Clinical trials: Type I Diabetes Mellitus
Diabetes Mellitus, Type 1
Home Intervention and Social Precariousness in Childhood Diabetes
A pilot study of children whose families are in a precarious situation, who will benefit from a targeted at-home intervention by a pediatric nurse.
- Trial name
- PRECADIAB (NCT04530292)
- Testing
- Intervention by a pediatric nurse at the child's home
- Where
- France
- Volunteers
- 29 people
- Sponsor
- University Hospital, Bordeaux
Type 1 Diabetes
Use of Mobile-based Technologies to Improve Diabetes Self-management and Postprandial Glucose Control
The project involve evaluation of a web-based nutrition education program and pilot-testing of a new smartphone app for real-time data logging to identify factors causing glycemic variability.
- Trial name
- NCT02556398
- Testing
- Sugar Sleuth
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Joslin Diabetes Center
Type 1 Diabetes
The Effects of Antecedent Hypoglycemia or Exercise on the Response of the Brain to Subsequent Hypoglycemia
The studies proposed in this application seek to use non-invasive techniques to examine the impact of repeated hypoglycemia on the brain.
- Trial name
- NCT00600730
- Testing
- Hyperinsulinemic euglycemic clamp with fMRi, Hyperinsulinemic hypoglycemic clamp study with fMRi
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
Diabetes Mellitus
Clinical Assessment of a Novel Microprobe Array Continuous Glucose Monitor for Type 1 Diabetes
The purpose of the study is to assess the safety and efficacy of the Imperial College Microprobe Array Continuous Glucose Sensor in healthy volunteers and in subjects with type 1 diabetes.
- Trial name
- NCT01908530
- Testing
- Microprobe glucose sensor
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diabetes Mellitus, Insulin-Dependent, Hypercholesterolemia
Statins in Children With Type 1 Diabetes and Hypercholesterolemia
Children with type1 diabetes (T1DM) have increased risk for cardiovascular disease (CVD) due to chronic increase in the blood sugars and inflammation.
- Trial name
- NCT01236365
- Testing
- Atorvastatin
- Where
- 5 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Type1diabetes
REACHOUT Mental Health Support Mobile App
The purpose of this study is to investigate the effectiveness of participation in a 6-month peer-led mental health support program, delivered via a mobile app (REACHOUT), to adults with type 1 diabetes compared to a wait-list…
- Trial name
- NCT05668507
- Testing
- REACHOUT Virtual Mental Health Support
- Where
- Canada
- Volunteers
- 225 people
- Sponsor
- University of British Columbia
Type 1 Diabetes
Fats And Carbohydrates Quality on Postprandial glycemIc Response in Type 1 Diabetes
The purpose of this study is to determine whether dietary fats may affect postprandial glycemic response differently according to their quality, and these effects may differ whether they are assumed in the context of meals with…
- Trial name
- FACILE (NCT02330939)
- Testing
- Low fat- Low glycemic index meal, MUFA- Low glycemic index meal, SAFA- Low glycemic index meal
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Federico II University
Type 1 Diabetes
Evaluation of Glycemic Changes During Exercise in Children With Type 1 Diabetes
The objectives of the study are: 1) to evaluate the effects of moderate exercise on SG evolution without insulin dose modification in patients with T1D under continuous subcutaneous insulin infusion (CSII) and multiple daily…
- Trial name
- TREAD-DIAB (NCT02824510)
- Testing
- Algorithmic changes in insulin therapy., Treadmill exercises, Insulin aspart, glargine and detemir
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Type 1 Diabetes Mellitus
MER3101: MAS-1 Adjuvanted Antigen-specific Immunotherapeutic for Prevention and Treatment of Type 1 Diabetes
The study is a randomized, double-masked, placebo-controlled, Phase 1 dose-escalation clinical trial. The objective of the trial is to determine if IBC adjuvanted with MAS-1 is safe and will favor tolerogenic pathways to restore…
- Trial name
- MER3101 (NCT03624062)
- Testing
- MAS-1 adjuvanted Insulin B-chain
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 1
Effect of a Dietary Intervention on Insulin Requirements in Type 1 Diabetes
The purpose of this study is to compare the effects of a low-fat, plant-based dietary intervention and a portion-controlled dietary intervention (compliant with current American Diabetes Association (ADA) guidelines) on the…
- Trial name
- T1D (NCT04944316)
- Testing
- Dietary intervention
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Physicians Committee for Responsible Medicine
Type 1 Diabetes Mellitus
Rilonacept in Diabetes Mellitus Type 1: Safety Study
This study is being done to see if an investigational drug called rilonacept is safe to use in patients with type 1 diabetes, and if it can slow the loss of the body's ability to secrete insulin in patients who are still able to…
- Trial name
- RID-A (NCT00962026)
- Testing
- Rilonacept
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Texas Southwestern Medical Center
Type 1 Diabetes
Regulatory T Cells in Type 1 Diabetes Patients Treated With IL-2
Type 1 diabetes is the most common severe chronic autoimmune disease worldwide and is caused by the autoimmune (loss of self tolerance) mediated destruction of the insulin producing pancreatic beta cells thus leading to insulin…
- Trial name
- DILT1D (NCT01827735)
- Testing
- Aldesleukin (Proleukin)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Type 1 Diabetes
Multicenter Assessment of the PDA-FIT System in Type 1 Diabetic Patients
TELEDIAB-1 is a national, multicenter, controlled, randomised trial. The Primary objective of the TELEDIAB-1 study is to demonstrate that the PDA-FIT system (PDA-Phone and/or telemonitoring) is able to improve metabolic control…
- Trial name
- TELEDIAB-1 (NCT00629304)
- Testing
- VISITS + PDA-FIT system, PDA-FIT System + telephone follow-up
- Where
- 18 sites in France
- Volunteers
- 180 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type 1 Diabetes Mellitus
Pilot Sleep Intervention to Improve Diabetes Management in School-Aged Children
Evaluate the feasibility, acceptability, and preliminary efficacy of a sleep-promoting intervention for school-aged children with type 1 diabetes and their caregivers in a pilot randomized trial.
- Trial name
- NCT03397147
- Testing
- Sleep Coach Jr.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus, Type 1
Comparison of Day and Night Closed-loop With Faster-acting Insulin Aspart With Insulin Aspart
The main objective of the study is to determine whether automated closed-loop using faster-acting insulin aspart will improve glucose control and reduce the burden of hypoglycaemia over a 23-hour period compared to insulin aspart…
- Trial name
- AP-MFT-01 (NCT03579615)
- Testing
- FIASP + closed loop device, Insulin aspart (standard of care insulin) + closed loop device
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Manchester University NHS Foundation Trust
Diabetes Mellitus Type 1
Effects of Exercise and Inhibition of Dipeptidyl Peptidase-4 on Insulin Secretion in Subjects With Type 1 Diabetes
Increasing evidence suggests pancreatic islet beta-cell regeneration occurs throughout the course of the disease in patients with type 1 diabetes.
- Trial name
- EXTYPE-1 (NCT02127047)
- Testing
- Sitagliptin, Exercise
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University Hospital, Basel, Switzerland
Diabetes Mellitus, Type 1
Study to Test Efficacy of Real-time Reminders on Apple Watch To Decrease Late or Missed Meal Boluses
This will be a randomized, cross-over, unblinded study with subjects randomized upon entry into the study to either begin using the Klue software for 6 weeks or to continue with their usual care for 6 weeks.
- Trial name
- NCT03809858
- Testing
- Klue App
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Type 1 Diabetes, Child, Only
Closed-loop Medtronic 780G System in Youth With Type 1 Diabetes
The goal of this observational study is to describe data on Israeli children and youth using the 780G system including data regarding glycemic control parameters, various questionnaires, sleep data, bioimpedance measures, and…
- Trial name
- NCT05908708
- Testing
- Medtronic 780G® hybrid closed loop
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Sheba Medical Center
Type 1 Diabetes Mellitus
Siplizumab in T1DM
This is a multicenter, Phase Ib, open-label, siplizumab dose-finding study in individuals aged 8-45 years with a Type 1 diabetes mellitus (T1DM) diagnosis. within 18 months of V0.
- Trial name
- DESIGNATE (NCT05574335)
- Testing
- Siplizumab
- Where
- 5 sites in United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes, Hypoglycemia
Delayed Mycophenolate Mofetil in Single-Donor Islet Allotransplantation in Type 1 Diabetes
The objective of this study is to assess the safety and efficacy of islet allotransplantation for the reestablishment of stable glycemic control in patients with type 1 diabetes, using anti-thymocyte globulin induction…
- Trial name
- NCT00285233
- Testing
- Allogeneic islets of Langerhans transplant
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
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