Clinical trials: Type 2 Diabetes Mellitus 1
Type 1 Diabetes
Closing the Loop in Adults With Sub-optimally Controlled Type 1 Diabetes Under Free Living Conditions
The main objective of this study is to determine whether day and night closed-loop insulin delivery for 12 weeks under free living conditions is superior to addition of real-time continuous glucose monitoring in adults with type…
- Trial name
- AP@home04 (NCT01961622)
- Testing
- Florence D2A or similar closed loop glucose control system, CSII with real-time CGM
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 33 people
- Sponsor
- University of Cambridge
Type 1 Diabetes, Type 2 Diabetes
A 2-Month Safety Follow-Up Trial
The main purpose of the trial is to evaluate pulmonary function in subjects who had completed any one of the 4 MKC parent trials (MKC-TI-009, MKC-TI-102, MKC-TI-103, or MKC-TI-030) for an additional 2-month safety follow-up.
- Trial name
- NCT00741429
- Testing
- Technosphere Insulin Inhalation Powder, Comparator
- Where
- 150 sites in United States, Brazil and 2 more
- Volunteers
- 649 people
- Sponsor
- Mannkind Corporation
Type 1 Diabetes Mellitus
Phase 2 Trial of BMF-219 in Participants With Type 1 Diabetes Mellitus
Phase 2 Trial of BMF-219 in Participants with Type 1 Diabetes Mellitus.
- Trial name
- NCT06152042
- Testing
- BMF-219
- Where
- 11 sites in United States, Canada
- Volunteers
- 37 people
- Sponsor
- Biomea Fusion Inc.
Diabete Type 2, Abdominal Obesity
Translational Study Using Human Abdominal Adipose Tissue Biopsies to Investigate the Role of Cannabinoid Receptor 1 (CB1) in Controlling Endocannabinoid and Adipokine Secretion
Abdominal obesity and type 2 diabetes are associated with the hyperactivation of the endocannabinoid system. Several animal and human studies indicate that circulating endocannabinoid (EC) levels are correlated with body fat.
- Trial name
- ENDOCATA (NCT04940962)
- Testing
- Sampling of adipose tissue
- Where
- France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Diabetes Mellitus, Type 1
Early Feasibility Study 2 of Outpatient Control-to-Range - Testing System Efficacy
An unblinded, randomized, cross-over design with each patient participating in two 40-hour outpatient admissions: (a) Experimental involving automated Control-to-Range (CTR) and (b) Control using Continuous Glucose Monitor (CGM)…
- Trial name
- NCT01714505
- Testing
- Diabetes Assistant (DiAs)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Diabetic Gastroparesis
Diabetic Gastroparesis Efficacy/Safety Study of TZP-102
The purpose of this study is to test the safety and effectiveness of 10 mg TZP-102 given prior to meals three times a day compared to placebo (capsule that looks like active study drug but contains no active drug), administered…
- Trial name
- DIGEST (NCT01664637)
- Testing
- 10 mg TZP-102
- Where
- 35 sites in United States, Poland
- Volunteers
- 120 people
- Sponsor
- Tranzyme, Inc.
Type 1 Diabetes Mellitus
Human Islet Transplantation in Brittle Type 1 Diabetes Mellitus. The GRAGIL 2 Study.
This research project is supported by a multicentric network of collaborators whose goal is to assess the efficacy of transplanting allogenic pancreas islets to restore insulin secretion in patients with brittle type 1…
- Trial name
- NCT00321256
- Testing
- human pancreatic islet transplantation
- Where
- 6 sites in France, Switzerland
- Volunteers
- 22 people
- Sponsor
- University Hospital, Grenoble
Diabetes, Diabetes (Insulin-requiring, Type 1 or Type 2)
Pilot Study of Intrapartum Insulin Pump
People with type 1 or type 2 diabetes often use insulin pumps to manage their blood sugar during pregnancy. These pumps can help keep blood sugar in a healthy range.
- Conditions
- Diabetes, Diabetes (Insulin-requiring, Type 1 or Type 2), Pregnancy
- Trial name
- NCT07420972
- Testing
- Insulin pump
- Volunteers
- 30 people
- Sponsor
- Medstar Health Research Institute
Hypoglycemia
Hypoglycemia Biomarkers to Predict Timing of a Hypoglycemic Event
The study aims to obtain a panel of biomarkers from hypoglycemic diabetic patients with either type 1 or type 2 diabetics and from control patients with type 1 or type 2 diabetes who didn't have hypoglycemia in the last 72 hours.
- Trial name
- NCT06652867
- Where
- Bahrain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons in Ireland - Medical University of Bahrain
Healthy Volunteers and Diabetes Participants
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 Diabetes
This is a Phase 1/2 randomized study of oral doses of PAL-119 in healthy volunteers and participants with diabetes.
- Trial name
- NCT07901595
- Testing
- PAL-119
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Paulex Bio Inc.
Type 2 Diabetes
Chronicare for Type 2 Diabetes (Chronicare-T2D)
This single-blind, single-center, randomized, controlled trial is designed to evaluate the utility of the Chronicare Disease Management Program in the management of subjects with T2D who are being treated with insulin glargine…
- Trial name
- CRX-T2D (NCT03997331)
- Testing
- CRx Health, Chronicare
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- QuiO
Diabetes, Diabetes Mellitus, Type 1 Diabetes
Argus 2.0 Adoption Study
This study evaluates the usability of the KOS Argus Continuous Glucose Monitoring (CGM) System, a noninvasive, wrist-worn device that estimates blood glucose levels using light-based sensors and artificial intelligence…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1 Diabetes, Diabetes Mellitus, Type 2, Prediabetes
- Trial name
- NCT07425236
- Testing
- KOS Argus Continuous Glucose Monitoring System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- KOS Inc.
Type 1 Diabetes
Safety of Overestimation of a Meal Insulin Bolus in the Context of Dual-hormone Closed-loop Operation - Part 2
In previous studies, investigators have studied if a pre-meal insulin bolus based on estimated carbohydrate meal size would alleviate the burden of carbohydrate counting without a significant degradation in postprandial glucose…
- Trial name
- NCT02798250
- Testing
- Dual-hormone closed-loop, Insulin, Glucagon
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes
Efficacy of Glycemic Improvement Project (GLITTER Study) in Type 1 Diabetes-GLITTER Study 2
The GLITTER Study 2 is a cluster randomized trial that will evaluate the impact of comprehensive and intensive management, comprising a team, technology, education, and peer resources, on metabolic control and psychological…
- Trial name
- NCT07097818
- Testing
- T1D team, structured education, peer support , and diabetes technologies, Routine Management
- Where
- 10 sites in China
- Volunteers
- 400 people
- Sponsor
- Second Xiangya Hospital of Central South University
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures, Third Wave
The CLIMATE-III Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, somatosensory amplification, risk and…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE-III (NCT06890208)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 176 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Diabetes, Diabetes Mellitus, Type 1
Special Survey for Paediatric Subjects
This study is conducted in Japan. The aim of this study is to collect safety and efficacy data when using NovoRapid® (insulin aspart) in children with type 1 and type 2 diabetes under normal clinical practice conditions.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01487382
- Testing
- insulin aspart
- Where
- Japan
- Volunteers
- 241 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes
Safety and Tolerability Study of Cotadutide in Japanese Obese Subjects With Type 2 Diabetes Melitus
This is a Phase 1 study designed to assess the safety and tolerability of MEDI0382 (Cotadutide) in Japanese T2DM patients.
- Trial name
- NCT04208620
- Testing
- Cotadutide
- Where
- 3 sites in Japan
- Volunteers
- 16 people
- Sponsor
- AstraZeneca
Kidney Transplant Recipients
The Efficacy, Mechanism & Safety of Sodium Glucose Co-Transporter-2 Inhibitor & Glucagon-Like Peptide 1 Receptor Agonist Combination Therapy in Kidney Transplant Recipients
The study aims to determine the short-term efficacy, mechanisms and safety of 12 weeks of dapagliflozin and semaglutide combination therapy in 20 KTR, with and without T2D.
- Trial name
- HALLMARK (NCT05938712)
- Testing
- Dapagliflozin 10 MG, Semaglutide, 1.0 mg/mL
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Type 1 Diabetes
Closing the Loop for 36 Hours in Adolescents With Type 1 Diabetes
High variability of blood sugar levels and high incidence of night-time hypoglycaemia (low blood sugar) in young people with type 1 diabetes (T1D) make achieving the treatment goals in this population extremely challenging.
- Trial name
- NCT01074801
- Testing
- Closed-loop insulin delivery, Standard insulin pump treatment
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Cambridge
Diabetes, Type 1, Diabetes, Type 2
Safety of Inhaled Insulin With Type 1 and Type 2 Diabetes
Pulmonary Safety in Diabetics with T/I
- Trial name
- NCT00308737
- Testing
- Technosphere® Insulin Inhalation Powder, Usual Care
- Where
- 176 sites in United States, Canada and 6 more
- Volunteers
- 2,053 people, healthy volunteers welcome
- Sponsor
- Mannkind Corporation
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