Clinical trials: Type 2 Diabetes Risk
Type 2 Diabetes Mellitus, Cardiovascular Disease
The Effect of a Traditional Dietary Intervention on Diabetes Mellitus and Cardiovascular Disease Risk Factors in a First Nation Community: A Pilot Study
The purpose of this study is to evaluate whether or not a traditional First Nations diet (high protein) and/or a dietary intervention based upon current Canadian dietary recommendations (high carbohydrate/high fiber) effects risk…
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Disease, Obesity
- Trial name
- SLHDP (NCT00707460)
- Testing
- Dietary Intervention (Macronutrient composition)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Obesity, Type 2 Diabetes
Epigenetic Effects of a Single Bout of Exercise on Cardiovascular Risk Factors and the Metabolome
The purpose of this study is to determine the ability of acute exercise to regulate fat metabolism in muscle of overweight and obese people compared to lean people.
- Conditions
- Obesity, Type 2 Diabetes, Cardiovascular Diseases, Acute Exercise
- Trial name
- NCT05034380
- Testing
- Acute exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Metabolic Syndrome X
Exercise and Technology to Reduce Risk in a Rural Population With Metabolic Syndrome
Cardiovascular diseases are the leading cause of death among Canadians. In those with diabetes, cardiovascular complications are responsible for more than 70% of deaths.
- Trial name
- NCT01944124
- Testing
- Mobile Health, Exercise Prescription
- Where
- Canada
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cardiovascular Diseases, Diabetes Mellitus, Type 2
The Japan Diabetes Optimal Integrated Treatment Study for 3 Major Risk Factors of Cardiovascular Diseases
(Intervention study) The objective of the study is to confirm the superiority of the intensive therapy to the conventional therapy concerning the prevention of the incidence or exacerbation of vascular complications caused by…
- Trial name
- J-DOIT3 (NCT00300976)
- Testing
- Lifestyle consultation: weight control, diet, exercise
- Where
- Japan
- Volunteers
- 2,542 people
- Sponsor
- Japan Foundation for the Promotion of International Medical Research Cooperation
Obesity
Comparison of Weight Loss Induced by Bariatric Surgery vs Conventional Treatment
Patients with overweight or obesity are in need to loose weight and represent a particularly challenging medical condition. Undoubtedly, any intervention achieving a negative energy balance over an extended time period will…
- Trial name
- NCT01572090
- Testing
- Lifestyle Changes, Adjustment of oral antidiabetics/insulin therapy, Laparoscopic sleeve gastrectomy
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Type 2 Diabetes, Impaired Glucose Tolerance
Exercise Effects on Cardiovascular Risk Factors, Quality of Life, Muscle Function in Type 2 Diabetes and Healthy Persons
A sedentary lifestyle is known to be a risk factor to developing type 2 diabetes. The aim of this study was to determine the effects of adding regular Nordic walking to daily physical activity.
- Trial name
- SMIDIG (NCT00852982)
- Testing
- Exercise
- Where
- Sweden
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Diabetes Mellitus, Type 2, Dental Caries
Are Diabetics Type 2 More Prone to Dental Caries?
Background: Diabetes mellitus (DM) is well known for long-term complications to general and oral health. Periodontal disease has a bidirectional association with the development of type 2 diabetes (T2DM) (Mealey, 2006; Taylor…
- Trial name
- NCT04883086
- Where
- United Kingdom
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
NIDDM
APAD2: Effects of Rehabilitation Programme in Adapted Physical Activity (APA) Among Type 2 Diabetics
The principal objective is to assess and analyze the effects of a six month programme in Adapted Physical Activity (APA) on physical activity, compliance, and insulin resistance among type 2 diabetics.
- Trial name
- NCT00234273
- Testing
- Rehabilitation programme in Adapted Physical Activity (APA), Therapeutic education primarily focused on dietary
- Where
- 4 sites in France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Coronary Heart Disease, Dyslipidemia
Cardiovascular Risk Factor Management in HIV Infection
There is growing evidence that antiretroviral therapy (ART) increases the risk of coronary heart disease (CHD) through metabolic side effects, such as dyslipidemia, insulin resistance, and type II diabetes.
- Conditions
- Coronary Heart Disease, Dyslipidemia, Diabetes Mellitus, Non-Insulin-Dependent, HIV Infection
- Trial name
- NCT00264394
- Testing
- Updated CHD risk profiles, Guidelines
- Where
- 7 sites in Switzerland
- Volunteers
- 4,097 people
- Sponsor
- University Hospital, Basel, Switzerland
Type 2 Diabetes, Chronic Disease
Prevention Strategies for Adolescents at Risk of Diabetes
The primary aim of PRE-STARt Phase 1 is to pragmatically evaluate and refine a risk assessment tool to identify those children with chronic disease risk factors (including Type 2 Diabetes).
- Trial name
- PRE-STARt (NCT02545140)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 634 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Anemia of Pregnancy, Gestational Diabetes
SMART Health Pregnancy 2 - Intervention to Reduce Anaemia and Cardiometabolic Risk During Pregnancy and in the First Year Following Birth
The goal of this clinical trial is to determine if a complex intervention called SMARThealth Pregnancy can improve the detection and management of high-risk conditions during pregnancy and in the first year after birth in women…
- Conditions
- Anemia of Pregnancy, Gestational Diabetes, Gestational Hypertension, Pre-Eclampsia
- Trial name
- NCT05752955
- Testing
- SMARThealth Pregnancy
- Where
- India
- Volunteers
- 3,446 people
- Sponsor
- The George Institute
Type2 Diabetes, Obesity
Time RestrIcted Feeding For Improving Diabetes Risk (TRIFFID)
This study will explore the effects of eight weeks of time-restricted feeding (TRF) on body weight and composition, glycaemic control, 24-hour glucose profiles, glucoregulatory hormones, and cardiovascular risk in men at high…
- Trial name
- TRIFFID (NCT03590158)
- Testing
- TRF
- Where
- Australia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Diabetes Mellitus, Type 2
A Real-world Study to Investigate Cardiovascular Risk Profile Among Newly Diagnosed Type 2 Diabetes Mellitus (T2DM) Participants
The purpose of the study is to investigate the cardiovascular disease (CVD) risk profile among participants newly diagnosed with type 2 diabetes mellitus (T2DM) in Southeast Asia (CRISTAL SEA).
- Trial name
- CRISTALSEA (NCT07532863)
- Testing
- No treatment given
- Where
- 6 sites in Indonesia, Malaysia and 2 more
- Volunteers
- 400 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes, Chronic Kidney Diseases
Subclinical Primary Aldosteronism in Diabetes At-Risk for Kidney Disease
The aim of this protocol is to assess the presence and severity of primary aldosteronism pathophysiology in patients with type 2 diabetes who have, or are at-risk for developing, chronic kidney disease.
- Trial name
- SubPA-DKD (NCT06190158)
- Testing
- Oral sodium suppression test, Saline suppression test, Captopril suppression test
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Brigham and Women's Hospital
Type 2 Diabetes Mellitus, Hypoglycemia
Hypoglycemia Risk Assessment in Elderly and Senile Female Patients With Type 2 Diabetes Mellitus
Hypoglycemia poses a particular danger for elderly patients with type 2 diabetes mellitus (T2DM). According to data, more than 30% of patients aged 60-69 years experience hypoglycemic episodes, and among persons over 85 years…
- Conditions
- Type 2 Diabetes Mellitus, Hypoglycemia, Frailty, Sarcopenia
- Trial name
- HYPOGLYCEMIA16 (NCT07887334)
- Testing
- Comprehensive Geriatric Assessment, Sarcopenia assessment, Laboratory assessment
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Samara State Medical University
Cardiovascular Diseases, Diabetes Mellitus, Type 2
Exercise Training in Older Diabetic Women
Type 2 diabetics (non-insulin-dependent) are more than five times as likely to suffer an initial myocardial infarction (MI; heart attack) compared to nondiabetics.Female diabetics in particular, have a higher mortality rate for…
- Trial name
- NCT00341614
- Testing
- 3-month Exercise Training and Diet Education
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of San Francisco
Abdominal Obesity, Metabolic Syndrome
Growth Hormone Treatment in Men With High Risk of Developing Type 2 Diabetes Mellitus
The overall aim of this study is to investigate the effects of GH treatment in men with the Metabolic Syndrome and a high risk of developing type 2 DM.
- Conditions
- Abdominal Obesity, Metabolic Syndrome, Obesity
- Trial name
- GHDM (NCT00781547)
- Testing
- recombinant human growth hormone
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Göteborg University
Diabetes Mellitus, Type 2, Adverse Event
Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes
Lowering of blood pressure (BP) in high-risk hypertensive individuals reduces major adverse cardiovascular and cerebrovascular events. Diabetic patients with hypertension benefit from BP lowering treatment.
- Conditions
- Diabetes Mellitus, Type 2, Adverse Event, Blood Pressure, Prehypertension
- Trial name
- IPAD (NCT03264352)
- Testing
- Allisartan Isoproxil, Amlodipine 5mg, Standard treatment by current guideline
- Where
- China
- Volunteers
- 11,414 people
- Sponsor
- XueQing Yu
Type 2 Diabetes Mellitus (T2DM), Coronary Artery Disease
SGLT2 Inhibitors on Coronary Atherosclerosis Progression Via Perivascular Adipose Tissue in Diabetes
This study is a multicenter, randomized controlled trial to test whether an SGLT2 inhibitor (dapagliflozin), a type of diabetes medication, can slow down or even reverse the progression of coronary atherosclerosis (plaque buildup…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Coronary Artery Disease, Atherosclerosis
- Trial name
- SCOPE (NCT07614230)
- Testing
- Dapagliflozin (DAPA), Standard Care (Treatment as Usual)
- Where
- 2 sites in China
- Volunteers
- 144 people
- Sponsor
- Junjie Yang
Type 2 Diabetes, Cardiovascular Diseases
The Impact of Consumption of Eggs in the Context of Plant-Based Diets on Endothelial Function, Diet Quality, and Cardio-Metabolic Risk Factors in Adults at Risk for Type 2 Diabetes
Purpose To assess the impact of inclusion of 2 eggs daily for 6 weeks in an otherwise vegan diet compared to a vegan diet on cardio-metabolic risk and dietary pattern in adults at risk for type 2 diabetes.
- Trial name
- NCT04316429
- Testing
- Egg included vegan phase, Vegan Phase
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Griffin Hospital