Clinical trials: Type 2 Diabetes (T2D)
Type 1 Diabetes, Type 2 Diabetes
Prospective Evaluation of a Dose Guidance System for People With Diabetes Initiating Basal Insulin or Using Insulin Injections
A prospective, randomized, single blind, two-arms, multicenter study. The study aims to assess the safety of a dosing-guided system (DGS) that provides direct advice on insulin dosing recommendations and diabetes management to…
- Trial name
- DGS (NCT06966427)
- Testing
- Dosing Guidance System to be used with both time and amount of insulin as input, Dosing Guidance System to be used with only time of insulin as input
- Where
- 2 sites in Israel, Slovenia
- Volunteers
- 45 people
- Sponsor
- Rabin Medical Center
Type 2 Diabetes
Effectiveness of Pre-medical Consultation Diabetes Self-care Education Programme on Glycemic Control in Type 2 Diabetes
This proposed project is a prospective randomized controlled trial to examine the clinical effects of pre-medical consultation structured diabetes self-care education program on intervention group (IG) versus control group (CG)…
- Trial name
- PMC-SEP (NCT04092569)
- Testing
- Pre-medical consultation structured diabetes self-care education programme
- Where
- Hong Kong
- Volunteers
- 120 people
- Sponsor
- Chinese University of Hong Kong
Type2 Diabetes, Complication of Bariatric Procedure
Efficacy and Safety of One-anastomosis Versus Roux-en-Y Gastric Bypass for Type 2 Diabetes Remission
Diabetes mellitus (T2DM) is the most common complication of obesity patients. According to previous literature reports, weight loss and metabolic surgery are powerful means to treat obesity complicated with T2DM.
- Trial name
- ORDER (NCT05015283)
- Testing
- The laparoscopic One-anastomosis gastric bypass will consist of:, The laparoscopic Roux-en-Y gastric bypass will consist of:
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Beijing Friendship Hospital
Coronary Artery Disease, Type 2 Diabetes Mellitus
Comparison Between Pioglitazone and SES With type2 DM
Drug-eluting stents have been shown to decrease restenosis, but were associated with an increased rate of death, as compared with bare-metal stents.
- Trial name
- NCT00482183
- Testing
- Pioglitazone
- Volunteers
- 38 people
- Sponsor
- Showa University
Type2diabetes, Diabetic Foot
THE EFFECT OF ONLINE TRAINING ON FOOT CARE
The aim of this study is to determine the effect of online trainings on diabetic foot care on foot care behavior and self-efficacy attitudes of individuals with type II diabetes.
- Trial name
- NCT05473494
- Testing
- training group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Maltepe University
Diabete Type 2, Hypertension
A Study to Compare the Pharmacokinetics and Safety of the ATB-U101 and ATB-U1011+ATB-U1012 and ATB-1011+ATB-1012 in Healthy Caucasian Participants
The goal of this Phase 1 clinical trial is to compare the pharmacokinetics and safety of a fixed-dose combination tablet (ATB-U101) versus co-administration of its individual components in healthy Caucasian adult volunteers.
- Trial name
- NCT07590466
- Testing
- ATB-U101, ATB-1011, ATB-U1011
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Autotelicbio
Type 2 Diabetes, Insulin Resistance
Intermittent Fasting for Metabolic Health, Does Meal Timing Matter?
Obesity is a serious medical condition, the adverse consequences of which include increased risk of cardiovascular disease, diabetes mellitus, reduced fertility and cancer.
- Trial name
- NCT02633722
- Testing
- Lifestyle intervention B, Lifestyle Intervention D
- Where
- Australia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Type 2 Diabetes
Characterization of Cardiovascular Risk Profile and Therapeutic Management in Patients With Type 2 Diabetes Mellitus in Italy
CardioMET is an observational, multicenter, real-life registry, intending to collect data on patients with Type 2 Diabetes Mellitus, attending internal medicine and cardiology outpatient clinics.
- Trial name
- CardioMET (NCT07375069)
- Testing
- data collection
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- Federico II University
Diabetic Nephropathy
6-Month Safety And Efficacy Study Of TTP488 In Patients With Type 2 Diabetes And Persistent Albuminuria
Current research indicates that TTP488 may be a viable agent for the treatment of diabetic nephropathy. The purpose of this study is to determine the safety and efficacy of a six-month regimen of daily orally-administered TTP488…
- Trial name
- NCT00287183
- Testing
- PF-04494700 (TTP488)
- Where
- 19 sites in Canada
- Volunteers
- 110 people
- Sponsor
- Pfizer
Diabetes Mellitus, Non-Insulin-Dependent
Evaluation of the Effect on Glucose Control and the Safety and Tolerability of AC2993 in Patients With Type 2 Diabetes Mellitus
This is a multicenter, randomized, blinded, placebo-controlled, short-term, dose-response study to examine the effects on glucose control of AC2993 as compared to placebo in patients with type 2 diabetes.
- Trial name
- NCT00044694
- Testing
- AC2993 2.5 mcg
- Where
- 33 sites in United States
- Volunteers
- 156 people
- Sponsor
- AstraZeneca
Obesity
Creation of Side-to-Side Compression Anastomosis Using the Magnetic Anastomosis System
This is an operationally seamless, open-label, multicenter study enrolling up to 50 subjects with obesity and with or without type 2 diabetes at up to 5 study centers across Canada and Europe who will undergo sleeve gastrectomy…
- Trial name
- NCT05322122
- Testing
- Side-to-side anastomosis duodeno-ileostomy diversion procedure
- Where
- 4 sites in Belgium, Canada and 2 more
- Volunteers
- 49 people
- Sponsor
- GT Metabolic Solutions, Inc.
Diabetes Mellitus, Type 2
Insulin Glulisine in Adult Subjects With Type 2 Diabetes Receiving Insulin Glargine as Basal Insulin
The purpose of this study is to compare the change in glycemic control, as measured by hemoglobin A1c (HbA1c) from baseline to study week 24, in subjects receiving insulin glulisine as mealtime insulin following a variable bolus…
- Trial name
- NCT00135057
- Testing
- insulin glulisine, insulin glargine
- Where
- United States
- Volunteers
- 281 people
- Sponsor
- Sanofi
Diabetes Mellitus, Type 2
Continuous Glucose Monitoring & Management In Type 2 Diabetes (T2D)
A Study to assess if patients with Type 2 diabetes (T2D) who have suboptimal glycemic control using multiple oral agents are able to make lifestyle changes resulting in improved glycemic control by use of real-time continuous…
- Trial name
- COMMITED (NCT03620357)
- Testing
- CGM, SMBG
- Where
- 10 sites in United States, Canada
- Volunteers
- 72 people
- Sponsor
- DexCom, Inc.
Type 2 Diabetes Mellitus
Study About Effect of Saxagliptin on Circulating Endothelial Progenitor Cells and Endothelial Function in Newly Diagnosed Type 2 Diabetic Patients
In this study, the investigators aim to investigate whether saxagliptin modulate endothelial progenitor cells number and flow-mediated dilation in newly diagnosed, treatment-naive type 2 diabetic patients.
- Trial name
- NCT02920801
- Testing
- saxagliptin, Metformin
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Shanghai Zhongshan Hospital
Type2 Diabetes
Lipoprotein-associated Phospholipase A2 in Patients With Type 2 Diabetes
Lipoprotein-associated phospholipase A2 (LP-PLA2) is a good marker of cardiovascular risk and inflammation. This study aims at the characteristic and clinical significance of LP-PLA2 test in patients with type 2 diabetes(T2D).
- Trial name
- NCT03362112
- Volunteers
- 1,713 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Overweight and Obesity, PreDiabetes
Continuous Glucose Monitors (CGM) for Type 2 Diabetes (T2D) Risk Evaluation
The purpose of this research study is to determine whether continuous glucose monitors (CGM) are a safe, effective, and acceptable way to evaluate type 2 diabetes risk in youth as compared to the standard 2-hour oral glucose…
- Conditions
- Overweight and Obesity, PreDiabetes, Insulin Resistance
- Trial name
- NCT05404711
- Testing
- CGM
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mary Ellen Vajravelu, MD
Healthy Volunteers
Multiple Dose Pharmacokinetics of Canagliflozin/Metformin 150/1,000 mg Fixed Dose Combination
The purpose of this study is to evaluate the multiple dose pharmacokinetics of 2 Canagliflozin/extended release Metformin (CANA/MET XR) fixed dose combination tablets (150 mg/1,000 mg each) following once-daily oral dosing in…
- Trial name
- NCT02039245
- Testing
- CANA/MET XR FDC
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Type 2 Diabetes
A HR20031 BE Study on Healthy Subjects
The purpose of this study is to assess the bioequivalence between HR20031 FDC tablet and co-administration of SHR3824 tablets, SP2086 tablets and metformin XR tablets.
- Trial name
- NCT05682495
- Testing
- ARM A, ARM B, ARM C
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Type 2 Diabetes
Effect of GLP-1 on Angiogenesis
GLP-1 receptor agonists are introduced in the treatment of type 2 Diabetes (T2D) and their efficacy is documented. However, safety aspects are also important to evaluate with respect to micro and macrovascular complications…
- Trial name
- ANGIOSAFE 1 (NCT02686177)
- Testing
- Liraglutide, Metformin or sulfonylurea
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 2 Diabetes Mellitus
Diabetes Knowledge Assessment
To assess the knowledge of both type 2 diabetics and non-diabetics on diabetes, nutrition, and exercise. Although type 2 diabetics should know more about their disease and its needs, it is not expected they will know…
- Trial name
- NCT00198900
- Testing
- survey of information
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health