Clinical trials: Type 2 Diabetes Risk
Obesity & Overweight, Type 2 Diabetes
Effects of HIIT Following PTR Programme
Caloric restriction programmes are highly effective and safe interventions for inducing rapid weight loss and improvements in glycaemic control.
- Trial name
- HIITpostLCD (NCT07565935)
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Nottingham
Cardiovascular Disease, Diabetes Mellitus Type 2
A Study on The Potential of Aleglitazar to Reduce Cardiovascular Risk in Patients With Stable Cardiovascular Disease and Glucose Abnormalities
This randomized, double-blind, placebo-controlled, parallel group, multicenter study will evaluate the potential of aleglitazar to reduce cardiovascular risk in patients with stable cardiovascular disease and glucose…
- Trial name
- NCT01715818
- Testing
- aleglitazar
- Where
- 392 sites in United States, Argentina and 25 more
- Volunteers
- 1,999 people
- Sponsor
- Hoffmann-La Roche
Sarcopenia, Obesity Type 2 Diabetes Mellitus
Sarcopenia Risk in Obese T2DM Patients
This study aims to measure handgrip strength, walking speed, and the risk of muscle wasting in obese patients who have had diabetes for 5 years or longer, and to evaluate the relationship of these measures with factors that may…
- Trial name
- NCT07905274
- Testing
- physical examination
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Bandırma Onyedi Eylül University
Type 2 Diabetes Mellitus
Effect of Efpeglenatide on Cardiovascular Outcomes
Primary Objective: To demonstrate that efpeglenatide 4 and 6 mg was noninferior to placebo on 3-point major adverse cardiac events (MACE) in Type 2 diabetes mellitus (T2DM) participants at high cardiovascular (CV) risk.
- Trial name
- AMPLITUDE-O (NCT03496298)
- Testing
- Efpeglenatide (SAR439977)
- Where
- 353 sites in United States, Argentina and 26 more
- Volunteers
- 4,076 people
- Sponsor
- Sanofi
Obesity, Overweight
A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, Type 2 Diabetes, and Increased Cardiovascular Risk
The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with a placebo in participants with obesity or overweight, type 2 diabetes, and increased cardiovascular risk.
- Conditions
- Obesity, Overweight, Cardiovascular Diseases, Diabetes Mellitus, Type 2
- Trial name
- ENLIGHTEN-10 (NCT07900633)
- Testing
- Eloralintide
- Where
- 309 sites in United States, Argentina and 19 more
- Volunteers
- 3,000 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes Mellitus, Obesity
Vitamin D Status and Lipid Profile in Obese Adults With Type 2 Diabetes
This prospective, single-center, cross-sectional observational study aims to evaluate the association between serum 25-hydroxyvitamin D concentrations and lipid profile parameters among adults with obesity and established type 2…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Dyslipidemia, Vitamin D Deficiency
- Trial name
- VILD-T2D (NCT07729553)
- Volunteers
- 150 people
- Sponsor
- Sinai University
Type 2 Diabetes
Targeting the Carotid Bodies to Reduce Disease Risk Along the Diabetes Continuum
Our overall goal is to advance our understanding of the contribution of the carotid body chemoreceptors in glucose regulation and the development of type 2 diabetes.
- Trial name
- NCT05219994
- Testing
- Hyperoxia Exposure, Normoxia Exposure
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Diabetic Foot Ulcer, Type 2 Diabetes Mellitus With Complication
Implementation of a Preventive Diabetic Foot Care Program for Patients at Risk of Diabetic Foot
This study aims to evaluate the effect of a preventive diabetic foot care program on the knowledge, behavior, self-management, and glycemic control levels of type 2 diabetic patients at risk of diabetic foot.
- Trial name
- NCT06770829
- Testing
- DiaFOOTCare Program, Ministry of Health and Education
- Volunteers
- 78 people
- Sponsor
- Akdeniz University
Coronary Heart Disease, Dyslipidemia
Cardiovascular Risk Factor Management in HIV Infection
There is growing evidence that antiretroviral therapy (ART) increases the risk of coronary heart disease (CHD) through metabolic side effects, such as dyslipidemia, insulin resistance, and type II diabetes.
- Conditions
- Coronary Heart Disease, Dyslipidemia, Diabetes Mellitus, Non-Insulin-Dependent, HIV Infection
- Trial name
- NCT00264394
- Testing
- Updated CHD risk profiles, Guidelines
- Where
- 7 sites in Switzerland
- Volunteers
- 4,097 people
- Sponsor
- University Hospital, Basel, Switzerland
Pediatric Obesity, Type 2 Diabetes
A Family Based Intervention to Reduce the Risk of Type 2 Diabetes in Children
The purpose of this study was to determine if a family-focused lifestyle intervention helps to improve the health status, behaviors, and adjustment of overweight children.
- Conditions
- Pediatric Obesity, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- FBI (NCT01146314)
- Testing
- Family Focused Lifestyle Intervention
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Nemours Children's Clinic
Type 2 Diabetes Mellitus, Binge-Eating Disorder
Preventing Type 2 Diabetes in Black Emergent Adult
Black Americans are disproportionately affected by diabetes, with nearly double the rates of type 2 diabetes mellitus (T2DM), compared to non-Hispanic White adults.
- Conditions
- Type 2 Diabetes Mellitus, Binge-Eating Disorder, Binge Eating, Obesity
- Trial name
- NCT06848244
- Testing
- Appetite Awareness Training (AAT), Diabetes Prevention Program (DPP)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Diabetes Mellitus, Type 2
Immune Profile and Complication Risk in Type 2 Diabetes
The aim of this study is to investigate the relation between individual differences in pattern recognition molecules (PRM's) in the innate immune system and the prevalence and development of vascular complications in patients…
- Trial name
- IMPACT (NCT00674271)
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Type 2 Diabetes, Gestational Diabetes
Exploring Nutritype Signature of Type 2 Diabetes Risks in Women Post-Gestational Diabetes Mellitus
Women post-gestational diabetes mellitus (GDM) have more than 7-fold increased risk of having future type 2 diabetes mellitus (T2DM).
- Trial name
- NCT04190199
- Testing
- Observational
- Where
- Malaysia
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Cardiovascular Diseases, Type 2 Diabetes Mellitus (T2DM)
EValuation Of poLygenic Scores and CT imAging In Risk Factor Modification in Patients With diabEtes
This study is a three-arm, parallel-group, randomised controlled trial evaluating the effect of using cardiac CT imaging or polygenic risk score in cardiovascular risk factor modification in patients with diabetes.
- Trial name
- VOLTAIRE (NCT07091162)
- Testing
- CTCA results, PRS results
- Where
- Australia
- Volunteers
- 79 people
- Sponsor
- Monash University
Pre-Gestational Diabetes, Type2diabetes
A Randomized Controlled Trial of Diabetes Screening Immediately Postpartum (DIP) and Follow Up PP CARE
DIP : To conduct a pragmatic, non-blinded randomized controlled trial (pRCT) of immediate in-patient postpartum OGTT prior to delivery discharge (intervention) versus 4-12 week outpatient postpartum OGTT (current standard care)…
- Conditions
- Pre-Gestational Diabetes, Type2diabetes, Pregnancy in Diabetic, Pregnancy, High Risk
- Trial name
- NCT05909046
- Testing
- Immediate inpatient postpartum OGTT, Standard of care 4-12 week postpartum OGTT
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Ohio State University
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Prevalence and Risk Evaluation of Diabetic Complications of the Foot in A Large Canadian Population
The study aims to assess foot complications among patients with diabetes in Canada, using patient data collected during diabetes foot assessments performed by the LMC Chiropody Team between February 27, 2018 and April 17, 2019.
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Foot Deformities, Onychauxis
- Trial name
- PEDAL (NCT04327622)
- Where
- Canada
- Volunteers
- 5,084 people
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Blood Pressure, Glucose Intolerance
Effect of Dragon Fruit Consumption in Individuals at Risk of Type 2 Diabetes
In this project, an edible product based on dragon fruit will be tested to determine its effect on blood glucose levels and blood pressure in individuals at risk of type 2 diabetes.
- Trial name
- NCT05199636
- Testing
- Dragon fruit product
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Microalbuminuria, Endothelial Dysfunction
Microalbuminuria as a Cardiovascular Risk Factor (PRECISED Substudy)
Microalbuminuria (MA) is an independent cardiovascular risk factor in diabetic and non-diabetic subjects. However, in the setting of type 2 diabetes, microalbuminuria could be a marker of either early diabetic nephropathy or…
- Conditions
- Microalbuminuria, Endothelial Dysfunction, Diabetic Nephropathy, Diabetic Retinopathy
- Trial name
- NCT02409511
- Testing
- non intervention
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Colon Cancer, Lung Cancer
Predictive Genetic Risk Assessment Trial
This proof-of-principle clinical trial at Mayo Clinic studies how patients and their physicians understand and utilize predictive genetic risk assessment.
- Conditions
- Colon Cancer, Lung Cancer, Atrial Fibrillation, Diabetes Type 2
- Trial name
- PGT (NCT00782366)
- Testing
- SNP analysis
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Type 2 Diabetes Mellitus, Cardiovascular Diseases
Soluble TREM-1 in Diabetes-Associated Cardiovascular Complications
Cardiovascular disease is the leading cause of illness and death among individuals with type 2 diabetes mellitus (T2DM). Chronic low-grade inflammation contributes significantly to blood vessel damage, atherosclerosis, and…
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Diseases, Coronary Artery Disease, Heart Failure
- Trial name
- NCT07847112
- Volunteers
- 85 people
- Sponsor
- Assiut University