Clinical trials: Ulcerative
Foot Ulcer, Diabetes
Improving Diabetic Foot Ulcers With Atorvastatin
Lower limb complications are a substantial matter in the diabetic population and studies show that the annual incidence of foot ulcers ranges from 1.0-4.1% while the cumulative lifetime incidence is approximately 15%.
- Trial name
- NCT00134550
- Testing
- Atorvastatin (10 mg or 80 mg)
- Where
- 2 sites in Norway
- Volunteers
- 13 people
- Sponsor
- Asker & Baerum Hospital
Ulcerative Colitis
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis
The main aim of this study is to learn if TAK-279 reduces bowel inflammation and symptoms compared to placebo. Another aim is to compare any medical problems that participants have when they take TAK-279 or placebo and how well…
- Trial name
- NCT06254950
- Testing
- TAK-279
- Where
- 141 sites in United States, Australia and 20 more
- Volunteers
- 213 people
- Sponsor
- Takeda
Pyoderma Gangrenosum
Deucravacitinib in PG
The main goal of this study is to see if the study drug called "Deucravacitinib" is safe and effective in treating people with pyoderma gangrenosum (PG).
- Trial name
- NCT05821374
- Testing
- Deucravacitinib
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Sickle Cell Leg Ulcer
Test of the Safety, Effectiveness, & Acceptability of An Improvised Dressing for Sickle Cell Leg Ulcers in the Tropics
One in 300 Jamaicans have HbSS sickle cell disease, and of these, up to 70% will suffer from sickle cell leg ulcers (SCLUs). Of these, 24% will have a chronic SCLU (one lasting longer than 6 months).
- Trial name
- SCLUJamaica (NCT04479618)
- Testing
- Usual Practice, Improvised dressing, Advanced dressing
- Where
- Jamaica
- Volunteers
- 48 people
- Sponsor
- Benskin, Linda, PhD, RN, SRN (Ghana), CWCN, CWS, DAPWCA
Sickle Cell Disease
Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers
The investigators are conducting a Phase II prospective and placebo controlled study of a topical cream containing sodium nitrite compared to the current standard of care.
- Trial name
- NCT02863068
- Testing
- Topical Sodium Nitrite
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- caterina P minniti
Diabetic Foot Ulcer
The Purpose of This Study is to Assess Clinical Efficacy and Safety of Berovenal® Intended to Promote Treatment and to Expedite Chronic Diabetic Foot Ulcer Healing
The goal of this clinical investigation is to evaluate clinical efficacy of medical device Berovenal® intended to promote treatment and to expedite healing of chronic diabetic foot ulcer in male or female subjects aged 18-85…
- Trial name
- NCT06584617
- Testing
- Berovenal®, NU-GEL Hydrogel with Alginate
- Where
- 9 sites in Germany, Poland
- Volunteers
- 66 people
- Sponsor
- VULM s.r.o.
Non-Bleeding Peptic Ulcers
DLBS2411 Treatment for Ulcer Healing in Non-Bleeding Peptic Ulcers
This is a 2-arm, prospective, double-blind, double-dummy, randomized-controlled study using DLBS2411 at a dose of 250 mg twice daily (before morning and evening meals), or omeprazole at a dose of 40 mg once daily (before morning…
- Trial name
- NCT02262169
- Testing
- Omeprazole, DLBS2411
- Where
- Indonesia
- Volunteers
- 32 people
- Sponsor
- Dexa Medica Group
Acute Coronary Syndrome
Gastrointestinal Ulceration in Patients on Dual Antiplatelet Therapy After Percutaneous Coronary Intervention
To determine the rate of symptomatic and asymptomatic gastrointestinal erosions and ulcerations in patients on dual antiplatelet (aspirin and clopidogrel) therapy after percutaneous coronary intervention (PCI).
- Trial name
- NCT00413309
- Testing
- Video Capsule Endoscopy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Diabetic Foot Ulcers, Hyperbaric Therapy
Hyperbaric Oxygen Therapy and Angiogenesis in Diabetic Patients With Foot Ulcers
Diabetic foot ulcers are a major cause of morbidity and mortality, accounting for approximately two-thirds of all non-traumatic amputations performed in the United States.
- Conditions
- Diabetic Foot Ulcers, Hyperbaric Therapy, Angiogenesis
- Trial name
- NCT00475202
- Where
- Israel
- Sponsor
- Assaf-Harofeh Medical Center
Early Gastric Cancer, Gastric Dysplasia
Does Early Re-administration of Aspirin/Clopidogrel Increase the Risk of Bleeding From Artificial Ulcer After EMR or ESD?
Aspirin and/or clopidogrel users are increasing due to increased prevalence of cardiovascular or cerebrovascular disease with an aging society in Korea.
- Trial name
- NCT01621451
- Testing
- aspirin and/or clopidogrel
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Asan Medical Center
Aphthous Ulcer
The Efficacy of Nigella Sativa Oil Mouth Rinse in the Management of Recurrent Minor Aphthous Ulcer
This research aims to investigate the effectiveness of Nigella Sativa Oil Mouth Rinse application both clinically and biochemically as a suitable affordable treatment modality for Management of Recurrent Minor Aphthous Ulcer
- Trial name
- NCT06013202
- Testing
- Nigella Sativa Oil Mouth Rinse, isotonic (normal saline) with concentration 0.90% of sodium chloride (NaCl)
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nada Sherif
Duodenal Ulcer，DU
A Phase 3 Randomised Controlled Trial to Evaluate Efficacy and Safety of Anaprazole in Patients With Duodenal Ulcers.
A phase 3,double-blinded, double dummy, parallel, non-inferiority, randomised controlled multicenter trial to evaluate efficacy and safety of 4 weeks treatment of Anaprazole 20mg QD compared with rabeprazole 10mg QD in patients…
- Trial name
- NCT04215653
- Testing
- Anaprazole Sodium, Rabeprazole
- Volunteers
- 448 people
- Sponsor
- Sihuan Pharmaceutical Holdings Group Ltd.
High-Flow Nasal Cannula Therapy
The Application Effect of Modified Pressure-Reducing Fixation Protective Nasal Strip in the Nursing Care of Patients Receiving High-Flow Nasal Cannula Therapy
This study was a prospective, randomized controlled trial that included 60 patients receiving high-flow nasal cannula (HFNC) therapy.
- Trial name
- HFNC; pressure (NCT06720129)
- Testing
- the modified pressure-reducing fixation protective nasal strip, Standard care alone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ying Zhou
Infection, Soft Tissue, Infection, Wound
Direct Antibiotic Delivery of Cefazolin Into Soft Tissue Infections Using Subcutaneous Injection and Ultrasonic Dispersion
This study focuses on a new drug delivery system (Direct Antibiotic Delivery) to treat soft tissue infections. In this study, cefazolin is delivered directly to the target tissues using subcutaneous injection of antibiotic…
- Conditions
- Infection, Soft Tissue, Infection, Wound, Cellulitis, Diabetic Foot Ulcer
- Trial name
- DAD (NCT01238276)
- Testing
- Cefazolin, Silberg Tissue Preparation System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sonescence, Inc.
Pressure Ulcer (PU), Pressure Injury
Prevention of Community Acquired Pressure Ulcers Using SSKIN Bundle at Home
Pressure ulcers remain a significant healthcare burden in community and home care settings, particularly among immobile patients.
- Conditions
- Pressure Ulcer (PU), Pressure Injury, Wounds and Injuries
- Trial name
- NCT07848685
- Testing
- Structured SSKIN Bundle Caregiver Training Program, Routine Verbal Instruction on Pressure Ulcer Prevention
- Where
- Saudi Arabia
- Volunteers
- 106 people
- Sponsor
- Hiba Hussein, MD
Venous Ulcers
Safety and Efficacy of Gaseous Nitric Oxide on Venous Stasis Leg Ulcers
The purpose of this study is to determine whether nitric oxide (NO)gas is effective in the treatment of venous ulcers of the lower leg.
- Trial name
- NCT00613808
- Testing
- Nitric Oxide 200ppm Group B
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Nitric BioTherapeutics, Inc
Ulcerative Colitis
Phosphatidylcholine (LT-02) for Induction of Remission in Ulcerative Colitis
The purpose of this study is to compare two different dosing regimens of phosphatidylcholine versus placebo for the induction of remission in ulcerative colitis patients non-responsive to standard mesalamine treatment.
- Trial name
- PROTECT-1 (NCT02142725)
- Testing
- LT-02
- Where
- Germany
- Volunteers
- 468 people
- Sponsor
- Dr. Falk Pharma GmbH
Venous Thromboses, Venous Stasis
Evaluation of the OsciPulse Rapid Cycling Compression Device Effects on Venous Blood Flow
This study will evaluate the effects on venous blood flow of the investigational device, OsciPulse system, which is an external intermittent limb compression device.
- Trial name
- NCT05087108
- Testing
- OsciPulse system, Reference Therapy 1, Refence Therapy 2
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- OsciFlex LLC
Pressure Ulcer, Diabetic Foot Ulcer
An Open, Non-comparative, Multicenter Investigation to Evaluate the Safety and Performance of Exufiber Ag+, a Gelling Fiber Silver Dressing, When Used in Medium to High Exuding Chronic Wounds
An open, non-comparative, multicenter investigation to evaluate the safety and performance of Exufiber Ag+, a gelling fiber silver dressing, when used in medium to high exuding chronic wounds
- Conditions
- Pressure Ulcer, Diabetic Foot Ulcer, Venous Leg Ulcer
- Trial name
- NCT05494450
- Testing
- ExufiberAG+
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Molnlycke Health Care AB
DFU, VLU
BIO-SEE: Bioburden Imaging Outcome Study for Equivalence Evaluation
The study aims to demonstrate the substantial equivalence of the cureVision cV system's performance in detecting moderate to high bacterial loads in direct comparison to the comparator device for fluorescence imaging in wounds…
- Conditions
- DFU, VLU, Surgical Wound, Wounds
- Trial name
- NCT07611318
- Testing
- cureVision cV
- Where
- 5 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Capsicure, LLC
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