Clinical trials: Type 2 Diabetes (T2D)
Diabetes Mellitus, Type 2
Study Assessing Saxagliptin Treatment In Type 2 Diabetic Subjects Who Are Not Controlled With Metformin Alone
The purpose of this clinical research study is to learn whether Saxagliptin added to Metformin therapy is more effective than Metformin alone as a treatment for type 2 diabetic subjects who are not sufficiently controlled with…
- Trial name
- NCT00121667
- Testing
- Saxagliptin + Metformin, Pioglitazone
- Where
- 152 sites in United States, Argentina and 7 more
- Volunteers
- 1,462 people
- Sponsor
- AstraZeneca
Type 2 Diabetes
The Mobile Diabetes Mgmt. Study With Type 2 Diabetes
A Multi-center, Randomized, Parallel, Open Clinical Trial to Evaluate the Glycemic Control Effect of the Mobile Healthcare Service Using U-Healthcare Clinical Decision Support System (CDSS) and U-Healthcare Gateway in Patients…
- Trial name
- NCT02451631
- Testing
- Traditional care with paper, Health-on G App. + Physician Web
- Where
- 3 sites in South Korea
- Volunteers
- 184 people
- Sponsor
- Healthconnect
Diabetes Mellitus Type 2
A Study of a GLP-1 Analogue in Patients With Type 2 Diabetes Treated With Metformin.
This 6 arm study will evaluate the efficacy, safety, pharmacokinetics and pharmacodynamics of multiple doses and regimens of a GLP-1 analogue in patients with type 2 diabetes who are treated with a stable dose of metformin.
- Trial name
- NCT00423501
- Testing
- taspoglutide
- Where
- 49 sites in United States, Australia and 8 more
- Volunteers
- 306 people
- Sponsor
- Hoffmann-La Roche
Type 2 Diabetes Mellitus
Safety, Tolerability, and Activity of ISIS 113715 in People With Type 2 Diabetes Mellitus Who Have Not Received Prior Treatment
The aim of this study is to evaluate the safety, tolerability, and pharmacokinetics of five ISIS 113715 intravenous dose cohorts in drug-naïve type 2 diabetics.
- Trial name
- NCT00330330
- Testing
- ISIS 113715
- Where
- 10 sites in Poland, Russia
- Volunteers
- 96 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Type2 Diabetes Mellitus
A Phase 2 Study of DS-8500a in Japanese Subjects With Type 2 Diabetes Mellitus (T2DM)
The objectives of the study is to evaluate the efficacy, safety, and dose of DS-8500a compared with placebo in patients with type 2 diabetes mellitus.
- Trial name
- NCT02628392
- Testing
- DS-8500a, Sitagliptin
- Where
- Japan
- Volunteers
- 368 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Diabetes Mellitus, Type 2
An Evaluation of the Pharmacokinetics of an Oral Contraceptive (Brevicon) When Co-administered With Albiglutide .
This study will be an open-label study to evaluate the effect of albiglutide on the pharmacokinetics and pharmacodynamics of a standard oral contraceptive regimen (Brevicon).
- Trial name
- NCT01077505
- Testing
- albiglutide, Oral contraceptive (Brevicon)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus, Type 2
Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-64565111 in Type 2 Diabetes Mellitus (T2DM)
The purpose of this study is to assess the safety and tolerability of JNJ-64565111 in adult Men and Women (of non-child bearing potential) with Type 2 Diabetes Mellitus.
- Trial name
- NCT02862431
- Testing
- JNJ-64565111
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Janssen Research & Development, LLC
Type 2 Diabetes
Observational Cohort Study Evaluating the Effectiveness of an Education Program (NGAYDAUTIEN) in Combination With Gliclazide MR in the Management of Uncontrolled Type 2 Diabetic Patients.
The primary objective is to assess the change of HbA1c level from baseline after a 6-month follow up among uncontrolled patients with T2D who will be initiated to Diamicron® MR 60 (originator product) plus an educational program…
- Trial name
- EDUDIA (NCT06704802)
- Where
- France
- Volunteers
- 678 people
- Sponsor
- Servier Affaires Médicales
Type 2 Diabetes Mellitus
Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus Not Currently Treated With Antidiabetic Therapy
Primary Objective: To demonstrate the superiority of Sotagliflozin 400 milligrams (mg) versus placebo on hemoglobin A1c (HbA1c) reduction in participants with type 2 diabetes (T2D) who have inadequate glycemic control on diet and…
- Trial name
- NCT02926937
- Testing
- Sotagliflozin (SAR439954)
- Where
- 70 sites in United States, Canada and 1 more
- Volunteers
- 399 people
- Sponsor
- Lexicon Pharmaceuticals
Diabetes, Diabetes Mellitus, Type 2
Comparison of Self Adjustment Versus Standard of Care Treatment in Subjects With Type 2 Diabetes
This trial is conducted in the United States of America (USA). This trial aims for a comparison of the safety and efficacy in subjects with type 2 diabetes using either self titration or physician guided titration according to…
- Trial name
- PREDICTIVE™ (NCT00264901)
- Testing
- insulin detemir
- Where
- United States
- Volunteers
- 5,652 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes Mellitus, High Blood Sugar
A Relative Bioavailability Study Measuring the Extent and Rate of Absorption of Different Tablet Formulations of AZD1656 in Type 2 Diabetes Mellitus (T2DM) Patients
The purpose of this study is to assess the relative bioavailability by measuring the extent and rate of absorption of different tablet formulations of AZD1656 in T2DM patients.
- Trial name
- NCT01221519
- Testing
- AZD1656
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2
Pharmacokinetic Profile of Two Formulations of PB1023 Following Single Subcutaneous Injection in Subjects With Type 2 Diabetes Mellitus
Primary objective: To compare the pharmacokinetic profile of PB1023 after a single dose administered by subcutaneous injection of two formulations (concentrations).
- Trial name
- NCT01427257
- Testing
- Single Dose PB1023
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- PhaseBio Pharmaceuticals Inc.
Type 2 Diabetes
Efficacy, Safety and Tolerability of Pioglitazone-Azilsartan in Subjects With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the efficacy and safety of pioglitazone-azilsartan, once daily (QD), in subjects with type 2 diabetes mellitus with poor glycemic control.
- Trial name
- NCT00376181
- Testing
- Pioglitazone and Azilsartan, Pioglitazone
- Where
- 73 sites in United States, Argentina and 3 more
- Volunteers
- 96 people
- Sponsor
- Takeda
Type 2 Diabetes Mellitus
Sitagliptin Cardiovascular Outcomes Study (MK-0431-082)
This is a clinical trial designed to assess the cardiovascular outcome of long-term treatment with sitagliptin used as part of usual care compared to usual care without sitagliptin in participants with type 2 diabetes mellitus…
- Trial name
- TECOS (NCT00790205)
- Testing
- Sitagliptin
- Volunteers
- 14,671 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus Type 2
Insulin Analogue With Continuous Glucose Monitoring System (CGMS) Measurement
Primary objective: Difference in frequency of subjects with conventionally detected hypoglycemia by the subject [at least one measurement smaller/equal 60mg/dl documented in the 8-point profile in the case record form (CRF) or…
- Trial name
- SAFIR (NCT00354939)
- Testing
- Insulin glargine
- Volunteers
- 480 people
- Sponsor
- Sanofi
Obesity, Morbid, Diabetes Mellitus Type 2
Gut Hormone Profiling in Obese Patients With Type 2 Diabetes (MK-0000-134)
This study will examine changes in various gut-derived hormones in obese type 2 diabetic patients before and after elective bariatric surgery.
- Trial name
- NCT00957957
- Volunteers
- 22 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes Mellitus
Specified Drug-Use Survey of Alogliptin and Metformin Hydrochloride Combination Tablets "Survey on Long-term Use in Type 2 Diabetes Mellitus Patients With Renal or Hepatic Impairment or Advanced Age"
The purpose of this survey is to evaluate the long-term safety and efficacy of the alogliptin and metformin hydrochloride combination tablet in type 2 diabetes mellitus patients with renal impairment (mild), hepatic impairment…
- Trial name
- NCT03555565
- Testing
- Alogliptin and Metformin hydrochloride
- Where
- Japan
- Volunteers
- 1,026 people
- Sponsor
- Takeda
Diabetes Mellitus, Type 2
A Study To Compare the Effects of Insulin Peglispro and Glargine on Insulin Sensitivity and Meal Time Insulin Requirements in Type 2 Diabetics
This study will look into insulin sensitivity (how the body responds to insulin) and effects of meals on type 2 diabetics comparing insulin peglispro to insulin glargine.
- Trial name
- NCT02197520
- Testing
- Insulin Peglispro, Insulin Glargine, Insulin Lispro
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes Mellitus
A Study to Evaluate the Food Effect on Drug Availability, Pharmacokinetic (PK) Properties, Safety and Tolerability of Two Different Dose Combination Therapy of Saxagliptin/Dapagliflozin/Metformin Extended-release (XR) Against Individual Component Co-administration.
A Study to Assess the Fed-state Bioequivalence of a Triple Fixed-Combination Drug Product (FCDP) of 2.5 mg Saxagliptin / 5 mg Dapagliflozin / 1000 mg Metformin XR and 5 mg Saxagliptin /10 mg Dapagliflozin /1000 mg Metformin XR…
- Trial name
- NCT03169959
- Testing
- 2.5 mg Saxagliptin tablet, 5 mg dapagliflozin / 1000 mg metformin XR tablet, Triple FCDP - 2.5 mg saxagliptin / 5 mg dapagliflozin / 1000 mg metformin XR
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2
A Study of LY3437943 in Japanese Participants With Type 2 Diabetes Mellitus (T2DM)
The main purpose of this study is to learn about the side effects of LY3437943 when given to Japanese participants with type 2 diabetes mellitus.
- Trial name
- NCT04823208
- Testing
- LY3437943
- Where
- 4 sites in Japan
- Volunteers
- 64 people
- Sponsor
- Eli Lilly and Company
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