Clinical trials: Type I Diabetes Mellitus
Diabetes, Diabetes Mellitus, Type 1
Special Survey for Paediatric Subjects
This study is conducted in Japan. The aim of this study is to collect safety and efficacy data when using NovoRapid® (insulin aspart) in children with type 1 and type 2 diabetes under normal clinical practice conditions.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01487382
- Testing
- insulin aspart
- Where
- Japan
- Volunteers
- 241 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus
Rituximab in New Onset Type 1 Diabetes
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks the insulin-producing beta cells in the pancreas.
- Trial name
- TN05 (NCT00279305)
- Testing
- Anti-CD20 (rituximab)
- Where
- 16 sites in United States, Australia and 2 more
- Volunteers
- 87 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes
Circulating Biomarkers in the Development of Type 1 Diabetes
More than 100 million U.S. adults are now living with diabetes or prediabetes. Investigators still do not fully understand how diabetes develops and how the disease worsens.
- Trial name
- NCT05505669
- Testing
- One-time blood (up to 100 ml) will be drawn and the amount of blood drawn is based on weight. Saliva and urine will be collected during the blood draw visit.
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Type 1 Diabetes, Osteopenia
Skeletal Effects of Type 1 Diabetes on Low-Trauma Fracture Risk
Patients with Type 1 Diabetes Mellitus (T1DM) have a higher risk of low-trauma (osteoporotic) fracture that is 7-12 times higher than non-diabetics.
- Conditions
- Type 1 Diabetes, Osteopenia, Bone Loss, Fractures, Bone
- Trial name
- NCT05701254
- Testing
- Transilial bone biopsy
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Creighton University
Diabetes Mellitus, Type 1
Pilot Brief Communal Coping Intervention for Adults With Type 1 Diabetes
We plan to develop a communal coping intervention aimed at instilling a shared appraisal of diabetes and increasing patient-partner collaboration.
- Trial name
- NCT05925556
- Testing
- Communal Coping Intervention
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Carnegie Mellon University
Diabetes Mellitus, Type 1
Optimizing Metabolic Control in Type 1 Diabetes - The Automatic Bolus Calculator Flash Study
This study aims to compare the effect of flash glucose monitoring (FGM) with traditional self-monitoring of blood glucose (SMBG) with or without carbohydrate counting and automated bolus calculation, in patients with type 1…
- Trial name
- NCT03682237
- Testing
- Carbohydrate counting, automated bolus calculation, Flash glucose monitoring (FGM)
- Where
- Denmark
- Volunteers
- 184 people
- Sponsor
- Steno Diabetes Center Copenhagen
Quality of Life, Burden, Dependency
Impact of the Use of a Closed-loop Insulin Therapy on the Burden of the Diabetes and the Quality of Life
The use by diabetes patients of real-time Continuous Glucose Monitoring (CGM) system is becoming widespread and has changed diabetic practice. Automated closed-loop (CL) insulin therapy has come of age.
- Trial name
- IMPLIQUE (NCT04939766)
- Testing
- Activation of a closed loop device in an insulin pump device with GCM
- Volunteers
- 250 people
- Sponsor
- VitalAire
Stress, Anxiety
Effect of Ear Massage on Stress, Anxiety, and Sleep Quality in Parents of Children With Type 1 Diabetes
The purpose of this clinical trial is to determine the effect of self-administered ear massage on stress, anxiety levels, and sleep quality in parents of children diagnosed with Type 1 diabetes.
- Conditions
- Stress, Anxiety, Sleep Quality
- Trial name
- NCT06829251
- Testing
- Effective Ear Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Mersin University
Type 1 Diabetes Mellitus
Autologous Hematopoietic Stem Cell Transplantation for Early Onset Type 1 Diabetes
This is a phase II trial in individuals who have been diagnosed with type 1 diabetes within the previous 6 months. The study is evaluating whether stem cell transplantation is safe when chemotherapy and immunotherapy are used in…
- Trial name
- NCT00807651
- Testing
- AHSCT, Insulin therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Diabetes, Diabetes Mellitus, Type 1
Safety of Inhaled Human Insulin in Subjects With Diabetes Mellitus and Chronic Obstructive Pulmonary Disease (COPD)
This trial is conducted in Europe, Asia and South America. A one-year clinical trial to compare the safety of inhaled human insulin to subcutaneous insulin aspart in subjects with type 1 or type 2 diabetes and chronic obstructive…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Chronic Obstructive Pulmonary Disease
- Trial name
- iINHALE 8 (NCT00472953)
- Testing
- inhaled human insulin, insulin aspart
- Where
- 27 sites in Argentina, India and 5 more
- Volunteers
- 38 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus, Hypoglycemia
Exercise-Induced Hypoglycemia Prevention in Adults With Type 1 Diabetes Using an Artificial Pancreas
This is a randomized crossover trial with 1:1 randomization to the admission sequence of using the Control AP system (rMPC - Naïve Model Predictive Control) vs.
- Trial name
- NCT03859401
- Testing
- EnMPC (Ensemble Model Predictive Control) AP Controller, rMPC (Naïve Model Predictive Control) AP Controller
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Marc Breton
Diabetes Mellitus
Adhesive Materials for Continuous Glucose Monitoring Systems
Within the present study 4 different band-aid/adhesive combinations will be tested in patients with type 1 diabetes and type 2 diabetes with regard to adherence to the body and allergic potential.
- Trial name
- NCT03340467
- Testing
- CGM patch
- Sponsor
- Metronom Health
Type 1 Diabetes Mellitus, Hypoglycemia
Hypoglycaemia Awareness Restoration Programme
Insulin treatment for type 1 diabetes inevitably carries risk of hypoglycaemia (low blood sugar) which can be severe enough to cause coma, seizure, even death.
- Trial name
- HARPdoc (NCT02940873)
- Testing
- HARPdoc courses, BGAT courses
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 99 people
- Sponsor
- King's College London
Diabetic Nephropathy
Drugs for High Blood Pressure and High Cholesterol in American Indians With Type 2 Diabetes
OBJECTIVES: I. Establish a long-term working relationship between clinical investigators and the Minnesota American Indian community. II.
- Trial name
- NCT00004266
- Testing
- Lisinopril, Nifedipine, Simvastatin
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes
Description of Patients With Type 1 Diabetes Treated With Teplizumab
Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease caused by the destruction of pancreatic β cells. T1D pathogenesis progresses through several stages: Stage 1 T1D includes the presence of β cell autoimmunity and thus…
- Trial name
- TEPLI-REAL (NCT06892002)
- Testing
- Teplizumab
- Where
- 27 sites in United States, Israel
- Volunteers
- 110 people
- Sponsor
- Sanofi
NSCLC Stage II, NSCLC Stage III
Efficacy of Anti-CTLA-4 Antibody Combined With Sintilimab and Chemotherapy as Neoadjuvant Therapy for Resectable Stage II-III Non-Small Cell Lung Cancer
This study aims to evaluate the major pathologic response (MPR) rate of neoadjuvant therapy with sintilimab (PD-1 inhibitor) + IBI310 (anti-CTLA-4 antibody) + chemotherapy, and to assess the efficacy of this treatment strategy in…
- Trial name
- NCT07410975
- Testing
- sintilimab+IBI310+chemotherapy
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Type 1 Diabetes Mellitus, Coronary Artery Disease
Vascular Inflammation in Adolescents With Type 1 Diabetes
The purpose of this study is to find out if diabetes damages the blood vessels of adolescents with good diabetes control compared to adolescents with less optimal control.
- Trial name
- NCT00933101
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Children's Mercy Hospital Kansas City
Type 1 Diabetes, Stress
The Influence of Psychobiological Adversity to Children and Adolescents With Type 1 Diabetes
The aims of this study are two fold: To show whether there is an increased environmental or genetic susceptibility to stress in patients with T1D and whether it influences diabetes management.
- Trial name
- NCT02575001
- Testing
- Psychological background determinations, Genetic susceptibility determination, Cortisol release test
- Where
- Slovenia
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana, Faculty of Medicine
Type2 Diabetes Mellitus, Chronic Kidney Disease
A Study of ONO-3310 in Healthy Adult Male Subjects and Chronic Kidney Disease Patients With Type 2 Diabetes Mellitus
To investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple oral doses of ONO-3310 in healthy Japanese adult male subjects and chronic kidney disease patients with type 2 diabetes…
- Trial name
- NCT07619157
- Testing
- ONO-3310
- Where
- Japan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Type 1 Diabetes
Two Way Crossover Closed Loop MPC vs Control IQ
An artificial pancreas (AP) is a control system for automatic insulin delivery. The investigators have implemented a missed meal bolus detection algorithm for use within an AP control system.
- Trial name
- NCT05799781
- Testing
- MPC closed-loop system, t:slim X2 pump with Dexcom G6 CGM and Control IQ
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Oregon Health and Science University
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