Clinical trials: Ulcer, Leg
Diabetes Mellitus, Ulcer Foot
Evaluation of the Management of Diabetic Foot Ulcers by Telemedicine on the Number of Hospital Days in Diabetic Patients
The TELEPIED project aims to show that it is possible to reduce the number of hospitalization days of a patient with ulcers of the foot thanks to a new organization of care, based on the intervention of a coordinating nurse…
- Trial name
- TELEPIED (NCT02986256)
- Testing
- Taking pictures, Visit at home
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Diabetic Foot Ulcer
Diabetic Foot Ulcers: Shorter Treatment Period Using Custom Felt Relief?
The Surgical Outpatient Clinic at Molde Hospital has since 2015 offered specialized treatment for patients with diabetic foot ulcers. This treatment is given by an interdisciplinary diabetic foot ulcer team.
- Trial name
- NCT04058639
- Testing
- "custom felt relief", standard relief treatment
- Where
- Norway
- Volunteers
- 74 people
- Sponsor
- Helse Møre og Romsdal HF
Venous Leg Ulcers
Effectiveness of Aurix Therapy in Venous Leg Ulcers
The aim of this trial is to demonstrate the effectiveness of complete wound healing in a prospective, open-label, randomized trial in which venous leg ulcers (VLU)n will be treated using Aurix and compared to patients receiving…
- Trial name
- NCT02352454
- Testing
- Aurix
- Where
- 23 sites in United States
- Volunteers
- 640 people
- Sponsor
- Nuo Therapeutics
Venous Ulcer
Clinical Trial With Adipose Tissue Stem Cells on Biological Matrix for the Treatment of Venous Ulcer of the Lower Limbs
Phase I-II, Multicenter, Randomized, Controlled, Proof of Concept Clinical Trial to determine feasibility, safety and efficacy of the use of Allogenic adipose-derived adult mesenchymal stem cells expanded on fibrinhyaluronic…
- Trial name
- NCT05962931
- Testing
- Bioengineered Artificial Mesenchimal Sheet (BAMS), Standard treatment (Control)
- Where
- 3 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Andalusian Network for Design and Translation of Advanced Therapies
Diabetic Foot Ulcer
Pilot Study of PHOENIX Wound Matrix® Impact on Chronic DFU Wound Microbiome
A Pilot Study to Determine the Impact of the Phoenix Wound Matrix® on the Wound Microbiome in Chronic Diabetic Foot Ulcers
- Trial name
- NCT04437537
- Testing
- Bioresorbable 3D electrospun synthetic matrix
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- RenovoDerm
Diabetic Foot
Implementation of Foot Thermometry and SMS and Voice Messaging to Prevent Diabetic Foot Ulcer
This study aims to implement daily temperature measurements of feet complemented by SMS and voice messaging to prevent diabetic foot ulcers in patients with type 2 diabetes mellitus at high risk of ulceration.
- Trial name
- NCT02373592
- Testing
- SMS and voice messaging, Thermometry
- Where
- 2 sites in Peru
- Volunteers
- 172 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Ulcer, Leg
Effect of Bee Venom Phonophoresis on Healing of Chronic Lower Limb Ulcers
PURPOSE: to determine the impact of bee venom phonophoresis in accelerating ulcers healing. BACKGROUND: Bee venom (BV) phonophoresis has been suggested as a noninvasive treatment for a number of inflammatory conditions and in…
- Trial name
- NCT05285930
- Testing
- Bee venom phonophoresis, low intensity ultrasound
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Diabetic Foot Ulcers
Randomized, Controlled Multicenter Trial of Vacuum Assisted Closure Therapy™ in Diabetic Foot Ulcers
To determine if topical negative pressure therapy delivered by the V.A.C.® device is clinically efficacious and cost effective in the treatment of diabetic foot ulcers.
- Trial name
- NCT00432965
- Testing
- Moist Wound Therapy, VAC Therapy
- Where
- 25 sites in United States, Canada
- Volunteers
- 335 people
- Sponsor
- KCI USA, Inc
Foot Ulcers, Diabetic, Plantar Foot Pressure
Plantar Load Analysis of Neuropathic and Neuroischaemic Diabetes-Related Foot Ulceration
This single-centre observational case-control study investigates how peripheral arterial disease influences plantar load in people with diabetes who have recently healed a plantar foot ulcer.
- Conditions
- Foot Ulcers, Diabetic, Plantar Foot Pressure, Fat Pad Atrophy, Peripheral Arterial Disease
- Trial name
- PLANE-DFU (NCT07901478)
- Testing
- Pedar™ In-Shoe Plantar Pressure Measurement System, STAMPS 3D Digital Image Correlation System, Weight-Bearing Ultrasound of the Plantar Fat Pad
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Diabetic Foot Ulcer
Comparison of Negative Pressure Wound Therapy Versus Moist Wound Dressing in Diabetic Foot Ulcer Patients
Diabetic foot ulcer is a common and disabling complication of diabetes mellitus. This randomized controlled trial will be conducted at Abbas Institute of Medical Sciences, Muzaffarabad to compare the efficacy of negative pressure…
- Trial name
- NCT07898202
- Testing
- Negative Pressure Wound Therapy, Moist Wound Dressing
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Abbas Institute of Medical Sciences
Foot Ulcer, Diabetic
A Study to Assess the Effect of Topical Recombinant Human Vascular Endothelial Growth Factor for Induction of Healing of Diabetic Foot Ulcers
This is a Phase II, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of three different doses of topically applied telbermin in subjects ≥ 18 years old with diabetic foot ulcers.
- Trial name
- NCT00351767
- Testing
- telbermin
- Volunteers
- 170 people
- Sponsor
- Genentech, Inc.
Diabetes Mellitus, Diabetic Foot Disease
Gremlin-1 and Wagner Classification: Potential Biomarker for Amputation in Diabetic Foot Patients
The aim of the approach to diabetic foot patients is to heal the wound, mobilize the patient, increase the quality of life, and reduce DA-related amputations as much as possible.
- Conditions
- Diabetes Mellitus, Diabetic Foot Disease, Diabetic Foot Ulcer, Diabetic Neuropathy
- Trial name
- NCT06753604
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Seyma Acik
Wound Heal
A RCT Evaluating the Clinical Benefit of a Silver Dressing in the Treatment of Venous Leg Ulcers
Approximately 178 patients with a venous leg ulcer will be included in the investigation evaluating wound healing. All subjects are randomized to one of two treatment arms with an intervention period of 4 weeks followed by a 8…
- Trial name
- NCT05923749
- Testing
- Biatain Ag, Cutimed Siltec Sorbact
- Where
- 13 sites in United States, Denmark and 2 more
- Volunteers
- 180 people
- Sponsor
- Coloplast A/S
Diabetes Mellitus Foot Ulcer
Platelet Rich Plasma and Autologous Fat Graft for Diabetic Ulcer
Conventional management of diabetic ulcers is associated with slow healing, high costs and repeated trips to clinic. Stem cells contained in fat grafts can differentiate into pro-healing cells and release growth factors with…
- Trial name
- NCT03085550
- Testing
- Fat grafting, Fat grafting + platelet rich plasma
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University College, London
Diabetic Foot, Regional Anesthesia
Efficacy of Continuous Sciatic Nerve Block in Diabetic Foot Patients
Patients who underwent surgery for diabetic foot were divided into three groups: sciatic nerve block (Group B), continuous nerve catheter (Group C) .
- Conditions
- Diabetic Foot, Regional Anesthesia, Catheter Blockage, Wound Heal
- Trial name
- NCT04212325
- Testing
- Group C (Continuous sciatic nerve block), Group S (sciatic nerve block)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gulhane School of Medicine
Diabetic Foot Ulcer
Trial of Dehydrated Human Amnion/Chorion Membrane (dHACM) In the Management of Diabetic Foot Ulcers
The objective of this study is to evaluate the percentage of patients with complete diabetic foot ulcer (DFU) closure following up to 12 weeks of treatment with either dehydrated human amnion/chorion membrane (dHACM) plus…
- Trial name
- NCT01693133
- Testing
- Standard of Care: Moist Wound Therapy and Offloading, EpiFix plus Standard of Care
- Where
- 20 sites in United States
- Volunteers
- 132 people
- Sponsor
- MiMedx Group, Inc.
Renal Disease, Peripheral Arterial Disease
The Effects of INP on Peripheral Circulation in Dialysis Patients and Patients With PAD and Leg Ulcers
This experimental study will look at the effects of INP therapy for two patient groups: 1) patients with reduced peripheral circulation and chronic wounds in patients with renal disease (dialysis patients); 2) and peripheral…
- Conditions
- Renal Disease, Peripheral Arterial Disease, Arterial Leg Ulcers
- Trial name
- NCT02622308
- Testing
- FlowOx™
- Where
- Norway
- Volunteers
- 4 people
- Sponsor
- Oslo University Hospital
Diabetic Foot Ulcer
Cellular Reprogramming-Enhanced Skin Grafting for Diabetic Foot Ulcers
Diabetic foot ulcer is one of the refractory wounds and always poses many challenges in clinical practice. This study was conducted to have a prospective, randomised, controlled study compare the safety and efficacy of the…
- Trial name
- CREST-DFU (NCT02070835)
- Testing
- autologous skin cell, skin graft
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Hu Zhicheng
Sickle Cell Leg Ulcer
Test of the Safety, Effectiveness, & Acceptability of An Improvised Dressing for Sickle Cell Leg Ulcers in the Tropics
One in 300 Jamaicans have HbSS sickle cell disease, and of these, up to 70% will suffer from sickle cell leg ulcers (SCLUs). Of these, 24% will have a chronic SCLU (one lasting longer than 6 months).
- Trial name
- SCLUJamaica (NCT04479618)
- Testing
- Usual Practice, Improvised dressing, Advanced dressing
- Where
- Jamaica
- Volunteers
- 48 people
- Sponsor
- Benskin, Linda, PhD, RN, SRN (Ghana), CWCN, CWS, DAPWCA
Diabetic Foot Ulcer, Diabetic Foot
Treatment of Chronic Diabetic Foot Ulcers by Minimally Invasive Surgery
Despite the development of the control of DM and the great interest for the complications of the disease, even today the diabetic foot represents a challenge for the orthopaedic surgeon.
- Conditions
- Diabetic Foot Ulcer, Diabetic Foot, Diabetic Foot Infection, Diabetic Foot Ulcer Neuropathic
- Trial name
- DiabeticMIS1 (NCT03010215)
- Testing
- Distal Metatarsal Minimally invasive Osteotomy (DMMO)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Padova