Clinical trials: Ulcer Venous
Chronic Venous Leg Ulcers
TruSkin®: Study for Treatment of Chronic Venous Leg Ulcers
The purpose of this study is to compare the clinical outcomes of TruSkin® and an Active Comparator in patients with chronic venous leg ulcers.
- Trial name
- NCT02936128
- Testing
- TruSkin, Wound Cover
- Where
- 7 sites in United States
- Volunteers
- 7 people
- Sponsor
- Osiris Therapeutics
Diabetic Foot Ulcer, Venous Leg Ulcer
The Avelle® Negative Pressure Wound Therapy System on Chronic Wounds
This study seeks to demonstrate the performance of Negative Pressure Wound Therapy on chronic wounds such as diabetic foot ulcers and venous leg ulcers.
- Trial name
- SPACE (NCT05666570)
- Testing
- Avelle NPWT
- Where
- Colombia
- Sponsor
- ConvaTec Inc.
Leg Ulcers
Bioengineered Skin and Wound Healing
This study will look at whether a graft of bioengineered skin (BSC), known commercially as Apligraf, stimulates the healing process in a person's own skin at the edge of a wound (known as the edge effect).
- Trial name
- NCT00007280
- Testing
- Bioengineered skin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Roger Williams Medical Center
Post Thrombotic Syndrome, Venous Thromboembolism
Long Term Assessment of Post Thrombotic Syndrome : OPTIMEV Study ( SPOT )
Post-thrombotic syndrome (PTS) is a frequent and burdensome complication of deep-vein thrombosis (DVT). In the absence of curative treatment of established PTS, its management is based on the prevention of its occurrence thanks…
- Conditions
- Post Thrombotic Syndrome, Venous Thromboembolism, Cardiovascular Diseases
- Trial name
- SPOT (NCT03054727)
- Testing
- Villalta phone score > or = to 5, Villalta phone score < 5
- Where
- France
- Volunteers
- 2,475 people
- Sponsor
- Association des Médecins Vasculaires Hospitaliers
Ulcers, Wound - in Medical Care
Study on the Effectiveness of Hypothermal Sulphurous Water in Wound Hygiene
This is an interventional double arms pilot study on the effectiveness of hydrogen sulfide (H2S) rich and microbiologically pure spa sulphurous water, in the wound hygiene of hard-to heal wounds, set in an italian spa facility.
- Conditions
- Ulcers, Wound - in Medical Care, Wounds and Injuries, Wound Healing
- Trial name
- NCT06725797
- Testing
- wound hygiene with hypothermal sulfurous water by packs, wound hygiene with hypothermal sulfurous water by limb full immersion
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Roma La Sapienza
Venous Ulcer
Effectiveness of XCell on Autolytic Debridement of Venous Ulcers
This clinical trial is designed to evaluate the effect of XCell cellulose wound dressing for its ability to naturally (autolytically) remove nonviable tissue and create a healthy vascular wound bed.
- Trial name
- XCell (NCT00446823)
- Testing
- XCell cellulose wound dressing, Impregnated gauze dressing
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Xylos Corporation
Venous Leg Ulcer
Evaluation of Cirvo™ Mobile Compression Device for Treatment of Venous Leg Ulcers
This study in venous leg ulcer (VLU) patients will evaluate the use of Cirvo™ therapy for the treatment of VLU when applied for a minimum of two hours daily for up to 12 weeks.
- Trial name
- HEAL I (NCT03544788)
- Testing
- Cirvo™ Therapy
- Where
- United States
- Sponsor
- Radial Medical, Inc.
Venous Leg, Venous Leg Ulcer (VLU)
Evaluating the Durability of Closure for Venous Leg Ulcers
The goal of this observational study is to determine the durability of closure for venous leg ulcer subjects that achieved closure in the THOR trial.
- Conditions
- Venous Leg, Venous Leg Ulcer (VLU), Venous Leg Ulcer, Venous Ulcer
- Trial name
- THORSDOTTIR (NCT06697925)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Kerecis Ltd.
Chronic Venous Disease
Surface NeuroMuscular Electrical Stimulation in the Treatment of Chronic Venous Leg Ulcers
This study aims to determine if the use of surface neuromuscular electrical stimulation, applied to various motor points on the lower limb to elicit muscle contraction when combined with compression bandaging accelerates the rate…
- Trial name
- NCT01801891
- Testing
- VASGARD stimulator, Compression bandaging
- Where
- 2 sites in Ireland
- Volunteers
- 25 people
- Sponsor
- Professor Stewart Walsh
Venous Ulceration
A Study of Risk Factors for Venous Ulceration in Patients With Varicose Veins of Lower Extremities.
Varicose veins of lower extremities can lead to adverse consequences such as ulceration and hemorrhage, which seriously endangering the physical and mental health and quality of life for patients.
- Trial name
- NCT05519176
- Where
- China
- Volunteers
- 1,234 people
- Sponsor
- Yibing Wang
Non-healing Wound
Treatment of Wounds Using Oasis® ECM
The purpose of this clinical study is to gather post-market clinical evidence on the use of Oasis ECM as a treatment for donor site wounds in the community setting in the United Kingdom.
- Trial name
- NCT03632031
- Testing
- Oasis Extracellular Matrix, Standard Care (in control arm)
- Where
- 2 sites in United Kingdom
- Volunteers
- 41 people
- Sponsor
- Cook Biotech Incorporated
Chronic Wound, Burn Wound
Wound Healing Endpoint and Recurrence
This study is a continuation of a previously approved protocol conducted at Ohio State University and Indiana University. The first two aims of the original protocol have been completed, and this protocol will finish enrollment…
- Conditions
- Chronic Wound, Burn Wound, Diabetic Foot Ulcers, Pressure Ulcers
- Trial name
- NCT02577120
- Testing
- Epiceram Skin Barrier Function, Vaseline Petroleum Jelly
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Sashwati Roy
Chronic Ulcer
Feasibility and Safety and Evaluation of the Potential Efficacy of Autologous Platelet-rich Plasma in the Treatment of Vascular Venous Ulcers
INTRODUCTION: Vascular ulcers are an important pathology in the daily medical practice in all the assistance levels, and they have big repercussion referring to individual, social and labour levels, supposing a big consumption of…
- Trial name
- PRP-2012 (NCT01817218)
- Testing
- Platelet Rich Plasma, Osakidetza protocol
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Basque Health Service
Venous Thromboses, Venous Disease
The GORE® VIABAHN® FORTEGRA Venous Stent Iliofemoral Study
This study is a prospective, non-randomized, multicenter, single-arm, clinical study to evaluate the performance, safety and efficacy of the GORE® VIABAHN® FORTEGRA Venous Stent (formerly known as GORE® VIAFORT Vascular Stent)…
- Conditions
- Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis
- Trial name
- NCT05489588
- Testing
- GORE® VIAFORT Vascular Stent
- Where
- 24 sites in United States
- Volunteers
- 165 people
- Sponsor
- W.L.Gore & Associates
Venous Leg Ulcer
Efficacy and Safety of a New Compression System URGO BD001 in the Treatment of VLU (FREEDOM)
The aim of this study is to evaluate the therapeutic efficacy and the safety of the new compression system URGO BD001 in the management of venous or mixed predominantly venous leg ulcers.
- Trial name
- FREEDOM (NCT04613687)
- Testing
- Compression bandage
- Volunteers
- 52 people
- Sponsor
- Laboratoires URGO
Venous Ulcer
Preliminary Testing of New Treatment for Chronic Leg Wounds
The primary objectives of this study are to evaluate the efficacy, dosing, and safety of an intra-ulcer injection H5.020CMV.PDGF-b in adults who have a venous leg ulcer.
- Trial name
- NCT01858272
- Testing
- H5.020CMV.PDGF-b and limb compression bandage
- Volunteers
- 15 people
- Sponsor
- University of Pennsylvania
Venous Leg Ulcers, Diabetic Foot Ulcers
Single-Use Negative Pressure Wound Therapy System vs. Traditional Negative Pressure Wound Therapy System (tNPWT)
The aim of this study is to compare the clinical efficacy of two types of NPWT systems; the traditional negative pressure wound therapy (tNPWT) system and the single-use negative pressure wound therapy (PICO) system.
- Trial name
- NPWT (NCT02470806)
- Testing
- PICO System, tNPWT System
- Where
- 17 sites in United States, Canada
- Volunteers
- 164 people
- Sponsor
- Smith & Nephew, Inc.
Diabetic Foot Ulcer, Venous Leg Ulcer
Modified Multi-Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of DFU and VLUs
This is a multicenter, prospective, randomized controlled modified multi-platform (matriarch) trial evaluating several cellular, acellular, and matrix-like products (CAMPs) and standard of care versus standard of care alone in…
- Conditions
- Diabetic Foot Ulcer, Venous Leg Ulcer, Ulcer Foot, Leg Ulcer
- Trial name
- NCT06560502
- Testing
- Standard of Care-DFU, AmnioCore - DFU, Amnio Quad-Core - DFU
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Stability Biologics
Chronic Venous Hypertension With Ulcer and Inflammation, Venous Ulcer Pain
Electromagnetic Field Therapy to Improve Healing of Chronically Venous Ulcer
Chronically venous ulcer in lower extremities is a permanent and disabling disease. Venous insufficience is the main cause of chronic ulcer. There is a high prevalence and frequency of the disease, primarily among elderly people.
- Trial name
- NCT01561170
- Testing
- Active Pulsed Electro-Magnetic Field (PEMF)
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Venous Ulcer
Randomized Clinical Trial (RCT) to Compare the Efficacy of Coban 2 Versus SSB in the Treatment of Venous Leg Ulcers
The study purpose is to compare healing rates, cost effectiveness, quality of life and safety of 12 week compression therapy for the treatment of venous leg ulcers with the 3M™ Coban™ 2 Layer Compression System versus…
- Trial name
- NCT00558662
- Testing
- Coban 2, SSB
- Where
- 16 sites in Belgium, Germany and 2 more
- Volunteers
- 234 people
- Sponsor
- Solventum US LLC