Clinical trials: Type 2 Diabetes Risk
Type 2 Diabetes Mellitus
Acetylcarnitine and Insulin Sensitivity
Decreased insulin sensitivity (e.g. insulin resistance) is a hallmark and a major pathogenic factor of type 2 diabetes. It is the key factor of the metabolic syndrome - a cluster of arterial hypertension, obesity, impaired…
- Trial name
- NCT00393770
- Testing
- L-acetylcarnitine
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Insulin Sensitivity, Glucose Metabolism Disorders
Bisphenol A and Muscle Insulin Sensitivity
This study examine oral bisphenol A consumption on muscle insulin sensitivity and hepatic glucose suppression. Half of the participants will receive a diet plus BPA and the other half will receive a diet plus no bisphenol A.
- Conditions
- Insulin Sensitivity, Glucose Metabolism Disorders, Microtia
- Trial name
- NCT03771066
- Testing
- bisphenol A
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- California Polytechnic State University-San Luis Obispo
Type 2 Diabetes, Inflammation
Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids
Every 3 minutes a new case of diabetes is diagnosed in Canada, mostly type 2 diabetes (T2D) increasing the risk for heart disease.
- Conditions
- Type 2 Diabetes, Inflammation, Insulin Sensitivity/Resistance, Fatty Acids, Omega-3
- Trial name
- NCT04485871
- Testing
- Omega-3 fatty acids
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 2 Diabetes Treated With Insulin, Hypoglycemia
Reducing Treatment Risk in Older Adults With Diabetes
This study will evaluate the impact of academic detailing (evidence-based provider education) with or without patient pre-visit preparation (elicitation of values and preferences) on safe insulin de-prescribing among older…
- Conditions
- Type 2 Diabetes Treated With Insulin, Hypoglycemia, Primary Health Care, Polypharmacy
- Trial name
- RETRO-DM (NCT04585191)
- Testing
- Conversation Aid, Attention Control Educational Handout
- Where
- 4 sites in United States
- Volunteers
- 450 people
- Sponsor
- Kaiser Permanente
Obesity, Type 2 Diabetes
Strength Training and Nutrition Development for African American Youth
The investigators are conducting an intervention study to examine the effects of a 16-week exercise and diet interventions on prevention of disease, specifically type 2 diabetes and heart disease, in African American youth.
- Conditions
- Obesity, Type 2 Diabetes, Cardiovascular Risk, Cancer
- Trial name
- STAND (NCT01441323)
- Testing
- Nutrition, Strength Training & Nutrition
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Insulin Sensitivity, Type 2 Diabetes
Effect of Diacylglycerol Oil on Risk Factors of Type 2 Diabetes and Complicating Disease, and Mechanism
Diacylglycerol oil has been shown to lower postprandial and fasting serum triacylglycerol levels and reduce body fat. The investigators hypothesize that replacing dietary fat with diacylglycerol oil reduces excess body fat in…
- Conditions
- Insulin Sensitivity, Type 2 Diabetes, Cardiovascular Disease
- Trial name
- NCT01802541
- Testing
- diacylglycerol oil, triacylglycerol oil
- Volunteers
- 127 people
- Sponsor
- Zhejiang University
Type 2 Diabetes, Gestational Diabetes
Randomized Trial to Evaluate the Effectiveness of Nurse Case Management
The management of high-risk pregnancies require substantial use of medical resources. Our goal is to determine the effectiveness of a nurse case management program in which case managers are assigned to patients with high-risk…
- Conditions
- Type 2 Diabetes, Gestational Diabetes, Hypertension, Preterm Delivery
- Trial name
- NCT00295256
- Testing
- nurse case manager
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Diabetes Mellitus, Type 2
Screening for Early Evidence of Diabetes
This is a pivotal study to determine the accuracy of a new device (SCOUT) in screening persons for pre-diabetes or diabetes. SCOUT will be compared to the standard screening test (Fasting Plasma Glucose), using the Oral Glucose…
- Trial name
- SEED (NCT00614783)
- Where
- 15 sites in United States
- Volunteers
- 3,478 people, healthy volunteers welcome
- Sponsor
- VeraLight, Inc.
Metabolic Syndrome, Diabete Type 2
Metformin Versus Vildagliptin in Reducing Risk of Metabolic Syndrome Complications Progression
Several crosssectional and prospective studies have shown that metabolic syndrome and its related components are associated with both prevalent and incident CKD .
- Conditions
- Metabolic Syndrome, Diabete Type 2, Kidney Insufficiency
- Trial name
- NCT04485845
- Testing
- Vildagliptin, Captopril Tablets, MetFORMIN 500 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 39 people
- Sponsor
- Cairo University
Hypertension, Diabetes Mellitus, Type 2
Effectiveness of a Case Management Model for Patients With Hypertension and Type II Diabetes in Chile
The purpose of this study is to evaluate whether a new model of health care for chronic patients, based on Case Management and guided by a nurse which targets the patient´s risk, is more effective than usual care at Primary…
- Trial name
- NCT02762695
- Testing
- Case Management, Usual Care
- Where
- Chile
- Volunteers
- 616 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Diabetes Type 2
Peer Comparison-based Risk Communication
The study objective is to evaluate the feasibility of delivering a risk communication intervention, Peer comparison-based Risk Communication (PRICOM), in the primary care setting for adults with poor T2DM control.
- Trial name
- PRICOM (NCT06837428)
- Testing
- Peer comparison-based Risk Communication (PRICOM)
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- SingHealth Polyclinics
Coronary Arteriosclerosis, Diabetes Mellitus, Type 2
Establish The Benefits Of Using Various Starting Doses Of Atorvastatin On Achievement Of Cholesterol Targets (ACTFAST)
Physicians tend to always use the lowest dose of statins to initiate therapy even in subjects who require large reductions in cholesterol.
- Conditions
- Coronary Arteriosclerosis, Diabetes Mellitus, Type 2, Cerebrovascular Accident, Dyslipidemia
- Trial name
- ACTFAST (NCT00442845)
- Testing
- Atorvastatin (Lipitor)
- Where
- 121 sites in Cameroon, Canada and 3 more
- Volunteers
- 2,080 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Type 2 Diabetes
Continuous Glucose Monitoring for High-Risk Type 2 Diabetes in the Hospital (Cyber GEMS)
Given the known serious consequences of uncontrolled blood sugars during hospitalization, this research plans to study an alternative seamlessly integrated continuous glucose monitoring (CGM) system in the hospital to test a…
- Trial name
- Cyber GEMS (NCT05307237)
- Testing
- Dexcom G6 Continous Glucose Monitoring Management, Usual Care - Blinded Continuous Glucose Monitoring Management
- Where
- United States
- Volunteers
- 518 people
- Sponsor
- Scripps Whittier Diabetes Institute
Hypertension, Diabetes Mellitus
Diabetes Risk Evaluation and Microalbuminuria in Saskatchewan First Nations Peoples
This randomized controlled trial was designed to assess whether a community-based treatment strategy implemented by home care nurses would be effective in controlling hypertension in First Nations people with existing…
- Trial name
- DREAM3 (NCT00741702)
- Testing
- Nurse administered treatment algorithm
- Volunteers
- 95 people
- Sponsor
- Sunnybrook Health Sciences Centre
Type 2 Diabetes
Middle-School Based Primary Prevention Trial of Type 2 Diabetes
HEALTHY was a primary prevention trial conducted in 42 middle schools at 7 locations across the US to impact risk factors for type 2 diabetes in adolescents.
- Trial name
- HEALTHY (NCT00458029)
- Testing
- integrated program of nutrition, activity, behavior, and promotion
- Where
- 8 sites in United States
- Volunteers
- 4,603 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 2 Diabetes
Italian Diabetes and Exercise Study 2
Current guidelines recommend supervised mixed (aerobic+resistance) physical activity to ensure optimal benefits to control blood glucose, lipids, blood pressure, and other cardiovascular risk and to minimize injuries.
- Trial name
- IDES-2 (NCT01600937)
- Testing
- Theoretical & practical exercise counseling
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Metabolic Fitness Association, Italy
Diabetes Mellitus, Type 2
Effectiveness of a High-risk Diabetic Patients Program
The purpose of this study is to determine whether case management for type 2 diabetic patients with target-organ damage improves quality of care compared to usual care.
- Trial name
- NCT01051245
- Testing
- Case manager counseling, Usual care
- Where
- Argentina
- Volunteers
- 223 people
- Sponsor
- Hospital Italiano de Buenos Aires
Central Insulin Resistance, Diabetes Mellitus, Type 2
Central Insulin Sensitivity in Individuals With Type 2 Diabetes (T2D) and at Risk for Developing T2D
Beside well described peripheral effects, insulin can also affect the human central nervous system. Centrally acting insulin seems to have an influence e.g. on whole-body metabolism and food intake.
- Conditions
- Central Insulin Resistance, Diabetes Mellitus, Type 2, PreDiabetes
- Trial name
- NCT05856877
- Testing
- Human nasal insulin
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Atherosclerosis, Cardiovascular Diseases
Action to Control Cardiovascular Risk in Diabetes (ACCORD)
The purpose of this study is to prevent major cardiovascular events (heart attack, stroke, or cardiovascular death) in adults with type 2 diabetes mellitus using intensive glycemic control, intensive blood pressure control, and…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Hypercholesterolemia, Hypertension
- Trial name
- ACCORD (NCT00000620)
- Testing
- Anti-hyperglycemic Agents, Anti-hypertensive Agents
- Where
- 7 sites in United States, Canada
- Volunteers
- 10,251 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pre Diabetes, Obesity
MapTrek to Increase Activity Among Patients at Risk for Type 2 Diabetes
The overarching objective of our work is to provide an inexpensive and scalable m-health tool to increase both volume and intensity of physical activity and reduce sedentary behavior in patients at risk for type 2 diabetes.
- Trial name
- NCT03193229
- Testing
- MapTrek, Fitbit
- Where
- United States
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Philip Polgreen