Clinical trials: Type II Respiratory Failure
Acute Hypercapnic Respiratory Failure, Acute Hypoxemic Respiratory Failure
Pilot Physiological Evaluation of an Investigational Mask with Expiratory Washout.
The goal of this pilot randomized cross-over study is to compare the effect of a full-face mask with expiratory washout to a conventional full face mask on non-invasive ventilation (NIV) in patients with acute hypercapnic, and…
- Trial name
- NCT06007495
- Testing
- Investigational full-face mask with expiratory washout, Conventional full-face mask - single-limb, Conventional full-face mask - dual-limb
- Where
- 2 sites in Canada
- Volunteers
- 32 people
- Sponsor
- Fisher and Paykel Healthcare
Hypercapnic Respiratory Failure
Comparison of BPAP ST/T and BPAP ST / T Mode With AVAPS for Hypercapnic Respiratory Failure in ED
The aim of the present study; To compare the effects of respiratory support options available for NIMV at the emergency department; i.e.
- Trial name
- NCT03398239
- Testing
- Noninvasive mechanical ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Dokuz Eylul University
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study B, RCT
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT04790617)
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 183 people
- Sponsor
- University of Calgary
Acute Mechanical Ventilatory Failure
Weaning From Prolonged Mechanical Ventilation
Patients requiring the use of artificial ventilation (also called mechanical ventilation) for more than 21 days account for more than 37% of all ICU costs.
- Trial name
- NCT01541462
- Testing
- Weaning
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- RML Specialty Hospital
Acute Hypercapnic Respiratory Failure
Hemolung RAS Registry Program
The purpose of the Hemolung RAS Registry Program is to collect retrospective, de-identified, standard of care data following the commercial use of the Hemolung RAS.
- Trial name
- NCT01855815
- Volunteers
- 99 people
- Sponsor
- Alung Technologies
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Non-invasive Positive Pressure (NPPV ) for Severe Stable Chronic Obstructive Pulmonary Disease
Assessment of the effect and safety of noninvasive positive pressure ventilation for severe stable chronic obstructive pulmonary disease
- Trial name
- NCT02499718
- Testing
- BiPAP mode
- Where
- China
- Volunteers
- 368 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Adherence, Treatment
High-Flow in Hypercapnic Stable COPD Patients
Monocentric, prospective, open, randomized 1:1, controlled study to evaluate the impact of nasal high-flow (NHF) on nocturnal transcutaneous PCO2 (PtCO2) compared to non-invasive ventilation ± Long-Term Oxygen Therapy (LTOT) in…
- Trial name
- HIGH-FLOW (NCT04281316)
- Testing
- Nasal High Flow installation, Non Invasive Ventilation, Training session
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Grenoble
Pulmonary Disease, Chronic Obstructive
Efficacy and Physiology of Nasal High Flow Therapy
The effects of a nasal high-flow (NHF) therapy in patients with chronic obstructive hypercapnic respiratory failure are still not sufficiently known yet.
- Trial name
- NCT02083120
- Testing
- NHF therapy, Long term Oxygen Therapy (LOT)
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Institut für Pneumologie Hagen Ambrock eV
Respiratory Failure, Ventilatory Failure
Non-Invasive Monitoring of Respiratory Function in Spontaneously Breathing Patients With COVID-19 Infection
This study uses the AirGo band to monitor changes in tidal ventilation in spontaneously breathing patients with COVID-19 associated respiratory failure.
- Conditions
- Respiratory Failure, Ventilatory Failure, COVID-19, Pneumonia
- Trial name
- NCT04356443
- Testing
- AirGo Respiratory Monitor
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
COPD, Severe Early-Onset, Ventilatory Failure
Customized Masks in Non-Invasive Mechanical Ventilation
In non-invasive mechanical ventilation (NIMV), the interface is the primary determinant of success, as adherence and quality of therapy mainly depend on it.
- Conditions
- COPD, Severe Early-Onset, Ventilatory Failure, Als, Non Invasive Ventilation
- Trial name
- NCT06215391
- Testing
- 3d printed mask
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Hospital Universitario 12 de Octubre
Chronic Obstructive Pulmonary Disease (COPD)
Respiratory Muscle Function in COPD Exacerbations
There is evidence that noninvasive mechanical ventilation (NIV) is effective in the treatment of severe exacerbations of COPD presenting respiratory acidosis.
- Trial name
- NCT01869387
- Testing
- Non-invasive ventilation
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Parc de Salut Mar
COPD, Respiratory Failure
Inspiratory Muscle Training in Hypercapnic COPD
The trial intends to investigate, whether inspiratory muscle training in hypercapnic patients improves inspiratory muscle strength, inspiratory muscle endurance and endurance to walk within six minutes.
- Trial name
- NCT00291460
- Testing
- inspiratory muscle training
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Krankenhaus Kloster Grafschaft
Neuromuscular Diseases, Central Hypoventilation
'Fitness To Fly' Tests In Children With Type II Respiratory Failure
The conventional hypoxic challenge test might not predict 'fitness-to-fly' equally well in all patients. Patients at risk of hypercapnia with supplemental oxygen are not well studied.
- Trial name
- NCT03824223
- Testing
- Hypoxic challenge test
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Heart Failure, Congestive, Pulmonary Disease, Chronic Obstructive
Capturing Outcomes of Clinical Activities Performed by a Rounding Pharmacist Practising in a Team Environment
We, the researchers, propose to link a clinical pharmacist with an internal medicine or family medicine team to provide pharmaceutical care to all patients assigned to the team.
- Conditions
- Heart Failure, Congestive, Pulmonary Disease, Chronic Obstructive, Pneumonia, Diabetes Mellitus, Type 2
- Trial name
- NCT00351676
- Testing
- Integration of a team based clinical pharmacist, Optimizing therapeutic treatments, Optimizing processes of care
- Where
- 3 sites in Canada
- Volunteers
- 452 people
- Sponsor
- University of Alberta
Asthma Bronchiale, Breast Neoplasms
Digital Implementation of the German S3 Clinical Practice Guideline for Multimorbidity
The web application gp-multitool.de is a digital tool for implementing the German S3 clinical practice guideline for multimorbidity of the German Society of General Practitioners and Family Physicians in primary care.
- Conditions
- Asthma Bronchiale, Breast Neoplasms, Coronary Disease, Diabetes Mellitus, Type 2
- Trial name
- NCT06831994
- Testing
- gp-multitool.de
- Where
- Germany
- Volunteers
- 659 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Respiratory Failure, Hypoxia
HVNI vs NIPPV in Type 2 Respiratory Failure
The purpose of this study is to determine if high velocity nasal insufflation (HVNI) is comparable to non-invasive positive pressure ventilation (NIPPV) in treatment of emergency patients with acute respiratory acidosis.
- Conditions
- Respiratory Failure, Hypoxia, Hypercapnia
- Trial name
- SHINE (NCT07065656)
- Testing
- Vapotherm high velocity therapy (HVT) 2.0 (Vapotherm, Inc, Exeter, NH), Respironics Vision V60
- Volunteers
- 84 people
- Sponsor
- National University Hospital, Singapore
Hypercapnic Respiratory Failure
High-flow Air Via Nasal Cannula vs Non-invasive Continuous Positive Airway Pressure for Hypercapnic Respiratory Failure
The study will be performed as a randomized controlled non-inferiority trial. HFA has been increasingly used in the last years to treat hypoxic respiratory failure (i.e.
- Trial name
- HIGHforHyper (NCT03944525)
- Testing
- High flow nasal cannula, Continuous positive airway pressure
- Where
- Austria
- Volunteers
- 62 people
- Sponsor
- Medical University of Vienna
Comparison Between HVNI vs Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure
HVNI vs Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure
1. To study the efficacy and safety of high flow nasal oxygenation using high velocity nasal insfflation technique(HiVNI) in comarison with non invasive positive pressure ventilation in COPD patients with acute hyercapnic…
- Trial name
- NCT04998383
- Testing
- HVNI
- Volunteers
- 100 people
- Sponsor
- Assiut University
Postoperative Pulmonary Complications, Diaphragm
Perioperative Diaphragm Point of Care Ultrasound
It is a prospective observational study of a cohort of patients who underwent brachial plexus blockage above the clavicle, and in which diaphragmatic function is observed in both hemidiaphragms by ultrasound (using Diaphragm…
- Conditions
- Postoperative Pulmonary Complications, Diaphragm, Brachial Plexus Block
- Trial name
- DPOCUS (NCT03688724)
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- Hospital General Universitario de Valencia
Respiratory Failure
Non-Invasive Ventilation After Extubation in Hypercapnic Patients
The purpose of this study is to assess the efficacy of noninvasive ventilation in the prevention of extubation failure and mortality in patients with chronic respiratory disorders and hypercapnic respiratory failure during…
- Trial name
- NCT00539708
- Testing
- Non-invasive ventilation
- Where
- Spain
- Volunteers
- 106 people
- Sponsor
- Hospital Clinic of Barcelona