Clinical trials: Type I Diabetes Mellitus
Preeclampsia, Type 1 Diabetes
Urine-plasminogen as a Predictor for Development Of Preeclampsia in Pregnant Women With Type 1 Diabetes Mellitus
A tonic active epithelial Na+ channel (ENaC) in pre-eclampsia (PE) escaped normal hormonal control may offer an attractive explanatory model for the pathophysiology of established PE. The channel is activated by plasmin.
- Trial name
- NCT01821053
- Where
- Denmark
- Volunteers
- 85 people
- Sponsor
- Odense University Hospital
Type 1 Diabetes
Bet Cell Therapy in Diabetes Type 1
Primary outcome measurement is a parameter of functional beta cell mass at 6 months PT. Functional beta-cell mass will be calculated using the AUC/min between 150 and 160 min during hyperglycemic clamp at 180 mg/dl.
- Trial name
- NCT01379729
- Testing
- Transplantation of encapsulated beta cells.
- Where
- 2 sites in Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Diabetes Mellitus, Type 1
Study of the Impact of PROximity Support for Patients With Type 1 DIABetes Treated With an Insulin Pump or Closed Loop.
Amidst medical innovations, many Type 1 diabetes patients using advanced therapy show improved control but still suffer from diabetes-related distress.
- Trial name
- PRO-DIAB-1 (NCT06050642)
- Testing
- enhanced care model provided by Timkl, a home support provider
- Where
- France
- Volunteers
- 340 people
- Sponsor
- timkl
Type 1 Diabetes Mellitus
Protection Against Pneumococcal Infection in Children With T1DM
Children/ young people with diabetes may be at a higher risk of acquiring certain infections. These infections include those caused by a bacterium called the pneumococcus which can cause pneumonia, meningitis and ear infections.
- Trial name
- T1DM (NCT01939522)
- Testing
- 13-valent pneumococcal conjugate vaccine (PCV13)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Oxford
Type 1 Diabetes
Resistance Training in Type 1 Diabetes Mellitus
The purpose of this study is to learn how different resistance training programs affects blood sugar in young athletes with T1DM.
- Trial name
- NCT05315037
- Testing
- Resistance Training
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Louisville
Type 1 Diabetes Mellitus, Diabetic Retinopathy
The Fenofibrate And Microvascular Events in Type 1 Diabetes Eye.
The purpose of this study is to evaluate the potential benefits of 145 mg of daily fenofibrate in adults with type 1 diabetes mellitus and pre-existing non-proliferative diabetic retinopathy.
- Conditions
- Type 1 Diabetes Mellitus, Diabetic Retinopathy, Diabetic Nephropathies
- Trial name
- FAME 1 EYE (NCT01320345)
- Testing
- Fenofibrate
- Where
- 24 sites in Australia, Hong Kong and 2 more
- Volunteers
- 412 people
- Sponsor
- University of Sydney
Type 1 Diabetes Mellitus
CBT in Adolescents With Type 1 Diabetes
The effectiveness of cognitive behavioural therapy (CBT) for adolescents with type 1 diabetes will be tested. This structured, time-limited, problem-orientated therapy will be used to impact on psychosocial factors influencing…
- Trial name
- NCT00360061
- Testing
- Cognitive Behaviour Therapy
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Bristol
Type 1 Diabetes Mellitus
Cardiopulmonary Fitness, Lung Function, Muscular Oxygen Saturation, and Quality of Life in T1DM
The purpose of this study is to compare the differences of 1. cardiopulmonary fitness 2. lung function 3. muscular oxygen saturation 4. quality of life between type 1 diabetes mellitus and healthy adults.
- Trial name
- NCT01727661
- Testing
- exercise testing with near-infrared spectroscopy, lung function testing, quality of life
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Type I Diabetes Mellitus
Clinical Trial of Efficacy and Safety of Subetta in the Combined Treatment of Patients With Type I Diabetes Mellitus
The purpose of this study is: to assess clinical efficacy of Subetta in the combined treatment of type I diabetes mellitus; to assess safety of Subetta in the combined treatment of type I diabetes mellitus.
- Trial name
- NCT01868594
- Testing
- Subetta
- Where
- 15 sites in Russia
- Volunteers
- 200 people
- Sponsor
- Materia Medica Holding
Type 1 Diabetes
Primary Intervention With Mucosal Insulin
A dose with proven drug bioavailability to the immune system for use in a phase II/III primary T1DM (type 1 diabetes) vaccination trial (POINT study) in genetically at risk subjects.
- Trial name
- Pre-POINT (NCT02620553)
- Testing
- Human Insulin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 1 Diabetics Who Are Pregnant or Planning Pregnancy
Continuous Glucose Monitoring in Women With Type 1 Diabetes in Pregnancy Trial
The primary objective of the study is to determine if RT CGM (Real Time-Continuous Glucose Monitoring) can improve glycemic control in women with T1D who are pregnant or planning pregnancy.
- Trial name
- CONCEPTT (NCT01788527)
- Testing
- CGM
- Where
- 31 sites in United States, Canada and 4 more
- Volunteers
- 325 people
- Sponsor
- Mount Sinai Hospital, Canada
Type 1 Diabetes Mellitus
BD FlowSmart™ Subcutaneous Insulin Infusion Set User Preference and Claims Study
Continuous Subcutaneous Insulin Infusion (CSII) via insulin pump therapy has been shown to improve quality of life and glucose control in many patients with diabetes opting for this treatment modality.
- Trial name
- NCT02662842
- Testing
- FlowSmart Infusion Set, Current Infusion Set
- Where
- 4 sites in United States
- Volunteers
- 75 people
- Sponsor
- Becton, Dickinson and Company
Type 1 Diabetes Mellitus
A Safety, Tolerability, and Efficacy Study of VC-01™ Combination Product in Subjects With Type I Diabetes Mellitus
The purpose of this trial is to test if VC-01™ combination product can be implanted subcutaneously in subjects with Type 1 Diabetes and maintained safely for two years.
- Trial name
- NCT02239354
- Testing
- VC-01™ Combination Product
- Where
- 2 sites in United States, Canada
- Volunteers
- 19 people
- Sponsor
- ViaCyte
Type 1 Diabetes, Type 2 Diabetes
An Online, Compassion Intervention for Adults with Type 1 and Type 2 Diabetes Mellitus (T1DM; T2DM).
The goal of this research study is to evaluate a programme that is based on Compassionate Mind Training (CMT) over four-weeks. The programme intends to share information and strategies to reduce diabetes distress, self-criticism…
- Trial name
- NCT05749029
- Testing
- Four Week Self-Compassion Course
- Where
- United Kingdom
- Volunteers
- 157 people
- Sponsor
- Canterbury Christ Church University
Diabetes Mellitus
DSME or DSME + MI in T1DM on Glycemic Control
This study evaluates the effect of diabetic knowledge and self care behavior (DSME) alone or DSME plus motivational interviewing on glycemic control among children and adolescents with DM type 1.
- Trial name
- NCT03104829
- Testing
- Motivational interviewing, DSME participants in this arm will receive standard care for diabetes (DSME) at the beginning of the study and 3 months later
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Diabetes Mellitus
Use of CoG by Patients With Diabetes Mellitus
The CNOGA Combo Glucometer (CoG) employs an invasive glucose meter using blood glucose teststrips and requiering a capillary blood sample obtained from a fingerstick and in addition, a non-invasive optical component for…
- Trial name
- NCT03840161
- Testing
- non-invasive tissue glucose prediction
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Sciema UG
Diabetes, Diabetes Mellitus
Gastric Ultrasound of Diabetic and Non-Diabetic Patients Following Preoperative Fasting Instructions
This study evaluates the amount of fluid remaining in the stomach of diabetic patients after a standard fasting period, and compare it with non-diabetic patients coming for elective surgical procedures.
- Conditions
- Diabetes, Diabetes Mellitus, Diabetes Mellitus Type 1, Diabetes Mellitus Type 2
- Trial name
- NCT02888951
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- University Health Network, Toronto
Type 1 Diabetes Mellitus
Prevention of de Novo Allosensitization in Islet Transplant Recipients Following Complete Graft Loss
This is a single-center, prospective, open label study in islet transplant recipients after complete islet graft rejection/loss, defined as stimulated c-peptide ≤0.3 ng/mL.
- Trial name
- NCT01999361
- Testing
- Myfortic
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Rodolfo Alejandro
Diabetes Mellitus, Type 1
Insulin-Glucose-Glucagon Network: Defining a Type 1 Diabetes Progression Index
The type 1 Diabetes (T1D) TrialNet Pathway To Prevention (PTP) Study assesses and recruits at-risk subjects into clinical trials aimed at preventing the development of full blown T1D.
- Trial name
- NCT02663661
- Testing
- Metabolic Challenge Admission, CGM home test
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Type 1 Diabetes
Incretin Hormones in Type-1 Diabetes Mellitus Glycemic Response in Type-1 Diabetes Mellitus
The purpose of this study is to investigate whether secretion of incretin hormones is intact and to what extent endogenous as well as exogenous GLP-1 controls postprandial glucose excursions in patients with type-1 diabetes…
- Trial name
- NCT00832741
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
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