Clinical trials: Type1 Diabetes
Diabetes Mellitus, Type 1, Hypertension
Correlation of Flicker Induced and Flow Mediated Vasodilatation in Patients With Endothelial Dysfunction and Healthy Volunteers.
A couple of studies have shown that illuminating the eye with diffuse flickering light is accompanied by an increase of retinal vessel diameters, optic nerve head blood flow and retinal blood flow.
- Conditions
- Diabetes Mellitus, Type 1, Hypertension, Hypercholesterolemia, Regional Blood Flow
- Trial name
- NCT00432029
- Testing
- Forearm blood flow measurement, Flow mediated dilation (FMD), Zeiss Retinal Vessel Analyzer (RVA), Stimulation with Flicker-light
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Type 1 Diabetes
The Effect of Omega-3 Supplementation on Nerve Structure and Function in Type 1 Diabetes
Nerves are made of different fats including omega-3s and omega-6s; however, dietary intakes of omega-6s are very high and omega-3 intakes are very low.
- Trial name
- NCT02034266
- Testing
- Omega-3 supplementation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Eduardo Ng
Type 1 Diabetes (Juvenile Onset), Type 1 Diabetes
Type 1 Diabetes Autonomic and Vascular Function
The goal of this clinical trial is to investigate the autonomic and vascular function in men and women with Type 1 diabetes. The main questions it aims to answer are: 1.
- Conditions
- Type 1 Diabetes (Juvenile Onset), Type 1 Diabetes, Diabetes, Autoimmune
- Trial name
- NCT06786546
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Type 1 Diabetes Mellitus
CBT in Adolescents With Type 1 Diabetes
The effectiveness of cognitive behavioural therapy (CBT) for adolescents with type 1 diabetes will be tested. This structured, time-limited, problem-orientated therapy will be used to impact on psychosocial factors influencing…
- Trial name
- NCT00360061
- Testing
- Cognitive Behaviour Therapy
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Bristol
Type I Diabetes
Anti-IL-1 Treatment in Children Diabetic Keto-Acidosis (DKA) at Diagnosis of Type 1 Diabetes
This is a randomized, double-blind, placebo-controlled phase 2 study. Specific aim is to evaluate feasibility and safety of anti-IL-1 (interleukin 1) treatment in the course of standard therapy for diabetic ketoacidosis in…
- Trial name
- NCT01477476
- Testing
- Anakinra
- Where
- 2 sites in United States
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes Mellitus
Effect of Dietary Carbohydrate Content and Inulin-Fructooligosaccharide Supplementation on Glycemic Control in Individuals With Type 1 Diabetes Mellitus
Diabetes is a chronic metabolic disease in which nutrients such as carbohydrates, fats and proteins cannot be utilized sufficiently due to the inability to produce insulin or defects in the effect of the produced insulin.
- Trial name
- NCT07673523
- Testing
- fructooligosaccharide and inulin, Dietary carbohydrate 30%, Dietary carbohydrate 50-55%
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Type 1 Diabetes, Diabetic Kidney Disease
Pathogenesis of Kidney Disease in Type 1 Diabetes: a Modern Kidney Biopsy Cohort (The PANDA Study)
Diabetic kidney disease (DKD) occurs in up to 40% of people with type 1 diabetes (T1D), often leading to kidney failure and markedly magnifying risks of cardiovascular disease and premature death.
- Conditions
- Type 1 Diabetes, Diabetic Kidney Disease, Diabetes Complications, Diabetic Nephropathies
- Trial name
- PANDA (NCT05319990)
- Testing
- Aminohippurate Sodium Inj 20% Diagnostic aid/agent used to measure effective renal plasma flow (ERPF), Iohexol Inj 300 MG/ML Diagnostic aid/agent used to measure glomerular filtration rate (GFR)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
Anti-diabetic Effects of Liraglutide in Adolescents and Young Subjects With Type 1 Diabetes
This is the first prospective randomized double-blind placebo-controlled study to investigate the effect of a GLP-1 analog, specifically liraglutide, on blood glucose levels and variability in subjects with type 1 diabetes…
- Trial name
- NCT01722227
- Testing
- Liraglutide
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University at Buffalo
Type 1 Diabetes Mellitus
Neuropsychological and Neuroanatomical Studies of Young Children With and Without Type 1 Diabetes Mellitus
This study is being conducted to see if Type 1 diabetes mellitus has any affect on learning, behavior and development in young children and whether there are associated changes on their MRI scan.
- Trial name
- NCT00449891
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Stanford University
Type 1 Diabetes, Type 2 Diabetes
Blood Glucose Response to Meals of Varying Glycemic Index in Youth With Type 1 & 2 Diabetes
Research to date suggests that the selection of lower glycemic index foods, that is, foods provoking a slower, more sustained blood sugar response, may result in improved glycemic control in youth with diabetes.
- Conditions
- Type 1 Diabetes, Type 2 Diabetes, Impaired Glucose Metabolism
- Trial name
- NCT00545727
- Testing
- Diet, Standard diet
- Volunteers
- 36 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Type 1 Diabetes
Evaluation of Fats on Postprandial Glucose Control
The purpose of this study is examine the effect of different fat types on postprandial glucose control in patients with type 1 diabetes.
- Trial name
- Nabucco (NCT01869790)
- Testing
- Different fat types
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Joslin Diabetes Center
Diabetic Pregnancy, Insulin Resistance
Metformin Use to Improve Pregnancy Outcome in Women With Type 1 Diabetes.
The study investigates whether additional metformin medication in combination with regular insulin treatment will decrease the need of insulin for women with diabetes mellitus type 1 during pregnancy.
- Conditions
- Diabetic Pregnancy, Insulin Resistance, Type1diabetes
- Trial name
- NCT03765359
- Testing
- metforminhydrochloride
- Where
- 5 sites in Finland
- Volunteers
- 101 people
- Sponsor
- Tampere University Hospital
Insulin-Dependent Diabetes Mellitus
Interferon-Alpha for Diabetes Mellitus Type 1
This study will see if interferon-alpha given early in the disease can stop or slow the immune attack on insulin-producing cells.
- Trial name
- NCT00024518
- Testing
- 30,000 units hrINF-alpha, 5,000 hrINF-alpha
- Where
- 5 sites in United States
- Volunteers
- 57 people
- Sponsor
- The University of Texas Health Science Center, Houston
Diabetes Mellitus
Integration of Continuous Glucose Monitoring Into a BiHormonal Closed-Loop Artificial Pancreas
The investigators hypothesize that our closed-loop glucose-control system can provide BG control in subjects with type 1 diabetes using the estimated BG signal from a CGM as the input signal to the controller.
- Trial name
- CL2 (NCT01161862)
- Testing
- Bi-hormonal (insulin and glucagon) artificial pancreas
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Boston University Charles River Campus
Type 1 Diabetes, Obesity
Intermittent Fasting in Adults With Type 1 Diabetes
The majority of adults with type 1 diabetes (T1DM) have either overweight or obesity. As such, dietary management has been recommended as an adjunct to insulin treatment to improve glycemic control and facilitate weight loss in…
- Trial name
- NCT06134986
- Testing
- Time restricted eating, Daily calorie restriction
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Illinois Chicago
Type 1 Diabetes
Carbohydrates Under Target for Type 1 Diabetes Management
Recently there has been an increased interest in limiting intake of carbohydrates (CHO) for improving long term health. While healthcare professionals (HCPs) are sometimes reluctant to limit the CHO intake due to the lack of…
- Trial name
- NCT04084418
- Testing
- Control Diet, VLCHF Diet
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McGill University
Diabetes Mellitus
First Clinical Evaluation of a Novel Glucose Non-invasive Sensor Technology in Patients With Type 1 Diabetes
The primary aim of this clinical study is to find signal characteristics of VOCs detected by Sokru device during fasting, insulin injection and after glucose intake and to find the association with blood glucose variation in…
- Trial name
- VAARA (NCT05771090)
- Testing
- Sokru device
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- DCB Research AG
Type 1 Diabetes Mellitus (T1DM), Type 1 Diabetes Mellitus
Sequential Immune Modulation and Antigen-Specific Tolerance Induction for Disease Modification in Recent-Onset Type 1 Diabetes
This study tests a three-phase immune treatment for people recently diagnosed with Type 1 diabetes (within 6 months, with some insulin production remaining).
- Conditions
- Type 1 Diabetes Mellitus (T1DM), Type 1 Diabetes Mellitus, Autoimmune Diabetes
- Trial name
- MATIN-2 (NCT07610213)
- Testing
- Teplizumab, Intralymphatic Insulin Immunotherapy (ILIT)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Abdullah Kars
Type2 Diabetes
The Men Are Now United Program
The purpose of this application is to create and implement a targeted, culturally grounded, diabetes self-management intervention for Black men that uses social support, mobile health, and remote sensing technology to improve…
- Trial name
- MANUP (NCT03208686)
- Testing
- Intervention Group
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Michigan State University
Diabetes
Satisfaction of Specific Modes Related to Physical Activity in People Living With Type 1 Diabetes and Using an Hybrid Closed-loop System
The BF-ACT study is a single-center, non-interventional (RIPH3) descriptive study conducted at CHU Grenoble Alpes. It aims to evaluate the satisfaction of adults with type 1 diabetes using closed-loop insulin delivery systems…
- Trial name
- BF-ACT (NCT07567170)
- Testing
- Questionnar
- Where
- France
- Volunteers
- 900 people
- Sponsor
- University Hospital, Grenoble