Clinical trials: Type 2 Diabetes Risk
Type2 Diabetes Mellitus
SGLT-2 Inhibitor and Myocardial Perfusion, Function and Metabolism in T2 DM Patients at High Cardiovascular Risk
Patients with type 2 diabetes (T2 DM) have a markedly increased risk of heart disease and it is estimated that, in the danish population, up 80% percent of patients with type 2 diabetes die from heart disease.
- Trial name
- SIMPLE (NCT03151343)
- Testing
- Empagliflozin
- Where
- Denmark
- Volunteers
- 92 people
- Sponsor
- Caroline M Kistorp
Type 2 Diabetes
Vitamin D Supplementation on Cardiovascular Risk Factors
The purpose of the present pilot study is to determine the effect of vitamin D supplementation (4000 IU or 6000 IU once daily for 6 months) on reducing heart disease risk and in improving blood glucose control in type 2 Diabetes…
- Trial name
- NCT01412710
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Florida International University
Diabetes Mellitus Type II
Effect of Adding Vildagliptin on Beta Cell Function and Cardiovascular Risk Markers in Patients With Moderate Metabolic Control During Metformin Monotherapy
The aim of this pilot-study is to investigate the effect of Vildagliptin in comparison to glimepiride on beta cell function and the cardiovascular risk profile in patients previously treated with Metformin monotherapy.
- Trial name
- NCT01565096
- Testing
- Metformin, Vildagliptin, Glimepiride
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- ikfe-CRO GmbH
Type 2 Diabetes
Cohort Study in Type 2 Diabetes in China
This study is designed to assess the incidence of cardiovascular events occurred within an 12 month follow up period in type 2 diabetic patients with either high risk of cardiovascular disease (CVD) or history of coronary artery…
- Trial name
- CCDC (NCT01076023)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- China Cardiometabolic Registries
Diabetes Mellitus, Type 2
BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME).
The aim of the present study is to investigate the safety of BI 10773 treatment in patients with Type 2 Diabetes Mellitus and high cardiovascular risk.
- Trial name
- NCT01131676
- Testing
- BI 10773 low dose, BI 10773 high dose
- Where
- 615 sites in United States, Argentina and 40 more
- Volunteers
- 7,064 people
- Sponsor
- Boehringer Ingelheim
Obesity, Weight Reduction
Low-Dose Semaglutide for Weight Loss in Obese Non-Diabetic Pakistani Adults
This prospective, open-label, single-arm, single-center interventional pilot trial aims to evaluate the efficacy and safety of low-dose semaglutide for weight loss and cardiometabolic improvement in obese Pakistani adults without…
- Conditions
- Obesity, Weight Reduction, Cardiometabolic Risk Factors
- Trial name
- NCT07513168
- Testing
- Locally available low-dose semaglutide (0.25 mg, 0.5 mg, 1 mg)
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Asian Institute Of Medical Sciences
High Risk Hypertensive Patients
Study to Improve Quality of Care and Patient Health in the Field of Cardiovascular Risk Factors in General Practice
Observational studies performed in France and abroad in hypertensive patients at high cardiovascular risk have shown a wide gap between the therapeutic targets reached in ambulatory patients and those set by guidelines.
- Trial name
- ESCAPE (NCT00348855)
- Testing
- Cardiovascular drugs strategies, Compliance, Exercise
- Where
- 2 sites in France
- Volunteers
- 1,836 people
- Sponsor
- Collège National des Généralistes Enseignants
NAFLD, Liver Cirrhosis
Risk Factors for Advanced Fibrosis Among FLD Patients
The investigators investigate the heterogeneity fatty liver disease (FLD) as well as risk factors associated with progression of the liver diseases or development of cardiovascular complication.
- Conditions
- NAFLD, Liver Cirrhosis, Diabetes Mellitus, Type 2
- Trial name
- FLD_FU_HUS (NCT05971082)
- Testing
- Follow-up
- Where
- Finland
- Volunteers
- 1,000 people
- Sponsor
- Helsinki University Central Hospital
Obesity & Overweight, Type 2 Diabetes
Effects of HIIT Following PTR Programme
Caloric restriction programmes are highly effective and safe interventions for inducing rapid weight loss and improvements in glycaemic control.
- Trial name
- HIITpostLCD (NCT07565935)
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Nottingham
Type 2 Diabetes
Validation of a Predictive Risk Equation for Type 2 Diabetes in Families With Risk
Considering its epidemic-like development worldwide, associated with modifications in lifestyle, as well as its enormous social and economic weight, the prevention of type II diabetes is certain to be a central concern of health…
- Trial name
- DESCENDANCE (NCT01727349)
- Testing
- HbA1c measurement, Oral Glucoce Tolerance Test
- Where
- 17 sites in Belgium, France
- Volunteers
- 1,035 people, healthy volunteers welcome
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type 2 Diabetes Mellitus
Dapagliflozin, Cardio-Metabolic Risk Factors and Type-2 Diabetes
Dapagliflozin is a member of the sodium-glucose cotransporter-2 (SGLT2) inhibitor class antidiabetes agents which produces significant and sustained reductions in glycemic parameters in patients with type 2 diabetes (T2DM).
- Trial name
- NCT03377335
- Testing
- Dapagliflozin 10mg, Metformin
- Where
- Italy
- Volunteers
- 186 people
- Sponsor
- University of Palermo
Cardiovascular Disease, Diabetes Mellitus Type 2
A Study on The Potential of Aleglitazar to Reduce Cardiovascular Risk in Patients With Stable Cardiovascular Disease and Glucose Abnormalities
This randomized, double-blind, placebo-controlled, parallel group, multicenter study will evaluate the potential of aleglitazar to reduce cardiovascular risk in patients with stable cardiovascular disease and glucose…
- Trial name
- NCT01715818
- Testing
- aleglitazar
- Where
- 392 sites in United States, Argentina and 25 more
- Volunteers
- 1,999 people
- Sponsor
- Hoffmann-La Roche
Prediabetes
Effects of Yoghurt Consumption on Glucose Metabolism in Prediabetic Subjects
The purpose of this study is to explore the effects of yoghurt consumption on glucose metabolism in prediabetic subjects.
- Trial name
- SNOWFALL (NCT06836752)
- Testing
- Yoghurt, Milk
- Where
- France
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Diabetes Mellitus, Type 2
A Study of People With Type 2 Diabetes Who Have Diseases That Affect the Heart and Blood Vessels. The Study Will Also Look at the Treatment of a Group of These People in Hospitals in Portugal
This study aims to estimate the number of patients with cardiovascular disease and risk factors in patients who had been diagnosed with type 2 diabetes mellitus.
- Trial name
- PICT2RE (NCT03797885)
- Testing
- No treatment given
- Where
- 14 sites in Portugal
- Volunteers
- 730 people
- Sponsor
- Novo Nordisk A/S
Cardiovascular Disease, Type 2 Diabetes
Moderate Alcohol Consumption, Risk of Cardiovascular Disease and Type 2 Diabetes: Influence of Alcohol Oxidation
Moderate alcohol consumption is associated with a decreased risk of cardiovascular disease and type 2 diabetes. The association of alcohol consumption with cardiovascular disease is mediated by a functional polymorphism of…
- Trial name
- NCT00285909
- Testing
- Alcohol: 25 gday (white wine)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- TNO
Type 2 Diabetes Mellitus, Cardiovascular Diseases
Soluble TREM-1 in Diabetes-Associated Cardiovascular Complications
Cardiovascular disease is the leading cause of illness and death among individuals with type 2 diabetes mellitus (T2DM). Chronic low-grade inflammation contributes significantly to blood vessel damage, atherosclerosis, and…
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Diseases, Coronary Artery Disease, Heart Failure
- Trial name
- NCT07847112
- Volunteers
- 85 people
- Sponsor
- Assiut University
Overweight, Obese
Foundations for Health
Foundations for Health is a 12-week behavioral weight loss interventions primarily conducted via the internet aimed at helping overweight and obese young adults (ages 18-30) lose weight by increasing physical activity, decreasing…
- Trial name
- FFH (NCT01304615)
- Testing
- Decrease Energy Density of the Diet, Increase Steps per Day, Consumption of Self-made Meals
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Obesity, Overweight
Hybridized Three Steps Intervention to Prevent Diabetes in Venezuela
The American Diabetes Association recommends implementing the Diabetes Prevention Program (DPP) in subjects with prediabetes. In the DPP, weight reduction was the main predictor of a lower incidence of type 2 diabetes (T2D), each…
- Conditions
- Obesity, Overweight, PreDiabetes, Diabetes Mellitus, Type 2
- Trial name
- HITS (NCT04927871)
- Testing
- Total Diet Replacement (TDR), Medical Nutritional Therapy (MNT), Diabetes Prevention Program 4 months
- Where
- 2 sites in Venezuela
- Volunteers
- 156 people
- Sponsor
- Foundation for Public Health and Epidemiological Research of Venezuela
Microalbuminuria, Endothelial Dysfunction
Microalbuminuria as a Cardiovascular Risk Factor (PRECISED Substudy)
Microalbuminuria (MA) is an independent cardiovascular risk factor in diabetic and non-diabetic subjects. However, in the setting of type 2 diabetes, microalbuminuria could be a marker of either early diabetic nephropathy or…
- Conditions
- Microalbuminuria, Endothelial Dysfunction, Diabetic Nephropathy, Diabetic Retinopathy
- Trial name
- NCT02409511
- Testing
- non intervention
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Type 2 Diabetes Mellitus
The Impact of Frailty in Type 2 Diabetes
The purpose of our work; To investigate the effect of frailty on balance and fall risk in individuals with type 2 diabetes.The reason why participants the investigators invited to the study is participants diagnosis of Type 2…
- Trial name
- NCT05863611
- Testing
- arms
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University