Clinical trials: Type II Respiratory Failure
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Home Non-invasive Ventilation for Chronic Obstructive Pulmonary Disease Patients
Chronic Obstructive Pulmonary disease (COPD) patients with chronic hypercapnic respiratory failure are more likely to develop exacerbations.
- Trial name
- NIVOLD (NCT01526642)
- Testing
- Non Invasive Ventilation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Rouen
Acute Hypercapnic Respiratory Failure
ReAcT CO2: A Study to Assess TcCO2 to Guide Acute NIV
Arterial blood sampling is needed to monitor carbon dioxide and PH but is often painful. The aim of this study is to determine whether continuous carbon dioxide monitoring with a skin probe reduces the need for arterial blood…
- Trial name
- ReAcTCO2 (NCT05674760)
- Testing
- Trancutaneous CO2 monitoring (using TCM5 device), Arterial Blood Gas (ABG) sampling
- Volunteers
- 60 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Hypoxic Respiratory Failure, Hypercapnic Respiratory Failure
Snow Physical Properties and Human Ventilatory Response
Sufficient oxygenation is critical for completely buried avalanche victims to avoid life-threatening consequences during hypoxic exposure.
- Conditions
- Hypoxic Respiratory Failure, Hypercapnic Respiratory Failure, Avalanche Burial, Snow Physical Properties
- Trial name
- NCT03082105
- Testing
- Breathing in snow
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Pompe Disease
Phrenic Nerve and Diaphragm Electrophysiology in Pompe Disease
Pompe disease is traditionally considered a lysosomal myopathy. However, increasing experimental and clinical evidence suggests involvement of the entire motor unit, including motor neurons, peripheral nerves, neuromuscular…
- Trial name
- NCT07664930
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Hypercapnic Respiratory Failure, COPD
Treatment of Acute Hypercapnic Respiratory Failure With OptiflowTM or Optiflow+DuetTM Nasal Cannula in COPD-patients
Hypothesis Treatment with HFNC and OptiflowTM+Duet can significantly reduce PaCO2 and normalize pH in patients with COPD exacerbation and acute hypercapnic failure, compared to HFNC with OptiflowTM.
- Trial name
- DUACT (NCT06257667)
- Testing
- Respiratory Support
- Volunteers
- 138 people
- Sponsor
- Aalborg University Hospital
Hypercapnic Respiratory Failure, COPD, ARDS
Feasibility Study of the Hemolung Respiratory Assist System (Germany)
The purpose of this study is to evaluate the safety and efficacy of the Hemolung Respiratory Assist System (RAS) in patients with hypercapnic respiratory failure.
- Trial name
- NCT01021605
- Testing
- Hemolung Respiratory Assist System
- Where
- 7 sites in Germany
- Volunteers
- 21 people
- Sponsor
- Alung Technologies
Hypercapnic Respiratory Failure, Noninvasive Ventilation
Information-Motivation-Behavioral Skills Model-based Intervention to Domiciliary Non-invasive Ventilation of Patients
Domiciliary non-invasive ventilation (NIV) is a standard care for improving survival rates of selected patients with chronic hypercapnic respiratory failure (CHRF) and to improve the patients' hypercapnia, sleep quality…
- Trial name
- NCT05008211
- Testing
- Information-Motivation-Behavioral skills (IMB) model-based intervention, Control - usual care
- Where
- Hong Kong
- Volunteers
- 124 people
- Sponsor
- The University of Hong Kong
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Helmet Ventilation in Acute Hypercapnic Respiratory Failure
Lack of tolerance to the treatment, makes the interface choice for non-invasive ventilation (NIV) one of the key factor. To date the helmet is rarely used in Acute Hypercapnic Respiratory Failure (AHRF), because of its large dead…
- Trial name
- NCT01645358
- Testing
- Helmet (Starmed), Total Face mask (Respironics)
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
COPD
NIV-Training in Hypercapnic COPD Patients
The aim of the study is to investigate the additional effects of the use of NIV during exercise within a 3-week PR program on exercise capacity in COPD patients with chronic hypercapnic respiratory failure.
- Trial name
- NCT03803358
- Testing
- exercise training with non-invasive ventilation, standard exercise training without NIV
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Respiratory Insufficiency
Bedside Spirometry for Acute Lung Injury
The diagnosis of Acute Respiratory Distress Syndrome (ARDS) is a syndromic diagnosis that groups together patients who may have very different prognoses and respond differently to the same therapies.
- Trial name
- SPIRALI (NCT07750717)
- Testing
- Hand-held spirometer, NIV
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Hypercapnic Respiratory Failure
Use of EtCO2 as a PaCO2 Predictor Under Non Invasive Ventilation (NIV) in Cases of Acute Hypercapnic Respiratory Failure
In patients treated by Non invasive ventilation (NIV) due to acute hypercapnic respiratory failure, the interest of using the End-tidal Co2 measurement device "Capnostream" to evaluate PaCo2 and PaCo2 variations over time will be…
- Trial name
- NCT01489150
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- University of Lausanne Hospitals
Acute Respiratory Failure, Acute Hypoxemic Respiratory Failure
Comparing Closed-loop FiO2 Controller With Conventional Control of FiO2
During mechanical ventilation (MV) hypoxemic or hyperoxemic events should be carefully monitored and a quick response should be provided by the caregiver at the bedside.
- Conditions
- Acute Respiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxemic and Hypercapnic Respiratory Failure
- Trial name
- NCT04568642
- Testing
- Activate FiO2 controller, Deactivate FiO2 controller
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
COPD Exacerbation
High Flow Nasal Therapy Versus Noninvasive Ventilation in COPD Exacerbation
Randomized multicenter non-inferiority trial comparing High flow nasal therapy (HFNT) versus Noninvasive ventilation (NIV) in patients with chronic obstructive pulmonary disease (COPD) and acute hypercapnic respiratory failure.
- Trial name
- NCT03370666
- Testing
- HFNT, NIV
- Where
- 10 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Non-invasive Ventilation Versus Sham Ventilation in Chronic Obstructive Pulmonary Disease (COPD)
The investigators hypothesize that continuation of non-invasive ventilation (NIV) at home after an episode of acute hypercapnic respiratory failure (AHRF) treated by NIV in COPD patients would reduce the likelihood of death and…
- Trial name
- NCT00429156
- Testing
- Home non-invasive ventilation
- Where
- Hong Kong
- Volunteers
- 46 people
- Sponsor
- United Christian Hospital
Acute Hypercapnic Respiratory Failure
CO2 Clearance During Noninvasive Ventilation (NIV)
In this randomized cross over study the investigators will evaluate the effects on gas exchange and patients' tolerance of a new CO2 non rebreathing devices incorporated in the mask vs the traditional mask COPD patients…
- Trial name
- NCT03756415
- Testing
- DiMax Zero Total face mask "R",, traditional face mask
- Volunteers
- 20 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Pompe Disease
Detection of Pompe Disease in Adult Patients With Myopathies of Uncertain Origin or With Asymptomatic Hyper-CK-emia
The adult onset form can occur between the second and sixth decades of life as a form of proximal myopathy, predominantly in the pelvic girdle area.
- Trial name
- NCT01482494
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Jordi Perez Lopez
Acute Hypercapnic Respiratory Failure
Sedation During Noninvasive Ventilation (NIV)
In patients undergoing NIV for acute respiratory, lack of tolerance is one of the main reason of failure. This may result in a poor synchrony between the patient and the machine, leading to gross mismatching and potentially to an…
- Trial name
- REMI (NCT02264626)
- Testing
- Remifentanil
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Nasal High Flow Therapy, Intensive Care Unit
High Flow Therapy in ICUs Across Ibero America
The study aims to describe the use of Nasal High Flow (NHF) in the intensive care units of participating centers in Iberoamerica.
- Conditions
- Nasal High Flow Therapy, Intensive Care Unit, Ventilatory Failure, Hypoxia
- Trial name
- T-Calfi (NCT03364946)
- Testing
- No intervention
- Where
- 9 sites in Colombia, Dominican Republic and 2 more
- Volunteers
- 255 people
- Sponsor
- Fundación Santa Fe de Bogota
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Clinical Stabilization of Hypercapnia: NIPPV v HVNI
This study will evaluate the ability of High Velocity Nasal Insufflation [HVNI] to effect ventilation and related physiologic responses in hypercapnic patients when compared to noninvasive positive pressure ventilation [NIPPV].
- Conditions
- Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Dyspnea, Hypercapnic Acidosis
- Trial name
- HYPERACT (NCT04709562)
- Testing
- High Velocity Nasal Insufflation (HVNI), Noninvasive Positive Pressure Ventilation (NIPPV)
- Where
- 7 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Vapotherm, Inc.
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study C
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- NCT04791267
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary