Clinical trials: Ulcerative Colitis, completed
Dopamine Dysregulation Syndrome, Ulcerative Colitis
Effect and Mechanism of Dopamine on Ulcerative Colitis
Increased evidence suggests that dopamine acts as an important regulator of immune function. A substantial amount of dopamine exists in the gastrointestinal tract, especially in colonic lumen.
- Trial name
- NCT05214404
- Testing
- Patients diagnosed with ulcerative colitis
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Ulcerative Colitis
Effect of Probiotic Supplementation on the Immune System in Patients With Ulcerative Colitis in Amman, Jordan
Ulcerative colitis (UC) is a chronic Inflammatory bowel disease (IBD) that most likely results from the interaction between various environmental and genetic factors.
- Trial name
- NCT04223479
- Testing
- Probiotic Formula Capsule
- Where
- Jordan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Ulcerative Colitis, Pouchitis
Intestinal Ultrasound for the Evaluation of Pouchitis and Other Outcomes After Ileal Pouch-Anal Anastomosis
Intestinal ultrasound (IUS) has been studied in the evaluation of inflammatory bowel disease (IBD) and is increasingly used as a non-invasive, easy to use, cost-effective tool for point-of-care to assess disease activity and more…
- Trial name
- NCT06316999
- Testing
- Intestinal Ultrasound
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Disease Activity, Remission of Ulcerative Colitis
Maresin-1 and Resolvin-D1 Levels and Disease Activity in Ulcerative Colitis
Specialized pro-resolving mediators (SPMs), which are typically thought to be formed via consecutive steps of oxidation of polyenoic fatty acids, have been shown to suppress inflammation and promote timely resolution of…
- Conditions
- Disease Activity, Remission of Ulcerative Colitis, Ulcerative Colitis Flare
- Trial name
- NCT06652464
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Colitis, Ulcerative
Confocal Laser Endomicroscopy Findings in Patients With Proctosigmoiditis Before and After Initiation of Treatment
Confocal laser endomicroscopy (CLE) is a novel method in evaluation of microscopic structures in vivo. The examination is carried out with a confocal laser endomicroscope, which is either part of the endoscope (manufactured by…
- Trial name
- NCT01684514
- Testing
- Confocal laser endomicroscopy
- Where
- 2 sites in Denmark
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Ulcerative Colitis, Thromboembolism
Effect of Tofacitinib on Coagulation and Platelet Function, and Its Role in Thromboembolic Events
Post-authorization, prospective and unicenter clinical trial, in which patients with UC will be included. The treatment with anti-TNFα (infliximab, adalimumab or golimumab) or JAK-inhibitors (tofacitinib) will be initiated by…
- Trial name
- NCT05313620
- Testing
- Tofacitinib, Infliximab Adalimumab y Golimumab
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Inflammatory Bowel Diseases
Regulation of Mucosal Healing in Inflammatory Bowel Disease
The objective of the current study is to compare non-healing colonic ulcers in patients with inflammatory bowel disease (IBD) with iatrogenic colonic ulcers (biopsy sites) in healthy control patients and patients with rheumatoid…
- Trial name
- NCT04504136
- Testing
- Serial Biopsy
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Terrence A Barrett
Healthy Subjects
Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of OSE-127 in Healthy Subjects
This study is a first-in-human phase I randomised, double-blind, placebo-controlled, evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Single (IV and SC) and Multiple (IV only)…
- Trial name
- NCT03980080
- Testing
- OSE-127
- Where
- Belgium
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- OSE Immunotherapeutics
Ulcerative Colitis
Study for Safety and Tolerability of TOP1288 Administered Rectally in Healthy and Ulcerative Colitis Subjects
This study evaluates the safety and tolerability of TOP1288 rectal single and multiple ascending doses in healthy subjects and multiple doses in subjects with ulcerative colitis.
- Trial name
- NCT02463045
- Testing
- TOP1288
- Where
- United Kingdom
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Topivert Pharma Ltd
Irritable Bowel Syndrome, Ulcerative Colitis
Phenotyping IBS: Perceptions and Modulations of Visceral Sensations
The purpose of this research study is to improve the understanding of irritable bowel syndrome (IBS) and its underlying cause. The investigators will use magnetic resonance imaging (MRI) to observe differences in the brain…
- Conditions
- Irritable Bowel Syndrome, Ulcerative Colitis, Inflammatory Bowel Disease
- Trial name
- PMVS-P (NCT02693730)
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Inflammatory Bowel Disease, Crohn's Disease
ENhanced Recovery in CHildren Undergoing Surgery
The institution of perioperative Enhanced Recovery Protocols (ERPs) has been found to decrease hospital length of stay, in-hospital costs, and complications among adult surgical populations but data in pediatric populations are…
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- ENRICH-US (NCT04060303)
- Testing
- Perioperative surgical care
- Where
- United States
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Ulcerative Colitis, Crohn's Disease
The Innate Immune System and Inflammatory Bowel Disease
The study includes individuals with ulcerative colitis, Crohn's disease and healthy controls. The purpose of this study is to examine the innate immune system (IIS) by exposing peripheral blood monocytes to various ligands…
- Trial name
- NCT00516776
- Where
- Norway
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Ulcerative Colitis
TP0501 - Pharmaco-Scintigraphic-Study
This is a Phase I, open-label, single-site trial to evaluate the drug release, using Scintigraphic images and mesalazine plasma levels (PK) in healthy subjects.
- Trial name
- NCT02306772
- Testing
- TP05 Coating A, TP05 Coating B
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Tillotts Pharma AG
Irritable Bowel Syndrome, Colitis, Ulcerative
Advanced Metagenomic Analysis of Human Colonic Microbiota in Patients With Chronic GI Disorders
This clinical trial hypothesize that Gut Microbiota (bacteria, viruses, fungi)play a major role in the occurrence and progression of many chronic gastrointestinal diseases like Irritable Bowel Syndrome, Inflammatory Bowel…
- Conditions
- Irritable Bowel Syndrome, Colitis, Ulcerative, Crohn Disease, Colonic Neoplasms
- Trial name
- NCT01099111
- Where
- Saudi Arabia
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- King Fahad Medical City
Inflammatory Bowel Diseases, Ulcerative Colitis
Health-related Physical Fitness in Patients with Inflammatory Bowel Disease
Rationale: Existing literature suggests an impaired health-related physical fitness (HRPF) (i.e., body composition, aerobic capacity, muscular strength, muscular endurance, and flexibility) in patients with inflammatory bowel…
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT05482932
- Testing
- Health-related physical fitness assessment
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Ulcerative Colitis, Crohn's Colitis
RCT: HDWL vs Virtual Chromoendoscopy in the Detection of Intraepithelial Neoplasia in Longstanding Colitis
Colitis is inflammation of the large bowel and it is often caused by conditions known as ulcerative colitis and Crohn's disease.
- Trial name
- VIRTUOSO (NCT02822352)
- Testing
- Chromoendoscopy
- Where
- United Kingdom
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Inflammatory Bowel Disease, Crohn Disease
Pneumococcal Vaccination in Patients With Inflammatory Bowel Disease
Patients with inflammatory bowel disease (IBD) will be assessed for immunologic response to pneumococcal vaccination. Patients with IBD meet criteria as outlined by the Centers for Disease Control (CDC) for pneumococcal…
- Conditions
- Inflammatory Bowel Disease, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT00829595
- Testing
- 23-valent polysaccharide pneumococcal vaccine (Pneumovax TM)
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Ulcerative Colitis (UC)
Impact of BAFF Gene Polymorphisms on the Risk of Ulcerative Colitis and the Efficacy of Vedolizumab.
Relationships of B-cell Activating Factor Gene Polymorphisms With ulcerative colitis.
- Trial name
- NCT07564895
- Where
- China
- Volunteers
- 841 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Healthy Nutrition
Dietary Impact on Intestinal Sulfate Metabolism
This is a 5-week crossover pilot study of 15 highly motivated healthy volunteers who will consume two 7-day intervention diets: 1) a diet low in sulfur-containing amino acids (Low-S diet), emphasizing plant-based foods and fat…
- Trial name
- NCT05333900
- Testing
- Plant-Based Diet then animal-based diet, Animal-based diet then plant-based diet
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Ulcerative Colitis
The Effects of Moxibustion on Ulcerative Colitis
To investigate the mechanism and effects of moxibustion on patients with ulcerative colitis.
- Trial name
- NCT02931162
- Testing
- Herb-partitioned moxibustion
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian