Clinical trials: Type I Diabetes Mellitus
Diabetes Mellitus, Type 1
Long-term, Implantable Sensor Improves Health Outcomes in Patients With T1D
The implantable Eversense ® CGM System obtained CE marking in 2016 for the 90-day device and in 2017 for the 180-day device.There is interest in real-world clinical evidence on the use of Eversense regarding changes in HbA1c and…
- Trial name
- NCT04160156
- Testing
- Long term sensor
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University Magna Graecia
Diabetes Mellitus, Diabetes Mellitus, Type 1
PRECISION Study: Multi-center Study of Performance of a Novel Implanted CGM System Using a Next Generation Transmitter and Algorithm
The purpose of this multi-center, prospective clinical study is to evaluate the performance of a novel, implanted Senseonics continuous glucose monitoring system (Senseonics CGM System) compared to Yellow Springs Instrument (YSI)…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- PRECISION (NCT03251079)
- Testing
- Continuous glucose monitoring system
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Senseonics, Inc.
Type 2 Diabetes
Diabetes Nutrition Education and Healthy Food Resource for AIANs With T2D
Healthy nutrition habits are key to managing type 2 diabetes (T2D). However, American Indian and Alaska Natives (AI/ANs) often lack access to culturally relevant nutrition education and they disproportionately experience food…
- Trial name
- OKCICWCIE+ (NCT06077162)
- Testing
- Diabetes Nutrition Education Classes, Healthy Food Security Resource
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Colorado State University
Type 1 Diabetes
Enhanced Epidermal Antigen Specific Immunotherapy Trial -1
The study is a two centre, open-label, uncontrolled single group phase 1A study of C19-A3 GNP peptide (10 μg peptide equivalent content) administered via Nanopass microneedles every 28 days for 8 weeks (3 doses), with follow-up…
- Trial name
- EE-ASI-1 (NCT02837094)
- Testing
- C19-A3 GNP
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Cardiff University
type1diabetes, Adolescent Behavior
Disease Management in Adolescents With Type 1 Diabetes
Adolescence period; It is a transition period of rapid growth, development and maturation in biochemical, physical, social and spiritual terms, which lasts from the beginning of puberty to young adulthood.
- Conditions
- type1diabetes, Adolescent Behavior, Self Efficacy
- Trial name
- NCT06246279
- Testing
- Adaptation to Adolescence and Type 1 Diabetes Management Training Program
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Akdeniz University
Type 1 Diabetes
CSII in Type 1 Diabetes: Diet, Quality of Life & Cardiometabolic Risks - A Cross-Sectional Study
Glycaemic control is an important aspect of Type 1 diabetes (T1D) management for diabetologists and patients alike. Evidence suggests continuous subcutaneous insulin infusion (CSII) is an effective method of achieving this.
- Trial name
- NCT02258945
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Liverpool John Moores University
Type 1 Diabetes Mellitus
Study of How Single Rising Doses of SAR161271 Are Absorbed and Act in Patients With Type 1 Diabetes Mellitus (T1DM)
Primary Objective: To establish initial safety/tolerability and pharmacodynamic and pharmacokinetic profiles of four formulations of SAR161271 in patients with T1DM.
- Trial name
- NCT01053728
- Testing
- SAR161271, Insulin glargine HOE901
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Sanofi
Metabolic Acidosis, Diabetic Ketoacidosis
Diabetic Ketoacidosis Diagnosis and Management
This is the first and only study conducted on the use of capnography in children diagnosed with DKA to evaluate the initial clinical grading of DKA, monitor clinical improvement, and predict complications such as brain edema.
- Conditions
- Metabolic Acidosis, Diabetic Ketoacidosis, Brain Edema
- Trial name
- NCT06327737
- Testing
- Capnography
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Akdeniz University
Type 1 Diabetes
Etanercept in New Onset Type 1 Diabetes
The investigators hypothesized that the administration of Etanercept to children newly diagnosed with T1DM may be able to interdict the progression of T1DM.
- Trial name
- NCT00730392
- Testing
- Etanercept
- Volunteers
- 18 people
- Sponsor
- State University of New York at Buffalo
Type 1 Diabetes Mellitus
Long Term Surveillance of Islet Transplant Recipients Following Complete Graft Loss
This is a single-center, prospective, open label study in islet transplant recipients following islet graft loss.
- Trial name
- NCT02000687
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rodolfo Alejandro
Coping Behavior, Emotional Distress
Creative Arts Diabetes Initiative for Youth/Young Adults Transitioning to Adult Care
The Creative Arts Diabetes Initiative will offer facilitated art therapy with a group/peer-support environment to two groups of youth/young adults, one with type 1 diabetes, and one with type 2 diabetes.
- Conditions
- Coping Behavior, Emotional Distress, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- CADI (NCT02790892)
- Testing
- Art therapy - pre and post test measures
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Manitoba
Diabetes Mellitus, Type 1
Evaluation of a Mobile Application to Optimize Self-decision on Metabolic Control in Persons With Type 1 Diabetes
Adolescents with type 1 diabetes mellitus (T1 DM) tend to have poor metabolic control. There are no mobile applications in our language in our environment, and patients are accessible in addition to the difficulties involved in…
- Trial name
- DM-BLUE (NCT05143411)
- Testing
- PRE-test
- Where
- Dominican Republic
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidad Iberoamericana
Type 1 Diabetes
Supporting Treatment Adherence Needs in Diabetes
There is an unmet treatment need for depressed adolescents with type 1 diabetes. To address this unmet need, we have designed a new, family-based, cognitive-behavioral intervention to reduce depressive symptoms, improve family…
- Trial name
- STAND (NCT01030471)
- Testing
- Family-based cognitive-behavioral treatment
- Where
- United States
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Non-Nutritive Sweetener, Type 1 Diabetes
Cardiometabolic Effects of Non-Nutritive Sweeteners (NNS) in Type 1 Diabetes (T1D)
This project will apply a novel non-nutritive sweetener (NNS) dietary assessment tool with measurement of circulating NNS levels in a pediatric population, allowing correlation of NNS exposure to clinically meaningful…
- Conditions
- Non-Nutritive Sweetener, Type 1 Diabetes, type1diabetes, Type 1 Diabetes Mellitus
- Trial name
- NCT07434544
- Testing
- Cherry Sports Drink
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Type 1 Diabetes, Hypoglycemia
Slow Digestible Carbohydrates and Exercise in Adolescents With Type 1 Diabetes
In this within-subject cross-over study, the investigators hypothesize that corn-starch based supplements taken prior to exercise will decrease the risk of delayed hypoglycemia in adolescents with T1D, improve performance during…
- Trial name
- NCT05540132
- Testing
- maltodextrin, super starch
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Type 2 Diabetes Mellitus
An Ascending Dose, Single/Multiple Dosing, Food Effect Clinical Trial to Evaluate Pharmacokinetics, Safety and Tolerability in Healthy Subjects After Oral Administration of Gemigliptin (Phase I)
To determine the pharmacokinetic properties, safety and tolerability of single/multiple oral administration of Gemigliptin and Food effect in healthy Chinese subjects.
- Trial name
- NCT03864432
- Testing
- Gemigliptin 25mg, Gemigliptin 50mg, Gemigliptin 100mg
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- LG Chem
Type 1 Diabetes
Impact of Functional Insulinotherapy on Blood Glucose Variability Indicators in Patients With Type 1 Diabetes
The primary objective of this trial is to assess whether functional insulinotherapy decreases blood glucose variability at 3 months and 6 months, compared to initial values in type 1 diabetes patients.
- Trial name
- VARIAFIT (NCT00973492)
- Testing
- functional insulinotherapy class
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Association Grenobloise pour le Developpement D'etudes et de Recherches en Physiopathologie Endocrinienne, Diabetologie et Maladies de la Nutrition
Type 1 Diabetes Mellitus
The Effects of Fluoxetine and/or DHEA
(1) To determine how the Selective Serotonin Reuptake Inhibitor (SSRI), fluoxetine (Prozac), an antidepressant often used to treat depression, stimulates the participant's body's ability to defend against low blood sugar…
- Trial name
- NCT03228732
- Testing
- Fluoxetine, DHEA, Fluoxetine and DHEA
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Type 1 Diabetes
Impact of a Low-Carbohydrate Diet in Pediatric Type 1 Diabetes
Dietary carbohydrate consumption is a key factor influencing postprandial glycemia for patients with type 1 diabetes mellitus (T1DM).
- Trial name
- NCT03997409
- Testing
- Dietary Intervention
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Impact of Acetaminophen on Performance of Guardian™ Sensor (3) in Adults
The purpose of this study is to characterize the impact of acetaminophen ingestion on the performance of the Guardian™ Sensor (3) (i.e., C algorithm and Zeus algorithm) in subjects age 18 - 80 years.
- Trial name
- NCT04378114
- Testing
- Guardian™ Sensor (3) connected to a Guardian™ Connect Transmitter. C sensor algorithm applied retrospectively to raw sensor data., Guardian™ Sensor (3) connected to a Guardian™ Connect Transmitter. Zeus sensor algorithm applied retrospectively to raw sensor data., Acetominophen
- Where
- 6 sites in United States
- Volunteers
- 104 people
- Sponsor
- Medtronic MiniMed, Inc.
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