Clinical trials: Type I Diabetes Mellitus
Diabetic Polyneuropathy, Diabetes Mellitus
Evaluation of Corneal Confocal Microscopy for the Identification and Prediction of Neuropathy in Type 1 Diabetes
Through the multinational pooled dataset approach, this trial will aim to derive and validate specific in vivo Corneal Confocal Microscopy (CCM) parameter thresholds for the identification of diabetic polyneuropathy, and - more…
- Conditions
- Diabetic Polyneuropathy, Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT02423434
- Testing
- Exposure: Corneal nerve fibre morphology by the CCM Procedure
- Where
- 5 sites in United States, Australia and 2 more
- Volunteers
- 624 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Diabetes Mellitus, Type 1
A Psychosocial Education Programme for Young People With Type 1 Diabetes - the Youth Empowerment Skills (YES)
Adolescence is a period of intense physiological, psychological and social change. It can be a challenging period for young people with Type 1 diabetes and is associated with worsening blood sugar control and care disengagement.
- Trial name
- YES (NCT04670198)
- Testing
- Youth Empowerment Skills, Waiting-list control
- Where
- 5 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College London
Diabetes Mellitus, Type 1
¿Can mySugr App Improve Knowledge and Self-management of People With Type 1 Diabetes Mellitus?
This project is based on the contribution that an app can offer for improving knowledge and self-management of people with type 1 diabetes.
- Trial name
- NCT03819335
- Testing
- mySugr app, Standard care
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Obesity in Diabetes, Obesity/Therapy
Semaglutide Treatment in Type 1 Diabetes
The goal of this clinical trial is to investigate the efficacy of semaglutide on body weight, insulin dose requirements and improvements in glucose control and safety aspects in regards to risk of hypoglycemia and diabetic…
- Conditions
- Obesity in Diabetes, Obesity/Therapy, Type 1 Diabetes Mellitus (T1DM), Insulin Sensitivity/Resistance
- Trial name
- OBES1TY (NCT06909006)
- Testing
- Semaglutide 2.4mg
- Where
- Denmark
- Volunteers
- 122 people
- Sponsor
- Nordsjaellands Hospital
Diabetes Mellitus, Type 1
Pilot Study on the Effect of Oral Controlled-Release Alpha-Lipoic Acid on Oxidative Stress in Adolescents With Type 1 Diabetes Mellitus
The long-term effects of high blood sugar include blindness, kidney failure, and nerve damage that can ultimately cause loss of limbs.
- Trial name
- NCT00187564
- Testing
- controlled-release oral alpha-lipoic acid
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Diabetes, Diabetes Mellitus, Type 1
Investigating the Effectiveness of Tresiba® (Insulin Degludec) After Switching Basal Insulin in a Population With Type 1 or Type 2 Diabetes Mellitus
This trial is conducted in Europe. The aim of this trial is to investigate the effectiveness of Tresiba® (insulin degludec) after switching basal insulin in a population with type 1 or type 2 diabetes mellitus.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- EU-TREAT (NCT02662114)
- Testing
- No treatment given
- Where
- 7 sites in Austria, Denmark and 4 more
- Volunteers
- 2,302 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
The Effects of Metformin on Glycemic Control and Insulin Sensitivity in Adolescents With T1DM
The investigators intends to carry out a randomized, cross-over, prospective study which will last 48 weeks in youth with T1DM followed up by the center.
- Trial name
- NCT02765347
- Testing
- Metformin, Insulin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Type 1 Diabetes
Use of Mobile-based Technologies to Improve Diabetes Self-management and Postprandial Glucose Control
The project involve evaluation of a web-based nutrition education program and pilot-testing of a new smartphone app for real-time data logging to identify factors causing glycemic variability.
- Trial name
- NCT02556398
- Testing
- Sugar Sleuth
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Joslin Diabetes Center
Diabetes Mellitus, Healthy
Genetic Influence on Susceptibility to Type 1 Diabetes Mellitus
Type 1 diabetes mellitus is an autoimmune disease in which the body's immune cells attack the insulin-producing cells of the pancreas.
- Trial name
- NCT00001985
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes
Family Factors in Young People With Diabetes: a Qualitative Study
8 young people (aged 12-15yrs) with type 1 diabetes will be interviewed along with their families during this qualitative study.
- Trial name
- NCT04322071
- Testing
- Interview
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Southampton
Diabetes Mellitus, Type 1, Patient Reported Outcome
The Diabetes Patient Takes Responsibility
People with Type 1 diabetes (T1D) are randomized to follow the normal scheduled visit procedure in the outpatient clinic OR to have open access to the clinic, i.e.
- Conditions
- Diabetes Mellitus, Type 1, Patient Reported Outcome, Health Care Economics and Organizations
- Trial name
- DiaTast (NCT03083899)
- Testing
- Out-patient clinic on demand (patient-initiated), Scheduled out-patient clinic
- Where
- Denmark
- Volunteers
- 357 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Type1 Diabetes Mellitus
The Salivary Microbiome in Children With Type 1 Diabetes Mellitus
Aims: To profile the oral microbiome of children with type 1 diabetes mellitus, and to compare it to healthy children while taking into account other aspects of the oral environment.
- Trial name
- NCT03908021
- Testing
- Microbiome analysis and 16S rRNA gene-based analysis
- Where
- Israel
- Volunteers
- 66 people
- Sponsor
- Hadassah Medical Organization
Type I Diabetes Mellitus
Glutamine and Insulin Sensitivity in Type I Diabetes
Insulin is crucial to help the body metabolize ('burn') sugar (glucose). Even though juvenile (type 1) diabetes (T1D) is primarily due to the lack of insulin, patients with T1D tend to become less sensitive to insulin…
- Trial name
- NCT01467063
- Testing
- Glutamine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Nemours Children's Clinic
Type 2 Diabetes Mellitus (T2DM)
A Phase I Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Subcutaneous UBT38006 Injection in Healthy Adult Males
This study is a single-center, randomized, double-blind, placebo- and active-controlled, parallel-group, single-ascending dose (SAD) design.
- Trial name
- NCT07630233
- Testing
- UBT38006, Insulin Degludec Injection, Insulin Icodec Injection
- Where
- China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- The United Bio-Technology (Hengqin) Co., Ltd.
Diabetes Mellitus, Type 1
Algorithm to Control Postprandial, Post Exercise and Night Glucose Excursions in a Portable Closed Loop Format
In previous studies, we tested the feasibility of a bi-hormonal closed loop system. This system for automated control of blood glucose in patients with type 1 diabetes was tested in the clinical research center as well as at the…
- Trial name
- APPEL4 (NCT02160275)
- Testing
- Artificial Pancreas (Inreda Diabetic BV), Insulin pump therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 16 people
- Sponsor
- J.H. DeVries
Diabetes
Evaluation of Neurodevelopmental Trajectories in Children According to the Glycemic Profile Associated With Early Treatment Using an Automated Delivery System in Children With Type 1 Diabetes
ore than half of all new cases of type 1 diabetes (T1D) are diagnosed within the first decade of life. It has been reported that early onset of this disease may be associated with a decline in cognitive performance in adulthood…
- Trial name
- PROCEDE (NCT06461065)
- Testing
- AIDS, Brain MRI
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Type1diabetes
The Effect of Human Milk Oligosaccharides in Children With Type 1 Diabetes Mellitus
Type 1 diabetes mellitus (DM) is an autoimmune disease characterized by absolute insulin deficiency, defined as insulin-dependent diabetes mellitus and develops due to autoimmune damage of beta cells in the pancreas.
- Trial name
- NCT05521061
- Testing
- 2-fucosyllactose
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people
- Sponsor
- Ege University
Combined Hepatocellular-cholangiocarcinoma, Liver Neoplasms
Phase II Clinical Study on the Efficacy and Safety of the Combination of Cadonilimab and Capecitabine in Adjuvant Therapy for Combined Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
Title: A Study of Cadonilimab Combined with Capecitabine After Surgery for Mixed Type Liver Cancer This is a phase II clinical trial.
- Trial name
- NCT07243951
- Testing
- Cadonilimab, Capecitabine
- Volunteers
- 75 people
- Sponsor
- Shanghai Zhongshan Hospital
Stress, Anxiety
Effect of Ear Massage on Stress, Anxiety, and Sleep Quality in Parents of Children With Type 1 Diabetes
The purpose of this clinical trial is to determine the effect of self-administered ear massage on stress, anxiety levels, and sleep quality in parents of children diagnosed with Type 1 diabetes.
- Conditions
- Stress, Anxiety, Sleep Quality
- Trial name
- NCT06829251
- Testing
- Effective Ear Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Mersin University
Type 1 Diabetes Mellitus
Low Dose Cyclosporin and Methotrexate Therapy in Diabetes
The purpose of this study is to determine whether treatment with low dose cyclosporin and methotrexate can inhibit the development of new onset diabetes mellitus
- Trial name
- NCT00905073
- Testing
- cyclosporin and methotrexate
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Georgetown University