Clinical trials: Type 2 Diabetes Risk
Diabetes Mellitus, Type 2
High-intensity Interval Training Prescriptions to Reduce the Risk of Complications Linked to Type 2 Diabetes: the Role of Interval Length on Clinical Benefits and on Physiological Mechanisms
Type 2 diabetes (T2D) prevalence has steadily been rising in the past decades and its complications, including cardiovascular diseases (CVD), are a major public health concern.
- Trial name
- NCT04986345
- Testing
- High-intensity interval training (HIIT)-4, High-intensity interval training (HIIT)-10, Rest
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Université de Sherbrooke
Abdominal Obesity, Physical Activity
Physical Activity in Overweight Girls: Implications for Reversing Risk Factors for Type 2 Diabetes
In this randomized controlled trial, we will examine the effect of a 3-month exercise training (aerobic exercise versus resistance exercise) without calorie restriction on total and regional adiposity, ectopic fat in the liver…
- Trial name
- NCT01323088
- Testing
- Control, Resistance Exercise, Aerobic exercise
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Diabetes Mellitus Type 2, Cardiovascular Diseases
Cardiovascular Risk Factors in Patients With Diabetes -a Prospective Study in Primary Care
The purpose of this study is to prospectively explore the impact from the different cardiovascular risk factors on early cardiovascular organ damage in 761 middle aged patients with type 2 diabetes.
- Trial name
- CARDIPP (NCT01049737)
- Where
- Sweden
- Volunteers
- 761 people
- Sponsor
- Linkoeping University
Diabetes Mellitus, Type 2
Effects of Vitamin D3 and Prebiotics Supplementation on Cardiovascular Risk Factors in Patients With Type 2 Diabetes
The goal of this randomized, double-blind, placebo-controlled, 6-month supplementation study in individuals with type 2 diabetes is to investigate whether taking daily dietary supplements of vitamin D3 (1600 IU) or prebiotics…
- Trial name
- NCT06351566
- Testing
- Vitamin D3, Prebiotics
- Where
- 2 sites in China
- Volunteers
- 190 people
- Sponsor
- Huazhong University of Science and Technology
Type-2 Diabetes Mellitus, Ischemic Heart Disease
Risk Prediction in Type II Diabetics With Ischemic Heart Disease
The purpose of this study is to test whether cardiac autonomic dysfunction predicts is a prognostic marker in type-2 diabetics with ischemic heart disease
- Trial name
- NCT01422057
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Thebiosignals.com
Type 2 Diabetes
Characterization of Cardiovascular Risk Profile and Therapeutic Management in Patients With Type 2 Diabetes Mellitus in Italy
CardioMET is an observational, multicenter, real-life registry, intending to collect data on patients with Type 2 Diabetes Mellitus, attending internal medicine and cardiology outpatient clinics.
- Trial name
- CardioMET (NCT07375069)
- Testing
- data collection
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- Federico II University
PreDiabetes, Prediabetic State
Small Steps for Big Changes - Recipe for Health
The purpose of this study is to evaluate changes in HbA1c levels, diet, weight and waist circumference in Small Steps for Big Changes (SSBC) diabetes prevention program participants two year after program completion compared to…
- Trial name
- RFH (NCT05962983)
- Testing
- Small Steps for Big Changes Program
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- University of British Columbia
Colon Cancer, Lung Cancer
Predictive Genetic Risk Assessment Trial
This proof-of-principle clinical trial at Mayo Clinic studies how patients and their physicians understand and utilize predictive genetic risk assessment.
- Conditions
- Colon Cancer, Lung Cancer, Atrial Fibrillation, Diabetes Type 2
- Trial name
- PGT (NCT00782366)
- Testing
- SNP analysis
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cardiovascular Diseases Risk
Circulating Vascular Regenerative Cell Exhaustion in Individuals Without Type 2 Diabetes Who Are of South Asian or European Origins
ORIGINS-VRCE-2 is an observational study aimed to assess how blood vessel forming stem cells from individuals without diabetes or a history of cardiovascular disease differ between individuals of South Asian and European…
- Trial name
- ORIGINS-VRCE-2 (NCT06769347)
- Where
- 5 sites in Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
Type 2 Diabetes, Cardiovascular Risk
AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications
This study is being conducted to find out how well zenagamtide works and how safe it is compared to insulin glargine in participants with type 2 diabetes who are at higher risk of heart and blood vessel problems and are already…
- Trial name
- AMBITION 7 (NCT07797335)
- Testing
- Zenagamtide, Insulin glargine U-100
- Where
- 330 sites in United States, Argentina and 14 more
- Volunteers
- 1,778 people
- Sponsor
- Novo Nordisk A/S
NIDDM
Insulin Secretory Defects in Pima Indians at High Risk for NIDDM
The Pima Indians have the highest reported prevalence of NIDDM of any population in the world. Within this population, it is possible to identify subgroups of individuals at a particularly high risk for NIDDM.
- Trial name
- NCT00410800
- Where
- United States
- Volunteers
- 310 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cardiovascular Diseases, Diabetes Mellitus, Type 2
Evaluating a Web-Based Cardiovascular Disease Risk Factor Reduction Program Among American Indians
Cardiovascular disease (CVD) is a serious health concern for American Indians, but there have been few behaviorally based programs to lessen CVD risk among this population.
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Type 2, Hypertension, Obesity
- Trial name
- NCT00608387
- Testing
- Chronic disease management Web-based software
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Black Hills Center for American Indian Health
Diabetes Mellitus, Type 2
Risk of Acute Liver Failure Among Patients With Type 2 Diabetes Exposed to Oral Antidiabetic Treatments
The purpose of this study is to compare the incidence of hospitalization with acute liver failure among patients with type 2 diabetes who are new users of Saxagliptin and those who are new users of other oral antidiabetic drugs.
- Trial name
- NCT01086293
- Volunteers
- 113,505 people
- Sponsor
- AstraZeneca
Colon Cancer
Screening and Risk Factors of Colon Neoplasia
The investigators propose a screening population-based study to systematically evaluate the accuracy and clinical relevance of sDNA testing as a potential alternative to colonoscopy screening.
- Trial name
- NCT01647776
- Testing
- Stool DNA Test, biopsies of rectal and colon mucosa, Questionnaires
- Where
- United States
- Volunteers
- 3,315 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Diabetes
Vitamins C and Vitamin E and Cardiovascular Risk
The proposed study will examine the hypothesis that vitamin C and vitamin E given to type 2 diabetic individuals will provide effective anti-inflammatory, anti-thrombotic, and anti-oxidative atherosclerotic protection when…
- Trial name
- NCT00362518
- Testing
- Study Arm A, Study Arm B, Study Arm C
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Insulin-requiring Type 2 Diabetes Mellitus
Establishing Cardiovascular Biomarkers to Define Preferred Lantus® Use
The aim of this study is to observe changes in cardiovascular biomarkers during treatment with Lantus in patients with Type 2 Diabetes mellitus.
- Trial name
- NCT01500850
- Testing
- nph insulin, human insulin, Insulin Glargine
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- ikfe-CRO GmbH
CKD, Type 2 Diabetes
Fib to Alb Ratio in Type 2 Dkd
Aimed to investigate the association of fibrinogen to albumin ratio (FAR) with DKD type 2 and to prove its possible role as a novel biomarker to predict and prevent DKD progression.
- Trial name
- NCT05691985
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Diabetes Mellitus, Type 2
Incretin-based Drugs and Acute Pancreatitis
The purpose of this study is to determine whether incretin-based drugs (used to treat type 2 diabetes) taken either alone or in combination with other anti-diabetic drugs are associated with an increased risk of acute…
- Trial name
- NCT02476760
- Testing
- DPP-4 inhibitors, GLP-1 analogs, Insulins
- Where
- Canada
- Volunteers
- 1,417,914 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Diabetes Mellitus, Type 2, Prediabetic State
Sleep for Health Study on the Effects of Cognitive Behavioral Therapy for Insomnia on Diabetes Risk
This study tests whether providing cognitive behavioral therapy for insomnia (CBT-I) to people with prediabetes results in a reduction in glucose levels compared to a patient education control program.
- Conditions
- Diabetes Mellitus, Type 2, Prediabetic State, Sleep Initiation and Maintenance Disorders
- Trial name
- NCT06067139
- Testing
- SHUTi, Patient Education
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Kaiser Permanente
Cardiovascular Diseases, Heart Diseases
Heritage Study--Genetics, Exercise and Risk Factors
To document the role of the genotype in the cardiovascular and metabolic responses to aerobic exercise-training and the contribution of inherited factors in the changes brought about by regular exercise for several cardiovascular…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Diabetes Mellitus, Non-insulin Dependent, Diabetes Mellitus
- Trial name
- HERITAGE (NCT00005137)
- Testing
- exercise program
- Sponsor
- Washington University School of Medicine