Clinical trials: Type 2 Inflammatory Disorders
Type 2 Diabetes, Obesity
Effects of Medical and Surgical Weight Loss on Metabolism
This study will follow ,morbidly obese subjects as they undertake weight loss before and after laparoscopic gastric banding, examining markers of glucose and lipid metabolism, adipokines and measures of body fat.
- Trial name
- BOS (NCT00592735)
- Testing
- laparoscopic gastric banding
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Garvan Institute of Medical Research
Macroalbuminuric Diabetic Nephropathy
Effect of Enalapril and Losartan Association Therapy on Proteinuria and Inflammatory Biomarkers in Diabetic Nephropathy: a Clinical Trial on Type 2 Diabetes Mellitus
Chronic kidney disease (CKD)has become a significant health problem worldwide. Strategies to decrease the rate of progression of this disease and reduce the number of patients needing dialysis or renal transplantation are…
- Trial name
- NCT00419835
- Testing
- enalapril, losartan
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo
Platelet Indices, Type 2 Diabetes
Platelet Changes in Type 2 Diabetes
This study examines changes in platelet indices in people with type 2 diabetes compared to healthy people. It checks if these changes relate to inflammation markers (like hs-CRP) and blood sugar control.
- Conditions
- Platelet Indices, Type 2 Diabetes, Inflammatory Markers
- Trial name
- NCT07363122
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Treatment Adherence
Colchicine Has Anti-diabetic Effect
Colchicine has antidiabetic effect and may be an option for type 2 diabetes management
- Trial name
- NCT04377321
- Testing
- Colchicine Tablets
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Ministry of Health and Population, Egypt
Type 2 Diabetes Melitus, Inflammation Biomarkers
Effect of Vitamin D on Inflammatory Markers in Type 2 Diabetes Mellitus in Mexico.
Type 2 Diabetes Mellitus (T2DM) is a very common disease in Mexico, and its long-term complications affect years of healthy life and a high cost in treatmenty. T2DM is a chronic disease associated to inflammation.
- Trial name
- NCT06993064
- Testing
- 4000 IU of Vitamin D3
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Universidad Autonoma del Estado de Mexico
Anaplastic Lymphoma Kinase Positive (ALK +) Anaplastic Large Cell Lymphoma, Inflammatory Myofibroblastic Tumors
Pharmacokinetics, Safety, and Efficacy of Brigatinib Monotherapy in Pediatric and Young Adult Participants With ALK+ Anaplastic Large Cell Lymphoma, Inflammatory Myofibroblastic Tumors or Other Solid Tumors
The purpose of this study is to estimate the maximum tolerated dose (MTD)/ recommended phase 2 dose (RP2D) regimen and characterize the pharmacokinetics (PK) of brigatinib monotherapy (film-coated tablets and age-appropriate…
- Conditions
- Anaplastic Lymphoma Kinase Positive (ALK +) Anaplastic Large Cell Lymphoma, Inflammatory Myofibroblastic Tumors, Solid Tumors
- Trial name
- NCT04260009
- Testing
- Brigatinib, Brigatinib AAF
- Sponsor
- Takeda
Diabetes Mellitus, Type 2
Effects of Empagliflozin-Metformin, Sitagliptin-Metformin, and Metformin on Adipokines in Type 2 Diabetes
This study compared the impacts of empagliflozin-metformin, sitagliptin-metformin, and metformin monotherapy in treatment-naive overweight or obese adults with newly diagnosed type 2 diabetes mellitus in Erbil, Iraq.
- Trial name
- NCT07531108
- Testing
- Empagliflozin-Metformin, Sitagliptin-Metformin, Metformin
- Where
- Iraq
- Volunteers
- 186 people
- Sponsor
- Hawler Medical University
Pain
Pharmacokinetics & Safety of Diclofenac Potassium Oral Solution in Ped. Subjects (2-12 Yrs) With Mild-Mod. Acute Pain
As part of the Pediatric Research Equity Act (PREA) commitment, the objectives of the study are to characterize the pharmacokinetic (PK) profile and to determine the safety and tolerability of diclofenac potassium oral solution…
- Trial name
- NCT02287350
- Testing
- diclofenac potassium oral solution
- Where
- 5 sites in United States
- Volunteers
- 51 people
- Sponsor
- Depomed
Dermatitis, Atopic, Dermatitis
Effect of Benralizumab in Atopic Dermatitis
Atopic Dermatitis (AD), also known as eczema, is a common skin disease characterized by itchy lesions. The prevalence of AD has increased over the past few decades, with 15-30% of children and 2-10%of adults being affected.
- Conditions
- Dermatitis, Atopic, Dermatitis, Eczema, Skin Diseases
- Trial name
- NCT03563066
- Testing
- Benralizumab
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Obesity, Chronic Inflammation
Impact of Gut Hormones and Inflammatory Adipokines in Obese Patients Underwent Bariatric Surgery
Obesity and type 2 diabetes, dyslipidemia and related metabolic disease has become a threat to our national life and health which is showing a trend.
- Conditions
- Obesity, Chronic Inflammation, Type 2 Diabetes
- Trial name
- NCT02963662
- Testing
- laparoscopic Roux-en-Y gastric bypass, laparoscopic sleeve gastrectomy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gao Zhiguang
Type 2 Diabetes Mellitus, Atherosclerosis
Effects of 5-day Statin Withdrawal on Endothelial Progenitor Cells and Inflammatory Markers in Type 2 Diabetic Patients
Statins are commonly prescribed to lower cardiovascular risk in primary and secondary prevention. Despite their well known efficacy, statin withdrawal is a common event.
- Conditions
- Type 2 Diabetes Mellitus, Atherosclerosis, Dyslipidemia
- Trial name
- SStatin-EPC (NCT01600690)
- Testing
- Statin withdrawal
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- University of Padova
Diabetes Mellitus, Type 2
Perceived Stress and Negative Thoughts With Biomarkers in People With Type 2 Diabetes Mellitus and Healthy Subjects
The purpose of this study is to determine the effect of measured and induced negative feelings on glucose, tumor necrosis factor alpha, and cortisol levels in healthy participants and participants with type 2 diabetes mellitus.
- Trial name
- NCT04387045
- Testing
- Guilty feelings
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Francisco Carlos López Marquez
Atherosclerosis, Leukocyte Activation Disorder
Inflammatory Aspects of Glucose in Hyperlipidemia and Diabetes
In this study, we will investigate both inflammatory systems in healthy volunteers and patients with T2DM on insulin therapy and hyperlipidemia (both familial hyperlipidemia (FH) and familial combined hyperlipidemia (FCH)) during…
- Conditions
- Atherosclerosis, Leukocyte Activation Disorder, Type 2 Diabetes Mellitus, Familial Combined Hyperlipidemia
- Trial name
- INFORM (NCT02130505)
- Testing
- OGTT
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Sint Franciscus Gasthuis
Psoriatic Arthritis
PALACE 3: Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis
The purpose of this study is to determine whether apremilast is safe and effective in the treatment of patients with psoriatic arthritis and a qualifying psoriasis lesion.
- Trial name
- PALACE 3 (NCT01212770)
- Testing
- Apremilast 20mg, Apremilast 30mg
- Where
- 91 sites in United States, Australia and 14 more
- Volunteers
- 505 people
- Sponsor
- Amgen
Dyslipidemia Associated With Type II Diabetes Mellitus
Type 2 Diabetic Patients Maintained on Statin Therapy
Patients with diabetes mellitus (DM) are at increased risk of atherosclerotic cardiovascular disease (ACVD). The achievement of the LDL-C target with statins for the reduction of ACVD risk is recommended.
- Trial name
- NCT03784703
- Testing
- Atorvastatin 40 Mg Oral Tablet, Rosuvastatin 10 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Damanhour University
MASH - Metabolic Dysfunction-Associated Steatohepatitis, T2DM (Type 2 Diabetes Mellitus)
A Study of Chiglitazar in Patients With Metabolic Dysfunction-associated Steatohepatitis and Type 2 Diabetes Mellitus
This trial aims to evaluate the efficacy and safety of chiglitazar as a combination therapy for patients with MASH and T2DM.
- Trial name
- CHIG-MASH (NCT07303803)
- Testing
- Chiglitazar, vitamin E, Polyene Phosphatidyl choline
- Where
- 17 sites in China
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Psoriatic Arthritis, Osteoarthitis
CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Registry
CARTIZ is a prospective observational clinical registry of adults in Mexico receiving tirzepatide (a dual GLP-1/GIP receptor agonist) under an independent clinical indication - typically type 2 diabetes, insulin resistance…
- Conditions
- Psoriatic Arthritis, Osteoarthitis, Knee, Diabetes (DM)
- Trial name
- CARTIZ (NCT07567378)
- Testing
- Tirzepatide
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- JULIO GRANADOS MONTIEL
Diabetes Mellitus, Type 2
The Effects of Breakfast Size on Hormonal Profile in Adults With Type 2 Diabetes Mellitus
Studies has found a connection between breakfast consumption and obesity and obesity-related complications, but only few studies examined the effect of breakfast size.
- Trial name
- NCT01178723
- Testing
- breakfast size
- Where
- 2 sites in Israel
- Volunteers
- 48 people
- Sponsor
- Wolfson Medical Center