Clinical trials: Type 2 Diabetes Risk
Type 2 Diabetes Mellitus, Hypoglycemia
Role of CGMS Usage in Predicting Risk for Hypoglycemia
This is a clinical study to examine rates hypoglycemia (self-report, EHR review, and review of values from a FDA approved continuous glucose monitoring system (CGMS)). Subjects will wear either blinded or unblinded CGMS.
- Trial name
- NCT03481530
- Testing
- Continuing Glucose Monitor System
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Minnesota
Type 2 Diabetes
Evaluation of the Effect of Pulsatile Cuts Stendo3 on Vascular Function Patients With Diabetes Type 2
The purpose of the study is to demonstrate an improvement of vascular function, and particularly dependent vasodilation flow and micro-vasculature, by STENDO for diabetic patients compared to a control period in crossover.
- Trial name
- STENDO3 (NCT02359461)
- Testing
- Combination pulsatile Stendo3
- Where
- France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cardiovascular Diseases
EVOC - EVs in Obesity and Cardiometabolic Disease
The goal of this observational study is to research the impact of molecular signals from the heart, liver and fat tissue on cardiovascular disease risk, and the presentation of Type II Diabetes and diseases that affect the heart…
- Trial name
- EVOC (NCT06408961)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Type 2 Diabetes Mellitus, Binge-Eating Disorder
Preventing Type 2 Diabetes in Black Emergent Adult
Black Americans are disproportionately affected by diabetes, with nearly double the rates of type 2 diabetes mellitus (T2DM), compared to non-Hispanic White adults.
- Conditions
- Type 2 Diabetes Mellitus, Binge-Eating Disorder, Binge Eating, Obesity
- Trial name
- NCT06848244
- Testing
- Appetite Awareness Training (AAT), Diabetes Prevention Program (DPP)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Type-2 Diabetes Mellitus, Ischemic Heart Disease
Risk Prediction in Type II Diabetics With Ischemic Heart Disease
The purpose of this study is to test whether cardiac autonomic dysfunction predicts is a prognostic marker in type-2 diabetics with ischemic heart disease
- Trial name
- NCT01422057
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Thebiosignals.com
Diabetes Mellitus, Type 2
Effectiveness of a High-risk Diabetic Patients Program
The purpose of this study is to determine whether case management for type 2 diabetic patients with target-organ damage improves quality of care compared to usual care.
- Trial name
- NCT01051245
- Testing
- Case manager counseling, Usual care
- Where
- Argentina
- Volunteers
- 223 people
- Sponsor
- Hospital Italiano de Buenos Aires
Type 2 Diabetes Mellitus, Vitamin D Deficiency
Effect of Vitamin D Supplementation on Glucose Tolerance in Subjects at Risk for Diabetes With Low Vitamin D.
Type 2 diabetes (T2D) is an increasingly common and serious condition. Studies show that low vitamin D levels are associated with increased diabetes risk and that vitamin D may protect against diabetes by reducing chronic…
- Trial name
- EVIDENCE (NCT01726777)
- Testing
- Control, Vitamin D
- Where
- 3 sites in Canada
- Volunteers
- 71 people
- Sponsor
- University of Toronto
Diabetes Mellitus, Type 2
Effects of Empagliflozin-Metformin, Sitagliptin-Metformin, and Metformin on Adipokines in Type 2 Diabetes
This study compared the impacts of empagliflozin-metformin, sitagliptin-metformin, and metformin monotherapy in treatment-naive overweight or obese adults with newly diagnosed type 2 diabetes mellitus in Erbil, Iraq.
- Trial name
- NCT07531108
- Testing
- Empagliflozin-Metformin, Sitagliptin-Metformin, Metformin
- Where
- Iraq
- Volunteers
- 186 people
- Sponsor
- Hawler Medical University
Low Density Lipoprotein Cholesterol Goal Achievement
of PATient Education Related to CV Risk factOrs in Type 2 Diabetes Mellitus(Patrol).
An observational, non-interventional, multi-centre study to provide further information on the utility of test for a predictive marker by investigating the current prevalence of high sensitivity CRP (hs-CRP) testing and…
- Trial name
- DART (NCT00925717)
- Where
- 22 sites in South Korea
- Volunteers
- 4,045 people
- Sponsor
- AstraZeneca
Dipeptidyl-Peptidase 4 Inhibitors, LDL Cholesterol
Randomized Evaluation of Anagliptin Versus Sitagliptin On Low-density lipoproteiN Cholesterol in Diabetes Trial
The purpose of this study is to determine whether Anagliptin or Sitagliptin are effective in reducing the low-density lipoprotein cholesterol in patients with type 2 diabetes and cardiovascular risk factors on statin.
- Conditions
- Dipeptidyl-Peptidase 4 Inhibitors, LDL Cholesterol, Glycosylated Hemoglobin, Diabetes Mellitus
- Trial name
- REASON (NCT02330406)
- Testing
- Anagliptin, Sitagliptin
- Where
- Japan
- Volunteers
- 353 people
- Sponsor
- Institute for Clinical Effectiveness, Japan
Type 2 Diabetes Mellitus
Telemonitoring System Study in Participants With Type 2 Diabetes Mellitus (MK-0000-347)
The primary goal is to evaluate whether a home telehealth system that enables the participant to monitor their body weight, blood glucose values and blood pressure values, associated with remote educational support and feedback…
- Trial name
- NCT02194608
- Testing
- Home telehealth system
- Volunteers
- 500 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes Mellitus
Gliflozins and Cardiovascular Risk Factors in Type 2 Diabetes (GIOIA)
GIOIA represents a multicenter pragmatic prospective cohort study, aimed at evaluating the effects of SGLT2 inhibitors currently marketed (dapagliflozin, canagliflozin, empagliflozin) on markers of vascular, myocardial and renal…
- Trial name
- GIOIA (NCT03918148)
- Testing
- SGLT-2i, DPP-4i
- Where
- Italy
- Volunteers
- 1,150 people
- Sponsor
- University of Campania Luigi Vanvitelli
Diabetes Mellitus, Type 2, Prediabetic State
PREDICT-DM: Community Pharmacy-Based Point-of-Care Testing for Undiagnosed T2DM
The goal of this observational study is to learn whether community pharmacy-based risk assessment and point-of-care HbA1c testing can help detect undiagnosed type 2 diabetes and prediabetes among adults in Irbid Governorate…
- Conditions
- Diabetes Mellitus, Type 2, Prediabetic State, Prediabetes / Type 2 Diabetes, T2DM
- Trial name
- PREDICT-DM (NCT07795918)
- Where
- Jordan
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Birth Defects, Type 2 Diabetes
Exenatide Pregnancy Registry - Type 2 Diabetes in Pregnancy
This is an observational, prospective cohort study describing pregnancy outcomes in women with pre-existing (prior to pregnancy) type 2 diabetes who have been exposed to any formulation of exenatide during pregnancy.
- Conditions
- Birth Defects, Type 2 Diabetes, Preterm Birth
- Trial name
- Exenatide (NCT00579150)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- AstraZeneca
PreDiabetes
The Lifestyle Education About Prediabetes (Leap) Study
This research tested whether a standard version or very low-carbohydrate version of the Diabetes Prevention Program better improves outcomes like blood glucose control and body weight for patients with prediabetes.
- Trial name
- LEAP (NCT05235425)
- Testing
- Standard NDPP, Very low-carbohydrate diet
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- University of Michigan
Insulin Resistance, Depression
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
The investigators are doing this study to learn more about how to prevent type 2 diabetes in teenage girls. The purpose of this study is to find out if taking part in a cognitive-behavioral therapy group, exercise training group…
- Conditions
- Insulin Resistance, Depression, Depressive Disorder, Mood Disorders
- Trial name
- CBTeX (NCT05543083)
- Testing
- Cognitive-Behavioral Therapy followed by Exercise Training, Exercise Training followed by Cognitive-Behavioral Therapy, Cognitive-Behavioral Therapy Only
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Obesity, Insulin Resistance
Endothelial Function in Young Hispanic Adults at Risk for Type 2 Diabetes
Diabetes is a major public health problem. Hispanics/Latinos are known to be at higher risk for type 2 diabetes. The function of the endothelium has played a key role in the understanding of vascular complications in people with…
- Trial name
- NCT01926938
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Atherosclerotic Cardiovascular Disease, Symptomatic Atherosclerosis
An Extension Trial of Inclisiran in Participants With Cardiovascular Disease and High Cholesterol
This clinical study was designed to assess the efficacy, safety, and tolerability of long-term dosing of inclisiran and evolocumab given as subcutaneous injections in participants with high cardiovascular risk and elevated…
- Conditions
- Atherosclerotic Cardiovascular Disease, Symptomatic Atherosclerosis, Type2 Diabetes, Familial Hypercholesterolemia
- Trial name
- ORION-3 (NCT03060577)
- Testing
- Inclisiran, Evolocumab
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 382 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Foot Ulcer, Type 2 Diabetes Mellitus With Complication
Implementation of a Preventive Diabetic Foot Care Program for Patients at Risk of Diabetic Foot
This study aims to evaluate the effect of a preventive diabetic foot care program on the knowledge, behavior, self-management, and glycemic control levels of type 2 diabetic patients at risk of diabetic foot.
- Trial name
- NCT06770829
- Testing
- DiaFOOTCare Program, Ministry of Health and Education
- Volunteers
- 78 people
- Sponsor
- Akdeniz University
Type 2 Diabetes, Impaired Glucose Intolerance
G-CREDIT (Gangnam-Cohort for Risk Evaluation of Diabetes and Impaired Glucose Tolerance)
The prevalence of type 2 diabetes has consistently increased and type 2 diabetes can cause many types of vascular complications. Diabetes develops due to glucose intolerance.
- Trial name
- NCT02726256
- Volunteers
- 500 people
- Sponsor
- Yonsei University