Clinical trials: Type I Diabetes Mellitus
Type 1 Diabetes
Multi-center Trial in Adult and Pediatric Patients With Type 1 Diabetes Using Hybrid Closed Loop System and Control at Home
The purpose of this study is to evaluate the safety and effectiveness of the Hybrid Closed Loop system (HCL) in adult and pediatric patients with type 1 diabetes in the home setting.
- Trial name
- NCT02748018
- Testing
- 670G and 770G Insulin Pump, Subject's Current Diabetes Therapy
- Where
- 36 sites in United States, Canada and 7 more
- Volunteers
- 959 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes, Insulin
The Use of Faster Acting Aspart in Type 1 Diabetes Patients
Data on switching from traditional mealtime insulins to fast-acting insulin aspart (Fiasp) in routine clinical practice are sparse.
- Conditions
- Type 1 Diabetes, Insulin, Time in Range
- Trial name
- NCT04711382
- Where
- Belgium
- Volunteers
- 438 people
- Sponsor
- University Hospital, Antwerp
Diabetes, Diabetic Foot
Diabetic Foot Ulcer Study Comparing Cytal Wound Matrix 1-Layer to Standard of Care
This is a two-armed randomized controlled trial (RCT) primarily aimed at determining if application of Cytal Wound Matrix 1-Layer intervention to diabetic foot ulcers shows improved wound closure rates when compared to standard…
- Conditions
- Diabetes, Diabetic Foot, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT03626623
- Testing
- Cytal Wound Matrix 1-Layer, Standard of Care (SOC)
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Integra LifeSciences Corporation
Type 1 Diabetes
Rapamycin Versus Mycophenolate Mofetil in Kidney-Pancreas Recipients
This study was designed to determine which maintenance immunosuppressive agent, rapamycin or mycophenalate mofetil, resulted in better outcome in patients with type 1 diabetes and renal failure, who presented for a…
- Trial name
- NCT00533442
- Testing
- Rapamycin, Mycophenolate Mofetil, Tacrolimus
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- University of Miami
Type 1 Diabetes
To Evaluate add-on Effect of Nisha-Amalaki Tablets Along With Insulin on Glycemic Control in Type 1 Diabetes Patients (RCTNA)
Type-I diabetes mellitus (T1DM) is an autoimmune condition, in which the pancreas reduces/stops insulin production. Patients with T DM have to take insulin injections with every meal and also usually a long-acting preparation.
- Trial name
- NCT06487598
- Testing
- inj insulin to one group, Inj Insulin with Tab Nisha-Amalaki 500 mg twice a day
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Hirabai Cowasji Jehangir Medical Research Institute
Diabetes, Diabetes Mellitus, Type 1
Observational Study of Type 1 and Type 2 Diabetes Patients Having Switched From Human Premixes to NovoMix®30
This trial is conducted in Europe. The aim of this observational study is to evaluate the blood glucose control (HbA1c) using NovoMix® 30 for treatment of type 1 and type 2 diabetes under normal clinical practice conditions in…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00675493
- Testing
- biphasic insulin aspart 30
- Where
- Romania
- Volunteers
- 942 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Exercise and the Menstrual Cycle in Type 1 Diabetes
Female participants with type 1 diabetes using oral contraceptives will be asked to wear a continuous glucose monitor for at least three days on two separate occasions (once during the last week of active pills and once during…
- Trial name
- NCT05188014
- Testing
- Luteal Phase Aerobic Exercise, Follicular Phase Aerobic Exercise
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of Alberta
Type 1 Diabetes
Feasibility Study of Family Teamwork Peer-Delivery
The purpose of this study is to 1) convene African American and Latino Community Coalitions to adapt Family Teamwork (FT) for school-age youth, and integrate FT with the Smart and Secure Children (SSC) program community-based…
- Trial name
- TEAM (NCT04053504)
- Testing
- Family Teamwork-Peer Delivery
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Baylor College of Medicine
Self Care
Evaluation of the Eversense Continuous Glucose Monitoring System in Type I Diabetic Youth
The purpose of this clinical investigation is to provide pilot clinical data to direct pivotal study development for the pediatric indication of the Senseonics Continuous Glucose Monitoring System (CGM) measurements when compared…
- Trial name
- FNH (NCT03815552)
- Testing
- Eversense Continuous Glucose Monitoring
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Type 1 Diabetes Mellitus
Does Protein and Fat Content of Meal Increase Glucose Concentrations
The study investigated the effects of fat protein counting (CFP) in addition to carbohydrate (CARB) counting for calculating prandial insulin dosage on blood glucose profile in patients with type 1 diabetes (T1D) on basal-bolus…
- Trial name
- NCT03333525
- Testing
- Calculation of insulin dosages for different meals
- Volunteers
- 30 people
- Sponsor
- TC Erciyes University
Type 1 Diabetes Mellitus, Type 1 Diabetes Mellitus With Hypoglycemia
Glycemic Excursions in Patients With Type 1 Diabetes Mellitus Using Closed-loop Systems
The study aims to compare glycemic excursions during several life situations (such as periods of driving, periods of night sleep, periods of occupation, periods of physical activity, and periods of stress) in patients with type 1…
- Conditions
- Type 1 Diabetes Mellitus, Type 1 Diabetes Mellitus With Hypoglycemia, Drive
- Trial name
- SAFEDRIVE (NCT06382350)
- Testing
- MiniMed 780 G
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital, Motol
Type 1 Diabetes
Use of the Paradigm 722 System to Improve Glycemic Control in Adult and Adolescent Subjects With Type 1 Diabetes
The purpose of this study is to determine whether Type 1 Diabetic subjects using the Paradigm 722 System, which is a glucose sensor-augmented insulin pump, can improve glycemic control when compared to subjects using the Paradigm…
- Trial name
- STAR1 (NCT00211510)
- Testing
- Paradigm 722 sensor augmented pump, Paradigm 715 insulin pump
- Where
- 7 sites in United States
- Volunteers
- 146 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes Mellitus
The Effect of Probiotics on Type 1 Diabetes Mellitus in Children
In this study, investigators try to administer probiotics (Lactobacillus salivarius + Lactobacillus johnsonii + Bifidobacterium lactis from glac biotech Co., Ltd.) to children T1DM patients for 6 months to observe if the…
- Trial name
- NCT03880760
- Testing
- L. johnsonii MH-68, B. animalis subsp. lactis CP-9 and L. salivarius AP-32
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- China Medical University Hospital
Type 1 Diabetes
Early Automated Insulin Delivery (AID) Pilot for Newly Diagnosed T1D
Type 1 diabetes is a common chronic medical condition among youth in the US that requires intensive glycemic management to prevent long-term morbidity and mortality.
- Trial name
- NCT07501338
- Testing
- Tandem Automated Insulin Delivery System
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Stanford University
Diabetes Mellitus, Type 1, Systolic Dysfunction
Tumor Necrosis Factor-alpha Levels and Cardiac Functions in Type 1 Diabetes Mellitus
The goal of this clinical trial is to learn about the effect of type 1 diabetes mellitus on cardiac functions and evaluate the correlation of the dysfunction with the tumor necrosis factor-α (TNF-α) an inflammation-related…
- Conditions
- Diabetes Mellitus, Type 1, Systolic Dysfunction, Diastolic Dysfunction
- Trial name
- NCT06129448
- Testing
- transthoracic echocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sirnak State Hospital
Diabetes, Diabetes Mellitus, Type 1
Observational Study to Evaluate the Safety While Using Levemir®
This study is conducted in Africa. The aim of this observational study is to evaluate the incidence of serious adverse drug reactions while using insulin Levemir® under normal clinical practice conditions in Egypt.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00701155
- Testing
- insulin detemir
- Where
- Egypt
- Volunteers
- 3,593 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Closed-loop Glucose Control for Automated Management of Type 1 Diabetes
We hypothesize that our integrated closed-loop glucose-control system can provide effective, tight, and safe blood glucose (BG) control in type 1 diabetes, thereby establishing the feasibility of closed-loop BG control.
- Trial name
- NCT00811317
- Testing
- Closed-loop
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Diabetes, Diabetes Mellitus, Type 1
Post Marketing Surveillance (PMS) Study of Ryzodeg™ (Insulin Degludec/Insulin Aspart) in Patients With Diabetes Mellitus in Routine Clinical Practice in India
This study is conducted in Asia. The aim of this study is to evaluate long term safety and efficacy in patients with diabetes mellitus in routine clinical practice in India.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT02230618
- Testing
- insulin degludec/insulin aspart
- Where
- 35 sites in India
- Volunteers
- 1,029 people
- Sponsor
- Novo Nordisk A/S
Diabetes Type 1
A Clinical Trial to Evaluate The Effects of Semaglutide and Empagliflozin Combined to Automated Insulin Delivery on Diabetes Control in Adults Living With Type 1 Diabetes
The goal of this clinical trial is to learn if Empagliflozin and Semaglutide, individually and combined, added to Automated Insulin Delivery (AID) works to improve time-in-range in adults living with Type 1 Diabetes.
- Trial name
- SEMPA (NCT06894784)
- Testing
- Intervention Period 1: Semaglutide + Empagliflozin
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Type 1 Diabetes
The REPOSE (Relative Effectiveness of Pumps Over MDI and Structured Education) Trial
For type-1 diabetes, the aim of insulin therapy is to keep blood glucose close to normal while avoiding hypoglycaemia but this is severely limited by the relative crudeness of current insulin delivery in comparison with the…
- Trial name
- REPOSE (NCT01616784)
- Testing
- CSII (Insulin Pump) plus DAFNE, MDI (levemir® & quick acting insulin) plus DAFNE
- Where
- 8 sites in United Kingdom
- Volunteers
- 267 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
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