Clinical trials: Type 2 Diabetes Risk
Obesity, Hypercholesterolemia
The Effect of CBT- Based Weight Loss Program on Obesity
The investigators purpose is to study how CBT (cognitive behavioral therapy)-based weight loss program affects on eating behavior, weight loss and risk factors for CHD (coronary heart diseases)and type 2 diabetes.
- Conditions
- Obesity, Hypercholesterolemia, Diabetes Mellitus, Type 2, Anhedonia
- Trial name
- CognObe (NCT01606904)
- Testing
- Cognitive behavioral therapy -based weight loss program
- Where
- Finland
- Volunteers
- 62 people
- Sponsor
- University of Oulu
Insulin Treated Type 2 Diabetes With High Risk of Hypoglycemia
Efficacy of Flash Glucose-Sensing Technology on the Occurrence of Cardiac Arrhythmias Associated With Hypoglycemia
Hypoglycemia, frequently asymptomatic, may lead to cardiac arrythmias and induce an increased risk of cardiovascular morbidity and mortality in patients with type 2 diabetes (T2D).
- Trial name
- NCT03570138
- Testing
- FREESTYLE LIBRE device, a Flash Continuous Glucose Monitoring System, Usual self monitoring Blood Glucose device
- Where
- 7 sites in France
- Volunteers
- 200 people
- Sponsor
- Poitiers University Hospital
Obesity, Insulin Resistance
Endothelial Function in Young Hispanic Adults at Risk for Type 2 Diabetes
Diabetes is a major public health problem. Hispanics/Latinos are known to be at higher risk for type 2 diabetes. The function of the endothelium has played a key role in the understanding of vascular complications in people with…
- Trial name
- NCT01926938
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM)
Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring.
The goal of this clinical trial is to develop and evaluate a novel diabetes ketoacidosis risk mitigation strategy to support the safe use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) therapy in participants with type 1…
- Conditions
- Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), Chronic Kidney Disease, Diabetic Ketoacidosis
- Trial name
- SCOUT-CKD (NCT07325201)
- Testing
- Sotagliflozin initiation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- HealthPartners Institute
Diabetes
Microbial Determinants of Dementia Risk in Type 2 Diabetics of Mexican Descent
Type 2 diabetes (T2D) predisposes individuals to neurodegeneration and dementia, including Alzheimer's Disease (AD); yet the link between metabolic and neurodegenerative disorders remains unknown.
- Trial name
- NCT04602650
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Sedentary Behavior, Affect
Effects of Multi-day Interruptions in Sitting on Type 2 Diabetes-relevant Outcomes in Children
The overall objective of this in-lab randomized controlled trial is to test the efficacy of multi-day interruptions in sedentary behavior vs.
- Conditions
- Sedentary Behavior, Affect, Metabolic Disturbance, Anxiety
- Trial name
- NCT04469790
- Testing
- SIT+WALK, EX
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Type 2 Diabetes
Effect of Vildagliptin Versus Dapagliflozin as Add on Therapy to Metformin on Cardiovascular Risk Factors
The overarching hypothesis of this study is that vildagliptin (vilda) as add on therapy to metformin (met) in Egyptian type 2 diabetic obese patient will produce an equal, if not better, glycemic control and will reduce…
- Trial name
- NCT07077525
- Testing
- Dapagliflozin + Metformin, Vildagliptin + Metformin
- Where
- Egypt
- Volunteers
- 196 people
- Sponsor
- Al-Azhar University
Prediabetic State, Metabolic Syndrome
Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects
The aim of this prospective interventional study is to investigate the metabolic effects of consuming artificial and natural sweeteners in persons with prediabetes.
- Conditions
- Prediabetic State, Metabolic Syndrome, Insulin Resistance, Thrombosis
- Trial name
- Sweetheart (NCT07377097)
- Testing
- Saccharin, Sucralose, Erythritol
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
At Risk for Type 2 Diabetes Mellitus, Pre Diabetes
Primary and Secondary Prevention of Type 2 Diabetes Mellitus in Clark County
This pilot and feasibility study aims to assess the effectiveness of a nutrition education intervention using the Cooking Matters for Adults Curriculum (SNAP-Ed).
- Trial name
- NCT06387797
- Testing
- Cooking Matters for Adults (CMA+), Cooking Matters for Adults (CMA)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Type 2 Diabetes, Chronic Disease
PRE-STARt Intervention - Trial of an Interactive Family Based Lifestyle Programme
To investigate whether the interactive family based lifestyle programme leads to behaviour change at 6 months with the primary outcome being increased levels of moderate to vigorous physical activity (MVPA).
- Conditions
- Type 2 Diabetes, Chronic Disease, Obesity
- Trial name
- NCT02845791
- Testing
- Interactive Lifestyle programme workshop
- Where
- United Kingdom
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Diabetes Mellitus, Non-insulin Dependent, Cardiovascular Diseases
Heavy Metals, Obesity and Cardiovascular Risk - Ancillary to Look AHEAD
To evaluate the relationship of baseline toenail chromium concentrations to weight loss, as well as the interaction between heavy metals and the beneficial effects of weight loss.
- Conditions
- Diabetes Mellitus, Non-insulin Dependent, Cardiovascular Diseases, Obesity, Myocardial Infarction
- Trial name
- NCT00031213
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Birth Defects, Type 2 Diabetes
Exenatide Pregnancy Registry - Type 2 Diabetes in Pregnancy
This is an observational, prospective cohort study describing pregnancy outcomes in women with pre-existing (prior to pregnancy) type 2 diabetes who have been exposed to any formulation of exenatide during pregnancy.
- Conditions
- Birth Defects, Type 2 Diabetes, Preterm Birth
- Trial name
- Exenatide (NCT00579150)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- AstraZeneca
Cardiovascular Diseases, Type 2 Diabetes Mellitus (T2DM)
EValuation Of poLygenic Scores and CT imAging In Risk Factor Modification in Patients With diabEtes
This study is a three-arm, parallel-group, randomised controlled trial evaluating the effect of using cardiac CT imaging or polygenic risk score in cardiovascular risk factor modification in patients with diabetes.
- Trial name
- VOLTAIRE (NCT07091162)
- Testing
- CTCA results, PRS results
- Where
- Australia
- Volunteers
- 79 people
- Sponsor
- Monash University
Obesity, Cardiovascular Risk Factor
Coordinating Pragmatic Primary Care Population Management for Obesity
The C3PO pilot and feasibility study uses a rigorous, mixed-method research design to provide information needed to refine and implement a technology-mediated primary care outreach intervention approach before conducting a larger…
- Trial name
- C3PO (NCT03998046)
- Testing
- Outreach Support for Weight Loss Goal Setting and Self-Weighing, Outreach Decision Support to Encourage Linkages to Intensive Community Lifestyle Interventions, Adaptive Tailoring of Information Delivery and Intensity of Primary Care Outreach Support
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Diabetes Mellitus, Type 2
Understanding of Genetic Risk Information for Type 2 Diabetes
This research study is being conducted to learn about how health and genetic literacy (i.e., how well a person understands health and genetic information) affects a person's ability to understand genetic risk information for Type…
- Trial name
- NCT01186354
- Testing
- Receiving results via genetic counselor
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Duke University
Cardiovascular Diseases
EVOC - EVs in Obesity and Cardiometabolic Disease
The goal of this observational study is to research the impact of molecular signals from the heart, liver and fat tissue on cardiovascular disease risk, and the presentation of Type II Diabetes and diseases that affect the heart…
- Trial name
- EVOC (NCT06408961)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Overweight and Obesity, PreDiabetes
Clinical Effectiveness of Body Fat Distribution Imaging in Real-World Practice: The BODY-REAL Study
The overall goal is to determine the real-world feasibility and utility of body fat imaging using rapid MRI to enhance risk perception, induce behavioral change, and improve clinical outcomes in overweight and obese individuals.
- Conditions
- Overweight and Obesity, PreDiabetes, Type 2 Diabetes, Cardiovascular Risk Factor
- Trial name
- BODY-REAL (NCT04763772)
- Testing
- Body Fat Distribution Imaging Report, Basic Weight Information, Patient Provided
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University Hospitals Cleveland Medical Center
Type2diabetes
Use of AI in Cardiometabolic Risk Prediction in Asian Indians
The Investigators are recruiting T2DM patients (n, 500) from Fortis-CDOC Hospital. Patients' weight, BMI, lipid profile, liver and kidney function tests, EGG, glycemic parameters, blood pressure, etc.
- Trial name
- NCT05939869
- Testing
- Medical and Clinical History
- Where
- India
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Metabolic Syndrome
Relation Between Serum Uric Acid and Metabolic Syndrome in Type 2 DM
This study will be undertaken to evaluate the association of serum uric acid (SUA) level with metabolic risk factors in patients with type 2 diabetes and their relation to eGFR status
- Trial name
- NCT04575389
- Testing
- Serum uric acid levels ,HBA1C , fasting plasma glucose ,lipid profile , creatinine level
- Volunteers
- 100 people
- Sponsor
- Assiut University
Fat Burn, Diabetes Mellitus, Type 2
Physical Exercise, Diet, and Health in People With Type 2 Diabetes: Longitudinal Design of the EDUGUTION Study
This longitudinal design study is a continuation of the EDUGUTION project (Ref: PID2019-110063RA-I00; Clinical Trial: NCT05261373), a randomized controlled trial that was approved by the Clinical Research Ethics Committee of…
- Conditions
- Fat Burn, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Metabolism Disorder
- Trial name
- NCT06219850
- Testing
- No intervention
- Volunteers
- 120 people
- Sponsor
- University of Cadiz