Clinical trials: Ulcerative
Inflammation, Veins
The Role of Pyroptosis in Chronic Venous Disease
Enrollment criteria and clinical data collection: following the principles of medical ethics, the development of inclusion and exclusion criteria.
- Conditions
- Inflammation, Veins, Complication, Varicose Veins
- Trial name
- PYROCVD (NCT03744858)
- Testing
- Peripheral blood draw
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Pressure Ulcers
Wound Management for Sacral Pressure Ulcers With Necrotic Tissue
Evaluation of a wound care debridement product and a moisturizer on sacral pressure ulcer wounds
- Trial name
- NCT02224638
- Testing
- TheraHoney HD, SkinTegrity
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Medline Industries
Scleroderma, Systemic
Treprostinil Iontophoresis in Systemic Sclerosis Digital UlcErations. A Proof of Concept Study
The study is conducted to confirm the good tolerance of a continuous cathodal iontophoresis of the treprostinil hydrogel administered during 10 days on the pulp of the finger of healthy volunteer and on the ischemic digital…
- Trial name
- TISSUE-PoC (NCT03120533)
- Testing
- Iontophoresis of treprostinil
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Colitis, Ulcerative
Confirmatory Clinical Study in Active Ulcerative Colitis
The main goal of the study is to check if MH002 works and is safe to use. In a previous study in 45 patients with Ulcerative Colitis, MH002 was found to have favorable effects.
- Trial name
- StarFish-UC (NCT07296315)
- Testing
- Low-dose MH002, High-dose MH002
- Where
- 49 sites in United States, Czechia and 5 more
- Volunteers
- 204 people
- Sponsor
- MRM Health NV
Inflammatory Bowel Diseases, Ulcerative Colitis
Individualization Treatment Through a Self-managed Web-based Solution in Ulcerative Colitis
This study investigates the effect of individualized monotherapy with Mesalazine (Pentasa Sachet ®) on time to remission in patients with mild to moderate UC in an eHealth setting.
- Trial name
- NCT03604536
- Where
- Denmark
- Volunteers
- 1 people
- Sponsor
- Nordsjaellands Hospital
The Study Focuses on Skin Assessment and PI Staging in ICU Patients
AI-Assisted Skin Assessment for Pressure Injury Prevention in Critical Care Nurses
The goal of this clinical trial is to learn whether an artificial intelligence (AI)-assisted skin assessment tool can improve the accuracy of pressure-injury staging in critical-care nurses.
- Trial name
- IT-PIP (NCT07318571)
- Testing
- ChatGPT Skin Assessment
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Ulcerative Colitis Acute
Upadacitinib Combined With Corticosteroids vs Corticosteroid Monotherapy Induction for Inpatients and Outpatients With Acute Severe Ulcerative Colitis
This trial is being conducted to learn more about the optimal sequence of various medications in the management of acute severe ulcerative colitis (ASUC).
- Trial name
- ACUTE (NCT07258771)
- Testing
- Oral Upadacitinib, Intravenous Methylprednisolone, Oral prednisolone Taper
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Berinstein, Jeffrey
Crohn Disease, Ulcerative Colitis
Inflammatory Bowel Diseases Remission Registry
The inflammatory bowel diseases (IBDs), ulcerative colitis (UC) and Crohn's disease (CD), are characterized by lifelong relapsing-remitting gastrointestinal inflammation, with symptoms of abdominal pain, diarrhea, and rectal…
- Conditions
- Crohn Disease, Ulcerative Colitis, Pouchitis
- Trial name
- NCT04912999
- Where
- Israel
- Volunteers
- 1,000 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Active Ulcerative Colitis
Superdonor FMT in Patients With Ulcerative Colitis
In the last decades fecal microbiota transplantation (FMT) has been established as a highly effective option in the treatment of recurrent Clostridioides difficile infection (rCDI), with a success rate of nearly 90%.
- Trial name
- NCT05739864
- Testing
- FMT
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ulcerative Colitis
Study for the Treatment of Ulcerative Colitis With Adacolumn (Companion to US Study 512-04-205)
The purpose of the study is to demonstrate the safety and effectiveness of the Adacolumn Apheresis System to treat the signs and symptoms of ulcerative colitis.
- Trial name
- NCT00219414
- Testing
- Adacolumn Apheresis System
- Volunteers
- 42 people
- Sponsor
- Otsuka Frankfurt Research Institute GmbH
Pyoderma Gangrenosum
A 2-Year, Open-Label, Safety Extension Study of Gevokizumab in Subjects With Pyoderma Gangrenosum
The study will evaluate the long-term safety of gevokizumab in treating active PG ulcers
- Trial name
- NCT02318914
- Testing
- gevokizumab
- Where
- 40 sites in United States, Australia and 1 more
- Volunteers
- 15 people
- Sponsor
- XOMA (US) LLC
Venous Stasis Ulcers
The Effects of Pulsed Elelectro-Magnetic Fields ("PEMF") in the Treatment of Venous Stasis Leg Ulcers
The purpose of this study is to determine the clinical effectiveness of a low-power PEMF device, a medium-power PEMF device and a high-power PEMF device as compared to a sham device to treat leg ulcers resulting from venous…
- Trial name
- VSLU (NCT03416049)
- Testing
- PEMF therapy with a high-power PEMF device, PEMF therapy with a medium PEMF power device, PEMF therapy with a low-power PEMF device
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- PEMF Systems, Inc.
Inflammatory Bowel Diseases, COVID
PROTECT-ASUC: Covid-19 Pandemic Response Of assessmenT, EndosCopy and Treatment in Acute Severe Ulcerative Colitis
Whether the perceived changes in management of Acute Severe Ulcerative Colitis during the COVID pandemic are widespread, and whether they have any impact on patient outcomes
- Trial name
- PROTECT-ASUC (NCT04411784)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Pressure Ulcer
A Multicentre Clinical Test of the Ultracore Repose® Mattress to Prevent Pressure Ulcers Cat. II-IV in Nursing Homes
A mixed method desgin study will be conducted to study pressure ulcer incidence Cat. II-IV (including deep- tissue injury,unstageable), not associated with the use of medical devices, on the Ultracore Repose® mattress (Frontier…
- Trial name
- NCT04625348
- Testing
- Ultracore Repose® mattress, experiences and perceptions of healthcare workers
- Where
- 5 sites in Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Ghent
Inflammatory Bowel Disease, Crohn's Disease
Low Dose Naltrexone in Symptomatic Inflammatory Bowel Disease
The investigators will be looking at the efficacy of the use of once daily use of low dose naltrexone (4.5mg) in subjects with symptomatic inflammatory bowel disease.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT01810185
- Testing
- Low dose naltrexone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Santa Barbara Cottage Hospital
Gastro-esophageal Reflux Disease With Ulceration.
Relationship of Obesity With GERD Among Nigerians
Obesity is a strong risk factor for GERD. This study assessed the role of obesity among patients having erosive GERD and controls.
- Trial name
- NCT02888808
- Testing
- Gastroscopy
- Volunteers
- 160 people
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate
Safety, Dosage, and Microbiome Engraftment Study of MGT-006 for Ulcerative Colitis (ROOT Study)
Ulcerative colitis is a condition that causes inflammation and ulcers in the large intestine. MGT-006 is an investigational oral capsule containing viable gut microbiota from screened human donors.
- Trial name
- ROOT (NCT07913347)
- Testing
- MGT-006, Vancomycin hydrochloride, Amoxicillin hydrate/ Fosfomycin calcium hydrate/ Metronidazole
- Where
- 12 sites in United States, Japan
- Volunteers
- 54 people
- Sponsor
- Metagen Therapeutics, Inc.
Achalasia, Gastric Fistula
Outcome Analysis of POEM and Endoluminal Therapies
Evaluation of current and newly developed endoluminal therapies in the management of Upper and Lower GI conditions.
- Conditions
- Achalasia, Gastric Fistula, Weight Gain After Primary Weight Loss Surgery, Marginal Ulcer
- Trial name
- NCT03123835
- Testing
- Endoscopic Intervention
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Gastric Ulcer
A 12-month, Phase 3, Open-label, Multi-center Study to Evaluate the Long-term Safety of PN400 (VIMOVO)
This study uses an open-label design and will be conducted in approximately 60 sites aiming to enroll a total number of 200 subjects to ensure that at least 100 subjects will have 12 months exposure to PN400 (VIMOVO).
- Trial name
- NCT00527904
- Testing
- PN400 (VIMOVO), PN 400 (VIMOVO)
- Where
- United States
- Volunteers
- 239 people
- Sponsor
- POZEN
Diabetic Foot, Plantar Fasciitis
Joints Mobilization Versus Myofascial Release on Diabetic Patients With Painful Heel
Diabetes mellitus (DM) increases stiffness and thickness of foot structures. This may alter the foot's biomechanics and increase plantar pressure distribution, mainly on the forefoot region.
- Trial name
- NCT03851848
- Testing
- Joint mobilization (JM), Myofascial release (MFR)
- Where
- Saudi Arabia
- Volunteers
- 46 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
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