Clinical trials: Type 2 Diabetes Risk
Obesity, Microalbuminuria
Evaluation of the Rimonabant Impact on the Regression of Asymptomatic Damage Caused by Cardiovascular Risk Factors
Primary objective: To assess the effect on microalbuminuria levels of treatment with rimonabant 20 mg versus a placebo during a 12 month period.
- Conditions
- Obesity, Microalbuminuria, Diabetes Mellitus, Type 2, Dyslipidemia
- Trial name
- RIALTO (NCT00458081)
- Testing
- Rimonabant
- Where
- Spain
- Volunteers
- 174 people
- Sponsor
- Sanofi
Prediabetes, Impaired Glucose Tolerance
Step Up For Health Study: A Pedometer and Website Intervention in Those With Prediabetes
This study will examine whether a physical activity program, specifically increasing walking steps, offered over the internet is able to increase physical activity in adults with prediabetes.
- Trial name
- NCT05412264
- Testing
- Website intervention
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Diabetes Mellitus, Type 2, Diabetes Complications
Arterial Stiffness and Complication Risk in Type 2 Diabetes
Background The prevalence and incidence of type 2 diabetes is increasing globally. A common complication of diabetes is the disease of the blood vessels, vascular diseases, which can cause disorders like myocardial infarction…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Complications, Diabetic Angiopathies, Diabetic Nephropathies
- Trial name
- NCT02001532
- Where
- Denmark
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Type II Diabetes Mellitus, Intermediate Hyperglycemia (IHG)
Engagement of coMmunity Through Participatory Learning and Action for cOntrol and preVEntion of Type II Diabetes and Its Risk Factors [EMPOWER-D]
This project aims to adapt, implement, and evaluate Participatory Learning and Action (PLA) based intervention in rural areas of KPK, Pakistan which includes Peshawar and Swabi for TIIDM prevention and control.
- Trial name
- NCT06561126
- Testing
- Participatory, Learning and Action Based Intervention
- Where
- Pakistan
- Volunteers
- 12,744 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
PreDiabetes
Precision Medicine for Preventing Type 2 Diabetes: a Step Forward
The prevalence of type 2 diabetes (T2D) has been rising rapidly with an increased burden to the healthcare system. As such T2D prevention is highly recommendable, and, theoretically, it can definitely be successful.
- Trial name
- PRE-MED2 (NCT05147961)
- Testing
- Digital Health, Standard care
- Where
- 2 sites in Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Atherosclerosis, Type 2 Diabetes
Vitamin C and Cardiovascular Risk
Study Goal #1: Determine the optimal oral dose of vitamin C to reduce surrogate markers of atherosclerosis (blockages in blood vessels) following the consumption of an atherogenic high fat lunch in type 2 diabetic individuals.
- Trial name
- NCT00534014
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of New Mexico
Type 2 Diabetes, Urinary Tract Infections
SGLT-2 and DPP-4 Inhibition, Subclinical Inflammation of the Genito-urinary Tract and Risk of Infections.
In this observational study, 60 subjects with type 2 diabetes (T2D) and eligible, as per good clinical practice, for therapy with SGLT-2 inhibitor, will be randomized to receive a SGLT-2 inhibitor or a fixed dose combination of…
- Trial name
- UTI-flog (NCT04735042)
- Testing
- Empagliflozin / Linagliptin or Dapagliflozin/Saxagliptin Pill, Empagliflozin or Dapagliflozin Pill
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Pisa
Mortality of Patients with CVD, Mortality of Patients with CVD and T2DM
The Impact of Type 2 Diabetes Mellitus on Cardiovascular Events in Saudi Arabia Now and Future
Cardiovascular disease (CVD) and Type 2 diabetes mellitus (T2DM) are major global health challenges with significant morbidity and mortality. In Saudi Arabia, the prevalence of CVD and T2DM is increasing.
- Conditions
- Mortality of Patients with CVD, Mortality of Patients with CVD and T2DM, Mortality of Patients with T2DM, Mortality of Patients with Neither
- Trial name
- NCT06674161
- Volunteers
- 80 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Diabetes Type 2
Metformin Effects According to SLC16A11 Carrier Status
This prospective observational study will evaluate whether the SLC16A11 risk variant influences the response to metformin in adults with type 2 diabetes.
- Trial name
- Met-SLC16A11 (NCT07760883)
- Where
- Mexico
- Volunteers
- 154 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Type 2 Diabetes
Evaluation of Myocardial Perfusion Heterogeneity Imaging in Diabetes Patients (EVADIAB)
Long-term additive prognostic value of heterogeneity myocardial perfusion imaging of SPECT over clinical and ischemia in high-risk diabetic patients
- Trial name
- EVADIAB (NCT02316054)
- Testing
- MPHI
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Grenoble
Type 2 Diabetes Mellitus
LOADD (Lifestyle Over and Above Drugs in Diabetes) Study
In the past, nutritional management formed the cornerstone of treatment of type 2 diabetes (T2DM). More recently, this aspect of treatment has received less attention as drug therapy aimed not only to lower glucose, but also to…
- Trial name
- NCT00124553
- Testing
- Intensive dietary advice
- Where
- New Zealand
- Volunteers
- 220 people
- Sponsor
- Edgar National Centre for Diabetes Research
Type2diabetes
Validation of Existing Diabetes Risk Models in a Swedish Population
The goal of this observational study is to validate existing non-invasive diabetes clinical prediction models in a Swedish population.
- Trial name
- NCT05609266
- Volunteers
- 115,642 people, healthy volunteers welcome
- Sponsor
- Umeå University
Retinal Function, Cognitive Dysfunction
Retinal and Cognitive Dysfunction in Type 2 Diabetes
The retina shares similar embryologic origin, anatomical features and physiological properties with the brain and hence offers a unique and accessible "window" to study the correlates and consequences of subclinical pathology in…
- Conditions
- Retinal Function, Cognitive Dysfunction, Microperimetry
- Trial name
- RECOGNISED (NCT04281186)
- Where
- Spain
- Volunteers
- 510 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Type 2 Diabetes
Effects of Exercise on sRAGE Levels and Cardiometabolic Risk Factors
The purpose of this study is to examine the effects of exercise on diverse cardiometabolic risk factors and indicators of atherosclerosis in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT01542775
- Testing
- Aerobic Exercise Group, Control Group
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Korea University
Obesity, Childhood, Diabetes Mellitus, Type 2
The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort
The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort study is a unique and comprehensive longitudinal study of 630 Caucasian children and their parents that was designed to investigate the natural history and…
- Conditions
- Obesity, Childhood, Diabetes Mellitus, Type 2, Cardiovascular Risk Factor, Pediatric ALL
- Trial name
- QUALITY (NCT03356262)
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Health Behavior, Blood Glucose, High
The Genetic Effects of rs7903146 and Dietary Intake on Type 2 Diabetes Mellitus Risk in a Healthy Population
This study investigates the association of genetic effects of rs7903146 and dietary intake on type 2 Diabetes Mellitus (T2DM) risk in a healthy population.
- Conditions
- Health Behavior, Blood Glucose, High, Diet Habit, Genetic Predisposition
- Trial name
- NCT04446754
- Where
- United Kingdom
- Volunteers
- 73 people
- Sponsor
- St Mary's University College
Diabete Type 2
Peel Family Diabetes Prevention Program
The goal of this Hybrid Type 2 effectiveness-implementation pilot randomized controlled trial is to assess the feasibility and preliminary effectiveness of a community-based wellness coaching intervention (the intervention) to…
- Trial name
- Peel FDPP (NCT07675551)
- Testing
- Family Dyad Health and Wellness Coaching Session, Educational Material
- Where
- 2 sites in Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Trillium Health Partners
Covid19
Comorbidities and Risk Score in COVID-19 Patients
Retrospective multi-center cohort study. Consecutive patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) up to October 2020 will be included.
- Trial name
- Comorbidities (NCT04670094)
- Where
- 5 sites in Italy
- Volunteers
- 4,555 people
- Sponsor
- University of Milano Bicocca
Type 2 Diabetes, Impaired Glucose Intolerance
G-CREDIT (Gangnam-Cohort for Risk Evaluation of Diabetes and Impaired Glucose Tolerance)
The prevalence of type 2 diabetes has consistently increased and type 2 diabetes can cause many types of vascular complications. Diabetes develops due to glucose intolerance.
- Trial name
- NCT02726256
- Volunteers
- 500 people
- Sponsor
- Yonsei University
Type 2 Diabetes Mellitus, Cardiovascular Disease
Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints (Core and Extension Phases)
The purpose of this study was to determine whether, in patients with type 2 diabetes and pre-existing disease of the heart and the circulatory system and/or the kidney, aliskiren at a target dose of 300 mg once daily (compared to…
- Trial name
- ALTITUDE (NCT00549757)
- Testing
- Aliskiren
- Where
- 776 sites in United States, Argentina and 35 more
- Volunteers
- 8,606 people
- Sponsor
- Novartis Pharmaceuticals