Clinical trials: Type 2 Diabetes Mellitus Remission
Diabetes Mellitus Type 2 in Obese
Implementation of a Very Low Calorie Diet for Remission of Type 2 Diabetes in the Community
The complications associated with uncontrolled type-2 diabetes mellitus (T2DM) are numerous; reducing the quality of life for the patient and consuming a considerable portion of healthcare finances.
- Trial name
- NCT03536377
- Testing
- very low calorie liquid diet
- Where
- 4 sites in Barbados
- Volunteers
- 100 people
- Sponsor
- The University of The West Indies
Ketosis Prone Diabetes
Modeling Ketosis-Prone Diabetes Remission Via Diverse Mechanisms of Glucotoxicity
The goal of this study is to quantify day-to-day changes in blood glucose during treatment towards remission in ketosis-prone diabetes (KPDM) and describe them using a mathematical model of KPDM pathogenesis and remission.
- Trial name
- NCT06699810
- Testing
- Continuous Glucose Monitoring, Insulin
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Emory University
Diabetes Mellitus, Type 2, Overweight and Obesity
Dietary Strategies for Remission of Type 2 Diabetes
In this project, the investigators will perform a multicenter randomised controlled trial to determine whether advice to consume a moderate, whole food-based low-carbohydrate high-fat (LCHF) ad libitum diet (CarbCount program)…
- Conditions
- Diabetes Mellitus, Type 2, Overweight and Obesity, Hypertension, Glucose Intolerance
- Trial name
- CARBCOUNT (NCT04943926)
- Testing
- Energy restricted diet, Low carbohydrate high fat diet
- Where
- Norway
- Volunteers
- 600 people
- Sponsor
- University of Bergen
Type 2 Diabetes
Triple Hypoglycemic Regimens In Patients With Newly Diagnosed Type 2 Diabetes Mellitus
This study is a multicenter, randomized, controlled study. A sample size of 240 cases is proposed to be included. The inclusion criteria are: (1) patients with newly diagnosed type 2 diabetes; (2) age between 18 and 65 years old…
- Trial name
- TRED (NCT07374328)
- Testing
- Semaglutide (1 Mg Dose), Sitagliptin (DPP4 inhibitor)
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Type 2 Diabetes Mellitus
Determinants of Diabetes Remission After Gastric Bypass Surgery
Longitudinal study of beta cell function up to 2 years after GBP surgery. Evaluation of the role of endogenous glucagon-like peptide-1 (GLP-1).
- Trial name
- NCT02287285
- Testing
- Exendin9
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Blandine Laferrere
Diabete Type 2
Impact of Changes in Muscle Secretome in the Remission of Type 2 Diabetes Mellitus Induced by Bariatric Surgery
Bariatric surgery is recognized as a therapeutic modality of type 2 diabetes. The mechanisms of this remission of diabetes remain poorly understood.
- Trial name
- MYDIASECRET (NCT03341793)
- Testing
- Muscle biopsy and blood test
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Diabetes, Diabetes Mellitus, Type 2
Self-control Trial to Evaluate the Remission Rate in Newly Diagnosed Type 2 Diabetes Patients After Treatment With Insulin Aspart
This trial is conducted in Asia. The aim of this trial is evaluate the remission rate in newly diagnosed subjects with type 2 diabetes after short-term intensive treatment with insulin aspart and insulin NPH.
- Trial name
- NCT00494988
- Testing
- insulin aspart, insulin NPH
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus Type 2 in Obese, Hypertension
Vegetarian Ketogenic Diet VS Omnivore Ketogenic Diet - Protocol of a Keto-vege Diet for Remission of Type 2 Diabetes
Diabetes is one of the biggest public health challenges of the 21st century because of the costs associated with its management, which are estimated at more than three billion dollars per year in Quebec.
- Conditions
- Diabetes Mellitus Type 2 in Obese, Hypertension, Diabetes Mellitus Type 2 With Hyperglycemia, Inflammation
- Trial name
- DT2-OFF (NCT05579561)
- Testing
- Diet
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- BloomedIn
Obesity & Overweight, Type 2 Diabetes
Effects of HIIT Following PTR Programme
Caloric restriction programmes are highly effective and safe interventions for inducing rapid weight loss and improvements in glycaemic control.
- Trial name
- HIITpostLCD (NCT07565935)
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Nottingham
Diabetes, Type 2, Obesity &Amp; Overweight
Calorie Restricted Dietary Intervention in Type 2 Diabetes Patients With Obesity for Remission
This study aims to induce remission of type 2 diabetes through dietary intervention for weight reduction.
- Trial name
- K-Direct2 (NCT07753447)
- Testing
- Contrave ER, Low-calorie meal box
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Yeouido St. Mary's Hospital
Type 2 Diabetes Mellitus
Impacts of PIO/MET Following Short-term Intensive Insulin Treatment in Newly Diagnosed Type 2 Diabetes
Short-term intensive insulin therapy (SIIT) induces glycemic remission in patients with newly diagnosed type 2 diabetes. But remission rate reduces over time.
- Trial name
- NCT03196362
- Testing
- Pioglitazone + Metformin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Diabetes Mellitus Type 2
Effects on Remission of Type 2 Diabetes Mellitus Following Gastric Bypass Alone vs Gastric Bypass Combined With Truncal Vagotomy
This randomized, triple-blind clinical trial investigates whether adding truncal vagotomy to Roux-en-Y gastric bypass (RYGB) enhances remission of type 2 diabetes mellitus (T2DM) in patients with obesity.
- Trial name
- VagusSx (NCT07278115)
- Testing
- Roux-en-Y Gastric Bypass plus Truncal Vagotomy, Roux-en-Y Gastric Bypass
- Where
- 2 sites in Greece
- Volunteers
- 40 people
- Sponsor
- University Research Institute for the Study of Genetic & Malignant Disorders in Childhood
Obesity & Overweight, Type 2 Diabetes Mellitus (T2DM)
MRI Assessment of Pancreatic Fat Changes and Islet Function Recovery After Bariatric Surgery in Obese Patients
This study evaluates changes in pancreatic fat and recovery of pancreatic function in obese patients undergoing laparoscopic sleeve gastrectomy (LSG), a weight-loss surgery.
- Conditions
- Obesity & Overweight, Type 2 Diabetes Mellitus (T2DM), Pancreatic Steatosis, Insulin Resistance
- Trial name
- PANFAT-BS (NCT07464223)
- Testing
- Laparoscopic Sleeve Gastrectomy (LSG)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- yu li，MD
Type 2 Diabetes Mellitus (T2DM)
Lifestyle Intervention for Type 2 Diabetes in Primary Care (CREDOenAP)
The purpose of this clinical trial is to determine whether an intensive lifestyle intervention can achieve remission of type 2 diabetes mellitus (T2DM) in adult patients treated in primary care.
- Trial name
- CREDOenAP (NCT07207980)
- Testing
- CREDOenAP intervention
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Parc Sanitari Pere Virgili
Diabetes Mellitus, Type 2
Digital Diabetes Remission Trial
This is a multicentre, open-label Randomised Controlled Trial run in the United Kingdom. The main aims are to assess whether the Habitual Remission Programme (digital therapeutics + 12-week 800kcal/day low-energy diet, delivered…
- Trial name
- DIGEST (NCT05647226)
- Testing
- Digital therapeutic and intensive lifestyle programme, Standard of care
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Habitual Health Ltd
Type 2 Diabetes, Obesity & Overweight
Effectiveness of a Low-Calorie Diet Combined With Intensive Lifestyle Intervention Using Integrated Personalized Diabetes Management for Achieving Diabetes Remission in Patients With Type 2 Diabetes Mellitus
The goal of this clinical trial is to determine whether a low-calorie diet combined with intensive lifestyle intervention using Integrated Personalized Diabetes Management (iPDM) is more effective than standard care in achieving…
- Conditions
- Type 2 Diabetes, Obesity & Overweight, Remission, Lifestyle Intervention
- Trial name
- REMIT-DM (NCT07748949)
- Testing
- Low-calorie diet, Continous Glucose Monitor (CGM), Standard Care (in control arm)
- Where
- Thailand
- Volunteers
- 54 people
- Sponsor
- Chulalongkorn University
Type 2 Diabetes Mellitus
Visualizing Beta Cells After Bariatric Surgery
In order to evaluate the difference in beta cell mass in patients with and without complete resolution of type 2 diabetes mellitus (T2DM) after Roux en Y gastric bypass (RYGB) investigators aim to compare quantitative PET imaging…
- Trial name
- GLP1-bar (NCT02542059)
- Testing
- 68Ga-exendin PET/CT
- Where
- 2 sites in Netherlands
- Volunteers
- 24 people
- Sponsor
- Radboud University Medical Center
Type 2 Diabetes Mellitus, Diabetic Nephropathy
Study for the Effectiveness of Intensive Therapy Aiming at a Remission of Diabetic Nephropathy
Study for the effectiveness of intensive therapy aiming at the remission of diabetic nephropathy
- Trial name
- NCT00253786
- Testing
- Intensive multifactorial therapy, Standard therapy
- Where
- Japan
- Volunteers
- 312 people
- Sponsor
- Okayama University
Bariatric Surgery Candidate, Diabetes
Surgery Versus Best Medical Management for the Long Term Remission of Type 2 Diabetes and Related Diseases (REMISSION)
Bariatric surgery procedures induce weight loss through restriction and/or malabsorption. The mechanisms underlying type 2 diabetes remission and others metabolic improvements after Roux-en-Y Gastric Bypass (RYGB), sleeve…
- Trial name
- REMISSION (NCT02390973)
- Testing
- Sleeve Gastrectomy, Roux-en-Y Gastric Bypass, Biliopancreatic Diversion with Duodenal Switch
- Where
- Canada
- Volunteers
- 408 people
- Sponsor
- Laval University
Type 2 Diabetes Mellitus, Overweight and Obesity
Type 2 Diabetes Treatment and Remission With a Very Low-Calorie Ketogenic Diet (VLCKD) and Lifestyle Changes
There is a strong correlation between being overweight, specifically with abdominal fat, and type 2 diabetes mellitus (T2DM). Recent scientific literature has highlighted the connection between significant weight loss…
- Trial name
- NCT05984459
- Testing
- VLCKD
- Where
- Switzerland
- Volunteers
- 39 people
- Sponsor
- Cabinet Medical