Clinical trials: Ultrafiltration Failure, open to volunteers
Acute Kidney Injury, Fluid Overload
Early Deresuscitation Strategy Driven by Tissue Perfusion in Renal Replacement Therapy in Patients With Acute Renal Failure
In Intensive Care Unit (ICU) patients with acute kidney injury (AKI) and treated with renal replacement therapy (RRT) often present a fluid overload which is associated with morbidity (mechanical ventilation duration increase…
- Trial name
- EarlyDry (NCT05817539)
- Testing
- Fluid balance negativation, Body weight Stabilization
- Where
- 14 sites in France
- Volunteers
- 250 people
- Sponsor
- Hospices Civils de Lyon
Peritoneal Dialysis (PD), End Stage Renal Disease (ESRD)
DKK3 as a Biomarker of Peritoneal Fibrosis in Peritoneal Dialysis Patients
Peritoneal dialysis (PD) uses the peritoneal membrane as a natural filter to remove waste products from the blood in patients with kidney failure.
- Conditions
- Peritoneal Dialysis (PD), End Stage Renal Disease (ESRD), Peritoneal Fibrosis, Ultrafiltration Failure
- Trial name
- PERIMARK (NCT07806708)
- Testing
- Modified Peritoneal Equilibration Test and DKK3 Biomarker Measurement
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Universität des Saarlandes
End-stage Renal Disease
The Microcirculation, Dialysis Modality and Sequestered Salt
The aim of this clinical trial is to investigate the effect of 5 different dialysis treatments (combinations of dialysis mode and dialysis fluid sodium content) on the microcirculation (MC) and sequestered sodium content (SSC) in…
- Trial name
- MIMOSA (NCT06327750)
- Testing
- Hemodialysis (DNa = PNa), Hemodialysis (DNa<PNa), Hemodialysis after isolated ultrafiltration (DNa=PNa)
- Where
- 2 sites in Netherlands
- Volunteers
- 23 people
- Sponsor
- Amsterdam UMC, location VUmc
Congestive Heart Failure
Peritoneal Ultrafiltration in Cardio Renal Syndrome.
Randomized, controlled, unblinded, adaptive design clinical trial to evaluate the safety and efficacy of PolyCore (Polydextrin, L-Carnitine, D-xylitol) peritoneal ultrafiltration (PUF) in patients with heart failure and reduced…
- Trial name
- PURE (NCT03994874)
- Testing
- PolyCore (Polydextrin, L-Carnitine, D-xylitol)
- Where
- 3 sites in Italy
- Volunteers
- 84 people
- Sponsor
- Iperboreal Pharma Srl
End Stage Chronic Renal Failure, Congestive Heart Failure (CHF)
The FILTRATE Trial: High-Rate Ultrafiltration for Intravascular Congestion
The purpose of this study is to evaluate whether a personalized, high-rate fluid removal strategy guided by ultrasound is as safe and effective as the standard fluid removal rate for patients with advanced kidney disease who are…
- Conditions
- End Stage Chronic Renal Failure, Congestive Heart Failure (CHF), Intravascular Congestion, Fluid Overload
- Trial name
- FILTRATE (NCT07705269)
- Testing
- High-rate ultrafiltration, Standard fluid removal
- Where
- Mexico
- Volunteers
- 70 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Fluid Accumulation, Blood Pressure Management
Dry Weight Reduction Intervention Via Extra Ultrafiltration
Most patients who receive hemodialysis treatments have excess fluid in their body that has slowly built up over the course of kidney disease.
- Conditions
- Fluid Accumulation, Blood Pressure Management, End Stage Renal Disease (ESRD)
- Trial name
- DRIVE-UF (NCT07637110)
- Testing
- Ultrafiltration
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Washington
ESRD, CKD (Chronic Kidney Disease) Stage 5D
Effect of Canagliflozin on Ultrafiltration & Fibrosis in Patients on Peritoneal Dialysis
This is a phase II, proof-of-concept, placebo-controlled, double-blind, cross-over randomized clinical trial, assessing the effect of canagliflozin on peritoneal membrane function in patients on PD.
- Trial name
- CAN-PD (NCT06913647)
- Testing
- Canagliflozin 300 MG
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
End Stage Kidney Disease
Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis
Patients treated with hemodialysis (HD) bear increased risk of cardiovascular events, which results in high morbidity and mortality among this cohort of patients.
- Trial name
- ISO-UF (NCT05642156)
- Testing
- isolated Ultrafiltration (iso-UF)
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Medical University of Graz
Renal Failure Acute Chronic
Efficacy and Tolerability of the APD Treatment in PAED Patients
The Silencia PD (peritoneal dialysis) cycler offers a pediatric (PAED) mode with advanced features such as Time and Volume Optimization (TAVO), supporting precise and individualized treatment.
- Trial name
- SilenciaPAED (NCT07004907)
- Testing
- Treatment with the pedriatic mode of the APD cycler
- Volunteers
- 13 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH