Clinical trials: Ulcerative
Ulcerative Colitis (UC)
Effectiveness and Safety of Mirikizumab in Patients With Moderate-to-severe Ulcerative Colitis: a Real-life Retrospective Multicenter Study
This is a real-life, multicenter, retrospective observational study with the aim to evaluate effectiveness and safety of Mirikizumab in a real life setting from the baseline up to manteinance at 12, 24 and 52 weeks.
- Trial name
- MIRI REAL (NCT07695636)
- Where
- Italy
- Volunteers
- 282 people
- Sponsor
- IRCCS San Raffaele
Corneal Ulcer
Corneal Ulcer Prevention Through Health Education
A community-randomized trial comparing villages randomized to receive an intervention consisting of a trained community health volunteer who brings patients to the nearest Vision Centers or Primary Health Care Centers for…
- Trial name
- CUP (NCT02284698)
- Testing
- Health Education
- Volunteers
- 98,207 people, healthy volunteers welcome
- Sponsor
- Aravind Eye Care System
Vasopressor Adverse Reaction, Pressure Injury
The Effect of Vasopressor on Pressure Injury Development
Background: Vasopressors are life-saving agents that increase mean arterial pressure. The pharmacodynamic features of these agents and previous studies suggest that vasopressors may be an essential risk factor in developing…
- Conditions
- Vasopressor Adverse Reaction, Pressure Injury, Pressure Ulcer
- Trial name
- NCT06163352
- Testing
- Norepinephrine
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Koç University
Oral Mucositis (Ulcerative), Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy
Multicentre Real-life Data Collection Study With CareMin650™ in the Prevention and Treatment of Oral Mucositis and Radio- and/or Chemo-induced Dermatitis
Most patients with cancer or haematological malignancies who receive chemotherapy - broadly defined to include targeted therapies and immunotherapy - and/or external beam radiotherapy may experience serious and disabling adverse…
- Conditions
- Oral Mucositis (Ulcerative), Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy, Oral Mucositis (Ulcerative) Due to Radiation, Dermatitis
- Trial name
- NéoPBM (NCT07054528)
- Where
- France
- Volunteers
- 33,000 people
- Sponsor
- Centre Hospitalier de Valenciennes
Diabetes, Foot Ulcer
Use of INTEGRA™ Flowable Wound Matrix to Manage Diabetic Foot Ulcers
After determining if subjects meet the criteria to be included in the study they will be randomly placed in either Group 1 or 2 and patient will be blinded from randomization group.
- Trial name
- NCT01108263
- Testing
- INTEGRA™ Flowable Matrix (Collagen)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Georgetown University
Ulcerative Colitis Chronic Mild, Ulcerative Colitis Chronic Moderate
Lactobacillus Rhamnosus GG (ATCC 53103) in Mild-moderately Active UC Patients
This study is a randomized double-blind clinical trial that intends to evaluate the efficacy and safety of LGG administration at two different doses, for 1 month, in ulcerative colitis (UC) patients with mild-moderate disease…
- Trial name
- LGGinUC (NCT04102852)
- Testing
- Lactobacillus rhamnosus GG ATCC 53103
- Where
- Italy
- Volunteers
- 76 people
- Sponsor
- San Giovanni Addolorata Hospital
Dissection of Thoracic Aorta, Dissection of Thoracic Descending Aorta
European Multi-Centre Post-Market Registry on Thoracic Endovascular Arch Repair Using Castor™ and Cratos™
The Castor™ and Cratos™ Branched Aortic Stent Graft Systems are medical devices designed for the minimally invasive endovascular treatment of thoracic aortic pathologies in the descending aorta.
- Conditions
- Dissection of Thoracic Aorta, Dissection of Thoracic Descending Aorta, Aneurysm of Aorta, Thoracic, Penetrating Aortic Ulcers (PAUs)
- Trial name
- CEDAR (NCT07668687)
- Testing
- Implantation with Castor™ stent graft, Implantation with Cratos™ stent graft
- Where
- 4 sites in Germany, Switzerland
- Volunteers
- 100 people
- Sponsor
- Shanghai MicroPort Endovascular MedTech（Group）Co., Ltd
Crohn Disease, Ulcerative Colitis
Proactive Infliximab Optimization Using a Pharmacokinetic Dashboard Versus Standard of Care in Patients With Inflammatory Bowel Disease: The OPTIMIZE Trial
The OPTIMIZE Trial compares whether iDose dashboard-driven infliximab dosing (iDose-driven dosing) is more effective and safer than standard infliximab dosing for inducing and maintaining disease remission in inflammatory bowel…
- Conditions
- Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
- Trial name
- NCT04835506
- Testing
- Infliximab
- Where
- 25 sites in United States, Canada
- Volunteers
- 124 people
- Sponsor
- Beth Israel Deaconess Medical Center
Diabetic Foot Ulcer, Healing Delayed
Mean Healing Time of Wound After Vacuum Assisted Closure (VAC) Versus Conventional Dressing in Diabetic Foot Ulcer Patients
Comparison the mean healing time of wound after vacuum assisted closure(VAC) versus conventional dressing(CD) in diabetic foot ulcer(DFU) patients.
- Conditions
- Diabetic Foot Ulcer, Healing Delayed, Wound; Foot, Diabetes Mellitus
- Trial name
- NCT04959071
- Testing
- Vacuum assisted closure VAC vs conventional dressing
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Bahria University
Inflammatory Bowel Disease, Anemia
FERINJECT for Correction of Anaemia in IBD Patients, FER-IBD-COR
The purpose of this study is to determine how safe, tolerable and effective the new standardised dosage regimen of FERINJECT® infusions is, compared with a well established intravenous iron treatment.
- Conditions
- Inflammatory Bowel Disease, Anemia, Iron Deficiency, Iron-Deficiency Anemia
- Trial name
- FER-IBD-COR (NCT00810030)
- Testing
- Ferric carboxymaltose, Iron Sucrose
- Where
- Austria
- Volunteers
- 484 people
- Sponsor
- Vifor Pharma
Diabetic Neuropathic Ulcer
Allogeneic ABCB5-positive Stem Cells for Treatment of DFU "Malum Perforans"
The aim of this clinical trial is to investigate the efficacy (by monitoring the wound surface area reduction of Diabetic Foot Ulcers) and safety (by monitoring adverse events) of two doses of the allogeneic investigational…
- Trial name
- NCT03267784
- Testing
- allo-APZ2-DFU
- Where
- 7 sites in Germany
- Volunteers
- 23 people
- Sponsor
- RHEACELL GmbH & Co. KG
Crohn Disease (CD), Ulcerative Colitis (UC)
Modafinil For Fatigue in IBD: A Feasibility Randomised Controlled Trial
Fatigue is a big problem in people with inflammatory bowel disease (IBD). Even when IBD is well controlled, 50% of patients remain fatigued most of the time. Fatigue can be physical (e.g. feeling tired or weak) and mental (e.g.
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), Fatigue
- Trial name
- MFI (NCT07295834)
- Testing
- Modafinil
- Where
- 4 sites in United Kingdom
- Volunteers
- 70 people
- Sponsor
- Imperial College London
Pelvic Organ Prolapse, Urinary Incontinence
Vaginal Estradiol Use in Pessary Care
The primary outcome of this study compare the rate of pessary discontinuation at 6 months post-pessary fitting in women using vaginal estradiol versus those not using vaginal estradiol.
- Conditions
- Pelvic Organ Prolapse, Urinary Incontinence, Pessary Ulcer of Vagina, Vaginal Atrophy
- Trial name
- NCT05458375
- Testing
- Estradiol vaginal cream
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Ulcerative Colitis, Crohn Disease
Treat-to-Target of Endoscopic Remission in Patients With IBD in Symptomatic Remission
The purpose of this study is to compare the effectiveness and safety of a strategy of switching to an alternative targeted immunomodulator (TIM) therapy to treat to a target of endoscopic remission, versus continuing index TIM in…
- Trial name
- QUOTIENT (NCT05230173)
- Testing
- Pragmatic
- Where
- 24 sites in United States
- Volunteers
- 216 people
- Sponsor
- Mayo Clinic
Ulcerative Colitis
Safety, Tolerability and Pharmacokinetics of Oral NX-13 in Healthy Adults Male and Female Volunteers
This is a randomized, double-blind, placebo-controlled, ascending dose, multi-cohort study. The study will be conducted in 2 parts: a single ascending dose (SAD) part (Part A) followed by a multiple ascending dose (MAD) part…
- Trial name
- NCT04458805
- Testing
- NX-13 250 mg
- Where
- Australia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Landos Biopharma Inc.
Colon Cancer, Diverticulitis
General Surgical Outcomes Quality Improvement Database (UH-SOCRATES)
A database has been established to track the outcomes of all cases performed in the University Hospitals Department of Surgery in an effort to improve quality of surgical performance and case management.
- Conditions
- Colon Cancer, Diverticulitis, Colorectal Polyps, Crohn's Disease
- Trial name
- SOCRATES (NCT00622557)
- Where
- United States
- Volunteers
- 200,000 people
- Sponsor
- University Hospitals Cleveland Medical Center
Islet Cell Adenoma, Zollinger Ellison Syndrome
Interferon and Octreotide to Treat Zollinger-Ellison Syndrome and Advanced Non-B Islet Cell Cancer
This study will examine the safety and effectiveness of interferon-a and octreotide for the treatment of Zollinger-Ellison syndrome (gastrinoma) and advanced non-B islet cell cancer.
- Trial name
- NCT00001228
- Testing
- Interferon
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetic Foot, Amputation
Pattern and Type of Amputation and Mortality Rate Associated With Diabetic Foot in Jeddah, Saudi Arabia: A Retrospective Cohort Study
This study explored the pattern and type of amputations performed on patients with diabetic foot who were admitted to our institution, as well as the 7-year mortality rate of patients with diabetic foot at the same institution.
- Trial name
- NCT05123157
- Testing
- NO intervention
- Where
- Saudi Arabia
- Volunteers
- 358 people
- Sponsor
- King Abdulaziz University
Leg Ulcer
Treatment of Chronic Leg Ulcers With Autologous Stromal Vascular Fraction
Chronic leg ulcers are associated with decreased quality of life and an increased mortality. In many cases these ulcers are treated conservatively and the healing time can be several months.
- Trial name
- NCT02987101
- Testing
- Liposuction, Standard wound care, Adipose-Derived Regenerative Cells
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Odense University Hospital
Pressure Injury
Postoperative Pressure Injury in Patients Undergoing Prone Spinal Surgery
Patients undergoing surgery under general anesthesia are susceptible to pressure-induced soft tissue damage because there is no change in posture over an extended period of time.
- Trial name
- NCT03965169
- Testing
- Prone spinal surgery
- Where
- South Korea
- Volunteers
- 299 people
- Sponsor
- Seoul National University Hospital
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