Clinical trials: Type I Diabetes Mellitus
Insulin Resistance, Type 1 Diabetes
Validation of a 13C Glucose Breath Test Compared With the Euglycaemic Clamp Test
Insulin resistance can be assessed by the euglycaemic clamp technique. To date, this is the golden standard, but it is not suited for clinical practice. A 13C glucose breath test will be tested as a valid alternative.
- Trial name
- BRECLAIR (NCT04623320)
- Testing
- euglycaemic clamp test, 13C glucose breath test
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Antwerp
Diabetes Mellitus, Diabetes Mellitus, Type 1
Pharmacokinetics Study of Gamma-aminobutyric Acid
The purpose of this study is to determine upon administering GABA orally to a person how it is absorbed, distributed, as well as the drug's pharmacological effects on the body such as glucose levels, serum C-peptide and/or…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Metabolic Diseases
- Trial name
- GABA-PK (NCT01917760)
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Diabetic Peripheral Neuropathy
Safety and Efficacy of CBX129801 in Patients With Type 1 Diabetes
The purpose of the study is to determine the beneficial effects of CBX129801 (PEGylated synthetic human C-peptide) following weekly subcutaneous administration for 12 months in type 1 diabetes mellitus patients (T1DM) with mild…
- Trial name
- NCT01681290
- Testing
- CBX129801
- Where
- 29 sites in United States, Canada and 1 more
- Volunteers
- 250 people
- Sponsor
- Cebix Incorporated
Type 1 Diabetes
Glucose Variability in Type 1 Diabetes and Its Effect on Factors That Influence New Vessel Formation
The aim of the study is to see how glycaemic control and glycaemic variability affect levels of HIF, VEGF, erythropoietin and cortisol in Paediatric Type 1 diabetics on insulin pump therapy.
- Trial name
- INDIGO 2 (NCT01429467)
- Testing
- Continuous Glucose Monitor (CGM) and Telemedicine (Enlite Guardian real-time system Medtronic®)
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- University of Dundee
Diabetes Mellitus, Type 1
Assessment of an Automatic Closed-loop Insulin Delivery System
The overall aim of this research proposal is to determine the safety, feasibility and efficacy of an automatic closed-loop insulin delivery system.
- Trial name
- NCT02366767
- Testing
- Automatic closed-loop insulin delivery, Control
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Stanford University
Type 1 Diabetes
Role of Exenatide in Type 1 Diabetes
The purpose of this study is to see if giving exenatide and insulin before a meal would lower blood sugars after the meal. This study may help in developing new treatments to help control high blood sugars after meals.
- Trial name
- NCT00456300
- Testing
- Exenatide, Insulin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Montefiore Medical Center
Type 1 Diabetes, Type 2 Diabetes
Comparison of Noninvasive Blood Glucose Concentrations Relative to Finger Capillary Blood Glucose References
The purpose of the study is to prospectively evaluate a noninvasive, near-infrared based method for measuring glucose concentration relative to invasive blood reference measurements.
- Conditions
- Type 1 Diabetes, Type 2 Diabetes, Gestational Diabetes
- Trial name
- NCT01415544
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- InLight Solutions
Type 1 Diabetes
Effect of Different Fixed Pramlintide:Insulin Dose Ratios on Postprandial Glucose in T1DM
To examine the effects of different fixed pramlintide:insulin dose ratios in subjects with type 1 diabetes on postprandial plasma glucose concentrations
- Trial name
- NCT01708044
- Testing
- Pramlintide acetate
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type I, Hypoglycemia
Carnitine Levels and Carnitine Supplementation in Type I Diabetes
The purpose of this study is to determine whether type I diabetics with carnitine deficiency exhibit increased numbers of hypoglycemic (low blood sugars) events and if unrecognized hypoglycemia occurs during continuous 72-hour…
- Trial name
- NCT00351234
- Testing
- Carnitine (drug)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Mercy Hospital Kansas City
Diabetes Mellitus, Type 1
A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes
This study compares insulin icodec, an insulin taken once a week to insulin glargine, an insulin taken once a day. The study medicine will be investigated in participants with type 1 diabetes.
- Trial name
- ONWARDS 11 (NCT07076199)
- Testing
- Insulin icodec, Insulin glargine, Insulin aspart
- Where
- 182 sites in United States, Australia and 6 more
- Volunteers
- 877 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes, Pregnancy in Diabetic
PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life
This research study is called 'PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life: The PROMISE Study'.
- Trial name
- PROMISE (NCT06141434)
- Where
- 4 sites in United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 1
Efficacy and Safety of an Artificial-pancreas-like Learning-based Control in Type 1 Diabetes on Multiple Daily Injection Therapy
This study is designed as a blinded, multi-center, non-inferiority randomized controlled clinical trial. It aims to enroll hospitalized T1D diabetes patients, ensuring an equal distribution with a 1:1 ratio between the…
- Trial name
- ELITE (NCT06418464)
- Testing
- AP-A Dosage Decision Support System
- Volunteers
- 120 people
- Sponsor
- Peking University People's Hospital
Prediabetes, Type 1 Diabetes
TEFA Family Prevention: Glutenfree Diet to Preserve Beta-cell Function
To evaluate the effect of Gluten Free Diet (GFD) on beta-cell function and glucose metabolism in subjects with one or several islet autoantibodies without and with dysglycemia at baseline.
- Trial name
- TEFA (NCT02605148)
- Testing
- Gluten free diet, Omega 3 fatty acid, Vitamin D
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Lund University
Closed Loop, Diabetes Mellitus, Type 1
Diabeloop for Kids
An open-label, three-center, randomized, two-session, 4 days inpatient and 6-week follow-up home study phase, crossover study comparing Diabeloop closed-loop (CL) system and sensor-augmented pump (SAP) therapy.
- Conditions
- Closed Loop, Diabetes Mellitus, Type 1, Young Children (6 to 12 Years Old )
- Trial name
- DBL4K (NCT03671915)
- Testing
- Continuous Glucose Monitoring, External Insulin Pump, Diabeloop Software (Model predictive control)
- Where
- 3 sites in Belgium, France
- Volunteers
- 21 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type 1 Diabetes Mellitus
Metabolic Pathways of GRA in Patients With Type 1 Diabetes
A pilot study for individuals with Type 1 Diabetes who are willing to add a GRA (Glucagon Receptor Antagonist) to their current Diabetes treatment regimen.
- Trial name
- NCT03919617
- Testing
- REMD-477
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, San Diego
Type 1 Diabetes Mellitus, Sleep Quality
Safety and Effectiveness of the Luna System in People With Type 1 Diabetes Mellitus
The purpose of this research is to evaluate the effect of a wearable insulin pump on blood sugar levels during sleep. The study device works with continuous glucose monitors (CGM) to calculate and deliver rapid-acting insulin…
- Trial name
- AID4MDI (NCT06627517)
- Testing
- Episodic overnight patch pump
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Luna Diabetes
Type 1 Diabetes
GLP-1 Receptor Targeting in Diabetic and Healthy Individuals
The purpose of the study is to determine whether there are differences in pancreatic uptake of the radiotracer between healthy individuals and patients with type 1 diabetes.
- Trial name
- GLP-1-CPOP (NCT01825148)
- Testing
- radiolabeled Exendin
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Type 1 Diabetes
Early Detection of Type 1 Diabetes
T1D is an autoimmune disease characterized by the presence of autoantibodies usually assayed separately on venous blood. The use of a combined test on capillary blood using a blotting paper would facilitate the immunological…
- Trial name
- PREDIDIA (NCT06984185)
- Testing
- combined assay on capillary blotting paper
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Hospices Civils de Lyon
Diabetes Mellitus, Diabetes Mellitus, Type 1
Mesenchymal Stem Cells Transplantation in Newly Diagnosed Type-1 Diabetes Patients
Study Objects: Diabetes is an autoimmune disease which is mainly caused an immune reaction to beta cells in the pancreas. In this study, mesenchymal stem cells will be used for immune response modulation and improving…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Insulin-Dependent
- Trial name
- MSCTXT1DM (NCT04078308)
- Testing
- Intravenous Injection of autologous mesenchymal stem cells
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Royan Institute
Foot Transepidermal Water Loss in Patients in NIDDM, Foot Dryness in Patients With NIDDM
Ceramide Containing Multivesicular Emulsion Application . . .
We believe that using a ceramide based foot cream two times a day for two weeks will prevent water loss and overall foot dryness in patients with non-insulin dependent diabetes.
- Trial name
- NCT00947726
- Testing
- CeraVe
- Volunteers
- 10 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)