Clinical trials: Type I Diabetes Mellitus
Type 1 Diabetes Mellitus
Effect of Splitting Mealtime Insulin Doses After Mixed Meals High in Fat and Protein
The current management of type 1 diabetes mellitus (T1DM) depends on the use of intensive insulin therapy - either by insulin pump therapy or multiple daily injection (MDI) therapy - and the use of carbohydrate counting to…
- Trial name
- NCT04783376
- Testing
- : Insulin, lispro and regular insulin
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Sohag University
Type 1 Diabetes (T1D)
Effects of Bedtime Snack Composition on Overnight Glucose in Children and Adolescents With Type 1 Diabetes
This study compared four types of bedtime snacks in children and adolescents with type 1 diabetes treated with multiple daily insulin injections.
- Trial name
- NCT07778147
- Testing
- Carbohydrate-Only Bedtime Snack, Carbohydrate-Plus-Protein Bedtime Snack, Carbohydrate-Plus-Fat Bedtime Snack
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Didem Güneş Kaya
Diabetes Mellitus, Type 1, Hypoglycemia Unawareness
Regulation of Brain Glucose Metabolism in Type 1 Diabetes
This is a prospective randomized placebo-controlled double-blind crossover pilot study determining the effect of dichloroacetate on brain function under clamped hypoglycemia in T1DM.
- Trial name
- NCT05317455
- Testing
- Dichloroacetate
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Yale University
Type 1 Diabetes
A Feasibility Study to Evaluate the Performance of the Harmony 1 Sensors in Adults and Pediatrics
The purpose of this study is to demonstrate the performance of the Harmony 1 Sensor in subjects age 14 - 75 years.
- Trial name
- NCT02646878
- Testing
- Harmony 1 Sensor
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes
Testing MST to Improve Adherence Among Youth With Chronic Poor Metabolic Control
The protocol is a randomized clinical trial providing Multisystemic Therapy (MST), an intensive home-based family psychotherapy intervention, to a group of urban adolescents with poorly controlled Type 1 diabetes and their…
- Trial name
- NCT00519935
- Testing
- Multisystemic Therapy
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Wayne State University
Diabetes Mellitus, Type 1
DIABGAD - Trial to Preserve Insulin Secretion in Type 1 Diabetes Using GAD-Alum (Diamyd) in Combination With Vitamin D and Ibuprofen
The objectives of this study is to evaluate the safety and influence of treatment with GAD-Alum (Diamyd) combined with Vitamin D and Ibuprofen on preservation of residual insulin secretion in recently diagnosed Type 1 Diabetes…
- Trial name
- NCT01785108
- Testing
- GAD-Alum (Diamyd) 20 µg, GAD-Alum (Diamyd) 20 µg X 2, Vitamin D
- Where
- 10 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Johnny Ludvigsson
Type 1 Diabetes
Efficacy of Small Subcutaneous Glucagon Dose to Treat Hypoglycemia in Adults With Type 1 Diabetes
In the unfortunate case of severe hypoglycaemia, glucagon is the first-line treatment because of its potent and rapid action starting as fast as 5 minutes after subcutaneous or intramuscular injection.
- Trial name
- NCT01828125
- Testing
- Hypoglycaemic hyperinsulinemic clamp, Glucagon
- Where
- Canada
- Sponsor
- Institut de Recherches Cliniques de Montreal
Diabetes Mellitus, Type 1
A Study of LY900027 Given by Insulin Pump to Participants With Type 1 Diabetes Mellitus
The main purpose of this study is to learn more about a new formulation of insulin lispro when given by an insulin pump to participants with type 1 diabetes mellitus.
- Trial name
- NCT04161976
- Testing
- LY900027, Insulin Lispro
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Eli Lilly and Company
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating NN1218 in Subjects With Type 1 Diabetes
This trial is conducted in Europe. The aim of this trial is to investigate the absorption and effect in the body of NN1218 in subjects with type 1 diabetes.
- Trial name
- NCT01121289
- Testing
- NN1218, insulin aspart
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
GPPAD-POInT (Global Platform of Autoimmune Diabetes - Primary Oral Insulin Trial)
The GPPAD-POInT Study is designed as a randomized, placebo-controlled, double blind, multicentre, multinational primary prevention phase IIb study aiming to induce immune tolerance to beta-cell autoantigens through regular…
- Trial name
- NCT03364868
- Testing
- Oral Insulin
- Where
- 7 sites in Belgium, Germany and 3 more
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Type 1 Diabetes
A Reinforcement Approach to Improve Diabetes Management
The purpose of this project is to evaluate the efficacy of a behavioral economic intervention to improve self monitoring of blood glucose (SMBG) in adolescents and young adults with T1D.
- Trial name
- NCT02167243
- Testing
- Reinforcement for BG testing, Standard of care
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Yale University
Diabetes Mellitus, Type 1
An Open-label, Two-center, Randomized, Cross-over Study to Evaluate the Safety and Efficacy of Glycemic Control Using Hybrid-closed Loop vs. Advanced Hybrid Closed-loop in Young Subjects With Type 1 Diabetes
Closed-loop systems are becoming an integral part of diabetes management. These systems were uniformly proven to improve glycemic control, reduce hyperglycemia and hypoglycemia while modestly reducing HbA1c levels and improving…
- Trial name
- NCT04269668
- Testing
- Medtronic Minimed 670G 3.0 HCL, Medtronic Minimed 670G 4.0 AHCL
- Where
- 2 sites in Germany, Israel
- Volunteers
- 28 people
- Sponsor
- Rabin Medical Center
Motivational Interviewing, Type 1 Diabetes
The Effect of Motivational Interviewing in Children With Type 1 Diabetes
This research was conducted in a randomized controlled experimental way to determine the effect of motivational interviewing on hypoglycemia fear, caregiving, fatigue and self-compassion in parents of children with Type 1…
- Conditions
- Motivational Interviewing, Type 1 Diabetes, Hypoglycemia, Fatigue
- Trial name
- NCT06424574
- Testing
- motivational interview
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Stress, Diabetes Mellitus, Type 2
Decreasing Stress in Diabetes
The purpose of this study is to conduct a randomized controlled trial (RCT) to determine the effects of an online 6-month Mindfulness-based stress reduction (MBSR) intervention compared to an active control Stress Management…
- Conditions
- Stress, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- De-Stress (NCT04016415)
- Testing
- Mindfulness Based Stress Reduction, Stress Management Education
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- Milton S. Hershey Medical Center
Type 1 Diabetes
Biomarkers of Heterogeneity in Type 1 Diabetes
Biomarkers of heterogeneity in type 1 diabetes: establishment of a biobank and an integrated approach to clinical and metabolic phenotyping of individuals with established T1DM.
- Trial name
- NCT04977635
- Where
- 3 sites in Netherlands
- Volunteers
- 611 people
- Sponsor
- Diabeter Nederland BV
Diabetes Mellitus, Type 1
Evaluating the Efficacy and Quality of Life Impact of Transitioning to Advanced Hybrid Closed-Loop Insulin Pump Therapy in Romanian Children With Type 1 Diabetes Mellitus
The proposed study aims to demonstrate the potential benefits of transitioning T1DM children from predictive low glucose suspend insulin pump therapy to advanced hybrid closed-loop insulin pump therapy in Romania.
- Trial name
- NCT06326489
- Testing
- Switching to the Medtronic 780G insulin pump
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- ELIAS Emergency University Hospital
Diabetes Mellitus, Type 1, Epilepsy
Impact of Parental Perfectionistic Cognitions Self-compassion Intervention Effects on Shame in Child Health Context
Parents of children with long-term health conditions (LTCs) can experience shame related to parenting. Whilst self-compassion interventions (SCIs) can reduce parental shame, this has not been studied with parents of children with…
- Conditions
- Diabetes Mellitus, Type 1, Epilepsy, Asthma, Shame
- Trial name
- NCT03504605
- Testing
- Online self-compassion intervention
- Where
- United Kingdom
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Type 1 Diabetes
Faster Aspart on Insulin-pump Treated T1DM Patients
Observational retrospective study about effectiveness and safety of insulin Faster Aspart on continuous subcutaneous insulin infusion treated adult Type 1 Diabetes Mellitus (T1DM) patients in routine clinical practice.
- Trial name
- realFACI (NCT04233203)
- Testing
- Insulin Faster Aspart, Insulin pump
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Jesús Moreno Fernández
Diabetes Mellitus, Type 1, Albuminuria
Effect of Butyrate on Inflammation and Albuminuria in Patients With Albuminuria, Type 1 Diabetes and Intestinal Inflammation
The objective is to assess the impact of 12 weeks supplement of sodium-butyrate twice daily or placebo on intestinal inflammation and albuminuria.
- Trial name
- NCT04073927
- Testing
- Sodium butyrate
- Where
- 2 sites in Denmark, Finland
- Volunteers
- 48 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetes Mellitus, Type 1
Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation
The purpose of this study is to reverse hyperglycemia and insulin dependency, by islet cell transplantation, in patients with type 1 diabetes mellitus who have a stable kidney allograft.
- Trial name
- NCT00315588
- Testing
- Islet Transplantation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Rodolfo Alejandro
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