Clinical trials: Type1 Diabetes
Type1 Diabetes
Neural-net Artificial Pancreas (NAP)
This study is intended to assess a Neural-net Artificial Pancreas (NAP) implementation of an established AP controller - the University of Virginia Model Predictive Control Algorithm (UMPC).
- Trial name
- NAP (NCT05876273)
- Testing
- Neural-net Artificial Pancreas, University of Virginia Model Predictive Control
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Type1diabetes, Type1 Diabetes Mellitus
Modulation of Type 1 Diabetes Susceptibility Through the Use of Probiotics
Investigators aim to further the understanding of environmental factors that underlie the progression to Type 1 diabetes (T1D). Dysbiosis, defined as alterations in intestinal microbiota composition and function, has been…
- Trial name
- NCT03423589
- Testing
- VSL#3
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Diabetes type1
T1D Closed-loop and Physical Activity
"Physical activity is recognized as beneficial for patients living with type 1 diabetes (T1DM), with a demonstrated effect not only on HbA1c control [1] but also on reducing the incidence of diabetes-related complications [2,3].
- Trial name
- NCT06460558
- Testing
- Type 1 diabetes with insulin infusion system
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Type1 Diabetes
Optimising Consultation Summaries to Promote Good Health
Patient participation in decision making about their care promotes patient satisfaction and confidence. Further more, allowing patients to see letters written about them enables trust, encourages patients to be involved in…
- Trial name
- ONSET (NCT04002557)
- Testing
- Interview-Questionnaire
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- Imperial College London
Type1 Diabetes Mellitus
Hydroxychloroquine in Individuals At-risk for Type 1 Diabetes Mellitus
The study is a 2-arm, double blinded, multicenter, 2:1 randomized, placebo controlled clinical trial. Subjects will receive hydroxychloroquine or placebo and close monitoring for progression of T1D.
- Trial name
- TN-22 (NCT03428945)
- Testing
- Hydroxychloroquine
- Where
- 51 sites in United States, Australia and 4 more
- Volunteers
- 273 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type1 Diabetes Mellitus, Adiposity
Effect of Adiposity on Hepatic and Peripheral Insulin Resistance in Type 1 Diabetes
The purpose of this study is to assess the effects of adiposity on resistance to insulin's ability to suppress hepatic glucose production and to stimulate peripheral glucose metabolism in adolescents with type 1 diabetes.
- Trial name
- T1D (NCT03582956)
- Testing
- Euglycemic hyperinsulinemic clamp with tracer enhancement
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Yale University
Type1 Diabetes Mellitus
Efficacy and Safety of Highland Barley Diet on Glucose Variability in Patients With Type 1 Diabetes Mellitus
Approximately 80 patients will be enrolled in the study from China and randomized in a 1:1 ratio to one of the 2 treatment arms:diabetes diet+highland barley diet; or diabetes diet. Study treatment will continue for 12 weeks.
- Trial name
- NCT03766334
- Testing
- Highland Barley Diet
- Where
- China
- Sponsor
- Huazhong University of Science and Technology
Type1 Diabetes Mellitus, Type2 Diabetes Mellitus
"POWER2DM Evaluation Campaign"
Rationale: Hyperglycaemia is an important cause of long-term macro-and microvascular complications in all patients with diabetes mellitus.
- Conditions
- Type1 Diabetes Mellitus, Type2 Diabetes Mellitus, Diabetes Mellitus, Health Behavior
- Trial name
- POWER2DMEC (NCT03588104)
- Testing
- POWER2DM system, Usual care
- Where
- 2 sites in Netherlands, Spain
- Volunteers
- 222 people
- Sponsor
- Leiden University Medical Center
Type1 Diabetes Mellitus
Dapagliflozin Effects on Hypoglycemia
The purpose of this research study will be to test and evaluate if dapagliflozin has an effect on the amount of glucagon (a hormone produced by the pancreas and stomach that stimulates liver glucose production) produced by the…
- Trial name
- NCT03704818
- Testing
- Dapagliflozin 5mg
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, San Diego
Type1 Diabetes Mellitus
Comparison of Motor and Sensory Functions of the Hand in Children With Type 1 Diabetes Mellitus and Their Healthy Peers
Type 1 Diabetes Mellitus (T1DM) is a condition where the body cannot produce a hormone called insulin. Although it is commonly seen in children and young people, it can occur at any age.
- Trial name
- NCT06206317
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Erdal AYDIN
Type1diabetes, Type1 Diabetes Mellitus
The Dietary Education Trial in Carbohydrate Counting (DIET-CARB Study in Type 1 Diabetes
The study is designed to evaluate two different dietitian-led self-management approaches in carbohydrate counting compared to routine dietary care (control) on glycaemic control in adult patients with type 1 diabetes: 1.
- Conditions
- Type1diabetes, Type1 Diabetes Mellitus, Glucose Metabolism Disorders
- Trial name
- NCT03623113
- Testing
- BCC intervention, ABC-ACC intervention, Standard dietary education
- Where
- Denmark
- Volunteers
- 63 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type1 Diabetes Mellitus
Comparison of Real-time CGMS With Intermittently-scanned CGMS in Adolescents and Adults With Type 1 Diabetes Mellitus
Type 1 Diabetes Mellitus (T1DM) is characterized by absolute insulin deficiency. Despite multiple daily insulin injections, glycemic targets are usually not achieved in T1DM patients.Use of continuos glucose monitoring system…
- Trial name
- NCT05928260
- Testing
- Medtronic Guardian Connect Sensor 3, Abott Freestyle Libre Sensor, Self blood Glucose monitoring by a glucometer
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Type1 Diabetes Mellitus
Multiple Dose Study to Evaluate the Efficacy, Safety and Pharmacodynamics of REMD-477 in Subjects With Type 1 Diabetes Mellitus
This is a randomized, placebo-controlled, double-blind study to evaluate the efficacy, safety, and pharmacodynamics (PD) of multiple doses of REMD-477 in subjects who have Type 1 diabetes and are currently receiving insulin…
- Trial name
- NCT03117998
- Testing
- REMD-477
- Where
- 11 sites in United States
- Volunteers
- 154 people
- Sponsor
- REMD Biotherapeutics, Inc.
Diabetes type1
Simple Initiation of Advanced Hybrid Closed Loop System
Background and Aim. The new and advanced hybrid closed loop (AHCL) system MiniMed 780G automatically adjusts basal insulin delivery in addition to automated bolus corrections, based on continuous glucose monitoring (CGM)…
- Trial name
- 780GGS (NCT05069727)
- Testing
- Regular Protocol with advanced carbohydrate counting, Simplified Protocol with fixed carbohydrate content
- Where
- Qatar
- Volunteers
- 34 people
- Sponsor
- Sidra Medicine
Type1 Diabetes Mellitus
Wharton´s Jelly Derived Mesenchymal Stromal Cell Treatment of Adult Patients Diagnosed With Type I Diabetes
To investigate the safety and tolerance after allogeneic infusion of WJMSCs intravenously in adult patients diagnosed with type 1 diabetes.
- Trial name
- NCT03406585
- Testing
- ProTrans: Allogeneic transplantation with WJMSCs
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- NextCell Pharma Ab
Type1 Diabetes Mellitus, Autoimmune Diabetes
Safety and Efficacy of Umbilical Cord Blood Regulatory T Cells Plus Liraglutide on Autoimmune Diabetes
The purpose of this study is to investigate the safety and therapeutic effect of ex-vivo expanded umbilical cord blood regulatory T cells adjunct with Liraglutide on autoimmune diabetes.
- Trial name
- NCT03011021
- Testing
- Liraglutide, UCB-Treg, Insulin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Xiangya Hospital of Central South University
Diabetes type1
A Study to Assess the Safety and Tolerability of Different Doses of AG019 Administered Alone or in Combination With Teplizumab in Participants With Recent-onset Diagnosed Type 1 Diabetes (T1D)
The purpose of this study is to assess the safety and tolerability of different doses of AG019 administered alone or in combination with teplizumab in participants with recent-onset type 1 diabetes (T1D).
- Trial name
- NCT03751007
- Testing
- AG019 - Low Dose, Teplizumab, AG019 - High Dose
- Where
- 18 sites in United States, Belgium
- Volunteers
- 45 people
- Sponsor
- Precigen Actobio T1D, LLC
Type1 Diabetes Mellitus
The International Diabetes Closed Loop (iDCL) Trial: Protocol 1
The objective of the study is to assess the efficacy and safety of home use of a Control-to-Range (CTR) closed-loop (CL) system.
- Trial name
- iDCL (NCT02985866)
- Testing
- Artificial Pancreas, Sensor Augmented Therapy
- Where
- 7 sites in United States
- Volunteers
- 127 people
- Sponsor
- University of Virginia
Type1 Diabetes Mellitus
Efficacy of inControl Advice: A Decision Support System (DSS) for Diabetes
The purpose of this study is to reduce the frequency of hypoglycemia and severe hypoglycemic events in subjects who use insulin pens to treat their Type 1 Diabetes Mellitus (T1DM).
- Trial name
- DSS (NCT03093636)
- Testing
- Continuous Glucose Monitor (CGM)+Decision Support System (DSS), Continuous Glucose Monitor (CGM) alone
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Virginia
Type1 Diabetes Mellitus
Using an Artificial Pancreas System in Older Adult Type 1 Diabetes Mellitus Patients
To demonstrate that a new insulin pump system can prevent low glucose episodes and improve brain function in aged Type 1 diabetes mellitus subjects.
- Trial name
- T1DM AP (NCT03353792)
- Testing
- CL/AP system, usual diabetic care
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Yale University