concern for Latinos who not only have a higher incidence of the disease but also suffer great morbidity.
- Trial name
- SDSMP (NCT00496145)
- Testing
- Spanish Diabetes Self-Management Program
- Where
- United States
- Volunteers
- 567 people
- Sponsor
- Stanford University
Antiretroviral Therapy, Highly Active, Diabetes Mellitus, Type 2
Non-Communicable Diseases and Antiretroviral Therapy Outcomes in the RapIT Study Population
For national antiretroviral therapy (ART) programs, the most important health system goals in reducing morbidity and mortality among HIV-infection patients are to initiate treatment as early as eligibility criteria allow and to…
- Conditions
- Antiretroviral Therapy, Highly Active, Diabetes Mellitus, Type 2, Cardiovascular Diseases
- Trial name
- RapIT-NCD (NCT02012972)
- Testing
- Referral for NCD care
- Where
- South Africa
- Volunteers
- 354 people
- Sponsor
- Boston University
Type 2 Diabetes
The Effects of Dapagliflozin on HDL Particles Subtypes and Reverse Cholesterol Transport in Type 2 Diabetic Patients
In Phase 2b/3 clinical trials, Dapagliflozin has been shown to raise HDL cholesterol levels by about 4 mg/dl (1 mmol/l), which is generally considered a clinically-meaningful change.
- Trial name
- DAPA-HDL (NCT02327039)
- Testing
- Dapagliflozin
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- University of Padova
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Assessment of Mealtime Bolus Insulin Behavior
The main purpose of this study is to estimate missed bolus insulin doses in diabetics. This is a 12-week, single-arm, outpatient, exploratory study with two study periods in Type 1 or Type 2 diabetics, with an investigational…
- Trial name
- NCT03368807
- Testing
- Continuous Glucose Monitoring, Insulin Lispro
- Where
- 6 sites in United States
- Volunteers
- 79 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes
The OBSTACLE Hypoglycemia Study (MK-0000-158)
This study will assess the correlation between glycemic control and the hypoglycemia symptom score in patients with Type 2 diabetes, 12 weeks after addition of a sulfonylurea to an ongoing regime of oral hypoglycemic agents.
- Trial name
- NCT00907881
- Testing
- Sulfonylurea
- Volunteers
- 1,069 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes Mellitus
Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus on Background of Sulfonylurea Alone or With Metformin
Primary Objective: To demonstrate the superiority of Sotagliflozin 400 milligrams (mg) versus placebo on Hemoglobin A1c (HbA1c) reduction at Week 26 in participant with type 2 diabetes (T2D) who have inadequate glycemic control…
- Trial name
- NCT03066830
- Testing
- Sotagliflozin (SAR439954), Metformin, Sulfonylurea
- Where
- 76 sites in United States, Bulgaria and 8 more
- Volunteers
- 507 people
- Sponsor
- Lexicon Pharmaceuticals
T2DM (Type 2 Diabetes Mellitus)
The Efficacy and Safety of DWP16001 in Combination With Metformin in Patients With Type 2 Diabetes.
Therapeutic Confirmatory Study to Evaluate the Efficacy and Safety of DWP16001 in Combination with Metformin in Patients With Type 2 Diabetes Mellitus who Have Inadequate Glycemic Control on Metformin Alone.
- Trial name
- ENHANCE-M (NCT04634500)
- Testing
- Dapagliflozin
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Hypertension, Overweight or Obesity
Education to Decrease in Sodium Intake Evaluated With 24 Hour Urinary Sodium Excretion (RCT)
WHO identifies as an important risk factor and potentially modifiable to high sodium intake (>2g/day 5g salt/day). Also, an insufficient consumption of potassium ( 3.5 g/day).Therefore, the results of this research could be the…
- Conditions
- Hypertension, Overweight or Obesity, Diabetes Mellitus, Type 2
- Trial name
- RCT (NCT04894344)
- Testing
- Education group
- Where
- Mexico
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Hypertension, Diabetes Mellitus, Type 2
Proteus Discover in Subjects With Uncontrolled Hypertension and Type 2 Diabetes
The purpose of this study was to evaluate the efficacy of a new digital health offering, Proteus Discover to lower blood pressure and glycated hemoglobin in patients with uncontrolled hypertension and type 2 diabetes.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Hypercholesterolemia
- Trial name
- NCT02827630
- Testing
- Proteus Discover, Usual Care
- Volunteers
- 118 people
- Sponsor
- Proteus Digital Health, Inc.
Diabetes Mellitus, Type 2
Professional Continuous Glucose Monitoring as an Adjuvant Educational Tool for Improving Glycemic Control in Patients With Type 2 Diabetes.
The investigators conducted a three-month quasi-experimental study with an intervention and control group and ex-ante and ex-post evaluations in one family medicine clinic in Mexico City.
- Trial name
- NCT04667728
- Testing
- Professional continuous glucose monitoring (CGM) sensor (iPro™2)
- Where
- Mexico
- Volunteers
- 302 people
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Diabetic Retinopathy
Serum and Intraocular Levels of Erythropoietin and VEGF in Type 2 Diabetes Patients With Proliferative Retinopathy
Some studies have recently shown that the concentration of erythropoietin in the vitreous humor of diabetic patients suffering from diabetic retinopathy is higher than non-diabetic patients.
- Trial name
- UVA-EVA (NCT01871207)
- Where
- Italy
- Volunteers
- 53 people
- Sponsor
- Università degli Studi di Brescia
Obesity, Type 2 Diabetes
Effects of Oral Sodium Butyrate Supplementation on Body Weight Reduction in Overweight/Obese Individuals With and Without Type 2 Diabetes
The goal of this clinical trial (randomized controlled trial with parallel group design) is to evaluate the effects of oral sodium butyrate supplementation for 12 weeks, compared with placebo, in addition to a moderately…
- Trial name
- ButRed (NCT07252609)
- Testing
- Sodium Butyrate (NaBut)
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Federico II University
Type 2 Diabetes, Obesity
Canola-Mediterranean Diet Study in T2DM
The purpose of the study is to assess whether a Mediterranean-type weight-loss diet, enriched with canola oil, high in plant protein, and low in carbohydrates will produce blood sugar control, reduce coronary heart disease (CHD)…
- Conditions
- Type 2 Diabetes, Obesity, Overweight, Cardiovascular Diseases
- Trial name
- NCT02245399
- Testing
- A canola oil enriched mediterranean diet, A high wheat fiber diet
- Where
- 3 sites in Canada
- Volunteers
- 164 people
- Sponsor
- Unity Health Toronto
Type 2 Diabetes Mellitus
Remission Evaluation of a Metabolic Intervention in Type 2 Diabetes With Sitagliptin (REMIT-Sita)
The purpose of the study is to determine whether in patients with early type 2 diabetes,a short-term intensive metabolic intervention comprising of sitagliptin, metformin, basal insulin glargine and lifestyle approaches will be…
- Trial name
- NCT02623998
- Testing
- insulin glargine, sitagliptin/metformin, lifestyle therapy
- Where
- 6 sites in Canada
- Volunteers
- 102 people
- Sponsor
- Population Health Research Institute
Diabetes
The Effect of Korean Red Ginseng Supplementation on Glucose Control
This study is a randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effect of Korean red ginseng supplementation on glucose control in subjects with impaired fasting glucose, impaired glucose…
- Trial name
- NCT01911663
- Testing
- KRG
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Type 2 Diabetes Mellitus, Obesity
Resolution of Type 2 Diabetes Mellitus: Intensive vs. Conventional Glycaemic Control After Obesity Surgery
Obesity surgery is very effective in improving or even curing Type 2 Diabetes in patients with obesity. Many patients stop or reduce their medication after surgery and this can happen fairly quickly.
- Trial name
- GLUCOSURG1 (NCT01257087)
- Testing
- Insulin
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Imperial College London
Type 2 Diabetes Mellitus
Nutrition Education Intervention for Adults With Type 2 Diabetes
Aim: To implement a nutrition education programme (intervention) for adults with type 2 diabetes mellitus (T2DM) adapted from a primary health care setting to a tertiary hospital setting in South Africa and to evaluate the…
- Trial name
- NCT03334773
- Testing
- Nutrition education
- Where
- South Africa
- Volunteers
- 77 people
- Sponsor
- University of Pretoria
Obesity, Type 2 Diabetes
Role of Pancreatic Triglyceride Content in Beta-cell Function
The study evaluates if fat accumulates in the pancreas in individuals at risk of developing obesity-related diabetes. It also evaluates if the amount of fat in the pancreas can predict the residual functional capacity of the…
- Trial name
- NCT00602953
- Testing
- No intervention planned.
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
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