Clinical trials: Type I Diabetes Mellitus
Type 1 Diabetes
Low-dose rhIL-2 in Patients With Recently-diagnosed Type 1 Diabetes
Type 1diabetes (T1D) is caused by autoimmune destruction of the pancreatic islet ß-cells, leading to an absolute deficiency in insulin.
- Trial name
- DIABIL-2 (NCT02411253)
- Testing
- rhIL-2
- Where
- 34 sites in Belgium, France and 4 more
- Volunteers
- 141 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Biomarkers, Saliva
Application of Salivary Biomarkers in Risk Assessment for Oral Diseases in Children With Type 1 Diabetes
This research contributes to a deeper understanding of the etiopathogenesis of periodontal and other oral diseases in children with T1D.
- Conditions
- Biomarkers, Saliva, Type 1 Diabetes (T1D), Dental Care for Children
- Trial name
- NCT06924372
- Testing
- Taking saliva samples of unstimulated saliva will be collected in sterile containers, salivets., Dental status, Periodontal status
- Where
- Serbia
- Volunteers
- 112 people
- Sponsor
- University of Novi Sad
Diabetes Mellitus, Diabetes Mellitus, Type 1
Umbilical Cord Mesenchymal Stem Cells Infusion for Initial Type 1 Diabetes Mellitus
The purpose of this study is to determine whether umbilical cord Mesenchymal Stem Cells of treatment for initial type 1 diabetes is safe and effective.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Mesenchymal Stem Cells, Umbilical Cord
- Trial name
- NCT01219465
- Testing
- umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Qingdao University
Type 1 Diabetes
Hormone Responses During Hypoglycemia and the Accuracy of Continuous Glucose Monitors
The primary objective of this study will be to compare the glucose level at which counter-regulatory hormone responses occur during hypoglycemia in young children with diabetes, with the glucose level counter regulatory hormone…
- Trial name
- NCT00607139
- Where
- 6 sites in United States
- Volunteers
- 28 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus, Type I
Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation After Kidney Transplant
Type 1 diabetes mellitus (T1D) is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00790439
- Testing
- Low Molecular Weight Sulfated Dextran, Heparin, Mycophenolate Mofetil
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes, Diabetes Mellitus, Type 1
The Efficacy and Safety of Liraglutide as Adjunct Therapy to Insulin in the Treatment of Type 1 Diabetes
This trial is conducted globally. The aim of the trial is to confirm the efficacy and safety of liraglutide as adjunct therapy to insulin in the treatment of type 1 diabetes.
- Trial name
- ADJUNCT ONE™ (NCT01836523)
- Testing
- liraglutide
- Where
- 182 sites in United States, Argentina and 15 more
- Volunteers
- 1,398 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Diabetes Mellitus, Type 1
Efficacy and Safety of Levemir® Used as Basal Insulin
This study is conducted in Europe. The aim of this study is to evaluate efficacy and safety of insulin detemir (Levemir®) used as basal insulin on the glycaemic control, weight and incidence of hypoglycaemic events in insulin…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01548248
- Testing
- insulin detemir, insulin aspart
- Where
- Slovakia
- Volunteers
- 631 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes (T1D), Glucose Control
Need-driven Treatment of the Patients With Type 1 Diabetes
This prospective study evaluates the safety of extending the interval of routine calendar-based follow-up visits from every 12 months to every 24 months in patients with type 1 diabetes who are in good glycemic control and…
- Trial name
- NCT07128992
- Testing
- Control visit interval
- Volunteers
- 125 people
- Sponsor
- Tampere University Hospital
Diabetes Mellitus, Type 1
A Clinical Study to Investigate and Compare the Impact of High Protein Pasta, Lower Protein Pasta and White Rice on Blood Sugar Control in People With Type 1 Diabetes Mellitus (T1DM)
The aim of this clinical study is to investigate and compare the postprandial glycemic response to three different meal types rich in carbohydrates, that is, white pasta, high protein pasta and white rice consumed by individuals…
- Trial name
- NCT03362151
- Testing
- Regular pasta, High protein pasta, White rice
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Sansum Diabetes Research Institute
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Adipose Tissue Function After Pancreas Transplantation
Clinical measures of adipose tissue mass (BMI, waist circumference, waist-to-hip ratio) do not adequately explain the inter-individual and ethnic heterogeneity in diabetes. .
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, End Stage Renal Disease
- Trial name
- NCT01729130
- Testing
- Adipose tissue biopsy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Type 1 Diabetes Mellitus
Strategies to Enhance New CGM Use in Early Childhood (SENCE)
The primary objective of this study is to compare the efficacy and safety of CGM alone and CGM combined with a family behavioral intervention with a control group using home blood glucose monitoring (BGM) alone.
- Trial name
- SENCE (NCT02912728)
- Testing
- CGM + Family Behavioral Intervention, Standard CGM
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Jaeb Center for Health Research
Implementation Science, Type 1 Diabetes in Adolescence
Pilot Implementation Trial of Implementation Toolkits for Diabetes Coaching
The goal of this study is to learn if toolkits of implementation strategies (e.g., provider and staff education, clear plan for how to refer and bill) help pediatric type 1 diabetes medical and psychology providers deliver a…
- Conditions
- Implementation Science, Type 1 Diabetes in Adolescence, Implementation Strategies
- Trial name
- NCT07766811
- Testing
- Base Implementation Toolkit (BIT), BIT-Enhanced, BIT-Sustainment
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Diabetes Mellitus Complication, Renal Impairment
Accuracy and Treatment Experience of Two Glucose Monitoring Systems Tested in Patients With Type 1 Diabetes and Renal Impairment
The study aims to evaluate the accuracy of two commercial glucose monitoring systems in patients with type 1 or type 2 diabetes and renal impairment, including patients with or without dialysis.
- Trial name
- NCT03378271
- Testing
- Simultanious CGM/FGM
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Diabetes Mellitus, Type 1
Islet Transplantation in Type 1 Diabetic Kidney Allograft
The purpose of this study is to learn about the safety of islet transplantation when performed after kidney transplantation, which may provide more normal control of blood sugar without the need for insulin shots.
- Trial name
- NCT01241864
- Testing
- Allogenic islet cells (human, U. Chicago), Intraportal infusion of islet cells
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Type 1 Diabetes, Pregnancy in Diabetic
Telemedicine in Pregnant Women With Type 1 Diabetes Mellitus
Hypothesize that co-managing pregnant type 1 diabetics with telemedicine will have at least equivalent outcomes to those managed with standard care.
- Trial name
- NCT04278664
- Volunteers
- 5 people
- Sponsor
- Ana Braescu
Healthy, Type 1 Diabetes Mellitus
A First-in-human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM12460A
Study Design: Part 1.Randomized, double-blind, placebo-controlled, escalating single-dose design with Healthy volunteers Part 2.Open , sequential, two-period, single dose study with type 1 diabetes Part 3.Open, sequential…
- Conditions
- Healthy, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
- Trial name
- HM12460A (NCT01724814)
- Testing
- HM12460A
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Type2 Diabetes
DCB-DM101 in Healthy Volunteers and for Type 2 Diabetes Mellitus Patients
An Open-Label Phase I Study to Assess the Safety and Tolerability Profile of Three Escalating Doses of DCB-DM101 in Healthy Volunteers and Optimum Dose of DCB-DM101 as Add-on Treatment in Type 2 Diabetes Mellitus (T2DM) Patients
- Trial name
- NCT03033433
- Testing
- DCB-DM101
- Where
- Taiwan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- VitNovo, Inc.
Diabetes Mellitus ( Type 1 and Type 2), Hypertension
Care COMPASS Study
This is a prospective, single-arm, mixed-methods pilot study at a single academic medical center to observe the impact, feasibility and acceptability of an AI Care Companion tool on activation and confidence among patients with…
- Trial name
- NCT07904793
- Testing
- Guide My Care Tool
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Fitbit LLC
Type 1 Diabetes
Phase 1 Study to Explore the Safety and Pharmacokinetics of DAPAglifozin in Adolescents and Adults With Type 1 Diabetes
Dapagliflozin has been effective at lowering glucose and hemoglobin A1c (HbA1C) in subjects with tpye 2 diabetes (T2DM), when studied as monotherapy as well as in combination with insulin or oral anti-diabetic medications.This…
- Trial name
- DAPA-IIT1 (NCT02325206)
- Testing
- dapagliflozin
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Signaling Mechanisms and Vascular Function in Diabetes Mellitus
Ruboxistaurin is being tested to see if it is effective in treating certain diabetic complications, such as diseases of the blood vessels.
- Trial name
- NCT00761852
- Testing
- Ruboxistaurin
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
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