Clinical trials: Type I Diabetes
Type 1 Diabetes, Obesity
A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight
The main purpose of this study is to find out how well and how safely tirzepatide works in adults who have type 1 diabetes and obesity or overweight. Participation in the study will last about 49 weeks.
- Conditions
- Type 1 Diabetes, Obesity, Overweight
- Trial name
- SURPASS-T1D-1 (NCT06914895)
- Testing
- Tirzepatide
- Where
- 146 sites in United States, Argentina and 10 more
- Volunteers
- 905 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes, Type 1 Diabetes Mellitus
A Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar
This research study is testing whether a weekly medication called tirzepatide can help adults with type 1 diabetes use their insulin pump more easily, specifically by reducing or eliminating the need to count carbohydrates at…
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus, T1D, T1DM
- Trial name
- TZP (NCT07284511)
- Testing
- Tirzepatide, Tandem Control-IQ Automated Insulin Delivery System (with Dexcom G7 CGM), Carbohydrate Counting
- Where
- 4 sites in Canada, Switzerland
- Volunteers
- 105 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Diabetes, Diabetes Mellitus, Type 1
Efficacy and Safety of Insulin Detemir Versus Neutral Protamine Hagedorn (NPH) Insulin in Pregnant Women With Type 1 Diabetes
This trial is conducted in Africa, Europe, North and South America and Oceania. The aim of this trial is to compare the effect and safety on blood glucose control in pregnant women with type 1 diabetes of a modern insulin…
- Trial name
- NCT00474045
- Testing
- insulin detemir, NPH insulin, insulin aspart
- Where
- 98 sites in Argentina, Australia and 15 more
- Volunteers
- 470 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Comparison of Exposure and Activity of SAR341402 Mix 70/30 to NovoLog Mix 70/30, NovoMix 30 and SAR341402 Rapid-acting Solution in Patients With Type 1 Diabetes Mellitus
Primary Objectives: To demonstrate similarity in exposure of SAR341402 Mix 70/30 to NovoLog Mix 70/30 and NovoMix 30 (cohort 1).
- Trial name
- NCT03916601
- Testing
- SAR341402, Insulin Aspart
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Sanofi
Type 1 Diabetes
Effect of Automated Insulin Delivery on Early-stage Diabetic Complications
Aim of this study is to verify the effects of an advanced HCL (Medtronic Minimed™ 780G) compared to SAP with PLGS on metabolic outcomes and markers of early microvascular damage in a population of adults with T1D previously…
- Trial name
- AID-Comp (NCT05477030)
- Testing
- Medtronic MiniMed 780G with SmartGuard activation, Medtronic MiniMed 780G without SmartGuard activation
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- University of Milan
Type 1 Diabetes
TArgeting Type 1 Diabetes Using POLyamines (TADPOL)
The goal of this clinical trial is to test a drug known as DFMO in people with Type 1 Diabetes (T1D). The main question[s] it aims to answer are: Does it reduce stress on the cells that make insulin? Does it preserve what is left…
- Trial name
- TADPOL (NCT05594563)
- Testing
- DFMO
- Where
- 7 sites in United States
- Volunteers
- 74 people
- Sponsor
- Emily K. Sims
Type 1 Diabetes Mellitus
Molecular Quantification of Insulin mRNA
The objectives of this study are to: 1. quantitate the level of insulin mRNA in the while cell fraction of whole blood in selected groups of subjects, 2.
- Trial name
- NCT00324207
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Type 1 Diabetes, Exocrine Pancreatic Insufficiency
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Exocrine Pancreatic Dysfunction in Type 1 Diabetes
This study proposes to examine the contribution of CFTR variants to exocrine pancreatic insufficiency and hypoglycemic risk. Hypoglycemia is one the most frequent complications of type 1 diabetes management.
- Trial name
- NCT05385211
- Testing
- Frequency of hypoglycemia in people with type 1 diabetes and exocrine pancreatic insufficiency
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Diabetes, Diabetes Mellitus, Type 1
An Observational Study on Efficacy and Safety in Subjects Using Levemir® for the Treatment of Insulin Dependent Type 1 or Type 2 Diabetes
This observational study is conducted in Africa. The aim of this observational study is to evaluate the efficacy and the incidence of serious adverse drug reactions while using insulin Levemir® under normal clinical practice…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00738153
- Testing
- insulin detemir
- Where
- Morocco
- Volunteers
- 798 people
- Sponsor
- Novo Nordisk A/S
Type1diabetes
REACHOUT Mental Health Support Mobile App
The purpose of this study is to investigate the effectiveness of participation in a 6-month peer-led mental health support program, delivered via a mobile app (REACHOUT), to adults with type 1 diabetes compared to a wait-list…
- Trial name
- NCT05668507
- Testing
- REACHOUT Virtual Mental Health Support
- Where
- Canada
- Volunteers
- 225 people
- Sponsor
- University of British Columbia
Type 2 Diabetes
To Evaluate Safety and Tolerability After Multiple Oral Doses of AZD1656 in Type 2 Diabetes Patients on Top of Metformin
The purpose of this study is to assess safety and tolerablility of AZD1656 after multiple repeated oral doses in patients with type 2 diabetes on top of metformin.
- Trial name
- NCT00774553
- Testing
- AZD1656
- Where
- 2 sites in United States, India
- Volunteers
- 70 people
- Sponsor
- AstraZeneca
Type 1 Diabetes
Managing Insulin Pumps for Exercise (Study 2)
People with Type 1 Diabetes Mellitus (T1DM) like to take part in sport and exercise, but problems with metabolism and blood glucose control can make this difficult.
- Trial name
- NCT01398995
- Testing
- Reduction of basal insulin infusion to 50% of normal
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Buckinghamshire Healthcare NHS Trust
Type1diabetes
Adherence to Mediterranean Diet in Type 1 Diabetes Initiating Minimed 780G: Glucose Metrics vs Insulin Metrics, is There a Difference
In this observaltional study, 240 patients aged >12 years old with T1DM who are on multiple daily injections or insulin pump and are scheduled to start using MiniMed 780G system will be included.We aim to compare patients'…
- Trial name
- NCT06646107
- Testing
- MInimed 780G
- Where
- Greece
- Volunteers
- 240 people
- Sponsor
- Attikon Hospital
Diabetes, Type 1 Diabetes
The Role of South Asian vs European Origins on Circulating Regenerative Cell Exhaustion
ORIGINS-RCE is an observational, cross-sectional, two-arm study aimed at determining if an individual's ethnic origin influences the number of blood vessel-forming stem cells in the bloodstream.
- Conditions
- Diabetes, Type 1 Diabetes, Type 2 Diabetes, Ischemic Heart Disease
- Trial name
- ORIGINS-RCE (NCT05253521)
- Where
- 3 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
Solid Tumor Cancer
A Phase I, First-in-Human Study of GB268 (PD-1/CTLA-4/VEGF Trispecific Antibody) in Advanced Solid Tumors
This is a Phase I, First-in-Human, Open-Label, Multicenter Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of a Trispecific PD-1/CTLA-4/VEGF Antibody GB268 in Participants with Advanced Solid Tumors.
- Trial name
- NCT06934616
- Testing
- GB268
- Volunteers
- 330 people
- Sponsor
- Genor Biopharma Co., Ltd.
Type 1 Diabetes Mellitus
Diabetes Autoimmunity Study in the Young
Type 1 diabetes (T1D) affects 1.4 million people in the U.S. and its incidence has doubled over the past 20 years. The Diabetes Autoimmunity in the Young Study (DAISY) will estimate overall burden of T1D and other autoimmune…
- Trial name
- DAISY (NCT03205865)
- Volunteers
- 2,700 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes, Type 2 Diabetes
Closed Loop Glucose Control in a Simulated ICU Setting
This is a proof of concept safety study of a rule-based closed loop glucose control system designed for use in the intensive care unit setting.
- Conditions
- Type 1 Diabetes, Type 2 Diabetes, Stress Induced Hyperglycemia
- Trial name
- NCT07646067
- Testing
- FUSION closed loop glucose control system
- Volunteers
- 6 people
- Sponsor
- Ideal Medical Technologies
Blood Glucose Decrease During and After Defined Individual Exercise in T1DM
Exercise in Type 1 Diabetes Mellitus
Background: During and after exercise there is a twofold stimulation of glucose transporter type 4 in type 1 diabetes mellitus (T1DM) caused by an exogenous insulin injection and muscle contraction.
- Trial name
- ExT1DM (NCT02075567)
- Testing
- Experimental
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Diabetes, Diabetes Mellitus, Type 1
Long Term Safety Trial to Compare Insulin Treatment With Preprandial Inhaled Human Insulin to s.c. Insulin Aspart Both Combined With NPH in Subjects With Type 1 Diabetes
This trial is conducted in Oceania. The aim of this trial is to compare the safety of using pulmonary inhaled human insulin to s.c. insulin aspart both combined with NPH insulin in subjects with type 1 diabetes.
- Trial name
- NCT00725036
- Testing
- inhaled human insulin, insulin aspart, insulin NPH
- Where
- 18 sites in Australia
- Volunteers
- 305 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus
Long-Term Safety Study of Inhaled Insulin: An Up to Four-Year Extension of Therapy in Subjects With Type 1 or Type 2 Diabetes Mellitus
This is a long-term safety study for Phase 2 subjects who choose to remain on Exubera® (inhaled insulin).
- Trial name
- NCT00143247
- Testing
- Exubera® (inhaled insulin)
- Where
- 12 sites in United States
- Volunteers
- 173 people
- Sponsor
- Pfizer