Clinical trials: Type 2 Diabetes Mellitus With Complication
Diabetes Mellitus, Type 2, Diabetic Nephropathy
Enhancing Adherence in Type 2 Diabetes: The ENHANCE Study
This randomized study will test a behavioral intervention, based on social cognitive theory (SCT), to improve regimen adherence in three different groups of people with type 2 diabetes; (1) those with well controlled blood…
- Trial name
- ENHANCE (NCT00222846)
- Testing
- Attention control, Intervention
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- University of Pittsburgh
Type 2 Diabetes, Diabetic Nephropathy
Effects of Dapagliflozin Treatment on Urinary Proteomic Patterns in Patients With Type 2 Diabetes
Background: SGLT2 inhibitors are the first antiglycaemic drugs with a direct renal action. A part from reducing blood glucose, systemic blood pressure and albuminuria are decreased, while natriuresis is increased.
- Trial name
- DapKid (NCT02914691)
- Testing
- Dapagliflozine 10 mg once daily tablet treatment
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Peter Rossing
Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy
Microvascular Dysfunction in Diabetic Peripheral Neuropathy
This study primarily seeks to evaluate dysfunction of small blood vessels and their linkage to dysfunction of nerves in people with Type 2 Diabetes.
- Trial name
- NCT05118217
- Testing
- This is a non-interventional study
- Volunteers
- 72 people
- Sponsor
- University of Plymouth
Neuropathy Autonomic, Cardiac Autonomic Neuropathy
Diabetic Neuropathy Rapid Screening Test in Turkish Patients With Type 2 Diabetes: Sudoscan
Neuropathy is a frequently observed complication occurring in 60-70% of diabetic patients throughout their lives. In addition, neuropathy is a severe disease that progresses insidiously; its diagnosis can be delayed due to the…
- Conditions
- Neuropathy Autonomic, Cardiac Autonomic Neuropathy, Type2Diabetes, Diabetic Neuropathy Peripheral
- Trial name
- NCT05299918
- Volunteers
- 437 people
- Sponsor
- Istanbul University
Type 2 Diabetes Mellitus
Role of Canagliflozin on CD34+ Cells in Patients With Type 2 Diabetes
The investigators hypothesize that Cana may be able to improve number and function of CD34+ endothelial progenitor cells. The investigators also propose that this expected cardiovascular benefit is independent of HbA1C reduction.
- Trial name
- NCT02964585
- Testing
- Canagliflozin
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- George Washington University
Pregnancy, Gestational Diabetes
Diabetes Group Prenatal Care
The investigators primary objective is to conduct a pilot randomized trial to determine the effect of group prenatal care on self-care activities in women with diabetes.
- Conditions
- Pregnancy, Gestational Diabetes, Type 2 Diabetes
- Trial name
- NCT02444325
- Testing
- Group prenatal care
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- Washington University School of Medicine
Chronic Kidney Disease, Type 2 Diabetes
Autologous Neo-Kidney Augment (NKA) in Patients With Type 2 Diabetes and Chronic Kidney Disease (CKD)
A Phase II, Open-Label Safety and Efficacy Study of an Autologous Neo-Kidney Augment (NKA) in Patients With Type 2 Diabetes and Chronic Kidney Disease (RMTX-CL001).
- Trial name
- RMCL-CL001 (NCT02525263)
- Testing
- Neo-Kidney Augment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Prokidney
Type 2 Diabetes Mellitus, Obesity
Macrovascular and Microvascular Morbidity and Mortality After Metabolic Surgery Versus Medicines
The goal of this study is to compare the impact of metabolic surgery and a class of anti-diabetes medications (Glucagon-like peptide-1 receptor agonists,GLP-1 RAs) on occurrence of diseases involving small and large vessels such…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Microvascular Disease, Macrovascular Disease
- Trial name
- M6 (NCT06355219)
- Volunteers
- 3,932 people
- Sponsor
- Ali Aminian
Diabetic Foot
The Effect of Nurse-Led Diabetic Foot Self-Management Training Program
Diabetic foot is one of the most important chronic complications of Diabetes Mellitus (DM), which is a global health problem today.
- Trial name
- NCT05974592
- Testing
- Education
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Type 2 Diabetes Mellitus (T2DM), Cardiovascular Complications
An Epidemiological and Long-Term Endpoint Registry Study on Disease-Syndrome Correlation Patterns in Comorbid Population With Diabetes and Ischemic Cardio-Cerebrovascular Disease
Explore the characteristics of TCM syndrome elements and distribution patterns of syndrome types in comorbid populations; Screen for "high-risk syndrome patterns" and frequently co-occurring complex syndromes; Identify…
- Trial name
- Diabetes (NCT07104422)
- Volunteers
- 12,000 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Type 2 Diabetes Mellitus, Proteinuria
Comparing the Renal Effect of Dipeptidyl-peptidase 4 Inhibitors and Sulfonylureas
Dipeptidyl peptidase 4 (DPP-4) inhibitors and sulfonylureas have been extensively used in the treatment of type 2 diabetes mellitus (T2DM).
- Trial name
- NCT03983551
- Testing
- Dipeptidyl Peptidase 4 Inhibitor, Sulfonylurea
- Volunteers
- 101 people
- Sponsor
- Changhua Christian Hospital
Atherosclerosis, Cardiovascular Disease
A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event
The purpose of this study is to measure the change in high-sensitivity C-reactive protein (hsCRP), a marker of inflammation in the body, with clazakizumab compared with placebo in adults who have elevated hsCRP and at increased…
- Conditions
- Atherosclerosis, Cardiovascular Disease, Obesity, Hypertension
- Trial name
- CLARITY-CRP (NCT07783802)
- Testing
- Clazakizumab
- Where
- 46 sites in United States, Argentina and 2 more
- Volunteers
- 120 people
- Sponsor
- Eli Lilly and Company
Painful Diabetic Neuropathy (PDN), Peripheral Neuropathy With Type 2 Diabetes
The Treatment of Painful Diabetic Neuropathy With Diet
The purpose of this clinical trial is to determine whether targeted nutritional changes can improve symptoms of painful diabetic neuropathy.
- Conditions
- Painful Diabetic Neuropathy (PDN), Peripheral Neuropathy With Type 2 Diabetes, Vegan Diet
- Trial name
- NCT07509671
- Testing
- Diet, Medical management
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- AdventHealth
Diabetes Mellitus Type 2 Without Complication
Acute Effect of Empagliflozin vs Dapagliflozin Over Pulse Wave Velocity in Type Two Diabetes
To date one of the main independent biomarkers of cardiovascular disease is the arterial stiffness parameters measured by carotid-femoral pulse wave velocity.
- Trial name
- NCT05109949
- Testing
- Dapagliflozin 10Mg Tab, Empagliflozin 25 MG
- Where
- Mexico
- Volunteers
- 72 people
- Sponsor
- Centro Universitario de Ciencias de la Salud, Mexico
Type2diabetes, Diabetic Kidney Disease
NAD Augmentation in Diabetes Kidney Disease
A phase 2a trial randomized, double-blind, placebo-controlled, parallel group trial to determine whether NMN administration improves DKD, as indicated by a significantly greater reduction in UACR compared with placebo…
- Trial name
- DKD (NCT05759468)
- Testing
- Investigational Product - MIB 626
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Brigham and Women's Hospital
Diabetic Foot Ulcer
Matrix Metalloproteinase-1/Tissue Inhibitor of Metalloproteinase-1 (MMP-1/TIMP-1) Ratio and Diabetic Foot Ulcers
The primary objective of this study is to assess the sensitivity and specificity of a MMP-1/TIMP-1 ratio equal to 0.24 at study entry to predict wound healing at 12 weeks' follow up visit.
- Trial name
- DIAB-MMP2 (NCT00935051)
- Testing
- Picture + MMPs and TIMP1 at week 0 and week 4
- Where
- 2 sites in France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Grenoble
Diabetes Mellitus, Adult-Onset, Diabetes Complications
Pancreatic Cancer Can be Detected by Adrenomedullin in New Onset Diabetes Patients
Pancreatic Cancer is a leading cause of cancer-related death. To date, only one fifth of patients at diagnosis is presented resectable because the diagnosis is often delayed making the 5-year survival of this disease globally…
- Conditions
- Diabetes Mellitus, Adult-Onset, Diabetes Complications, Carcinoma, Pancreatic Ductal, Pancreatic Neoplasm
- Trial name
- PaCANOD (NCT02456051)
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- University of Roma La Sapienza
Diabetic Nephropathy, Chronic Kidney Disease
Efficacy of N-Acetylcysteine in Treatment of Overt Diabetic Nephropathy
Diabetic nephropathy has become the single most frequent cause of end-stage renal disease. On a molecular level, at least five major pathways have been implicated in glucose-mediated vascular and renal damage and all of these…
- Conditions
- Diabetic Nephropathy, Chronic Kidney Disease, Diabetes Type 2
- Trial name
- NCT00556465
- Testing
- N-acetylcysteine
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shiraz University of Medical Sciences
Diabetic Nephropathy, Type 2 Diabetes
The Differential Effects of Diabetes Therapy on Inflammation
This study aims to determine if different diabetes treatments have different effects on inflammation; in particular, kidney inflammation.
- Trial name
- NCT02150707
- Testing
- Dipeptidyl-Peptidase IV Inhibitors, Glucagon-Like Peptide 1
- Where
- Ireland
- Volunteers
- 17 people
- Sponsor
- University College Dublin
Type 2 Diabetes Mellitus With Kidney Complications
The Effect of Sodium Zirconium Cyclosilicate on Albuminuria in Patients With Type 2 Diabetes and Hyperkalemia
To investigate whether concomitant treatment with Lokelma can improve the efficacy of standard blockade of the renin-angiotensin system in patients with type 2 diabetes, diabetic nephropathy and hyperkalemia.
- Trial name
- ZIRCUS (NCT04063930)
- Testing
- LOKELMA 5 GM Powder for Oral Suspension
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Steno Diabetes Center Copenhagen