Clinical trials: Ulcerative Colitis
Ulcerative Colitis
Efficacy and Safety of Rectally Administered BBT-401-1S in Subjects With Ulcerative Colitis
This is an open label, single-arm, proof of mechanism study to explore the efficacy and safety of rectally administered BBT-401-1S in subjects with ulcerative colitis.
- Trial name
- NCT04478825
- Testing
- BBT-401-1S
- Where
- 2 sites in New Zealand
- Volunteers
- 2 people
- Sponsor
- Bridge Biotherapeutics, Inc.
Pharmacokinetics, Safety Issues
A Clinical Study With Adalimumab Biosimilar
The study aims to evaluate the pharmacokinetic profile, safety profile, and immunogenic potential of adalimumab of a new citrate-free formulation of adalimumab (Adalimumab Richmond) [Test Product] vs.
- Trial name
- NCT06291948
- Testing
- Humira® (adalimumab) AC Pen [Reference Product], Adalimumab Richmond [Test Product]
- Where
- Argentina
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Laboratorios Richmond S.A.C.I.F.
Crohn's Disease, Ulcerative Colitis
Treatment With the Specific Carbohydrate Diet for Children With Active Crohns Disease and Ulcerative Colitis
The aim of this study is to determine the tolerability and potential efficacy of dietary therapy, the Specific Carbohydrate Diet (SCD), in pediatric patients with Crohn's disease (CD) and Ulcerative Colitis (UC).
- Trial name
- SCD (NCT02213835)
- Testing
- Specific Carbohydrate diet (SCD)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- David Suskind
Proctitis, Proctosigmoiditis
The Safety and Tolerability of Budesonide Foam in Participants With Active Ulcerative Proctitis or Proctosigmoiditis
The purpose of this study is to evaluate safety and tolerability of cyclically-dosed rectal budesonide foam in participants with active ulcerative proctitis (UP) or ulcerative proctosigmoiditis (UPS).
- Trial name
- NCT01349673
- Testing
- Budesonide Foam
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Bausch Health Americas, Inc.
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)
Study on the Use of Traditional Chinese Medicine Diagnostic Tools to Assist in Identifying the Clinical Characteristics of Inflammatory Bowel Disease and Research on Metabolic Plastids of Tongue Coating
This study will be conducted at the outpatient clinic of China Medical University hospital. It is expected to enroll two groups of 30 subjects, including the experimental group must meet the clinical diagnosis of IBD, and the…
- Trial name
- NCT07314151
- Testing
- No intervention (observational study with diagnostic assessments only)
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Ulcerative Colitis
Combination CurQD and Vedolizumab in Ulcerative Colitis
The purpose of this research study is to test the efficacy and safety of the study intervention, CurQD or placebo (non-active pill), in combination with vedolizumab prescribed as standard of care for patients with ulcerative…
- Trial name
- Curve UC (NCT07665294)
- Testing
- CurQD, Vedolizumab
- Where
- 4 sites in United States, Israel
- Volunteers
- 160 people
- Sponsor
- Ryan C Ungaro
Ulcerative Colitis Mild, Ulcerative Colitis
Treatment of UC With Novel Therapeutics
This study is a clinical trial being done to investigate the efficacy of drug BRS201 as a treatment in patients with active mild ulcerative colitis.
- Trial name
- TURTLE (NCT06420375)
- Testing
- BRS201
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Ulcerative Colitis
A Study to Assess the Safety and Tolerability of PUR 0110 Rectal Enema in Normal Healthy Volunteers
This is a first-in-man study of a novel investigational botanical drug complex, PUR 0110 rectal enema, that has been shown to have potent anti-inflammatory, antioxidant and immunomodulatory effects following in vitro and in vivo…
- Trial name
- NCT01149694
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- PurGenesis Technologies Inc.
Colitis, Ulcerative
Antibiotics for the Treatment of Ulcerative Colitis
Ulcerative colitis (UC) is an acute and chronic inflammatory bowel disease, whose cause is unknown. However, it is widely accepted that bacteria living in the large bowel are essential for the development of the disease.
- Trial name
- NCT00355602
- Testing
- Cefuroxime, Ciprofloxacin, Clarithromycin
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Dundee
Colitis, Ulcerative
An Open Label Phase 4 Study to Evaluate Efficacy of Early Versus Late Use of Vedolizumab in Ulcerative Colitis
This multi-centre open label study will involve a minimum of 120 patients in 2 cohorts: 60 patients with 'early UC' defined as disease duration < 4 years and no other treatments than aminosalicylates and/or corticosteroids and 60…
- Trial name
- LOVE-UC (NCT02646657)
- Testing
- Vedolizumab 300 mg
- Where
- 20 sites in Belgium, Hungary and 1 more
- Volunteers
- 120 people
- Sponsor
- Geert D'Haens
Psoriasis, Colitis, Ulcerative
A Remotely Conducted Study to Assess Concentration of TREMFYA in Breast Milk of Lactating Women Who Are Receiving TREMFYA Therapeutically
The purpose of this post-marketing study is to assess the amount of guselkumab in breast milk of lactating women receiving guselkumab as part of their standard clinical care provided by their treating physician, for any of the…
- Conditions
- Psoriasis, Colitis, Ulcerative, Crohn Disease, Arthritis, Psoriatic
- Trial name
- NCT07654751
- Testing
- Breast Milk Sample Collection, Guselkumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Janssen Research & Development, LLC
Chronic Disease
Integrative Therapy of Chronic Diseases
The observational study aims to investigate the extent to which a two-week stay in an internal medicine clinic for integrative medicine and naturopathy results in an improvement of complaints, impairments, quality of life…
- Trial name
- InteChron (NCT04927403)
- Testing
- multimodal integrative naturopathic therapy concept
- Where
- 3 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Universität Duisburg-Essen
Inflammatory Bowel Diseases
West Hertfordshire Inflammatory Bowel Disease Technology Study
A retrospective and prospective, observational, non-interventional, cohort study to develop quantitative metrics from tools used as standard of care when diagnosing, assessing and monitoring patients with inflammatory bowel…
- Trial name
- WHITS (NCT05000242)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Perspectum
Inflammatory Bowel Disease
Multi-Center African-American Inflammatory Bowel Disease Study (MAAIS)
The investigators are doing the research to discover genes that cause Inflammatory Bowel Disease (IBD) specifically in the African American population.
- Trial name
- MAAIS (NCT01169194)
- Where
- United States
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Inflammatory Disease, Crohn Disease
Monitoring of Inflammatory Conditions
People with inflammatory diseases treated with immune-suppressing medication are recommended to have regular blood-tests to monitor for potential side-effects of this treatment on their blood count, liver and kidneys.
- Conditions
- Inflammatory Disease, Crohn Disease, Ulcerative Colitis, Rheumatoid Arthritis
- Trial name
- NCT05458531
- Testing
- Questionnaire, Semi-structured interview
- Where
- United Kingdom
- Volunteers
- 664 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Crohn´s Disease, Ulcerative Colitis
Endocytoscopy for in Vivo Determination of Mucosal Inflammatory Cells and Intestinal Disease Activity in Inflammatory Bowel Disease (IBD)
Precise activity assessment of inflammatory bowel disease (IBD) is essential to determine the extent and severity of the disease for further specific therapy.
- Trial name
- NCT01289366
- Testing
- Endocytoscopy
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Colitis, Ulcerative
Study to Evaluate the Pharmacodynamics of SB-656933 in Patients With Ulcerative Colitis
This study will involve the use of a new compound, SB-656933. Accumulation of inflammatory white blood cells (mostly polymorphonuclear neutrophils)in the gut (colon) may be contributing to the pathology of ulcerative colitis.
- Trial name
- NCT00748410
- Testing
- SB-656933
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- GlaxoSmithKline
Ulcerative Colitis
Evaluation of SPH3127 in Patients With Mild-to-Moderate Ulcerative Colitis
SPH3127-US-01 is a multi-center, randomized, double-blind, placebo-controlled study to evaluate the safety, pharmacokinetics, and preliminary efficacy of SPH3127 for the treatment of mild-to-moderate ulcerative colitis.
- Trial name
- NCT05019742
- Testing
- SPH3127
- Where
- 16 sites in United States
- Volunteers
- 3 people
- Sponsor
- Shanghai Pharma Biotherapeutics USA Inc.
Inflammatory Bowel Diseases, Colitis, Ulcerative
A Study of Kynteles Injection (Vedolizumab) in Adults With Moderate to Severe Ulcerative Colitis or Crohn's Disease or Chronic Pouchitis
In this study, participants with ulcerative colitis or Crohn's disease or pouchitis will be treated with Kynteles injection (Vedolizumab) according to their clinic's standard practice.
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease
- Trial name
- NCT04799496
- Where
- 43 sites in South Korea
- Volunteers
- 688 people
- Sponsor
- Takeda
Ulcerative Colitis
Efficacy, Pharmacodynamics, Safety and Tolerability of Oral BL-7040 in Patients With Moderately Active Ulcerative Colitis
The objective of the proposed study is to determine whether BL-7040 demonstrates clinical efficacy in patients with inflammatory bowel disease (IBD).
- Trial name
- NCT01506362
- Testing
- BL-7040
- Where
- 5 sites in Israel
- Volunteers
- 22 people
- Sponsor
- BioLineRx, Ltd.