Clinical trials: Type 2 Respiratory Failure
Acute Hypercapnic Respiratory Failure
Under the Nose Face Mask to Prevent Facial Pressure Ulcers During NIV for Acute Hypercapnic Respiratory Failure (AHRF)
Noninvasive ventilation (NIV) is essential to treat acute hypercapnic respiratory failure. However, facial pressure ulcers appearing during facemask-delivered noninvasive ventilation are a source of NIV failure by interface…
- Trial name
- UNDER PRESSURE (NCT04102735)
- Testing
- Under-the-nose facemask, Over-the-nose facemask
- Where
- 2 sites in France
- Volunteers
- 108 people
- Sponsor
- Centre Hospitalier Arras
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study A, RCT
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT04790604)
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of Calgary
Ventilatory Failure
Tele-monitoring of Patients With Home Mechanical Ventilation (HMV) Trough Telemedicine System (MyVENT)
The purpose of this study is to improve HMV treatment adherence using an integrated telemedicine platform (MyVENT system)
- Trial name
- MyVENT (NCT03971630)
- Testing
- Telemedicine
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope with Rising Temperatures: an Observational Study, 2nd Wave
The CLIMATE-II Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, somatosensory amplification, risk and…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE-II (NCT06407154)
- Where
- Germany
- Volunteers
- 578 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Coronavirus Infection, Ventilatory Failure
To Compare Videolaryngoscope Against Direct Laryngoscope for Intubation When Powered Air Purifying Respirator is Worn
Various guidelines for endotracheal intubation (insertion of breathing tube for mechanical ventilation) of Coronavirus Disease 2019 (COVID-19) patients recommend the use of videolaryngoscope (medical device used for intubation…
- Conditions
- Coronavirus Infection, Ventilatory Failure, Anesthesia Intubation Complication
- Trial name
- NCT04424953
- Testing
- McGrath videolaryngoscope, Direct laryngoscope
- Where
- Singapore
- Volunteers
- 28 people
- Sponsor
- Singapore General Hospital
Respiratory Insufficiency, Acute Hypercapnic Respiratory Failure
Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prospective Observational Single Center Study
This study targets adult patients treated with high flow nasal cannula (HFNC) at emergency department (ED) of Severance hospital, Yonsei university.
- Conditions
- Respiratory Insufficiency, Acute Hypercapnic Respiratory Failure, Acute Hypoxemic Respiratory Failure, Hypercapnic Acute
- Trial name
- NCT06064409
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Newborn Morbidity, Respiratory Failure
Comparing Two Different Modes of Ventilation in Pretem Neonates Bilevel VG and PRVC
Intubated preterm infants between 800-1200 grams and under 32 weeks of gestational age will start with PRVC ventilation mode, basal blood gases and work of breathing will measured.
- Conditions
- Newborn Morbidity, Respiratory Failure, Bronchopulmonary Dysplasia, Mechanical Ventilation Complication
- Trial name
- NCT04191239
- Testing
- GE ventilator with two different modes
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ankara City Hospital Bilkent
Respiratory Failure
Noninvasive Ventilation After Extubation in Hypercapnic Patients
The purpose of this study is to assess the efficacy of noninvasive ventilation (NIV) in the prevention of extubation failure and mortality in patients with either chronic respiratory disorders or hypercapnic respiratory failure…
- Trial name
- VHYPER (NCT01047852)
- Testing
- Noninvasive ventilation
- Where
- 6 sites in France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Bordeaux
Mechanical Ventilation
Mechanical Power-Guided Lung Protective Ventilation (VentCoach) in Acute Hypoxemic and/or Hypercapnic Respiratory Failure
The purpose of this research is to evaluate a different way of using the mechanical ventilator device to help better protect the lungs while the patient recovers.
- Trial name
- NCT07294768
- Testing
- VentCoach, Standard of Care
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Telemedicine for Improving Outcome in Inner City Patient Population With Hypercapneic Respiratory Failure
The Hypercapnia Telemedicine Outreach Program (E-TOUCH Study) aims to utilize telemedicine technology, as well as emergency medical services (EMS) home visits to address the problem with poor follow-up and compliance among…
- Conditions
- Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Obesity Hypoventilation Syndrome, Sleep Disordered Breathing
- Trial name
- ETOUCH (NCT03353064)
- Testing
- Vivify, EMS
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Albert Einstein Healthcare Network
Acute Hypercapnic Respiratory Failure
Impact of Negative Pressure Ventilation in Patients Hospitalized With Acute Hypercapnic Respiratory Failure
The study aims to find if using a Biphasic Cuirass Ventilation is as effective as using a Non invasive Positive Pressure Ventilation in patients admitted with acute hypercapnic respiratory failure.
- Trial name
- NCT06108284
- Testing
- Intervention Arm (Biphasic cuirass ventilation)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Missouri-Columbia
Prone Positioning, Covid19
Use of Combined Prone Positioning and High-Flow Nasal Cannula, and Non-invasive Positive Pressure Ventilation to Prevent Intubation in COVID-19 Infection
This research aims to understand if prone positioning combined with high-flow nasal cannula (HFNC) or non-invasive positive pressure ventilation (NIPPV) safely reduce the rate of intubation in acute hypoxemic and/or hypercapnic…
- Conditions
- Prone Positioning, Covid19, Hypoxemic Respiratory Failure, ARDS
- Trial name
- NCT04694638
- Testing
- Body position change
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Sleep Apnea
Opiate Sleep Disordered Breathing Study
Lay title: A study of breathing pauses during sleep in patients on long term opiates. Sleep apnoea is a term which refers to frequent breathing pauses during sleep.
- Trial name
- NCT00791674
- Where
- 2 sites in Australia
- Volunteers
- 50 people
- Sponsor
- Adelaide Institute for Sleep Health
Ventilatory Failure
Amount of Droplet Formed During Percutaneous Dilatational Tracheostomy
During the percutaneous dilatational tracheostomy (PDT), large amount of droplets and aerosols are spread to the environment especially with the effect of ventilation during the dilatation phase.
- Trial name
- NCT05813977
- Testing
- tritube
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Ankara Diskapi Training and Research Hospital
Hypercapnic Respiratory Failure
NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP
The goal of this study is to compare two different modes of noninvasive ventilation in hypercapnic respiratory failure. The investigators will compare AVAPS and BIPAP S/T and hypothesize that AVAPS will result in a decreased…
- Trial name
- NCT06047405
- Testing
- Average Volume-Assured Pressure Support (AVAPS), Bilevel Positive Airway Pressure Spontaneous Timed (BIPAP S/T)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Northwell Health
Acute Respiratory Distress Syndrome, Acute Hypoxemic Respiratory Failure
The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU
While most studies in the medical literature that indicate "music" as an intervention may recognize its impact and capacity to decrease pain perception, anxiety, and/or its role in the regulation of cardiac and respiratory…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
- Trial name
- NCT03642002
- Testing
- Toning, Ocean drum & SOK melody, SOK
- Where
- 3 sites in United States
- Volunteers
- 178 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Acute Cardiogenic Pulmonary Edema, Hypercapnic Respiratory Failure
High Flow Nasal Oxygen Versus VNI in Acute Hypercapnic Cardiogenic Pulmonary Edema
The purpose of this study is to determine whether high flow nasal oxygen (HFNO) therapy is non inferior to non invasive ventilation (NIV) in the immediate treatment of patients with acute hypercapnic cardiogenic pulmonary edema…
- Trial name
- OPTICAP (NCT02874339)
- Testing
- High flow nasal oxygen therapy, Non invasive ventilation
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Montpellier
Chronic Obstructive Pulmonary Disease, Respiratory Failure
Investigating Health Related Quality of Life in Patients With Chronic Respiratory Failure
To determine the quality of life of patients living with chronic respiratory failure and the impact interventions have on it.
- Conditions
- Chronic Obstructive Pulmonary Disease, Respiratory Failure, Neuromuscular Diseases, Ventilatory Failure
- Trial name
- CRF-QoL (NCT04236726)
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Exacerbation Copd, Acute Respiratory Distress
High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
Chronic obstructive lung disease is a disabling disease that affects people usually after several years of smoke tobacco exposure and affects millions of patients worldwide.
- Conditions
- Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure
- Trial name
- HiFOLD (NCT03033251)
- Testing
- Non Invasive Ventilation, High Flow Oxygen Cannula 50, High Flow Oxygen Cannula 30
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
COPD, Hypercapnic Respiratory Failure
The Effects of Airtrapping on Sleep and Breathing in Non Invasive Ventilation (NIV) in COPD
15 COPD patients will be surveyed in this prospective randomized crossover pilot study concerning non invasive ventilation. Patients will be treated over 2 nights in randomized order with Ventimotion2 (Weinmann) with and without…
- Trial name
- NCT01987661
- Testing
- BIPAP ST, Airtrap
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Institut für Pneumologie Hagen Ambrock eV