Clinical trials: Type I Diabetes Mellitus
Diabetes Mellitus, Type 1, Autoimmune Diseases
Exercise Snacks and Glutamine to Improve Glucose Control in Adolescents With Type 1 Diabetes
This project will assess the feasibility and efficacy of the use of exercise and dietary supplementation with a non essential amino acid - glutamine - a component of most protein supplements, on the regulation of plasma glucose…
- Conditions
- Diabetes Mellitus, Type 1, Autoimmune Diseases, Diabetes Mellitus, Endocrine System Diseases
- Trial name
- NCT03199638
- Testing
- Exercise
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Nemours Children's Clinic
Diabetes Mellitus, Type 1 Diabetes
Achieving Health in Emerging Adults With Diabetes (AHEAD) Program: A Clinical Trial Designed to Understand if Participation in a Clinical Program Developed Specifically to Support Emerging Adults With Type 1 Diabetes Leads to Improved Diabetes Outcomes.
The goal of this study is to determine whether the Achieving Health in Emerging Adults with Diabetes (AHEAD) Program helps emerging adults with type 1 diabetes improve their blood glucose management during the transition from…
- Trial name
- AHEAD Program (NCT07292558)
- Testing
- AHEAD Program
- Where
- United States
- Volunteers
- 306 people
- Sponsor
- University of British Columbia
Type 1 Diabetes Mellitus
Lypo-hypertrofia Characterization in Diabetes
Aim/hypothesis: Subcutaneous insulin absorption is one of the factors which strongly influence blood sugar control in patients with diabetes mellitus on insulin therapy.
- Trial name
- NCT02278926
- Testing
- Ultrasound, Tapping and body inspection to define the area of insulin injection
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Niguarda Hospital
Type 1 Diabetes
Junior KICkOFF: Diabetes Education for Children Under 11 Years
The aim of this study is to develop educational packages for children of primary school age with type 1 diabetes and their parents, and to undertake a small scale feasibility study to allow evaluation of the curriculum.
- Trial name
- NCT02610738
- Testing
- Junior KICk-OFF education programme
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Type 1 Diabetes
Evaluation of Security and Efficacy of Medtrum Hybrid Closed Loop System
The purpose of this study is to evaluate the safety and effectiveness of the MEDTRUM Hybrid Closed Loop (HCL) System in children, adolescents, and adults with type 1 diabetes (7-75 years old) in a home setting and to test the…
- Trial name
- SEECLOOP (NCT06363916)
- Testing
- Insulin Management System in Manual mode of operation, Insulin Management System in Automatic mode of operation
- Where
- 17 sites in France
- Volunteers
- 160 people
- Sponsor
- Medtrum France
Type 1 Diabetes, Nocturnal Hypoglycemia
Development and Assessment of Feasibility of Non-invasive Multiple Sensor Hypo-Sense as a Tool for Detection of Hypoglycemia
Hypo Sense is a non- invasive method for detection of hypoglycemia. The Hypo Sense combines an array of non-invasive sensors which monitors the patient's physiological parameters (heart \& respiration rate, perspiration, skin…
- Trial name
- Hypo-Sense (NCT02225379)
- Testing
- Hypo-Sense (non invasive sensor)
- Where
- Israel
- Volunteers
- 3 people
- Sponsor
- Rabin Medical Center
Type 1 Diabetes, Metabolic Syndrome
T1D, Metabolic Syndrome and Insulin Resistance
Patients with type 1 diabetes (T1D) and metabolic syndrome (MS) require high doses of insulin to achieve a glycemic control, due to insulin resistance (IR).
- Conditions
- Type 1 Diabetes, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT05503303
- Where
- Mexico
- Volunteers
- 19 people
- Sponsor
- Universidad Juárez Autónoma de Tabasco
Hypoglycemia Unawareness, Diabetes Mellitus, Type 1
Glucagon Infusion in T1D Patients With Recurrent Severe Hypoglycemia: Effects on Counter-Regulatory Responses
This is a prospective, randomized, controlled, double-blind, parallel 4-group trial with the primary analysis after 4 weeks of treatment with continuous subcutaneous glucagon infusion (CSGI) or placebo.
- Trial name
- NCT03490942
- Testing
- Glucagon
- Where
- 5 sites in United States
- Volunteers
- 49 people
- Sponsor
- Xeris Pharmaceuticals
Type 1 Diabetes
Effects of Low-calorie Sweetened Beverage Restriction in Youth With Type 1 Diabetes
This study will investigate whether low-calorie sweeteners (LCS) are helpful or harmful for preventing diabetes complications among children with Type 1 Diabetes (T1D).
- Trial name
- NCT04385888
- Testing
- Low-calorie sweetener restriction
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Allison Sylvetsky (Meni)
Type 1 Diabetes Mellitus
The Influence of Non-Caloric Artificial Sweeteners on Youth With Type 1 Diabetes
The investigators aim to further the understanding of environmental factors that may underlie variations in body composition seen in youth with Type 1 diabetes (T1D).
- Trial name
- NCT03889522
- Testing
- Bioelectrical Impedance Analysis, Total Body Dual-energy X-ray Absorptiometry, Blood draw
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical College of Wisconsin
Diabetes Mellitus, Type 1
PINIT Study: Primary Intranasal Insulin Trial
Type 1 diabetes (T1D) results from an autoimmune destruction of the insulin-producing beta cells. Administration of mucosal insulin in islet autoantibody-negative children who are genetically predisposed for T1D offers the…
- Trial name
- NCT03182322
- Testing
- intranasal insulin
- Where
- 2 sites in Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Diabetes, Diabetes Mellitus, Type 1
Effect of NN5401 in Japanese Subjects With Type 1 Diabetes
This trial is conducted in Japan. The aim of this clinical trial is to investigate the blood sugar lowering effect of NN5401 (insulin degludec/insulin aspart (IDegAsp)) in Japanese subjects with type 1 diabetes.
- Trial name
- NCT01051102
- Testing
- insulin degludec/insulin aspart, biphasic insulin aspart 30
- Where
- Japan
- Volunteers
- 21 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes
To Evaluate the Hormonal Response to Low Blood Sugar After a Single Oral Dose of AZD1656 Suspension
To evaluate the hormonal response to low blood sugar after a single oral dose of AZD1656 suspension.
- Trial name
- NCT00790153
- Testing
- Insulin, AZD1656
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Diabetes Mellitus
Study of IGRP-specific T Cell in Peripheral Blood of Type 1 Diabetes Mellitus
10 type 1 diabetes, 10 type 2 diabetes and 10 healthy controls matched with age and sex were enrolled in our study and their periphera blood mononuclear cells (PBMC) were isolated.
- Trial name
- NCT03136939
- Testing
- No intervention
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Peripheral Arterial Disease (PAD), Diabetes Mellitus (DM)
The Efficacy and Safety of REX-001 to Treat Ischemic Ulcers in Subjects With CLI Rutherford Category 5 and DM
This trial is a pivotal, placebo-controlled, double-blind, parallel-group, adaptive trial conducted in subjects with DM and CLI Rutherford Category 5.
- Conditions
- Peripheral Arterial Disease (PAD), Diabetes Mellitus (DM), Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT03174522
- Testing
- REX-001
- Where
- 15 sites in Czechia, Hungary and 4 more
- Volunteers
- 49 people
- Sponsor
- Ixaka Ltd
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Evaluation of the Effect of Pramlintide on Satiety and Food Intake
This is a single center, randomized, blinded, placebo-controlled, two-period, cross-over study to evaluate the effect of pramlintide on satiety and food intake in normal-weight and obese non-diabetic subjects and in…
- Trial name
- NCT00042601
- Testing
- Pramlintide acetate
- Where
- Australia
- Volunteers
- 51 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 1
cArdiopulmonary exerCise Test Assessing Multiple bIOmarkers iN Type 1 Diabetes
Collection of venous blood samples in male T1D patients to evaluate the behavior of different biomarkers (beta-hydroxybutyrate, lactate, glucose) during and after morning Aerobic (60% of VO2 max) and Symptom Limited Maximal…
- Trial name
- NCT05097339
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Hospital, Antwerp
Diabetes Mellitus, Type 1
Acceptability of Self-Led Mindfulness-Based Intervention
This study had two primary aims. First, the investigators examined the associations between mindfulness and diabetes-related outcomes.
- Trial name
- NCT05115175
- Testing
- Mindfulness-Based Stress Reduction
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Reno
Type 1 Diabetes, Autoimmune Diabetes
Is the Artificial Pancreas, Without Carbohydrate Counting, Efficient and Safe in an Outpatient Setting
This is a pilot, interventional clinical trial to assess the effectiveness and safety of artificial pancreas (AP) using the ARG algorithm closed-loop system in a monitored 3-day period outpatient study.
- Trial name
- NCT04793165
- Testing
- Non-hybrid closed-loop system with ARG algorithm
- Where
- Argentina
- Volunteers
- 5 people
- Sponsor
- Hospital Italiano de Buenos Aires
Diabetes Mellitus, Type 1
Mindfulness-based Arabic Guided Self-help for Parents of Children With Type 1 Diabetes
Kuwait ranks as the third country worldwide for the incidence of type 1 diabetes (T1D) with an incidence of 37.10 per 100,000 children.
- Trial name
- NCT03358394
- Testing
- A human-interventional study
- Where
- Kuwait
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- SHAHAH ALTAMMAR
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