Clinical trials: Type1 Diabetes Mellitus
Type1 Diabetes Mellitus
Using an Artificial Pancreas System in Older Adult Type 1 Diabetes Mellitus Patients
To demonstrate that a new insulin pump system can prevent low glucose episodes and improve brain function in aged Type 1 diabetes mellitus subjects.
- Trial name
- T1DM AP (NCT03353792)
- Testing
- CL/AP system, usual diabetic care
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Yale University
Type1 Diabetes Mellitus
Chinese Smartphone App for 6-18 Years With T1DM - RCT
Moving into the era of electronic communication, it changes the way we shall engage our children and adolescents. According to data of the Census and Statistics Department of Hong Kong releases in 2019, more than 80% and up to…
- Trial name
- NCT05418569
- Testing
- Intervention arm - A new smartphone application for pediatric type 1 DM, Standard diabetic eduction
- Where
- Hong Kong
- Volunteers
- 114 people
- Sponsor
- Chinese University of Hong Kong
Type1 Diabetes Mellitus
Effect of SGLT2i in Conjunction With the Artificial Pancreas on Improving the Glycemia in T1DM in the Outpatient Setting
The most advanced configurations of the Artificial Pancreas (AP) have not yet been demonstrated to sufficiently maximize time in target glycemia.
- Trial name
- CLASS17 (NCT03979352)
- Testing
- empagliflozin, artificial pancreas
- Where
- 2 sites in Canada
- Volunteers
- 28 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Type1 Diabetes
Yale-Harvard Hotel-based Closed-Loop Studies in Children (HY-GRAID)
The aim of this clinical study is to determine the feasibility, safety, and preliminary effectiveness of the Zone-Model Predictive Control Artificial Pancreas (ZMPC_AP) system in pediatric subjects with type 1 diabetes in an…
- Trial name
- HY-GRAID (NCT04255381)
- Testing
- Zone-Model Predictive Control Artificial Pancreas (ZMPC_AP)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Type1 Diabetes Mellitus
A Pilot Test of t:Slim X2 With Control-IQ Technology
A 36-48 hour admission testing the t:slim X2 with Control-IQ Technology
- Trial name
- NCT03368937
- Testing
- Tandem t:slim X2 with Control-IQ Technology
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Virginia
Type1 Diabetes Mellitus
A Study to Demonstrate Bioequivalence Between Insulin Glulisine U300 and Insulin Glulisine U100 After a Single Subcutaneous Dose Using the Euglycemic Clamp Technique, in Patients With Type 1 Diabetes Mellitus
Primary Objective: To demonstrate bioequivalence between insulin glulisine given as 300 Units/mL test formulation and insulin glulisine 100 Units/mL reference formulation after a single subcutaneous (SC) dose.
- Trial name
- NCT02910518
- Testing
- Insulin glulisine (U300), Insulin glulisine, Insulin aspart
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- Sanofi
Type1 Diabetes Mellitus
Additional Signals for Exercise, Stress and Sleep and Prediction of Glucose Levels for AP Systems
The objective of this research is to determine the most informative variables for detecting exercise, acute stress and sleep, identify select sensors that report these variables, and develop the algorithms to detect the…
- Trial name
- NCT04725799
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Illinois at Chicago
Type1 Diabetes Mellitus
The Salivary Microbiome in Children With Type 1 Diabetes Mellitus
Aims: To profile the oral microbiome of children with type 1 diabetes mellitus, and to compare it to healthy children while taking into account other aspects of the oral environment.
- Trial name
- NCT03908021
- Testing
- Microbiome analysis and 16S rRNA gene-based analysis
- Where
- Israel
- Volunteers
- 66 people
- Sponsor
- Hadassah Medical Organization
Type1 Diabetes Mellitus
Safety and Efficacy of BC LisPram
This pilot study is a 50-hour randomized, open-label, crossover study in an inpatient setting assessing the safety, pharmacodynamics, pharmacokinetics, and closed-loop efficacy of i) BC LisPram delivery and ii) rapid insulin…
- Trial name
- NCT04972175
- Testing
- 50-Hour Intervention - Rapid Insulin lispro, 50-Hour Intervention - BC LisPram
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Michael Tsoukas
Type1diabetes, Type1 Diabetes Mellitus
Evaluation of Coffee Therapy for Improvement of Renal Oxygenation
Over 1.25 million Americans have Type 1 Diabetes (T1D), increasing risk for early death from cardiovascular disease (CVD). Despite advances in glycemic and blood pressure control, a child diagnosed with T1D is expected to live up…
- Conditions
- Type1diabetes, Type1 Diabetes Mellitus, Diabetic Kidney Disease, Juvenile Diabetes
- Trial name
- COFFEE (NCT03878277)
- Testing
- Starbucks® Cold brew - 325ml bottle
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Type1 Diabetes Mellitus
Real-time Reminders To Decrease Late or Missed Meal Boluses
This study is examining whether the Klue app is effective in detecting missed or late meal boluses in patients with Type 1 diabetes.
- Trial name
- Klue (NCT03970889)
- Testing
- Klue
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stanford University
Type1 Diabetes
Multiple Ascending Dose (MAD) Study of IMT-002 in HLA-DQ8-positive Type 1 Diabetes
This study is designed to characterize the safety, steady-state pharmacokinetics (PK) of IMT-002, and will serve as a dose range identification for the pharmacodynamic effect of blocking self-antigen presentation in adults with…
- Trial name
- NCT04625595
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Immunomolecular Therapeutics, Inc.
Type1 Diabetes Mellitus, Enterovirus
The Diabetes Virus Detection and Intervention Trial
A randomized, double-blind, placebo-controlled study in 96 children and adolescents age 6-15 newly diagnosed with type 1 diabetes to describe the influence of antiviral treatment (Pleconaril and Ribavirin) on progression of…
- Trial name
- DiViDInt (NCT04838145)
- Testing
- Ribavirin + Pleconaril
- Where
- Norway
- Volunteers
- 96 people
- Sponsor
- Oslo University Hospital
Type1 Diabetes Mellitus
BOL-DP-o-05 as an Add-On Treatment of Subjects With Newly Diagnosed Type 1 Diabetes Mellitus
BOL-DP-o-05 as an Add-On Treatment for Preservation of Beta-Cell Function in Subjects With Newly-Diagnosed Type 1 Diabetes Mellitus (T1DM)
- Trial name
- NCT04102202
- Testing
- BOL-DP-o-05
- Sponsor
- Breath of Life International Pharma Ltd
Diabetes type1, Diabetes Mellitus, Type 1
Does the Use of Fiasp vs. Asp Lead to the Prolonged TIR in Children With Type 1 Diabetes?
The aim of the study is to assess whether the implementation of faster insulin aspart in children with Type 1 diabetes treated with intensive insulin therapy with the use of an insulin pump and using Real Time Continuous Glucose…
- Trial name
- NCT04772729
- Testing
- Insulin faster aspart (Fiasp, Novo Nordisk)
- Volunteers
- 77 people
- Sponsor
- Medical University of Warsaw
Type1 Diabetes Mellitus
Basal Insulin Glycemic ControL With DEglugec vs Aspart Via Pump
The purpose of this investigator-initiated trial is to compare the effect of a daily injection of insulin degludec vs. basal insulin delivery via Continuous Subcutaneous Insulin Infusion (CSII), both in combination with bolus…
- Trial name
- BIG LEAP (NCT04409587)
- Testing
- Aspart
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Mountain Diabetes and Endocrine Center
Type1 Diabetes Mellitus
FreeStyle Libre Plus Bluetooth Transmitter Adjunct: Can This Improve Glucose Accuracy and Reduce Burden of Hypoglycaemia
Advanced glucose monitoring systems have revolutionized diabetes care and enabled people with diabetes to achieve better diabetes control with reduced risk of hypoglycaemia.
- Trial name
- FSL-M (NCT04147637)
- Testing
- FreeStyle Libre with MiaoMiao, FreeStyle Libre alone
- Where
- Kuwait
- Sponsor
- Dasman Diabetes Institute
Type1 Diabetes Mellitus
DiabetesFlex - Patient Involvement and Patient-reported Outcome Measures in Type 1 Diabetes
The aim of this study is to investigate the effect of the use of DiabetesFlex in diabetes care compared to standard care in relation to patient involvement and relevance for specific group of persons with T1DM.
- Trial name
- NCT03202732
- Testing
- DiabetesFlex
- Where
- Denmark
- Volunteers
- 344 people
- Sponsor
- Annesofie Lunde Jensen
Type1 Diabetes Mellitus
A Study of LY900014 in a Medtronic Pump
The purpose of this study is to compare the study drug LY900014 to insulin lispro (Humalog) when both are delivered by the Medtronic MiniMed 670G System in adults with type 1 diabetes (T1D).
- Trial name
- NCT03760640
- Testing
- LY900014, Insulin Lispro
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Eli Lilly and Company
Islet Transplantation, Type1 Diabetes Mellitus
CGM Use in Islet Transplant Recipients
A study assessing glucose variability in subjects with Type 1 Diabetes who have had islet transplant.
- Trial name
- NCT03427931
- Testing
- Continuous Glucose Monitor (CGM)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Virginia