Clinical trials: Ulcer Venous
Venous Ulcer, Sickle Cell Ulcer
Fetal Cell Receptors Repertoire
The purpose of this study is to describe the transcriptomic profile of foetal cells in post-partum and more specifically to determine which chemokine receptors are overexpressed in foetal cells in post-partum women with wounds To…
- Conditions
- Venous Ulcer, Sickle Cell Ulcer, Diabetic Ulcer, Post-partum Women
- Trial name
- MoreCCR (NCT06031714)
- Testing
- Saliva sampling, Blood sampling, Interviews
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Skin Ulcer Venous Stasis Chronic
Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of CVU (Phase IIb)
The aim of this clinical trial is to investigate the efficacy (by monitoring the wound size reduction of CVUs) and safety (by monitoring adverse events [AEs]) of three dose groups of the investigational medicinal product (IMP)…
- Trial name
- NCT04971161
- Testing
- allo-APZ2-CVU
- Where
- 38 sites in Germany
- Volunteers
- 159 people
- Sponsor
- RHEACELL GmbH & Co. KG
Varicose Veins
Evaluation of Endovenous Sclerotherapy for Treatment of Varicose Veins
The overall objective will be to evaluate clinical predictors of outcomes in patients who undergo endovenous sclerotherapy for the treatment of varicose veins.
- Trial name
- NCT00954980
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Venous Leg Ulcer
Effect of VarIthena on Wound Healing in Venous Leg Ulcers (VLU)
A 12 month, multicenter, open-label registry to observe chronic venous insufficiency resulting in VLU treated with Varithena.
- Trial name
- VIEW-VLU (NCT03257254)
- Testing
- Varithena
- Where
- 14 sites in United States, Canada
- Volunteers
- 76 people
- Sponsor
- Boston Scientific Corporation
Varicose Ulcer
A Post-Marketing Clinical Study of Apligraf for Venous Leg Ulcers
Single site clinical study utilizing the novel technology of microarrays to identify and characterize the molecular mechanisms through which Apligraf promotes healing of venous leg ulcers.
- Trial name
- NCT00648674
- Testing
- Apligraf
- Sponsor
- Organogenesis
Patient Empowerment, Venous Leg Ulcer
The Impact of a Pluridisciplinary Education Program on Venous Leg Ulcer Size Reduction
Background and rationale: Venous leg ulcers (VLU) are slow healing wounds with a recurrence rate of 70% and a 60% risk of becoming chronic. The estimated VLU prevalence in the general population is 3%.
- Conditions
- Patient Empowerment, Venous Leg Ulcer, Interdisciplinary Communication
- Trial name
- vened (NCT04019340)
- Testing
- Education
- Where
- 3 sites in Switzerland
- Volunteers
- 87 people
- Sponsor
- School of Health Sciences Geneva
Chronic Wounds
Swab Sample Collection for the Detection of Bacterial Proteases
The objective of this study is to collect wound exudate (fluid) swab samples from Subjects who have wounds that show clinical signs of infection, as well as from Subjects who have wounds that do not show clinical signs of…
- Trial name
- NCT01881815
- Testing
- Swabs
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Systagenix Wound Management
Venous Thromboses, Colorectal Cancer
The Correlation of a D-dimer Testing Protocol With Venous Thromboembolism in Surgical Colorectal Patients
The purpose of this study is to evaluate the use of a D-dimer based protocol to screen for thrombotic events in colorectal surgical patients.
- Conditions
- Venous Thromboses, Colorectal Cancer, Diverticular Diseases, Crohn Disease
- Trial name
- NCT05246943
- Testing
- D-dimer and lower limb venous duplex
- Sponsor
- The University of Texas Medical Branch, Galveston
Venous Ulcer
Juxta-CuresTM Versus Bandaging for Venous Ulcers
Venous ulceration is a major burden on the NHS. Current treatment involves bandaging therapy which is replaced on a once or twice weekly basis.
- Trial name
- Juxta-Cures (NCT02790593)
- Testing
- Juxta-Cures™, Standard Compression, PicoPress®
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Colchester Hospital University NHS Foundation Trust
Venous Stasis Ulcers
Wound Fluid Protease Levels During Use of Novel Wound Dressing
This study is being conducted to characterize the way leg wounds respond to a new type of wound dressing, compared to wounds in patients who are not using the new dressing.
- Trial name
- NCT01567150
- Testing
- Novel Dressing
- Where
- 8 sites in United States
- Volunteers
- 35 people
- Sponsor
- Hollister Incorporated
Venous Ulcer, Foot Ulcer, Diabetic
Study of Combined Topical Growth Factor and Protease Inhibitor in Chronic Wound Healing
Leg and foot ulcers due to venous disease or diabetes are chronic wounds that can take 6 or more months to heal. Growth factors have been used to try and improve this healing, however, many such studies have failed, and that is…
- Trial name
- NCT02845466
- Testing
- Becaplermin, Promagran Dressing
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University
Venous Leg Ulcer
Intermittent Pneumatic Compression of the Thigh
Study Summary A leg ulcer is a long-lasting (chronic) sore that takes more than two weeks to heal. The majority of leg ulcers are caused either by problems with the veins in the legs; these are called 'venous leg ulcers' (VLU)…
- Trial name
- IPCOTT (NCT05659394)
- Testing
- Standard Wound Care Alone, Stand Wound Care plus IPC
- Where
- 5 sites in United States
- Volunteers
- 136 people
- Sponsor
- Huntleigh Healthcare Ltd
Venous Leg Ulcer
A Study in Patients With Venous Leg Ulcers and Measuring the Effects of Using Geko™ Device
This is a single centre open label study measuring lower limb physiology in patients with venous leg ulcers at the University Hospital of South Manchester.
- Trial name
- NCT02884323
- Testing
- geko™ device
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Firstkind Ltd
Venous Leg Ulcer
Finnish Venous Ulcer Study (FINNULCER Study)
This multicenter randomized controlled trial evaluates the effect of first-visit foam sclerotherapy (including sub-ulcer foam sclerotherapy) in patients with venous leg ulcer.
- Trial name
- NCT04737941
- Testing
- Endothermal Ablation, Foam Sclerotherapy
- Where
- 5 sites in Finland
- Volunteers
- 73 people
- Sponsor
- Oulu University Hospital
Venous Leg Ulcer, Wound Heal
COMS for Chronic Ulcers Treatment
Chronic leg and foot ulcers are defined as wounds that fail to heal in a timely manner, typically persisting for over 4 to 8 weeks without substantial healing despite standard care.
- Conditions
- Venous Leg Ulcer, Wound Heal, Magnetic Field Exposure
- Trial name
- NAZARÉ (NCT06528873)
- Testing
- Concurrent optical and magnetic stimulation (COMS) treatment
- Where
- 10 sites in Austria, France and 2 more
- Volunteers
- 122 people
- Sponsor
- Sebastian Probst
Burn, Trauma
Trial of Zesteem (Estradiol) in Healing of Split Thickness Skin Graft Donor Sites
This trial will assess the effects of Zesteem (estradiol) on the healing of split thickness skin graft donor sites in patients aged 18-85 years.
- Conditions
- Burn, Trauma, Varicose Ulcer
- Trial name
- NCT00426972
- Testing
- estradiol (Zesteem)
- Where
- 30 sites in Germany, Latvia and 2 more
- Volunteers
- 148 people
- Sponsor
- Renovo
Venous Stasis Ulcers, Venous Insufficiency
Taliderm Dressing for Venous Ulcers
The study will test a new wound healing dressing called Taliderm® on leg ulcers caused by chronic venous insufficiency (CVI). Some people with CVI have poor vein circulation that causes ulcers to develop on the lower legs.
- Trial name
- NCT00720239
- Testing
- Taliderm wound healing dressing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical University of South Carolina
Diabetic Foot Ulcer
High Intensity LED Photobiomodulation Therapy for Chronic Leg and Foot Ulcers
Diabetic and venous ulcers affect many people, and severe cases can end up in amputation and even death because of infection. In 2011, the total cost for care of diabetic foot ulcers alone, to the Canadian health care system, was…
- Trial name
- NCT04300205
- Testing
- High intensity LED light device
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Illumacell Inc.
Venous Leg Ulcers
Clinical Trial Evaluating an Amnion Membrane Allograft Intended for Use in the Management of Non- Healing Venous Leg Ulcers Versus Standard Of Care Alone
The main purpose of this research study is to compare the proportion of wound closure in subjects that receive E-GRAFT™ with SOC versus FIBRACOL™ with SOC.
- Trial name
- NCT06764953
- Testing
- E-GRAFT ™, FIBRACOL™
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Skye Biologics Holdings, LLC
Venous Leg Ulcer, Venous Insufficiency of Leg
Preliminary Investigation of a Smart Compression Therapy Prototype
Compression wraps treat venous leg ulcers when applied correctly. Often, clinicians apply the wraps at the wrong compression, or the wrap loosens, stopping clinical benefits.
- Trial name
- PRESUF-VLU (NCT05610241)
- Testing
- Compression Therapy System Prototype, Standard Compression
- Where
- Ireland
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- DeRoyal Industries, Inc.