Clinical trials: Type I Diabetes Mellitus
Type 1 Diabetes Mellitus
Adaptive Biobehavioral Control (ABC) of Automated Insulin Delivery
The purpose of this pilot study is to test the safety and feasibility of using two or three research modules in conjunction with an automated insulin delivery device (AID).
- Trial name
- NCT04784637
- Testing
- Web Simulation Tool (WST), Behavioral Adaptation Module (BAM), Auto Titration Module (ATM)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Virginia
Diabetes
Safety and Efficacy of Single Administration of Oshadi Oral Insulin in Type I Diabetes Patients
The study will be a non-randomized, open label, single dose, single blind, placebo control, single center, single arm study in Type I diabetes patients.
- Trial name
- NCT01120912
- Testing
- Oshadi Oral Insulin
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Oshadi Drug Administration
Type 1 Diabetes
Treatment of Patients With Newly Onset of Type 1 Diabetes With Mesenchymal Stem Cells
The main hypothesis of the investigators study is that the development of autoimmune diabetes may be halted att diagnosis by the immune modulatory properties of mesenchymal stem cells.
- Trial name
- NCT01068951
- Testing
- Mesenchymal stem cells
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University Hospital
Type 1 Diabetes
Artificial Pancreas With Different Stress Assessments in the Outpatient Setting
This feasibility study is a randomized crossover trial that will compare the efficacy and safety of an automated insulin delivery (AID) system in patients with type 1 diabetes using a Model Predictive Control (MPC) algorithm…
- Trial name
- NCT04142229
- Testing
- iAPS, Sensor-Augmented Pump
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Sansum Diabetes Research Institute
Diabetes, Diabetes Mellitus, Type 1
An Observational Study to Assess Safety and Effectiveness of Intravenous NovoRapid® in Hospitalised Subjects
This study is conducted in Asia. The aim of this observational study is to evaluate the side effects profile and benefits of using intravenous insulin aspart infusion in hospitalised subjects under normal clinical practice…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00700648
- Testing
- insulin aspart
- Where
- India
- Volunteers
- 3,024 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
Positron Emission Tomography (PET) Imaging of Pancreatic Beta-Cell Mass in Healthy and Type 1 Diabetic Patients
Pancreatic Islet beta-cells are responsible for synthesizing and secreting appropriate amounts of insulin to regulate blood glucose levels. One factor in the development of diabetes is the loss of beta-cells.
- Trial name
- NCT00958997
- Testing
- 18F-FP-DTBZ (18F-AV-133), Arginine-hydrochloride
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Yale University
Type 1 Diabetes
Insulin Resistance in Type I Diabetes in Pediatric Care
24 children (12 African-American, Hispanic, or American Indian, 12 Caucasian) previously diagnosed with type 1 diabetes mellitus will participate in this pilot study to evaluate the presence of hepatic and peripheral insulin…
- Trial name
- NCT00946426
- Testing
- Clamp
- Where
- United States
- Sponsor
- Nationwide Children's Hospital
Type 1 Diabetes
A Study to Evaluate Pneumococcal Polysaccharide Vaccine Effectiveness in Children With Type 1 Diabetes
The purpose of this study is to determine if children with type 1 diabetes have adequate immune response to PPSV23 vaccination and to assess factors affecting immune response.
- Trial name
- NCT04481243
- Testing
- Pneumovax 23- pneumococcal polysaccharide, Blood draw
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Mayo Clinic
Type 1 Diabetes
Medtronic MiniMed Implantable Insulin Pump
This research is being done to find out whether subjects previously treated with the implantable insulin pump (IIP) therapy, and now taking insulin by injection, will benefit from re-implantation of IIP.
- Trial name
- NCT00298740
- Testing
- Aventis U-400 Insulin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Diabetes Mellitus, Type 1
Diabetes AutoimmunitY Withdrawn in Established Patients (DAY)
The study is a prospective, randomized, double-blind, placebo-controlled, multicenter trial in subjects with established T1D.
- Trial name
- DAY (NCT03794960)
- Testing
- TOL-3021
- Sponsor
- Tolerion, Inc.
Diabetes Mellitus, Type 1
Postprandial Blood Glucose Control and Gastric Emptying in Type 1 Diabetes: Pathogenetic Factors and Therapeutic Options
This study evaluates the prevalence of gastric emptying (GE) in type 1 diabetic patients (DM1) free of chronic complications in comparison with a group of healthy control subjects.
- Trial name
- NCT02365740
- Testing
- gastric emptying test, gut hormones determination, Continuous Glucose Monitoring
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federico II University
Type 1 Diabetes Mellitus
HCL in Adults With T1DM, Markedly Elevated HbA1c, and Psychological Vulnerability
The objective of this study is to evaluate whether the mylife CamAPS FX hybrid closed loop (HCL) system improves glycemic control and quality of life in type 1 diabetes (T1DM) patients with a chronic lack of glycemic control and…
- Trial name
- Hi-Loop (NCT07509060)
- Testing
- mylife CamAPS FX hybrid closed-loop system
- Where
- 3 sites in Poland
- Volunteers
- 30 people
- Sponsor
- Jerzy Hohendorff
Type 1 Diabetes
Imaging of Type 1 Diabetes Progression
Type 1 diabetes results from the autoimmune destruction of the insulin-producing beta cells of the islets of Langerhans of the pancreas.
- Trial name
- NCT01521520
- Testing
- ferumoxytol
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Jason Gaglia
Type 1 Diabetes
A Study of LY2963016 Compared to Lantus® in Adult Chinese Participants With Type 1 Diabetes Mellitus
The purpose of this study is to compare long-acting basal insulin analog LY2963016 to Lantus® in combination with mealtime insulin lispro in adult Chinese participants with Type 1 Diabetes Mellitus (T1DM).
- Trial name
- NCT03338023
- Testing
- LY2963016, Lantus®, Insulin Lispro
- Where
- 20 sites in China
- Volunteers
- 272 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes, Type 2 Diabetes
Comparison of Insulin Pump and MDI for Pregestational Diabetes During Pregnancy
This study is investigating whether insulin treatment with the insulin pump or with multiple daily injections (MDI) gives better outcomes for mother and baby in pregnant women with pregestational diabetes.
- Conditions
- Type 1 Diabetes, Type 2 Diabetes, Pregnancy
- Trial name
- NCT02064023
- Testing
- insulin pump, multiple daily insulin injection
- Where
- 2 sites in Canada
- Volunteers
- 2 people
- Sponsor
- University of British Columbia
Atherosclerosis, Cardiovascular Diseases
Risk Factors for Atherogenesis in Type 1 Diabetes
To determine risk factors for atherogenesis in Type 1 diabetes.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Insulin-dependent, Heart Diseases
- Trial name
- NCT00035750
- Sponsor
- University of Wisconsin, Madison
Type 1 Diabetes
The Effect of Oxytocin on the Alpha Cell Response to Hypoglycaemia in Patients With Type 1 Diabetes
Investigating the effect of oxytocin on pancreatic endocrine functions by determining glucagon secretion during hypoglycemia in participants with type 1 diabetes.
- Trial name
- GLOXY-2 (NCT06881459)
- Testing
- Oxytocin
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Type 1 Diabetes, Motivational Interviewing
The Impact of Motivational Interviews Conducted Through Tele-Nursing on Diabetes Management
The deterioration of glycemic control in adolescents with Type 1 diabetes (T1DM) is a genuine cause for concern. Possible reasons for worsening glycemic control in youth include lack of monitoring, inadequate self-care…
- Trial name
- NCT06208618
- Testing
- Education and Motivational Interviews
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Eskisehir Osmangazi University
Diabetes Mellitus, Type 1, Adrenal Insufficiency
Hypoglycaemia (Low Blood Sugar) in Adults With Diabetes and Adrenal Failure
The purpose of this study is to measure how often low blood sugars occur in people who live with both adrenal insufficiency (AI) and diabetes and need to take insulin.
- Conditions
- Diabetes Mellitus, Type 1, Adrenal Insufficiency, Diabetes Mellitus Type 2 - Insulin-Treated
- Trial name
- HYPO-DIAD (NCT05806190)
- Testing
- Continuous Glucose Monitoring
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Imperial College Healthcare NHS Trust
Type 1 Diabetes
BetaFIT Study: Beta Cell Imaging After Faecal mIcrobiota Transplantation
The main goal is to investigate whether beta cell mass is correlated to beta cell function after autologous faecal microbial transplantation (FMT) in patients with newly diagnosed type 1 diabetes
- Trial name
- BetaFIT (NCT05622123)
- Testing
- 68Ga-NODAGA-Exendin-4
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
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